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1. Full Text The UK10K project identifies rare variants in health and disease
by Walter, Klaudia and Min, Josine L and Huang, Jie and Crooks, Lucy and Memari, Yasin and McCarthy, Shane and Perry, John and Xu, Changjiang and Futema, Marta and Lawson, Daniel and Iotchkova, Valentina and Schiffels, Stephan and Henicks, Auey E and Danecek, Petr and Li, Rui and Floyd, James and Wain, Louise and Barroso, Inês and Humphries, Steve and Hurles, Matthew and Zeggini, Eleftheria and Barrett, Jeffrey C and Plagnol, Vincent and Richards, Brent and Greenwood, Celia and Timpson, Nicholas and Durbin, Richard and Bala, Senduran and Clapham, Peter and Coates, Guy and Cox, Tony and Daly, Allan and Du, Yuanping and Edkins, Ted and Ellis, Peter and Flicek, Paul and Guo, Xiaosen and Guo, Xueqin and Huang, Liren and Jackson, David K and Joyce, Chris and Keane, Thomas and Kolb-Kokocinski, Anja and Langford, Cordelia and Li, Yingrui and Liang, Jieqin and Lin, Hong and Liu, Ryan and Maslen, John and Muddyman, Dawn and Quail, Michael A and Stalker, Jim and Sun, Jianping and Tian, Jing and Wang, Guangbiao and Wang, Jun and Wang, Yu and Wong, Kim and Zhang, Pingbo and Birney, Ewan and Boustred, Chris and Chen, Lu and Clement, Gail and Cocca, Massimiliano and Smith, G.D and Day, Ian N.M and Day-Williams, Aaron and Down, Thomas and Dunham, David and Evans, David M and Gaunt, Tom and Geihs, Matthias and Hart, Deborah and Howie, Bryan and Hubbard, Tim and Hysi, Pirro and Jamshidi, Yalda and Karczewski, Konrad and Kemp, John and Lachance, Genevieve and Lek, Monkol and Lopes, Margarida and MacArthur, Daniel G and Marchini, Jonathan and Mangino, Massimo and Mathieson, Iain and Metrustry, Sarah and Moayyeri, Alireza and Northstone, Kate and Panoutsopoulou, Kalliope and Paternoster, Lavinia and Quaye, Lydia and Ring, Susan and Ritchie, Graham R.S and Shihab, Hashem A and Shin, So-Youn and Small, Kerrin and Artigas, M.S and Soranzo, Nicole and Southam, Lorraine and ... and UCLEB Consortium and UK10K Consortium and The UK10K Consortium
Nature: international weekly journal of science, ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 82 - 89
textabstractThe contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes... 
INCIDENTAL FINDINGS | EXOME | SNP | LOW-FREQUENCY | MULTIDISCIPLINARY SCIENCES | COMMON | APOC3 | RISK | LOCI | HERITABILITY | GENOME-WIDE ASSOCIATION | Genetics, Population | Receptors, LDL - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Disease - genetics | Health | Genomics | Humans | Molecular Sequence Annotation | Male | United Kingdom | Sequence Analysis, DNA | Genome, Human - genetics | Adiponectin - blood | Exome - genetics | Reference Standards | Genetics, Medical | Alleles | Triglycerides - blood | Female | Lipid Metabolism - genetics | Genetic Variation - genetics | Cohort Studies | Genetic research | Research | Genetic variation | Identification and classification | Health aspects | Population genetics | Proteins | Studies | Haplotypes | Obesity | Genealogy | Disease | Quality | Population | Genomes | Mutation
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2. Full Text An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes
