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1. Full Text Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease
by Osellame, Laura D and Rahim, Ahad A and Hargreaves, Iain P and Gegg, Matthew E and Richard-Londt, Angela and Brandner, Sebastian and Waddington, Simon N and Schapira, Anthony H.V and Duchen, Michael R
Cell metabolism, ISSN 1550-4131, 06/2013, Volume 17, Issue 6, pp. 941 - 953
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Astrocytes - cytology | Mitochondrial Diseases - genetics | Electron Transport | Glucosylceramidase - genetics | Gaucher Disease - metabolism | Sequestosome-1 Protein | Heat-Shock Proteins - metabolism | Humans | Lysosomes - genetics | Cells, Cultured | Neurons - cytology | Mitochondria - metabolism | Parkinson Disease - genetics | Mice, Knockout | Animals | Gaucher Disease - genetics | Lysosomes - metabolism | Mitochondria - genetics | Mice | Parkinson Disease - metabolism | Autophagy - genetics | Adaptor Proteins, Signal Transducing - metabolism | alpha-Synuclein - metabolism | Disease Models, Animal | Proteins | High technology industry | Neurosciences | Developmental biology | Analysis | Quality control | Mitochondrial DNA | Index Medicus
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2. Pathogenic Mechanisms of Neurodegeneration in Parkinson Disease
by Mullin, Stephen and Schapira, Anthony H.V
Neurologic clinics, ISSN 0733-8619, 2015, Volume 33, Issue 1, pp. 1 - 17
Parkinson disease | α-Synuclein | Mitochondrial dysfunction | Lewy bodies | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Parkinson Disease - complications | Substantia Nigra - pathology | Humans | Protein-Serine-Threonine Kinases | Glucosylceramidase - metabolism | alpha-Synuclein - genetics | Parkinson Disease - genetics | Substantia Nigra - metabolism | Mutation - genetics | Nerve Degeneration - etiology | alpha-Synuclein - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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3. Full Text PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis
by Gegg, Matthew E and Schapira, Anthony H.V
Autophagy, ISSN 1554-8627, 02/2011, Volume 7, Issue 2, pp. 243 - 245
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Mitochondria | PINK1 | Mitofusin | Neurodegeneration | Parkinson disease | Mitophagy | Parkin | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Parkinson Disease - pathology | Humans | Gene Silencing | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Adenosine Triphosphate - biosynthesis | Autophagy | Ubiquitination | Mitochondrial Proteins - metabolism | Parkinson Disease - enzymology | Fluorescent Antibody Technique | Parkinson Disease - etiology | Index Medicus | mitophagy | parkin | mitochondria | neurodegeneration | mitofusin
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4. Full Text Randomized, double‐blind, multicenter evaluation of pramipexole extended release once daily in early Parkinson's disease
by Hauser, Robert A and Schapira, Anthony H.V and Rascol, Olivier and Barone, Paolo and Mizuno, Yoshikuni and Salin, Laurence and Haaksma, Monika and Juhel, Nolwenn and Poewe, Werner
Movement disorders, ISSN 0885-3185, 11/2010, Volume 25, Issue 15, pp. 2542 - 2549
treatment | Parkinson's disease | dopamine agonist | pramipexole extended release | Treatment | Pramipexole extended release | Dopamine agonist | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Biological and medical sciences | Medical sciences | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Severity of Illness Index | Double-Blind Method | Drug Administration Schedule | Levodopa - therapeutic use | Humans | Middle Aged | Male | Treatment Outcome | Parkinson Disease - drug therapy | Antiparkinson Agents - adverse effects | Delayed-Action Preparations - administration & dosage | Patient Satisfaction | Antiparkinson Agents - therapeutic use | Delayed-Action Preparations - adverse effects | Delayed-Action Preparations - therapeutic use | Quality of Life | Female | Aged | Antiparkinson Agents - administration & dosage | Benzothiazoles - therapeutic use | Benzothiazoles - adverse effects | Benzothiazoles - administration & dosage | Index Medicus
