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Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 1, pp. 25 - 35
Summary Background Palbociclib (PD-0332991) is an oral, small-molecule inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 with preclinical evidence of... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | EXEMESTANE | ONCOLOGY | CELL-CYCLE | POSTMENOPAUSAL WOMEN | HER2 | PLUS | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Piperazines - administration & dosage | Triazoles - administration & dosage | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Receptors, Estrogen - analysis | Molecular Targeted Therapy | North America | Nitriles - administration & dosage | Breast Neoplasms - enzymology | Time Factors | Postmenopause | Female | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Republic of Korea | Aromatase Inhibitors - administration & dosage | Pyridines - administration & dosage | Drug Administration Schedule | Administration, Oral | Biomarkers, Tumor - analysis | Europe | Proportional Hazards Models | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Treatment Outcome | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Breast Neoplasms - drug therapy | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Breast Neoplasms - genetics | Cyclin D1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Intention to Treat Analysis | South Africa | Aged | Biomarkers, Tumor - genetics | Receptor, ErbB-2 - analysis | Antimitotic agents | Care and treatment | Oncology, Experimental | Estrogen | Breast cancer | Research | Antineoplastic agents | Phosphotransferases | Cancer
Journal Article
by Voight, Benjamin F, PhD and Peloso, Gina M, PhD and Orho-Melander, Marju, PhD and Frikke-Schmidt, Ruth, DMSc and Barbalic, Maja, PhD and Jensen, Majken K, PhD and Hindy, George, MD and Hólm, Hilma, MD and Ding, Eric L, ScD and Johnson, Toby, PhD and Schunkert, Heribert, Prof and Samani, Nilesh J, Prof and Clarke, Robert, MD and Hopewell, Jemma C, PhD and Thompson, John F, Prof and Li, Mingyao, PhD and Thorleifsson, Gudmar, PhD and Newton-Cheh, Christopher, MD and Musunuru, Kiran, MD and Pirruccello, James P, BS and Saleheen, Danish, MBBS and Chen, Li, MSc and Stewart, Alexandre FR, PhD and Schillert, Arne, PhD and Thorsteinsdottir, Unnur, PhD and Thorgeirsson, Gudmundur, MD and Anand, Sonia, Prof and Engert, James C, PhD and Morgan, Thomas, MD and Spertus, John, Prof and Stoll, Monika, Prof and Berger, Klaus, Prof and Martinelli, Nicola, MD and Girelli, Domenico, Prof and McKeown, Pascal P, Prof and Patterson, Christopher C, PhD and Epstein, Stephen E, MD and Devaney, Joseph, PhD and Burnett, Mary-Susan, PhD and Mooser, Vincent, MD and Ripatti, Samuli, PhD and Surakka, Ida, BSci and Nieminen, Markku S, Prof and Sinisalo, Juha, MD and Lokki, Marja-Liisa, PhD and Perola, Markus, Prof and Havulinna, Aki, PhD and de Faire, Ulf, Prof and Gigante, Bruna, MD and Ingelsson, Erik, PhD and Zeller, Tanja, PhD and Wild, Philipp, MD and de Bakker, Paul I W, Prof and Klungel, Olaf H, PhD and Maitland-van der Zee, Anke-Hilse, PhD and Peters, Bas J M, PhD and de Boer, Anthonius, Prof and Grobbee, Diederick E, Prof and Kamphuisen, Pieter W, PhD and Deneer, Vera H M, PhD and Elbers, Clara C, PhD and Onland-Moret, N Charlotte, PhD and Hofker, Marten H, Prof and Wijmenga, Cisca, Prof and Verschuren, WM Monique, PhD and Boer, Jolanda MA, PhD and van der Schouw, Yvonne T, Prof and Rasheed, Asif and Frossard, Philippe and Demissie, Serkalem, PhD and Willer, Cristen, PhD and Do, Ron, PhD and Ordovas, Jose M, Prof and Abecasis, Gonçalo R, Prof and Boehnke, Michael, Prof and Mohlke, Karen L, PhD and Daly, Mark J, PhD and Guiducci, Candace, BS and Burtt, Noël P, BS and Surti, Aarti, BS and Gonzalez, Elena, BS and Purcell, Shaun, PhD and Gabriel, Stacey, PhD and Marrugat, Jaume, PhD and Peden, John, PhD and Erdmann, Jeanette, PhD and Diemert, Patrick, MD and Willenborg, Christina, MSc and König, Inke R, PhD and Fischer, Marcus, MD and Hengstenberg, Christian, MD and Ziegler, Andreas, PhD and Buysschaert, Ian, MD and Lambrechts, Diether, PhD and Van de Werf, Frans, Prof and Fox, Keith A, Prof and El Mokhtari, Nour Eddine, MD and Rubin, Diana, MD and Schrezenmeir, Jürgen, PhD and Schreiber, Stefan, Prof and ...