by Wheway, G and Schmidts, M and Mans, D.A and Szymanska, K and Nguyen, T.M and Racher, H and Phelps, I.G and Toedt, G and Kennedy, J and Wunderlich, K.A and Sorusch, N and Abdelhamed, Z.A and Natarajan, S and Herridge, W and Reeuwijk, J. van and Horn, N and Boldt, K and Parry, D.A and Letteboer, S.J.F and Roosing, S and Adams, M and Bell, S.M and Bond, J and Higgins, J and Morrison, E.E and Tomlinson, D.C and Slaats, G.G and Dam, T.J.P. van and Huang, L and Kessler, K and Giessl, A and Logan, C.V and Boyle, E.A and Shendure, J and Anazi, S and Aldahmesh, M and Hazzaa, S. Al and Hegele, R.A and Ober, C and Frosk, P and Mhanni, A.A and Chodirker, B.N and Chudley, A.E and Lamont, R and Bernier, F.P and Beaulieu, C.L and Gordon, P and Pon, R.T and Donahue, C and Barkovich, A.J and Wolf, L and Toomes, C and Thiel, C.T and Boycott, K.M and McKibbin, M and Inglehearn, C.F and Stewart, F and Omran, H and Huynen, M.A and Sergouniotis, P.I and Alkuraya, F.S and Parboosingh, J.S and Innes, A.M and Willoughby, C.E and Giles, R.H and Webster, A.R and Ueffing, M and Blacque, O and Gleeson, J.G and Wolfrum, U and Beales, P.L and Gibson, T and Doherty, D and Mitchison, H.M and Roepman, R and Johnson, C.A and Univ Washington Ctr Mendelian Geno and UK10K Consortium and University of Washington Center for Mendelian Genomics
Nature Cell Biology, ISSN 1465-7392, 2015, Volume 17, Issue 8, pp. 1074 - 1087
Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics... 
JOUBERT-SYNDROME | RPGRIP1 | TRANSPORT | CENTRIOLE BIOGENESIS | PROTEIN | C-ELEGANS | MUTATIONS | PHOTORECEPTOR CELLS | MASTER REGULATOR | PRIMARY CILIA | CELL BIOLOGY | Humans | Pregnancy Proteins - genetics | Databases, Genetic | Suppressor Factors, Immunologic - genetics | Photoreceptor Cells - ultrastructure | Pregnancy Proteins - metabolism | Ellis-Van Creveld Syndrome - genetics | Cerebellum - abnormalities | Genetic Testing - methods | Suppressor Factors, Immunologic - metabolism | Membrane Proteins - deficiency | Transfection | RNA Interference | HEK293 Cells | Kidney Diseases, Cystic - genetics | Genomics - methods | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Caenorhabditis elegans - metabolism | Cilia - pathology | Caenorhabditis elegans - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Abnormalities, Multiple | Genetic Markers | Eye Abnormalities - genetics | Cilia - metabolism | Zebrafish - genetics | Cilia - genetics | Mice, Knockout | Proteins - genetics | Caenorhabditis elegans - ultrastructure | Phenotype | Animals | Cerebellar Diseases - genetics | Ciliary Motility Disorders - pathology | Proteins - metabolism | Photoreceptor Cells - metabolism | Zebrafish - metabolism | Retina - abnormalities | High-Throughput Nucleotide Sequencing | Ciliary Motility Disorders - metabolism | Mutation | Ciliary Motility Disorders - genetics | RNA | Cilia and ciliary motion | Genetic research | Biosynthesis | Genetic aspects | Research | Gene expression | Properties | reverse genetics | cilia | ciliopathies | Joubert syndrome | whole-genome siRNA screen | Jeune syndrome
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3. Full Text Exome sequencing identifies DYNC2H1 mutations as a common cause of asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, renal or retinal involvement
by Schmidts, Miriam and Arts, Heleen H and Bongers, Ernie M H F and Yap, Zhimin and Oud, Machteld M and Antony, Dinu and Duijkers, Lonneke and Emes, Richard D and Stalker, Jim and Yntema, Jan-Bart L and Plagnol, Vincent and Hoischen, Alexander and Gilissen, Christian and Forsythe, Elisabeth and Lausch, Ekkehart and Veltman, Joris A and Roeleveld, Nel and Superti-Furga, Andrea and Kutkowska-Kazmierczak, Anna and Kamsteeg, Erik-Jan and Elçioğlu, Nursel and van Maarle, Merel C and Graul-Neumann, Luitgard M and Devriendt, Koenraad and Smithson, Sarah F and Wellesley, Diana and Verbeek, Nienke E and Hennekam, Raoul C M and Kayserili, Hulya and Scambler, Peter J and Beales, Philip L and Knoers, Nine VAM and Roepman, Ronald and Mitchison, Hannah M and UK10K
Journal of Medical Genetics, ISSN 0022-2593, 05/2013, Volume 50, Issue 5, pp. 309 - 323
Background Jeune asphyxiating thoracic dystrophy (JATD) is a rare, often lethal, recessively inherited chondrodysplasia characterised by shortened ribs and... 