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5. Etiology and Pathogenesis of Parkinson Disease
by Schapira, Anthony H.V
Neurologic clinics, ISSN 0733-8619, 08/2009, Volume 27, Issue 3, pp. 583 - 603
Parkinson disease | Proteosome | Oxidative stress | Mitochondria | Alpha-synuclein | Lewy body | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | DNA Polymerase gamma | Protein Kinases - metabolism | Glucosylceramidase - genetics | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Autophagy | DNA-Directed DNA Polymerase - genetics | Serine Endopeptidases - genetics | Ubiquitin Thiolesterase - metabolism | alpha-Synuclein - genetics | Protein-Serine-Threonine Kinases - metabolism | Genetic Predisposition to Disease | Risk Factors | Oncogene Proteins - metabolism | Parkinson Disease - genetics | Parkinson Disease - physiopathology | High-Temperature Requirement A Serine Peptidase 2 | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Protein Deglycase DJ-1 | Animals | Environment | Mutation | Ubiquitin-Protein Ligases - genetics | Parkinson Disease - etiology
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6. Full Text A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers
by Yang, Shi-Yu and Beavan, Michelle and Chau, Kai-Yin and Taanman, Jan-Willem and Schapira, Anthony H.V
Stem cell reports, ISSN 2213-6711, 03/2017, Volume 8, Issue 3, pp. 728 - 742
chaperone | PD modeling | dopaminergic neurons | GBA1 mutation | GBA1-associated PD | Parkinson disease | neural crest stem cells | ambroxol | glucocerebrosidase | α-synuclein | Cell & Tissue Engineering | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Ambroxol - pharmacology | Glucosylceramidase - genetics | Neural Crest - cytology | Humans | Adipose Tissue - cytology | Parkinson Disease - genetics | Enzyme Activation - drug effects | Neural Stem Cells - cytology | Dopaminergic Neurons - cytology | Animals | Neural Crest - embryology | Dopaminergic Neurons - metabolism | Heterozygote | Lysosomal-Associated Membrane Protein 1 - metabolism | Cell Differentiation | Mice | Parkinson Disease - metabolism | Autophagy - genetics | Mutation | Neural Stem Cells - metabolism | alpha-Synuclein - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Index Medicus
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7. Full Text Evaluation of the detection of GBA missense mutations and other variants using the Oxford Nanopore MinION
by Leija‐Salazar, Melissa and Sedlazeck, Fritz J and Toffoli, Marco and Mullin, Stephen and Mokretar, Katya and Athanasopoulou, Maria and Donald, Aimee and Sharma, Reena and Hughes, Derralynn and Schapira, Anthony H.V and Proukakis, Christos
Molecular genetics & genomic medicine, ISSN 2324-9269, 03/2019, Volume 7, Issue 3, pp. e564 - n/a
Oxford Nanopore MinION | Gaucher disease | mutation detection | GBA | mutation phasing | long‐read sequencing | Parkinson’s disease | long-read sequencing | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Glucosylceramidase - genetics | Reproducibility of Results | Gaucher Disease - genetics | Genetic Testing - standards | Humans | Reagent Kits, Diagnostic - standards | Sensitivity and Specificity | Sequence Analysis, DNA - standards | Mutation, Missense | Gaucher Disease - diagnosis | Genetic Testing - methods | Sequence Analysis, DNA - methods | Haplotypes | Parkinson's disease | Splicing | Neurodegenerative diseases | Health risks | Single-nucleotide polymorphism | Gene deletion | Risk analysis | Patients | Risk factors | Phasing | Heterozygosity | Missense mutation | Zygosity | Recombinants | Mutation | Porosity | Movement disorders | Gaucher's disease | Index Medicus
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8. Full Text Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines
by Beretta, Simone and Mattavelli, Laura and Sala, Gessica and Tremolizzo, Lucio and Schapira, Anthony H. V and Martinuzzi, Andrea and Carelli, Valerio and Ferrarese, Carlo
Brain (London, England : 1878), ISSN 0006-8950, 2004, Volume 127, Issue 10, pp. 2183 - 2192
EAAT1 | Leber hereditary optic neuropathy | Glutamate transport | Reactive oxygen species | Cybrids | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction | Neurology | Biological and medical sciences | Medical sciences | Diseases of striated muscles. Neuromuscular diseases | Nervous system (semeiology, syndromes) | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Humans | Hydrogen Peroxide - pharmacology | Glutamates - metabolism | Optic Atrophy, Hereditary, Leber - genetics | Excitatory Amino Acid Transporter 1 - metabolism | Amino Acid Transport System X-AG - metabolism | DNA, Mitochondrial - genetics | Optic Atrophy, Hereditary, Leber - metabolism | Rotenone - pharmacology | Cell Line, Tumor | Biological Transport - genetics | Biological Transport - physiology | Mutation | Energy Metabolism - genetics | Energy Metabolism - physiology | Energy Metabolism - drug effects | Index Medicus | Abridged Index Medicus
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9. Full Text Patterns of treatment for restless legs syndrome in primary care in the United Kingdom
by Martinez, Carlos, MD, MSc and Finnern, Henrik Walter, MSc and Rietbrock, Stephan, MD, MSc and Eaton, Susan, MSc and Chaudhuri, Kallol Ray, MD, FRCP, DSc and Schapira, Anthony H.V., MD, DSc, FRCP, FMedSci
Clinical therapeutics, ISSN 0149-2918, 2008, Volume 30, Issue 2, pp. 405 - 418
Internal Medicine | Medical Education | RLS | UK primary care | restless legs syndrome | treatment patterns | General Practice Research Database | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neurology | Biological and medical sciences | Nervous system as a whole | Medical sciences | Pharmacology. Drug treatments | Nervous system (semeiology, syndromes) | Health Resources - utilization | Clinical Laboratory Techniques - statistics & numerical data | Restless Legs Syndrome - diagnosis | Prevalence | Restless Legs Syndrome - epidemiology | Primary Health Care - statistics & numerical data | Humans | Middle Aged | Male | Treatment Outcome | Referral and Consultation - statistics & numerical data | Case-Control Studies | Databases as Topic | Incidence | Practice Patterns, Physicians' - statistics & numerical data | Drug Prescriptions - statistics & numerical data | Restless Legs Syndrome - drug therapy | Time Factors | Aged, 80 and over | Female | Aged | United Kingdom - epidemiology | Drug Utilization - statistics & numerical data | Cohort Studies | Tranquilizing drugs | Restless legs syndrome | Neurosciences | Care and treatment | Sleep | Analgesics | Antidepressants | Analysis | Family medicine | Universities and colleges | Antianxiety agents | Antidepressants, Tricyclic | Index Medicus
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10. Full Text Non-motor features of Parkinson disease
by Schapira, Anthony H.V and Chaudhuri, K. Ray and Jenner, Peter
Nature reviews. Neuroscience, ISSN 1471-003X, 07/2017, Volume 18, Issue 7, pp. 435 - 450
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Parkinson Disease - complications | Parkinson Disease - pathology | Olfaction Disorders - complications | Humans | Prodromal Symptoms | Sleep Wake Disorders - complications | Parkinson Disease - physiopathology | Constipation - complications | Brain - pathology | Parkinson Disease - diagnosis | Quality of Life | Depression - complications | Early Diagnosis | Neurotransmitter Agents - physiology | Development and progression | Care and treatment | Parkinson's disease | Health aspects | Quality of life | Neurodegenerative diseases | Abnormalities | Parkinsons disease | Disorders | Motors | Mental depression | Anatomy | Motor task performance | Sleep disorders | Sleep | Constipation | Movement disorders | Index Medicus
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