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The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 281 - 294
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small... 
Mitosis | Kinetochores | Chromatids | Microtubules | HeLa cells | Cellular immunity | Chromosomes | Anaphase | Cells | Mitotic spindle apparatus | Chemical biology | Spindle assembly checkpoint | Chromosome segregation | KINASE-ACTIVITY | MAD2 | BUDDING YEAST | spindle assembly checkpoint | TENSION | G/M TRANSITION | mitosis | HISTONE H3 PHOSPHORYLATION | MAMMALIAN-CELLS | CELL BIOLOGY | kinetochores | chromosome segregation | chemical biology | VERTEBRATE SOMATIC-CELLS | Cell Cycle Proteins - drug effects | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Mitosis - genetics | Aurora Kinase B | Microtubules - drug effects | Spindle Apparatus - genetics | Cell Cycle Proteins - genetics | Genes, cdc - physiology | Indoles - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Aneugens - pharmacology | Eukaryotic Cells - enzymology | Polyploidy | Protein Kinases - drug effects | Separase | Protein-Serine-Threonine Kinases - genetics | Genes, cdc - drug effects | Aurora Kinases | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Anaphase - drug effects | Phenotype | Anaphase - genetics | Animals | Eukaryotic Cells - drug effects | Mitosis - drug effects | Microtubules - genetics | Microtubules - enzymology | Protein-Serine-Threonine Kinases - drug effects | Eukaryotic Cells - cytology | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Thiones - pharmacology | Endopeptidases | Chromosome Segregation - genetics | Spindle Apparatus - enzymology | Research | Molecules | Genes | Index Medicus | mitosis; chromosome segregation; kinetochores; spindle assembly checkpoint; chemical biology
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 03/2019, Volume 10, Issue 3, pp. 324 - 328
The target residence time (RT) for a given ligand is one of the important parameters that have to be optimized during drug design. It is well established that... 
CHEMISTRY, MEDICINAL | buried hydrogen bonds | BINDING-KINETICS | DETERMINANTS | drug residence time | DYNAMICS | GPCR | MICE | OPINION | water networks | EXPRESSION | CCR2
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 1, pp. 306 - 316
Protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) is a brain specific phosphatase that regulates synaptic function and plasticity by modulation of... 
CHEMISTRY, MEDICINAL | INHIBITION | PTP1B | REDUCTION | ALZHEIMERS-DISEASE | SUBSTRATE | IDENTIFICATION | DEFICITS | EXPRESSION
Journal Article
Crystal Growth and Design, ISSN 1528-7483, 04/2014, Volume 14, Issue 4, pp. 2034 - 2047
The lipidic mesophase or in meso method for crystallizing membrane proteins has several high profile targets to its credit and is growing in popularity.... 
SYSTEM | COMPLEX | MATERIALS SCIENCE, MULTIDISCIPLINARY | DETERGENT | CRYSTALLOGRAPHY | CHEMISTRY, MULTIDISCIPLINARY | SOFTWARE | FEATURES | DIACYLGLYCEROL KINASE | STRUCTURAL BASIS | SUPERFAMILY | SENSORY RHODOPSIN-II | INSIGHTS | Human | Proteins | Binding | Membranes | Prostaglandins | Crystallization | Strategy | Mesophase
Journal Article
Structure (London, England : 1993), 11/2018
We determined two crystal structures of the chemokine receptor CCR2A in complex with the orthosteric antagonist MK-0812. Full-length CCR2A, stabilized by... 
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 07/1998, Volume 26, Issue 13, pp. 3311 - 3313
Human telomerase is a ribonucleoprotein (RNP) enzyme, comprising protein components and an RNA template that catalyses telomere elongation through the addition... 
RNA COMPONENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TETRAHYMENA TELOMERASE | Telomerase - genetics | Base Sequence | Humans | Polymerase Chain Reaction | Telomerase - metabolism | HeLa Cells | DNA Primers | Telomerase - isolation & purification | Chromatography, Affinity - methods | Index Medicus
Journal Article