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Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 288 - 297
Impaired erythropoiesis in the deletion 5q (del(5q)) subtype of myelodysplastic syndrome (MDS) has been linked to heterozygous deletion of RPS14; which encodes... 
MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN 5Q-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | DELETION 5Q | RISK MYELODYSPLASTIC SYNDROME | CELL BIOLOGY | HEMATOPOIETIC STEM-CELLS | MOUSE MODEL | DIAMOND-BLACKFAN ANEMIA | MYELOID-LEUKEMIA | SUPPRESSOR-CELLS | UP-REGULATION | Immunohistochemistry | Calgranulin A - metabolism | Humans | Immunity, Innate - genetics | Calgranulin A - genetics | Tumor Suppressor Protein p53 - genetics | Anemia - genetics | Flow Cytometry | Mass Spectrometry | Calgranulin B - genetics | Megakaryocytes | Cytokines - immunology | Disease Models, Animal | Erythropoiesis - genetics | Haploinsufficiency - genetics | Anemia - immunology | Ribosomal Proteins - genetics | In Situ Hybridization, Fluorescence | Blotting, Western | Mice, Knockout | Immunity, Innate - immunology | Microscopy, Confocal | Animals | Bone Marrow - pathology | Fluorescent Antibody Technique | Erythroid Precursor Cells - metabolism | Mice | Myelodysplastic Syndromes - genetics | In Vitro Techniques | Myelodysplastic Syndromes - pathology | Myelodysplastic Syndromes - immunology | Erythropoiesis - immunology | Hematopoietic Stem Cells | Erythropoiesis | Physiological aspects | Genetic aspects | Research | Cell differentiation | Hematopoietic stem cells | Proteins | Gene expression | Anemia | Erythrocytes | Apoptosis | Immune system
Journal Article
Nature, ISSN 0028-0836, 09/2018, Volume 561, Issue 7721, pp. 132 - 136
The human genome contains thousands of long non-coding RNAs1, but specific biological functions and biochemical mechanisms have been discovered for only about... 
INSTABILITY | GENE | NONCODING RNAS | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | SITES | HOMOLOGOUS RECOMBINATION | WIDE | REPLICATION STRESS | RNA-BINDING PROTEIN | Genomic Instability | Humans | RNA Splicing Factors - metabolism | Multiprotein Complexes - metabolism | Cell Nucleus - metabolism | Mass Spectrometry | DNA Repair Enzymes - metabolism | Binding Sites | Chromosome Segregation | DNA Topoisomerases, Type I - metabolism | Cell Survival | Cell Cycle Proteins - metabolism | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | DNA Replication | Nuclear Proteins - metabolism | RNA, Long Noncoding - genetics | Ribonucleoproteins - metabolism | Transcription Factors - metabolism | Multiprotein Complexes - chemistry | Cell Cycle | DNA Repair | Protein Binding | DNA Damage | RNA, Long Noncoding - metabolism | RNA-Binding Proteins - metabolism | RNA sequencing | Physiological aspects | Topoisomerases | Methods | Protein purification | DNA damage | Genomes | Experiments | DNA repair | Defects | Genomic instability | Proteins | Damage | Localization | Bioinformatics | Deoxyribonucleic acid--DNA | Phenotypes | Stability | DNA topoisomerase | Antisense RNA | Mass spectroscopy | Mammals | Gene expression | Suppressors | DNA biosynthesis | RNA-binding protein | Ribonucleic acids | Proteomics | Replication | Instability | Software | Scientific imaging | Nuclei (cytology) | Mass spectrometry | Non-coding RNA | Binding sites
Journal Article
Cancer Research, ISSN 0008-5472, 02/2017, Volume 77, Issue 3, pp. 753 - 765
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2009, Volume 106, Issue 12, pp. 4617 - 4622
Journal Article
Science, ISSN 0036-8075, 03/2018, Volume 359, Issue 6380, pp. 1161 - 1166
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 06/2017, Volume 24, Issue 19, pp. 2059 - 2085
The pyrrolo[2,3-d] pyrimidine nucleus is a deaza-isostere of adenine, the nitrogenous base of ATP, and is present in many ATP-competitive inhibitors of... 
Patents | Anticancer agents | Kinase inhibitors | Pyrrolo[2,3-d]pyrimidine | Anti-inflammatory agents | CHEMISTRY, MEDICINAL | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | DISCOVERY | anticancer agents | CYCLIN-DEPENDENT KINASES | BRAIN PENETRANT | BTK INHIBITORS | kinase inhibitors | RECEPTOR TYROSINE KINASES | IN-VIVO | patents | PHARMACOLOGY & PHARMACY | anti-inflammatory agents | HIGHLY POTENT | 4 IRAK4 | Anti-Inflammatory Agents - pharmacology | Humans | Neoplasms - enzymology | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Pyrimidines - chemistry | Neoplasms - drug therapy | Protein Kinase Inhibitors - chemistry | Pyrroles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Inflammation - drug therapy | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Drug Design | Anti-Inflammatory Agents - therapeutic use | Pyrroles - chemistry | Antineoplastic Agents - pharmacology | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Pyrroles - therapeutic use | Inflammation - enzymology | Medical research | Medical treatment | Clinical trials | Adenine | Derivatives | Kinases | Nuclei | Myeloproliferative diseases | Pyrimidines | Inhibitors | Pyrrolo[2,3-d]Pyrimidines | ATP
Journal Article
Nature, ISSN 0028-0836, 04/2019, Volume 568, Issue 7753, pp. 551 - 556
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2018, Volume 71, Issue 4, pp. 554 - 566.e7
Chromosomal rearrangements resulting in the fusion of , an androgen-regulated gene, and the ETS family transcription factor occur in over half of prostate... 
SWI/SNF (BAF) complexes | transcription factor | prostate cancer | TMPRSS2-ERG | ATP-dependent chromatin remodeling | ETS transcription factors | chromatin | epigenetics | ETS TRANSCRIPTION FACTORS | GENE FUSIONS | ANDROGEN RECEPTOR | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | ETV1 | ERG | CANCER PROGRESSION | IDENTIFICATION | FAMILY | CELL BIOLOGY | Chromatin - metabolism | Prostatic Neoplasms - metabolism | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Transcriptional Regulator ERG - metabolism | Male | Prostate - metabolism | DNA-Binding Proteins - metabolism | Prostate - pathology | Prostatic Neoplasms - genetics | Adenovirus E1A Proteins - metabolism | Organoids - metabolism | HEK293 Cells | Serine Endopeptidases - genetics | Nuclear Proteins - genetics | Binding Sites | Chromatin - chemistry | Proto-Oncogene Proteins - metabolism | Prostatic Neoplasms - pathology | Organoids - pathology | Signal Transduction | Carcinogenesis - genetics | Chromatin Assembly and Disassembly | Mice, Transgenic | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | DNA - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA - genetics | Transcription Factors - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Adenovirus E1A Proteins - genetics | Cell Line, Tumor | Protein Binding | Serine Endopeptidases - metabolism | Transcriptional Regulator ERG - genetics | Epigenetic inheritance | Anopheles | Chromatin | Analysis | Genes | Genomics | DNA binding proteins | Genetic transcription | Prostate cancer | Adenosine triphosphatase
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 09/2018, Volume 14, Issue 9, pp. 844 - 852
Primordial germ cells (PGCs) form during early embryogenesis with a supply of maternal mRNAs that contain shorter poly(A) tails. How translation of maternal... 
Embryonic growth stage | Poly(A) | Translation | Embryogenesis | Germ cells | Zebrafish | Regulatory sequences | Embryos | Mammalian cells | Painting
Journal Article