RETROGRADE INTRAFLAGELLAR TRANSPORT | CYTOPLASMIC DYNEIN | PRIMARY CILIARY DYSKINESIA | DEFECTS | CAENORHABDITIS-ELEGANS | CRYSTAL-STRUCTURE | IFT | DYNEIN MOTOR DOMAIN | GENETICS & HEREDITY | LIGHT INTERMEDIATE CHAIN | PELVIC-PHALANGEAL DYSTROPHY | Humans | Cytoplasmic Dyneins - genetics | Models, Molecular | Molecular Sequence Data | Ellis-Van Creveld Syndrome - genetics | Mutation - genetics | Sequence Analysis, DNA | Exome - genetics | Base Sequence | Polymorphism, Single Nucleotide - genetics | Protein Conformation | Cytoplasmic Dyneins - chemistry | Gene Components | Microscopy, Fluorescence | Causes of | Genetic aspects | Research | Myotonic dystrophy | Gene mutations | Health aspects | Developmental | Molecular Genetics | Diagnostics | Clinical Genetics | Genetic Screening | 1506 | Developmental Defects | Counselling
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4. Full Text Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm
by Onoufriadis, Alexandros and Shoemark, Amelia and Munye, Mustafa M and James, Chela T and Schmidts, Miriam and Patel, Mitali and Rosser, Elisabeth M and Bacchelli, Chiara and Beales, Philip L and Scambler, Peter J and Hart, Stephen L and Danke-Roelse, Jeannette E and Sloper, John J and Hull, Sarah and Hogg, Claire and Emes, Richard D and Pals, Gerard and Moore, Anthony T and Chung, Eddie M. K and Mitchison, Hannah M and UK10K
Journal of Medical Genetics, ISSN 0022-2593, 2014, Volume 51, Issue 1, pp. 61 - 67
Background Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous ciliopathy disorder affecting cilia and sperm motility. A range of... 
