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Molecular Cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 2, pp. 326 - 339
Journal Article
Cells, ISSN 2073-4409, 10/2019, Volume 8, Issue 10, p. 1226
Fibrosis in the liver is mainly associated with the activation of hepatic stellate cells (HSCs). Both activation and clearance of HSCs can be mediated by... 
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 9/2012, Volume 69, Issue 17, pp. 2919 - 2932
A disintegrin and metalloproteinase10 (ADAM10) has been implicated as a major sheddase responsible for the ectodomain shedding of a number of important surface... 
Life Sciences | Biochemistry, general | APP | Life Sciences, general | ADAM10 | Cadherin | Biomedicine general | Cell Biology | Tetraspanin | BETA-GLUCOCEREBROSIDASE | ALZHEIMER-DISEASE | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PRECURSOR PROTEIN | ALPHA-SECRETASE ADAM10 | CLEAVAGE | DISINTEGRIN METALLOPROTEASE | CELL BIOLOGY | DISINTEGRIN/METALLOPROTEINASE ADAM10 | ENDOPLASMIC-RETICULUM | UP-REGULATION | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Immunoprecipitation | Cadherins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Flow Cytometry | Amyloid beta-Protein Precursor - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Cadherins - genetics | Tetraspanins - genetics | Tetraspanins - metabolism | Real-Time Polymerase Chain Reaction | Membrane Proteins - genetics | RNA, Messenger - genetics | Cells, Cultured | ADAM10 Protein | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Protein Transport | Tetraspanins - antagonists & inhibitors | Two-Hybrid System Techniques | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Fluorescent Antibody Technique | Mice | ADAM Proteins - genetics | Cell Movement | Proteins | Enzymes | Eukaryotes | Yeast | Cellular biology | Proteases
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 2019, pp. 1 - 20
Disintegrin and metalloproteinases (ADAMs) 10 and 17 can release the extracellular part of a variety of membrane-bound proteins via ectodomain shedding... 
ADAM10 | ADAM17 | ADAM8 | Proteolysis | TAILS | Ectodomain shedding | Cystatin | Shedding | ADAM8 protein | Proteinase | Amino acids | Cardiomyocytes | Mass spectroscopy | Secretome | Cadherin | Substrates | Fibronectin | Proteins | Protease | Cystatin C | Cleavage | Mass spectrometry
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 22, pp. 16043 - 16058
Chemotherapeutic resistance evolves in about 70 % of ovarian cancer patients and is a major cause of death in this tumor entity. Novel approaches to overcome... 
Chemo resistance | ADAM17 | Amphiregulin | Tumor therapy | Ovarian cancer
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 09/2017, Volume 214, Issue 9, pp. 2547 - 2562
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2018, Volume 215, Issue 4, pp. 1205 - 1225
Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R), but therapeutic success is limited. EGF-R is stimulated by... 
COLON-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR RECEPTOR | EPITHELIAL-CELLS | INFLAMMATION | ACQUIRED-RESISTANCE | NECROSIS-FACTOR-ALPHA | MICE | IMMUNOLOGY | INTERLEUKIN-6 | METASTATIC COLORECTAL-CANCER | MACROPHAGE ACTIVATION | Prognosis | Intestine, Small - pathology | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Ki-67 Antigen - metabolism | RNA, Messenger - metabolism | Carcinogenesis - metabolism | ADAM17 Protein - metabolism | ADAM17 Protein - deficiency | Neoplasm Metastasis | Cell Nucleus - metabolism | Interleukin-6 - metabolism | Intestinal Neoplasms - genetics | Colorectal Neoplasms - metabolism | STAT3 Transcription Factor - metabolism | Disease Models, Animal | ErbB Receptors - metabolism | Organoids - pathology | Signal Transduction | Intestinal Neoplasms - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Gastrointestinal Microbiome | Tumor Burden | beta Catenin - metabolism | Adenomatous Polyposis Coli - metabolism | Intestinal Neoplasms - pathology | Carcinogenesis - pathology | Animals | Cell Line, Tumor | Colorectal Neoplasms - pathology | Neoplasm Staging | Animal models | Wnt protein | Epithelial cells | Colorectal carcinoma | Colorectal cancer | Antibodies | Gene sequencing | Interleukin 6 | β-catenin | Epidermal growth factor | Proteolysis | Intestine | Rodents | Down-regulation | Tumorigenesis | Metalloproteinase | Dysplasia | Myeloid cells | Transgenic mice | Stat3 protein | Ribonucleic acid--RNA | Signaling | Mice | Tumors | Cancer | 307 | 311
Journal Article