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animals (37) 37
biochemistry & molecular biology (28) 28
sodium-potassium-exchanging atpase - metabolism (25) 25
ouabain (23) 23
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testosterone (15) 15
phosphorylation (14) 14
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dehydroepiandrosterone (10) 10
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na+,k+-atpase (9) 9
physiological aspects (9) 9
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-atpase (6) 6
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cardiac glycosides - pharmacology (6) 6
cyclic amp response element-binding protein - metabolism (6) 6
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cardiotonic agents (4) 4
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catalysis (4) 4
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cnidarian venoms - pharmacology (4) 4
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American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2007, Volume 293, Issue 2, pp. 509 - 536
Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in mammals. Among them are the hydrophilic cardenolide ouabain and the... 
Cell proliferation | Arterial hypertension | Endogenous cardiotonic steroids | Rostafuroxin | Sodium/potassium-adenosinetriphosphatase | Cancer therapy | Ouabain | Marinobufagenin | Sodium pump | Oleandrin | Bufalin | Sodium metabolism | ouabain | PROTEIN-KINASE-C | PHYSIOLOGY | BOVINE ADRENOCORTICAL-CELLS | BUFALIN INDUCES APOPTOSIS | PLASMALEMMAL NA/K-ATPASE | cell proliferation | SIGNAL-TRANSDUCING FUNCTION | endogenous cardiotonic steroids | FACTOR-KAPPA-B | oleandrin | sodium/potassium-adenosinetriphosphatase | VASCULAR SMOOTH-MUSCLE | NA+-K+-ATPASE | CELL BIOLOGY | arterial hypertension | cancer therapy | OUABAIN-LIKE COMPOUND | sodium pump | DIGITALIS-LIKE COMPOUNDS | bufalin | rostafuroxin | sodium metabolism | marinobufagenin | Cardiac Glycosides - pharmacology | Neoplasms - metabolism | Antihypertensive Agents - pharmacology | Digoxin - metabolism | Calcium - metabolism | Humans | Myocardial Contraction - drug effects | Hypertension - drug therapy | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Antihypertensive Agents - metabolism | Ouabain - metabolism | Antineoplastic Agents - metabolism | Bufanolides - metabolism | Antineoplastic Agents - pharmacology | Blood Pressure - drug effects | Molecular Structure | Cell Death - drug effects | Sodium Chloride - metabolism | Ouabain - pharmacology | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Diabetes Mellitus - metabolism | Cardiovascular System - drug effects | Antihypertensive Agents - therapeutic use | Antineoplastic Agents - chemistry | Digoxin - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Neoplasms - drug therapy | Antihypertensive Agents - chemistry | Sodium-Potassium-Exchanging ATPase - metabolism | Animals | Myocytes, Cardiac - drug effects | Cardiovascular System - metabolism | Diabetes Mellitus - physiopathology | Cardiac Glycosides - chemistry | Myocytes, Cardiac - metabolism | Bufanolides - pharmacology | Cardiac Glycosides - metabolism | Cardiac Glycosides - therapeutic use | Cell Proliferation - drug effects | Neoplasms - pathology
Journal Article
The Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 05/2018, Volume 179, p. 73
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 06/2014, Volume 1843, Issue 6, pp. 1172 - 1181
Testosterone is known to mediate its effects by two different mechanisms of action. In the so-called “classical” pathway testosterone binds to cytosolic... 
Erk1/2 | Testosterone | Signaling | Gnα11 | CREB | Androgen receptor | Spermatogenic cell | GPCR | ATF-1
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 07/2019, Volume 191, p. 105372
Cardiotonic steroids such as ouabain are potent inhibitors of the sodium pump and have been widely used for centuries in the treatment of congestive heart... 