Developmental | DIAGNOSIS | Molecular Genetics | Clinical Genetics | ELECTRON-MICROSCOPY | DROSOPHILA | CHLAMYDOMONAS FLAGELLA | BODY ASYMMETRY | RANDOMIZATION | DISEASE | GENETICS & HEREDITY | Genetics | UNCONVENTIONAL MYOSIN | Other Respiratory Medicine | INSIGHTS | Humans | Male | Armadillo Domain Proteins - genetics | Kartagener Syndrome - genetics | Exome | Dyneins - chemistry | Cilia - ultrastructure | Female | Protein Interaction Domains and Motifs | Dyneins - metabolism | Genome-Wide Association Study | Armadillo Domain Proteins - chemistry | Models, Molecular | Cilia - metabolism | Cilia - genetics | Phenotype | Pedigree | Armadillo Domain Proteins - metabolism | Kartagener Syndrome - metabolism | Protein Binding | Protein Conformation | High-Throughput Nucleotide Sequencing | Dyneins - genetics | Mutation | Genome, Human | Evaluation | Usage | Dynein | Exome sequencing | Influence | Nucleotide sequencing | Research | Movement disorders | Risk factors | Mutation (Biology) | DNA sequencing | Index Medicus | New Loci | 1506
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5. Full Text X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3
by Olcese, C and Patel, M.P and Shoemark, A and Kiviluoto, S and Legene, M and Williams, H.J and Vaughan, C.K and Hayward, J and Goldenberg, A and Emes, R.D and Munye, M.M and Dyer, L and Cahill, T and Bevillard, J and Gehrig, C and Guipponi, M and Chantot, S and Duquesnoy, P and Thomas, L and Jeanson, L and Copin, B and Tamalet, A and Thauvin-Robinet, C and Papon, J.F and Garin, A and Pin, I and Vera, G and Aurora, P and Fassad, M.R and Jenkins, L and Boustred, C and Cullup, T and Dixon, M and Onoufriadis, A and Bush, A and Chung, E.M and Antonarakis, S.E and Loebinger, M.R and Wilson, R and Armengot, M and Escudier, E and Hogg, C and Amselem, S and Sun, Z and Bartoloni, L and Blouin, J.L and Mitchison, H.M and Schmidts, M and et al and UK10K Rare Grp and UK10K Rare Group
Nature Communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, p. 14279
By moving essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the transport... 
DEFECTS | PROTEIN | VARIANTS | MULTIDISCIPLINARY SCIENCES | IDENTIFIES MUTATIONS | ARMS | R2TP COMPLEX | OUTER | OF-FUNCTION MUTATIONS | MOTILITY | INNER | Sequence Deletion | Sperm Motility - genetics | Axonemal Dyneins - metabolism | Humans | Child, Preschool | Male | Kartagener Syndrome - genetics | Phylogeny | Cytoplasm - pathology | Axoneme - pathology | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | Cilia - ultrastructure | Adult | Female | Genetic Diseases, X-Linked - genetics | Microtubule Proteins - genetics | Child | Infant, Newborn | Disease Models, Animal | Microscopy, Electron, Transmission | Cilia - pathology | Genes, X-Linked - genetics | Molecular Chaperones - genetics | Zebrafish | Protein Folding | Apoptosis Regulatory Proteins - metabolism | Whole Exome Sequencing | Point Mutation | Sequence Alignment | Animals | Pedigree | Kartagener Syndrome - pathology | Adolescent | Genetic Diseases, X-Linked - pathology | HSP90 Heat-Shock Proteins - metabolism | Life Sciences | Genetics
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6. Full Text Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
