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Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. SCI-11 - SCI-11
Abstract AML (Acute Myeloid Leukemia) is an aggressive hematologic malignancy with a high rate of relapse. Therefore, it is important to identify novel... 
Journal Article
Cancer Research, ISSN 0008-5472, 10/2004, Volume 64, Issue 20, pp. 7183 - 7190
The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing... 
CYTOCHROME-C | BACULOVIRUS INHIBITOR | SURVIVIN EXPRESSION | X-LINKED INHIBITOR | ONCOLOGY | STRUCTURAL BASIS | IN-VIVO | ENDOTHELIAL-CELLS | SERINE-PROTEASE | LUNG-CANCER CELLS | CASPASE ACTIVATION | Proteins - physiology | Animals | Caspases - metabolism | Inhibitor of Apoptosis Proteins | Isoenzymes | Humans | Apoptosis - physiology | Enzyme Activation | Caspase Inhibitors
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 07/2018, Volume 23, Issue 1, pp. 3 - 4
In this issue of , demonstrate that leukemic stem cells (LSCs) have enhanced mitochondrial fission, which is positively regulated by FIS1. FIS1 is necessary to... 
CELLS | INHIBITION | ACUTE MYELOID-LEUKEMIA | CELL & TISSUE ENGINEERING | CELL BIOLOGY
Journal Article
Science, ISSN 0036-8075, 2014, Volume 344, Issue 6180, pp. 208 - 211
Journal Article
Core Evidence, ISSN 1555-1741, 03/2013, Volume 8, pp. 15 - 26
Obatoclax mesylate is an intravenously-administered drug under investigation in Phase I and II clinical trials as a novel anticancer therapeutic for... 
BCL-2 | Myelofibrosis | Obatoclax | Lymphoma | Leukemia | BH3 mimetic | Antimitotic agents | Reports | Dosage and administration | Lymphomas | Research | Antineoplastic agents | Drug therapy | Hematology | Cancer | Apoptosis | obatoclax | leukemia | myelofibrosis | lymphoma | Review
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5132 - 11
The role of mitochondria dynamics and its molecular regulators remains largely unknown during naive-to-primed pluripotent cell interconversion. Here we report... 
TRANSITION | TARGET | HOMEOSTASIS | ACETYL-COA | METABOLISM | PATHWAY | MULTIDISCIPLINARY SCIENCES | DYNAMICS | MUSCLE | DIFFERENTIATION | FATE | Regulators | Embryo cells | Stem cell transplantation | Metabolism | Embryos | Proteins | Mitochondria | Stem cells | Dynamin | Acetylation | Fusion protein | Pluripotency | Elongation | Glutamine
Journal Article
Nature, ISSN 0028-0836, 12/2016, Volume 540, Issue 7633, pp. 433 - 437
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e30215
The low frequency of p53 alterations e.g., mutations/deletions (similar to 10%) in multiple myeloma (MM) makes this tumor type an ideal candidate for... 
EFFICIENT APOPTOSIS | IN-VITRO | ACTIVATED PROTEIN-KINASE | ANTIMYELOMA ACTIVITY | MULTIDISCIPLINARY SCIENCES | N-TERMINAL KINASE | JUN NH2-TERMINAL KINASE | DEPENDENT APOPTOSIS | C-JUN | STRESS | SMALL-MOLECULE RITA | Cell Line | Cell Survival - drug effects | Apoptosis - drug effects | Furans - pharmacology | Humans | Tumor Suppressor Protein p53 - metabolism | Immunoblotting | JNK Mitogen-Activated Protein Kinases - metabolism | Multiple Myeloma - metabolism | Chromatin Immunoprecipitation | Signal Transduction - drug effects | Cell Line, Tumor | In Vitro Techniques | Real-Time Polymerase Chain Reaction | Chromatin | RNA | Genes | Analysis | Genetic aspects | Tumor proteins | Gene expression | Protein binding | Apoptosis | Drugs | Transcription factors | Phosphorylation | Substance abuse treatment | Immunoprecipitation | Nuclear magnetic resonance--NMR | Laboratories | p53 Protein | Leukemia | Genotoxicity | Multiple myeloma | Cytotoxicity | Feedback loops | Kinases | Positive feedback | Proteins | Angiogenesis | Signal transduction | Health care networks | Transcription activation | Life sciences | Inhibition | Medical research | Dexamethasone | Hematology | Tumor cells | Activator protein 1 | c-Jun protein | siRNA | Ribonucleic acid--RNA | Medicine | Signaling | Hospitals | DNA microarrays | Molecular modelling | Inhibitors | Cellular biology | Cell lines | Mutation | Disruption | Binding sites | Cancer | Nuclear magnetic resonance | Ribonucleic acid | NMR
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e78641
Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available.... 
KINASE 4/6 INHIBITOR | INITIATING CELLS | BASAL-LIKE | PATHWAY DISRUPTION | PHASE-II TRIAL | NEOADJUVANT CHEMOTHERAPY | CONSERVING SURGERY | MULTIDISCIPLINARY SCIENCES | RETINOBLASTOMA TUMOR-SUPPRESSOR | ANTITUMOR-ACTIVITY | PD 0332991 | Methotrexate - pharmacology | Doxorubicin - therapeutic use | Pharmacogenetics | Oligonucleotide Array Sequence Analysis | Neoplasm Invasiveness | Neoplastic Stem Cells - drug effects | Humans | Retinoblastoma Protein - metabolism | Gamma Rays - therapeutic use | Retinoblastoma Protein - deficiency | Treatment Outcome | Antineoplastic Agents - therapeutic use | Methotrexate - therapeutic use | Triple Negative Breast Neoplasms - drug therapy | Triple Negative Breast Neoplasms - metabolism | Triple Negative Breast Neoplasms - pathology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Triple Negative Breast Neoplasms - radiotherapy | Doxorubicin - pharmacology | Neoplastic Stem Cells - radiation effects | Anthracyclines | Chemotherapy | Stem cells | Radiation | Breast cancer | Methotrexate | Radiotherapy | Health aspects | Drug approval | Fluorouracil | Cancer | Drugs | Biotechnology | Phosphorylation | 5-Fluorouracil | Laboratories | Kinases | Cancer therapies | Doxorubicin | Proteins | CD44 antigen | Health care networks | Cell cycle | Epirubicin | Antineoplastic drugs | Radiation therapy | Patients | Cisplatin | Sensitivity | Hospitals | Fludarabine | Cell lines | Irradiation | Tumor suppressor genes | Mutation | Retinoblastoma | Tumors
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 20, Issue 5, pp. 674 - 688
Journal Article
Cancer Discovery, ISSN 2159-8274, 07/2017, Volume 7, Issue 7, pp. 670 - 672
Journal Article