Sodium pump | Steroidogenesis | Lipid droplet | Perilipin | Leydig cells | Ouabain | Phosphorylation | Seminal fluid | Extracellular signal-regulated kinase | Biosynthesis | siRNA | Congestive heart failure | Na+/K+-exchanging ATPase | Cyclic AMP response element-binding protein | Sodium | Somatic cells | Isoforms | Luteinizing hormone | Physiology | Progesterone | Steroid hormones
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 08/2017, Volume 1864, Issue 8, pp. 1382 - 1392
Tight junctions (TJ) between brain endothelial cells are essential for formation and maintenance of the blood-brain barrier (BBB). Although loss of BBB... 
Blood-brain-barrier | Tight junction | Gnα11 | DHEAS | ZO-1 | Claudin | LOCALIZATION | ACTIVATION | PDZ DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | CELL BIOLOGY | DISRUPTION | INHIBITION | ADHESION MOLECULE | BIOSYNTHESIS | Gn alpha 11 | ZONULA OCCLUDENS-1 | RNA, Small Interfering - genetics | GTP-Binding Protein alpha Subunits - antagonists & inhibitors | Receptors, Androgen - metabolism | Blood-Brain Barrier - ultrastructure | Brain - blood supply | Endothelial Cells - ultrastructure | Claudin-3 - genetics | Claudin-3 - metabolism | Zonula Occludens-1 Protein - metabolism | Tight Junctions - drug effects | Tight Junctions - metabolism | Zonula Occludens-1 Protein - agonists | Zonula Occludens-1 Protein - genetics | Cell Line | GTP-Binding Protein alpha Subunits - metabolism | Signal Transduction | Endothelial Cells - metabolism | Dehydroepiandrosterone Sulfate - pharmacology | Gene Expression Regulation | GTP-Binding Protein alpha Subunits - genetics | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Brain - drug effects | Tight Junctions - ultrastructure | Animals | Receptors, Androgen - genetics | Mice | Endothelial Cells - drug effects | RNA, Small Interfering - metabolism | Proteins | Testosterone | Brain | Dehydroepiandrosterone | Nervous system diseases | Physiological aspects | Sulfates | Endothelium
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 12/2013, Volume 1833, Issue 12, pp. 3064 - 3075
Dehydroepiandrosterone sulfate (DHEAS) is a circulating steroid produced in the adrenal cortex, brain, and gonads. Whereas a series of investigations attest to... 
Erk1/2 | Signaling | Gnα11 | DHEAS | CREB | Androgen receptor | ATF-1 | Spermatogenic cells
Journal Article
Cardiovascular Research, ISSN 0008-6363, 01/2011, Volume 89, Issue 1, pp. 6 - 8
Journal Article
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 11/2016, Volume 1863, Issue 11, pp. 2809 - 2819
In addition to the ubiquitous α1 isoform of the sodium pump, sperm cells also express a male-specific α4 isoform whose function has been associated with sperm... 
spermatogenic cells | sodium pump | signaling | integrin | Ouabain | alpha4 isoform
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 11/2016, Volume 1863, Issue 11, p. 2809
In addition to the ubiquitous [alpha]1 isoform of the sodium pump, sperm cells also express a male-specific [alpha]4 isoform whose function has been associated... 
RNA | Cardiotonic agents | Ouabain | Cyclic adenylic acid | Steroid hormones | Cardiac glycosides | Integrins
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 06/2014, Volume 1843, Issue 6, p. 1172
Testosterone is known to mediate its effects by two different mechanisms of action. In the so-called "classical" pathway testosterone binds to cytosolic... 
Testosterone | Physiological aspects | Steroid hormones
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 12/2013, Volume 1833, Issue 12, p. 3064
Dehydroepiandrosterone sulfate (DHEAS) is a circulating steroid produced in the adrenal cortex, brain, and gonads. Whereas a series of investigations attest to... 
Testosterone | Dehydroepiandrosterone | RNA | Physiological aspects | DNA binding proteins | Sulfates | Protein binding
Journal Article
Molecular Reproduction and Development, ISSN 1040-452X, 12/2016, Volume 83, Issue 12, pp. 1092 - 1101
Journal Article