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Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2009, Volume 9, Issue 11, pp. 1038 - 1048
The p38 kinase plays a central role in inflammation, and it has been the subject of extensive efforts in both basic research and drug discovery. This review... 
C-REACTIVE PROTEIN | RHEUMATOID-ARTHRITIS | SKELETAL-MUSCLE | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | MONOCYTE-CHEMOATTRACTANT PROTEIN-1 | SPINAL NERVE LIGATION | SMOOTH-MUSCLE-CELLS | PRIMARY SENSORY NEURONS | NF-KAPPA-B | P38 MAP KINASE
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, p. e0187580
Background There are no effective treatments or validated clinical response markers in systemic sclerosis (SSc). We assessed imaging biomarkers and performed... 
MOLECULAR SIGNATURES | GROWTH-FACTOR-BETA | SCLERODERMA LUNG | CHRONIC-PHASE | MULTIDISCIPLINARY SCIENCES | DURABLE CYTOGENETIC RESPONSES | KINASE INHIBITOR | IDIOPATHIC PULMONARY-FIBROSIS | IMATINIB MESYLATE | PDGF RECEPTOR | CHRONIC MYELOID-LEUKEMIA | Biomarkers - metabolism | Lung Diseases, Interstitial - etiology | Scleroderma, Systemic - diagnostic imaging | Lung Diseases, Interstitial - metabolism | Scleroderma, Systemic - diet therapy | Skin - metabolism | Humans | Middle Aged | Scleroderma, Systemic - metabolism | Male | Tomography, X-Ray Computed | Lung Diseases, Interstitial - drug therapy | Gene Expression Regulation - drug effects | Lung Diseases, Interstitial - diagnostic imaging | Dasatinib - administration & dosage | Scleroderma, Systemic - complications | Skin - diagnostic imaging | Adult | Female | Aged | Dasatinib | Lung diseases, Interstitial | Systemic scleroderma | Scleroderma (Disease) | Dosage and administration | Genetic aspects | Research | Gene expression | Biological markers | Drug therapy | Respiratory function | Medical services | Clinical trials | Arthritis | Kinases | Computed tomography | Bioindicators | Carbon monoxide | Safety | Scleroderma | Growth factors | Protein-tyrosine kinase | Tyrosine | Medical imaging | Cytokines | Therapeutic applications | Lung diseases | Medical treatment | Pharmacology | Inflammation | Assessments | Patients | Medicine | Lungs | Biopsy | Systemic sclerosis | Fibrosis | Pulmonary functions | Biomarkers | Skin | Pharmacokinetics
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2011, Volume 21, Issue 15, p. 4633
Pyrrolo[2,1-f][1,2,4]triazine based inhibitors of p38[alpha] have been prepared exploring functional group modifications at the C6 position. Incorporation of... 
Ketones | Analysis
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2010, Volume 20, Issue 23, p. 6886
The synthesis and structure-activity relationships (SAR) of p38[alpha] MAP kinase inhibitors based on a 5-amino-pyrazole scaffold are described. These studies... 
Journal Article
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 12/2010, Volume 20, Issue 23, pp. 6886 - 6889
The synthesis and structure-activity relationships (SAR) of p38a MAP kinase inhibitors based on a 5-amino-pyrazole scaffold are described. These studies led to... 
Animal models
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2006, Volume 49, Issue 23, pp. 6819 - 6832
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/1997, Volume 272, Issue 17, pp. 11541 - 11549
The role of intracellular oxidative stress in the mechanism of action of phosphotyrosine phosphatase (PTP) inhibitors was studied using three vanadium-based... 
SIGNAL-TRANSDUCTION | KINASE-ACTIVITY | PHOSPHORYLATION | RAT ADIPOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE PHOSPHATASES | T-CELL ACTIVATION | VANADATE | INDUCTION | TRANSCRIPTION FACTOR | LYMPHOCYTES-T
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2004, Volume 14, Issue 24, pp. 6061 - 6066
A series of substituted 2-(aminoheteroaryl)-thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase 56 .... 
pan-Src-family inhibitor | Lck inhibitor
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 06/2017, Volume 60, Issue 12, pp. 5193 - 5208
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2017, Volume 27, Issue 14, pp. 3101 - 3106
Journal Article
Current topics in medicinal chemistry, 2009, Volume 9, Issue 11, p. 1038
The p38 kinase plays a central role in inflammation, and it has been the subject of extensive efforts in both basic research and drug discovery. This review... 
Signal Transduction | Arthritis, Rheumatoid - drug therapy | Protein Kinase Inhibitors - therapeutic use | Humans | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | Inflammation - enzymology
Journal Article
Journal Article
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