by Haworth, Simon and Shapland, Chin Yang and Hayward, Caroline and Prins, Bram P and Felix, Janine F and Medina-Gomez, Carolina and Rivadeneira, Fernando and Wang, Carol and Ahluwalia, Tarunveer S and Vrijheid, Martine and Guxens, Mònica and Sunyer, Jordi and Tachmazidou, Ioanna and Walter, Klaudia and Iotchkova, Valentina and Jackson, Andrew and Cleal, Louise and Huffmann, Jennifer and Min, Josine L and Sass, Lærke and Timmers, Paul R. H. J and Turki, Saeed Al and Anderson, Carl A and Anney, Richard and Antony, Dinu and Artigas, María Soler and Ayub, Muhammad and Bala, Senduran and Barrett, Jeffrey C and Barroso, Inês and Beales, Phil and Bentham, Jamie and Bhattacharya, Shoumo and Birney, Ewan and Blackwood, Douglas and Bobrow, Martin and Bochukova, Elena and Bolton, Patrick F and Bounds, Rebecca and Boustred, Chris and Breen, Gerome and Calissano, Mattia and Carss, Keren and Charlton, Ruth and Chatterjee, Krishna and Chen, Lu and Ciampi, Antonio and Cirak, Sebahattin and Clapham, Peter and Clement, Gail and Coates, Guy and Cocca, Massimiliano and Collier, David A and Cosgrove, Catherine and Cox, Tony and Craddock, Nick and Crooks, Lucy and Curran, Sarah and Curtis, David and Daly, Allan and Danecek, Petr and Day, Ian N. M and Day-Williams, Aaron and Dominiczak, Anna and Down, Thomas and Du, Yuanping and Dunham, Ian and Durbin, Richard and Edkins, Sarah and Ekong, Rosemary and Ellis, Peter and Evans, David M and Farooqi, I. Sadaf and Fitzpatrick, David R and Flicek, Paul and Floyd, James and Foley, A. Reghan and Franklin, Christopher S and Futema, Marta and Gallagher, Louise and Gaunt, Tom R and Geihs, Matthias and Geschwind, Daniel and Greenwood, Celia M. T and Griffin, Heather and Grozeva, Detelina and Guo, Xiaosen and Guo, Xueqin and Gurling, Hugh and Hart, Deborah and Hendricks, Audrey E and Holmans, Peter and Howie, Bryan and Huang, Jie and Huang, Liren and Hubbard, Tim and Humphries, Steve E and Hurles, Matthew E and Hysi, Pirro and Jackson, David K and ... and UK10K Consortium and UK10K consortium
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 357 - 16
Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The... 
COMMON VARIANTS | IMPUTATION | GWAS | MULTIDISCIPLINARY SCIENCES | GROWTH | GENETIC ARCHITECTURE | LD SCORE REGRESSION | WEIGHT | BRAIN | HERITABILITY | GENOME-WIDE ASSOCIATION | Skull - metabolism | Gene Frequency | Humans | Middle Aged | RNA, Messenger - genetics | European Continental Ancestry Group | Male | Cephalometry | Genetic Loci | Tumor Suppressor Protein p53 - genetics | Genetic Variation | Gene Expression Regulation, Developmental | Skull - anatomy & histology | Adolescent | Alleles | Aged, 80 and over | Adult | Female | Aged | Genome, Human | Child | Head | p53 Protein | Genetic diversity | Frequency variation | Carriers | Gene frequency | Frequency spectrum | Skull | Adults | Children | Genetic factors | Variation | Age | Marcadors bioquímics | Genoma humà
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7. Full Text Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis
by Yang, Yongjie and van der Klaauw, Agatha A and Zhu, Liangru and Cacciottolo, Tessa M and He, Yanlin and Stadler, Lukas K. J and Wang, Chunmei and Xu, Pingwen and Saito, Kenji and Hinton, Antentor and Yan, Xiaofeng and Keogh, Julia M and Henning, Elana and Banton, Matthew C and Hendricks, Audrey E and Bochukova, Elena G and Mistry, Vanisha and Lawler, Katherine L and Liao, Lan and Xu, Jianming and O’Rahilly, Stephen and Tong, Qingchun and Inês Barroso, Barroso and O’Malley, Bert W and Farooqi, I. Sadaf and Xu, Yong and UK10K Consortium
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1718 - 14
Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor... 
