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Nature, ISSN 0028-0836, 07/2008, Volume 454, Issue 7204, pp. 656 - 660
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2008, Volume 27, Issue 19, pp. 2603 - 2615
Journal Article
Blood, ISSN 0006-4971, 02/2007, Volume 109, Issue 4, pp. 1503 - 1506
To generate transgenic mice that express Cre-recombinase exclusively in the megakaryocytic lineage, we modified a mouse bacterial artificial chromosome (BAC)... 
REPORTER | CELLS | RECOMBINATION | PROGENITORS | MOUSE | MURINE MEGAKARYOCYTES | HEMATOLOGY | EXPRESSION | Cell Lineage | Animals | Recombination, Genetic | Integrases - analysis | Chromosomes, Artificial, Bacterial | Mice, Transgenic | Megakaryocytes - physiology | Mice | Blood Platelets - physiology | Transgenes | Integrases - genetics | Platelet Factor 4 - genetics
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e14109
Background: The family of vascular endothelial growth factors (VEGF) contains key regulators of blood and lymph vessel development, including VEGF-A, -B, -C,... 
MULTISTAGE CARCINOGENESIS | FACTOR-A | LYMPH-NODE METASTASIS | FACTOR-C | COLORECTAL-CANCER | ANGIOGENIC SWITCH | BIOLOGY | MICE | VEGF-B | EXPRESSION | BETA-CELL CARCINOGENESIS | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Humans | Immunoblotting | Male | Pancreas - blood supply | Neovascularization, Pathologic - pathology | Insulin-Secreting Cells - metabolism | Female | Disease Models, Animal | Neuroendocrine Tumors - pathology | Neuroendocrine Tumors - metabolism | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Pancreas - pathology | Rats | Mice, Transgenic | Pancreatic Neoplasms - genetics | Pancreas - metabolism | Tumor Burden | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Neuroendocrine Tumors - genetics | Animals | Vascular Endothelial Growth Factor B - metabolism | Neovascularization, Pathologic - genetics | Vascular Endothelial Growth Factor B - genetics | Mice | Neovascularization, Pathologic - metabolism | Insulin-Secreting Cells - pathology | Physiological aspects | Genetic engineering | Neovascularization | Vascular endothelial growth factor | Analysis | Tumors | Regulators | Animal models | Physiological effects | Colorectal cancer | Biology | Biochemistry | Metastasis | Gene deletion | Kinases | Blood | Metastases | Angiogenesis | Biological effects | Clonal deletion | Transgenic animals | Rodents | Deletion | Tumorigenesis | Pancreas | Growth factors | Gene dosage | Medical research | Transgenic mice | Blood vessels | Breast cancer | Biophysics | Gene expression | Insulin | Vascular endothelial growth factor receptors | Musculoskeletal system | Placenta | Perfusion | Nitric oxide | Morphology | Infiltration | Islets of Langerhans | Cancer | Apoptosis
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 07/2002, Volume 30, Issue 14, pp. 3245 - 3252
SOX9 transcription factor is involved in chondrocyte differentiation and male sex determination. Heterozygous defects in the human SOX9 gene cause campomelic... 
SRY-RELATED GENE | AUTOSOMAL SEX REVERSAL | CAMPOMELIC DYSPLASIA | COACTIVATOR COMPLEX | NUCLEAR RECEPTORS | TRANSACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | II COLLAGEN GENE | TRANSCRIPTION FACTOR | EXPRESSION
Journal Article
Cell, ISSN 0092-8674, 2010, Volume 141, Issue 1, pp. 178 - 190
Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of... 