Lancet, The, ISSN 0140-6736, 08/2012, Volume 380, Issue 9841, pp. 572 - 580
Journal Article
by van der Harst, Pim, MD, PhD and van Setten, Jessica, PhD and Verweij, Niek, PhD and Vogler, Georg, PhD and Franke, Lude, PhD and Maurano, Matthew T., PhD and Wang, Xinchen, BSc and Mateo Leach, Irene, PhD and Eijgelsheim, Mark, MD, PhD and Sotoodehnia, Nona, MD, MPH and Hayward, Caroline, PhD and Sorice, Rossella, PhD and Meirelles, Osorio, PhD and Lyytikäinen, Leo-Pekka, MD and Polašek, Ozren, MD, PhD and Tanaka, Toshiko, PhD and Arking, Dan E., PhD and Ulivi, Sheila, PhD and Trompet, Stella, PhD and Müller-Nurasyid, Martina, PhD and Smith, Albert V., PhD and Dörr, Marcus, MD and Kerr, Kathleen F., PhD and Magnani, Jared W., MD, MSc and Del Greco M., Fabiola, PhD and Zhang, Weihua, PhD and Nolte, Ilja M., PhD and Silva, Claudia T., MSc and Padmanabhan, Sandosh, MD, PhD and Tragante, Vinicius, PhD and Esko, Tõnu, PhD and Abecasis, Gonçalo R., PhD and Adriaens, Michiel E., PhD and Andersen, Karl, PhD and Barnett, Phil, PhD and Bis, Joshua C., PhD and Bodmer, Rolf, PhD and Buckley, Brendan M., MD, PhD and Campbell, Harry, MD and Cannon, Megan V., PhD and Chakravarti, Aravinda, PhD and Chen, Lin Y., MD, MS and Delitala, Alessandro, PhD and Devereux, Richard B., MD and Doevendans, Pieter A., MD, PhD and Dominiczak, Anna F., MD and Ferrucci, Luigi, MD, PhD and Ford, Ian, PhD and Gieger, Christian, PhD and Harris, Tamara B., PhD and Haugen, Eric and Heinig, Matthias, PhD and Hernandez, Dena G., MSc and Hillege, Hans L., MD, PhD and Hirschhorn, Joel N., MD, PhD and Hofman, Albert, MD, PhD and Hubner, Norbert, MD and Hwang, Shih-Jen, PhD and Iorio, Annamaria, MD and Kähönen, Mika, MD, PhD and Kellis, Manolis, PhD and Kolcic, Ivana, MD, PhD and Kooner, Ishminder K., MD, PhD and Kooner, Jaspal S., MBBS, MD and Kors, Jan A., PhD and Lakatta, Edward G., MD and Lage, Kasper, PhD and Launer, Lenore J., PhD and Levy, Daniel, MD and Lundby, Alicia, PhD and Macfarlane, Peter W., DSc and May, Dalit, MD and Meitinger, Thomas, MD, MSc and Metspalu, Andres, PhD and Nappo, Stefania, MSc and Naitza, Silvia, PhD and Neph, Shane, BS and Nord, Alex S., PhD and Nutile, Teresa, PhD and Okin, Peter M., MD and Olsen, Jesper V., PhD and Oostra, Ben A., PhD and Penninger, Josef M., MD and Pennacchio, Len A., PhD and Pers, Tune H., PhD and Perz, Siegfried, MSc and Peters, Annette, PhD and Pinto, Yigal M., MD, PhD and Pfeufer, Arne, MD, MSc and Pilia, Maria Grazia, PhD and Pramstaller, Peter P., MD and Prins, Bram P., MSc and Raitakari, Olli T., MD, PhD and Raychaudhuri, Soumya, MD, PhD and Rice, Ken M., PhD and Rossin, Elizabeth J., MD, PhD and Rotter, Jerome I., MD and Schafer, Sebastian, PhD and Schlessinger, David, PhD and Schmidt, Carsten O., PhD and ...
Journal of the American College of Cardiology, ISSN 0735-1097, 2016, Volume 68, Issue 13, pp. 1435 - 1448
Journal Article
Journal Article
Ophthalmology, ISSN 0161-6420, 2014, Volume 121, Issue 11, pp. 2247 - 2254
Journal Article
Mayo Clinic Proceedings, ISSN 0025-6196, 2017, Volume 92, Issue 3, pp. 460 - 466
Journal Article
American Heart Journal, ISSN 0002-8703, 2011, Volume 161, Issue 5, pp. 893 - 899
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 140, Issue 1, pp. 190 - 203.e5
Background Type 2 airway inflammation plays a central role in the pathogenesis of allergen-induced asthma, but the underlying mechanisms remain poorly... 
Allergy and Immunology | Type 2 inflammation | mucociliary clearance | IL-13 | IL-33 | airway epithelium | CHRONIC-BRONCHITIS | SURFACE DEHYDRATION | OSMOTIC-PRESSURE | IMMUNOLOGY | CYTOKINE PROFILE | EPITHELIAL-CELLS | ALLERGY | CHANNEL-OVEREXPRESSING MICE | GENE-EXPRESSION | LUNG-DISEASE | CYSTIC-FIBROSIS | Asthma - physiopathology | Cell Count | Epithelial Cells - drug effects | Cells, Cultured | Mucociliary Clearance | Interleukin-13 - immunology | Mice, Transgenic | Sodium Channel Blockers - pharmacology | STAT6 Transcription Factor - genetics | Lung - cytology | Asthma - drug therapy | Animals | Epithelial Sodium Channels - genetics | Allergens - immunology | Aspergillus fumigatus - immunology | Epithelial Cells - immunology | Amiloride - therapeutic use | Asthma - immunology | Amiloride - pharmacology | Sodium Channel Blockers - therapeutic use | Bronchoalveolar Lavage Fluid - cytology | Lung - immunology | Disease Models, Animal | Pyroglyphidae - immunology | Allergens | Genetic engineering | Inflammation | Asthma | Dendritic cells | Flow cytometry | Transcription | Laboratories | Identification methods | Pathogenesis | Epithelial cells | Mucus | Lymphocytes T | Macrophages | Respiratory tract | Amiloride | Clonal deletion | Rodents | Deletion | Respiratory tract diseases | Chronic obstructive pulmonary disease | Children | Immune system | Sodium channels | Lymphoid cells | Cytokines | Hydration | Secretion | Lung diseases | House dust | Transgenic mice | Cystic fibrosis | Interleukin 13 | Gene expression | Epithelium | Eosinophilia | Allergies | Studies | Metaplasia | Lungs | Stat6 protein | Mice
Journal Article