OBESITY | SOCS-3 EXPRESSION | FOOD-INTAKE | ER STRESS | MULTIDISCIPLINARY SCIENCES | PROOPIOMELANOCORTIN NEURONS | PPAR-GAMMA | LEPTIN RESISTANCE | FOXO1 | SIGNAL TRANSDUCER | BALANCE | Obesity | Transcription | Neurons | Body weight | Stat3 protein | Weight loss | Homeostasis | Proopiomelanocortin | Body weight loss | Hypothalamus | High fat diet | Depolarization | Energy balance | Clonal deletion | Food intake | Rodents | Deletion | Steroid receptor coactivator 1 | Receptor mechanisms | Steroids | Food
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8. Full Text Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity
by Henicks, Auey E and Bochukova, Elena G and Marenne, Gaëlle and Keogh, Julia M and Atanassova, Neli and Bounds, Rebecca and Wheeler, Eleanor and Mistry, Vanisha and Henning, Elana and Körner, Antje and Muddyman, Dawn and McCarthy, Shane and Hinney, Anke and Hebebrand, Johannes and Scott, Robert A and Langenberg, Claudia and Wareham, Nick J and Surenan, Praveen and Howson, Joanna M M and Butterworth, Adam S and Danesh, John and Nordestgaard, Børge G and Nielsen, Sune F and Afzal, Shoaib and Papadia, Sofia and Ashford, Sofie and Garg, Sumedha and Millhauser, Glenn L and Palomino, Rafael I and Kwasniewska, Alexana and Tachmazidou, Ioanna and O'Rahilly, Stephen and Zeggini, Eleftheria and Barroso, Inês and Farooqi, I. Sadaf and Benzeval, Michaela and Burton, Jonathan and Buck, Nicholas and Jäckle, Annette and Kumari, Meena and Laurie, Heather and Lynn, Peter and Pudney, Stephen and Rabe, Birgitta and Wolke, Dieter and Overvad, Kim and Tjønneland, Anne and Clavel-Chapelon, Francoise and Kaaks, Rudolf and Boeing, Heiner and Trichopoulou, Antonia and Ferrari, Pietro and Palli, Domenico and Krogha, Vittorio and Panico, Salvatore and Tuminoa, Rosario and Matullo, Giuseppe and Boer, Jolanda Ma and Van Der Schouw, Yvonne and Weiderpass, Elisabete and Quiros, J. Ramon and Sánchez, María José and Navarro, Carmen and Moreno-Iribas, Conchi and Arriola, Larraitz and Melander, Olle and Wennberg, Patrik and Key, Timothy J and Riboli, Elio and Al-Turki, Saeed and Anderson, Carl A and Anney, Richard and Antony, Dinu and Soler Artigas, María and Ayub, Muhammad and Bala, Senduran and Barrett, Jeffrey C and Beales, Phil and Bentham, Jamie and Bhattacharyaa, Shoumo and Birney, Ewan and Blackwooda, Douglas and Bobrow, Martin and Bolton, Patrick F and Boustred, Chris and Breen, Gerome and Calissanoa, Mattia and Carss, Keren and Charlton, Ruth and Chatterjee, Krishna and Chen, Lu and Ciampia, Antonio and Cirak, Sebahattin and Clapham, Peter and Clement, Gail and Coates, Guy and Coccaa, Massimiliano and Collier, David A and Cosgrove, Catherine and Coxa, Tony and ... and EPIC-CVD Consortium and Understanding Soc Sci Grp and UK10K Consortium and Understanding Society Scientific Group and Kardiovaskulär forskning - hypertoni and Cardiovascular Research - Hypertension and EpiHealth: Epidemiology for Health and Lund University and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 4394 - 14
Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely... 
HEART | PATHWAYS | ALBRIGHT-HEREDITARY-OSTEODYSTROPHY | INCREASED RISK | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | G(S)ALPHA | MUTATIONS | SPECTRUM | SEQUENCING DATA | ASSOCIATION | GTP-Binding Protein alpha Subunits, Gs - metabolism | GTP-Binding Protein alpha Subunits, Gs - chemistry | Humans | Male | Case-Control Studies | GTP-Binding Protein alpha Subunits, Gs - genetics | Genetic Variation | Chromogranins - metabolism | Obesity, Morbid - genetics | Chromogranins - genetics | Female | Odds Ratio | Genetic Predisposition to Disease | Genetic Association Studies | Rodentia | Models, Molecular | Pediatric Obesity - diagnosis | Pediatric Obesity - genetics | Obesity, Morbid - diagnosis | Animals | Pedigree | Chromogranins - chemistry | Protein Conformation | Mice | Mutation | Obesity | Weight control | MKKS protein | Secretion | Population studies | Body weight loss | Children | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
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