CELLIMUNNO | HUMDISEASE | CELLCYLCE | Cellimunno | Cellcylce | Humdisease | LUNG | HEPATOCELLULAR-CARCINOMA | METASTASIS | ANGIOGENESIS | PATHOLOGICAL CONDITIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | PLACENTA GROWTH-FACTOR | MICE | HYPOXIA | PROGRESSION | CELL BIOLOGY | Neovascularization, Physiologic - drug effects | Pregnancy Proteins - antagonists & inhibitors | Papilloma - prevention & control | Carcinoma, Hepatocellular - prevention & control | Humans | Antibodies, Monoclonal - therapeutic use | Pregnancy Proteins - metabolism | Liver Neoplasms, Experimental - prevention & control | Skin Neoplasms - prevention & control | Angiogenesis Inhibitors - therapeutic use | Carcinoma, Hepatocellular - blood supply | Skin Neoplasms - blood supply | Eye Diseases - pathology | Papilloma - blood supply | Papilloma - chemically induced | Disease Models, Animal | Mice, Inbred C57BL | Choroid - blood supply | Mice, Transgenic | Liver Neoplasms, Experimental - blood supply | Skin Neoplasms - chemically induced | Animals | Placenta Growth Factor | Mice | Mice, Inbred BALB C | Basic Medicine | Medical and Health Sciences | Internal medicine | Medicin och hälsovetenskap | Molekylär medicin (genetik och patologi) | Molecular medicine (genetics and pathology) | MEDICINE | Dermatology and venerology,clinical genetics, internal medicine | Medical Genetics | Medicinsk genetik | MEDICIN | Medicinska och farmaceutiska grundvetenskaper | Invärtesmedicin | Dermatologi och venerologi, klinisk genetik, invärtesmedicin
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2007, Volume 170, Issue 4, pp. 1348 - 1361
In many human carcinomas, expression of the lymphangiogenic factor vascular endothelial growth factor-D (VEGF-D) correlates with up-regulated lymphangiogenesis... 
Pathology | LYMPH-NODE METASTASIS | FACTOR-D EXPRESSION | FACTOR-C | PANCREATIC-CANCER | VEGF-D | TUMOR ANGIOGENESIS | PROGNOSTIC-SIGNIFICANCE | FACTOR RECEPTOR-3 | PATHOLOGY | CARCINOMA | TRANSGENIC MICE | Leukocytes - pathology | Lymph Nodes - pathology | Lymphatic Vessels - ultrastructure | Humans | Pancreatic Neoplasms - blood supply | Recombinant Fusion Proteins - physiology | Immunoblotting | Male | Lung Neoplasms - physiopathology | Recombinant Fusion Proteins - metabolism | Lymphatic Vessels - metabolism | Lung Neoplasms - secondary | Female | Neovascularization, Pathologic - physiopathology | Vascular Endothelial Growth Factor D - genetics | Lung Neoplasms - genetics | Vascular Endothelial Growth Factor D - physiology | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Cells, Cultured | Lymphangiogenesis - physiology | Lymph Nodes - metabolism | Pancreatic Neoplasms - ultrastructure | Rats | Genotype | Mice, Transgenic | Neoplasm Metastasis - genetics | Vascular Endothelial Growth Factor D - metabolism | Animals | Lymphatic Vessels - pathology | Neoplasm Metastasis - physiopathology | Recombinant Fusion Proteins - genetics | Neovascularization, Pathologic - genetics | Mice | Leukocytes - metabolism | Lymphangiogenesis - genetics | Regular
Journal Article
Cancer Research, ISSN 0008-5472, 11/2007, Volume 67, Issue 22, pp. 10840 - 10848
Members of the vascular endothelial growth factor (VEGF) family are critical players in angiogenesis and lymphangiogenesis. Although VEGF-A has been shown to... 
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 07/2002, Volume 30, Issue 14, p. 3245
  SOX9 transcription factor is involved in chondrocyte differentiation and male sex determination. Heterozygous defects in the human SOX9 gene cause campomelic... 
Journal Article
01/2016
The present disclosure provides PDGFRbeta-Fc fusion proteins, or biologically active fragments thereof, comprising an extracellular domain of PDGFRbeta, or a... 
METALLURGY | PEPTIDES | ORGANIC CHEMISTRY | CHEMISTRY
Patent
01/2016
The present disclosure provides PDGFRbeta-Fc fusion proteins, or biologically active fragments thereof, comprising an extracellular domain of PDGFRbeta, or a... 
METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
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