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Annals of the New York Academy of Sciences, ISSN 0077-8923, 03/2010, Volume 1192, Issue 1, pp. 317 - 321
In recent years, it has been proposed that oxygen is not only an indispensable metabolic substrate, but also a regulatory signal, and that gradients of... 
collagen | hypoxia | chondrocytes | Hif-1α | VHL | matrix | Stem cells | Hypoxia | Rodents | Mutation
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 04/2010, Volume 1192, Issue 1, pp. 317 - 321
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 03/2010, Volume 1192, Issue 1, pp. 317 - 321
In recent years, it has been proposed that oxygen is not only an indispensable metabolic substrate, but also a regulatory signal, and that gradients of... 
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 04/2006, Volume 1068, Issue 1, pp. 66 - 73
:  In endochondral bone development chondrocytes undergo proliferation, hypertrophic differentiation, mineralization of the surrounding matrix, death, blood... 
hypoxia | HIF‐1α | chondrocytes | VHL | VEGF | Hypoxia | HIF-1α | Chondrocytes | HIF-1 alpha | VEGF ISOFORMS | ANGIOGENESIS | INDUCIBLE FACTOR 1-ALPHA | PROLYL HYDROXYLATION | ENDOCHONDRAL BONE-FORMATION | MULTIDISCIPLINARY SCIENCES | CELL-PROLIFERATION | EPIPHYSEAL CHONDROCYTES | GENE-EXPRESSION | GROWTH-PLATE | SKELETAL DEVELOPMENT
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2016, Volume 113, Issue 3, pp. E338 - E347
Pathologic extraskeletal bone formation, or heterotopic ossification (HO), occurs following mechanical trauma, burns, orthopedic operations, and in patients... 
Cartilage | Heterotopic ossification | Mesenchymal condensation | HIF1α | Prx | HYPOXIA-INDUCIBLE FACTOR | PX-478 | RISK-FACTORS | MULTIDISCIPLINARY SCIENCES | cartilage | heterotopic ossification | RECEPTOR | mesenchymal condensation | CANCER | HUMAN SKELETAL-MUSCLE | BONE-FORMATION | IN-VIVO | HIF1 alpha | GROWTH-FACTOR | HIF-1-ALPHA | Ossification, Heterotopic - drug therapy | Chondrogenesis - drug effects | Mustard Compounds - pharmacology | Chondrogenesis - genetics | Tendons - drug effects | Humans | Tenotomy | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Luminescent Measurements | Gene Regulatory Networks - drug effects | RNA, Messenger - metabolism | X-Ray Microtomography | Adipose Tissue - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tendons - surgery | Integrases - metabolism | Burns - complications | Wound Healing - drug effects | Disease Models, Animal | SOX9 Transcription Factor - metabolism | Mesenchymal Stromal Cells - drug effects | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Wounds and Injuries - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Messenger - genetics | Wounds and Injuries - complications | Ossification, Heterotopic - diagnostic imaging | Activin Receptors, Type I - metabolism | Sirolimus - pharmacology | Mice, Knockout | Up-Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Signal Transduction - drug effects | Models, Biological | Tendons - pathology | Ossification, Heterotopic - prevention & control | Ossification, Heterotopic - genetics | Adipose Tissue - drug effects | Burns - genetics | Biological Sciences | PNAS Plus
Journal Article
Bone, ISSN 8756-3282, 2010, Volume 47, Issue 2, pp. 190 - 196
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2013, Volume 19, Issue 11, pp. 1513 - 1517
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 03/2013, Volume 5, Issue 3, pp. 430 - 440
Mesenchymal stem cells (MSCs) are multi‐potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines... 
fat | bone | sirtuin | mesenchymal stem cells | cartilage | Fat | Cartilage | Bone | Sirtuin | Mesenchymal stem cells | MEDICINE, RESEARCH & EXPERIMENTAL | LIFE-SPAN | OXIDATIVE STRESS | OSTEOBLAST DIFFERENTIATION | BONE-MARROW | RUNX2 GENE-EXPRESSION | PROMOTES PROLIFERATION | CAENORHABDITIS-ELEGANS | STROMAL CELLS | SUPPRESSES OSTEOGENIC DIFFERENTIATION | CALORIE RESTRICTION | Mesenchymal Stromal Cells - enzymology | Sirtuin 1 - metabolism | Age Factors | Male | Green Fluorescent Proteins - genetics | Sirtuin 1 - genetics | Cell Differentiation - genetics | Blastomeres - metabolism | Cell Nucleus - metabolism | Time Factors | Female | Transcription, Genetic | Acetylation | Sirtuin 1 - deficiency | Chondrogenesis | Chondrocytes - metabolism | Adipogenesis | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Genotype | Mice, Transgenic | Mice, SCID | beta Catenin - metabolism | beta Catenin - genetics | Mice, Knockout | Phenotype | Animals | Embryo Transfer | Green Fluorescent Proteins - biosynthesis | Adipocytes - metabolism | Mice | Mutation | Osteoblasts - metabolism | Mesenchymal Stem Cell Transplantation | Osteogenesis | Apoptosis | Transcription | Mesenchyme | Stem cell transplantation | Arthritis | Adipocytes | Myocytes | Kinases | Bone (trabecular) | Osteoblasts | Nuclei | Experiments | Aging | Bone marrow | Bone (cortical) | Localization | Catenin | Immunoglobulins | Cell differentiation | Metabolism | Gene expression | SIRT1 protein | Osteoblastogenesis | Deacetylation | Chondrocytes | Stem cells | Software | Binding sites
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 09/2016, Volume 31, Issue 9, pp. 1652 - 1665
Journal Article