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Journal of Ethnopharmacology, ISSN 0378-8741, 02/2020, Volume 248, p. 112298
A wide variety of traditional herbal remedies have been used throughout history for the treatment of symptoms related to acute respiratory infections (ARIs).... 
Antibacterials | Co-infection | Chemoinformatics | Influenza | Antivirals | Rhinovirus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, Volume 178, pp. 606 - 622
The hydrophobic pocket within viral capsid protein 1 is a target to combat the rhino- and enteroviruses (RV and EV) using small molecules. The highly conserved... 
Common cold | Pleconaril | Enterovirus | Drug design/discovery | Antivirals | Rhinovirus | CHEMISTRY, MEDICINAL | ANTI-VIRAL ACTIVITY | INVITRO ACTIVITY | ANTIRHINOVIRAL ACTIVITY | COXSACKIEVIRUS B3 | BETA-DIKETONES | CYTOCHROME-P450 3A ACTIVITY | ANTIVIRAL ACTIVITY | ANTIPICORNAVIRUS ACTIVITY | PYRIDYL IMIDAZOLIDINONES | IN-VITRO ACTIVITY | Viral proteins | Amino acids | Drug approval
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 8, p. e104233
The amino acid substitution of aspartic acid to glycine in hemagglutinin (HA) in position 222 (HA-D222G) as well as HA222D/G polymorphism of pandemic (H1N1)... 
UNITED-STATES | NEURAMINIDASE | INCREASED VIRULENCE | SUBSTITUTION | SEVERE DISEASE | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | ADAPTATION | MICE | D222G | RECEPTOR-BINDING | Influenza A Virus, H1N1 Subtype - immunology | Humans | Molecular Sequence Data | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Antibodies, Viral - blood | Sialic Acids - chemistry | Trachea - virology | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Lung - virology | Base Sequence | Viral Tropism | Sialic Acids - immunology | Influenza A Virus, H1N1 Subtype - genetics | Gene Expression | Lung - pathology | Orthomyxoviridae Infections - pathology | Host Specificity | Polymorphism, Genetic | Trachea - immunology | Trachea - pathology | Animals | Immune Evasion | Receptors, Virus - chemistry | Receptors, Virus - immunology | Mice | Mice, Inbred BALB C | Orthomyxoviridae Infections - virology | Antibodies, Neutralizing - blood | Lung - immunology | Orthomyxoviridae Infections - immunology | Evolution, Molecular | Tropism | Pandemics | Epithelial cells | Body weight | Viruses | Amino acids | Infections | Genomes | Body weight loss | Glycine | Amino acid substitution | Penicillin | Hemagglutinins | Evolution | Influenza A | Aspartic acid | Trachea | Pathogens | Stagnation | Virology | Pathogenicity | Acids | Lungs | Swine flu | Influenza | Galactose | Polymorphism
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 09/2019, Volume 116, Issue 38, pp. 19109 - 19115
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e61597
Recent epidemiological developments demonstrated that gene segments of swine influenza A viruses can account for antigenic changes as well as reduced drug... 
ANTIBODIES | TRANSMISSION | GERMANY | EVOLUTION | MULTIDISCIPLINARY SCIENCES | ADAMANTANE RESISTANCE | SUSCEPTIBILITY | AMANTADINE RESISTANCE | H1N1 | H3N2 | EXPERIMENTAL-INFECTION | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Oseltamivir - therapeutic use | Swine Diseases - virology | Vaccination | Male | Antibodies, Viral - blood | Swine | Neuraminidase - chemistry | Female | Orthomyxoviridae Infections - drug therapy | Oseltamivir - pharmacology | Swine Diseases - drug therapy | Antiviral Agents - pharmacology | Antiviral Agents - therapeutic use | Orthomyxoviridae Infections - veterinary | Viral Proteins - chemistry | Viral Proteins - antagonists & inhibitors | Influenza A Virus, H1N2 Subtype - immunology | Swine Diseases - prevention & control | Animals | Virus Replication | Neuraminidase - antagonists & inhibitors | Influenza Vaccines | Orthomyxoviridae Infections - virology | Sus scrofa | Influenza viruses | Influenza vaccines | Prevention | Epidemics | Swine influenza | Comparative analysis | Drug therapy | Epidemiology | Shedding | Pandemics | Medical services | Clinical trials | Viruses | Homology | Systematic review | Infections | Vaccines | Dyspnea | Respiratory organs | Influenza A | Antigens | Organs | Fever | Hogs | Lungs | Influenza | Comparative studies | Livestock | Respiration
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2015, Volume 104, Issue 9, pp. 3208 - 3219
The neuraminidase (NA) inhibitor zanamivir ( ) is potently active against a broad panel of influenza A and B strains, including mutant viruses, but suffers... 
synthesis | prodrug | neuraminidase inhibitor | influenza A | bioavailability | pharmacokinetics | guanidine bioisoster | drug-like properties | amidine | drug‐like properties | guanidine bioisoster; amidine | CHEMISTRY, MEDICINAL | HYDROXYLATION | DRUG DESIGN | LANINAMIVIR | GUANIDINO-OSELTAMIVIR | CHEMISTRY, MULTIDISCIPLINARY | NEURAMINIDASE INHIBITOR RESISTANCE | INFLUENZA-A VIRUS | REDUCTION | PHARMACOLOGY & PHARMACY | ABSORPTION | EMERGENCY USE AUTHORIZATION | H1N1 INFLUENZA | Antiviral Agents - pharmacokinetics | Influenza A Virus, H3N2 Subtype - drug effects | Rats, Wistar | Biological Availability | Guanidines - pharmacology | Zanamivir - pharmacokinetics | Enzyme Inhibitors - pharmacokinetics | Amidines - pharmacokinetics | Madin Darby Canine Kidney Cells | Orthomyxoviridae Infections - drug therapy | Cell Line | Antiviral Agents - pharmacology | Administration, Oral | Orthomyxoviridae Infections - metabolism | Enzyme Inhibitors - pharmacology | Rats | Zanamivir - pharmacology | Influenza A Virus, H1N1 Subtype - drug effects | Animals | Prodrugs - pharmacokinetics | Dogs | Neuraminidase - antagonists & inhibitors | Amidines - pharmacology | Guanidines - pharmacokinetics | Prodrugs - pharmacology | Glycerin | Hydroxylation | Guanidine | Influenza | Glycerol | Pharmacists | Zanamivir | Protein binding | Drug dosages | Bioavailability | Index Medicus
Journal Article
Journal Article
Natural Product Reports, ISSN 0265-0568, 12/2011, Volume 29, Issue 1, pp. 11 - 36
Covering: 2000 to 2011 The imminent threat of influenza pandemics and repeatedly reported emergence of new drug-resistant influenza virus strains demonstrate... 
CHEMISTRY, MEDICINAL | ACTIVE-SITE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | A H1N1 VIRUS | 3-DIMENSIONAL STRUCTURE | IN-VITRO | INHIBITOR SUSCEPTIBILITY | SEASONAL INFLUENZA | BIOLOGICAL EVALUATION | FRUIT-JUICE CONCENTRATE | ANTIINFLUENZA VIRAL ACTIVITIES
Journal Article