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Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 192 - 197
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CFT1A, a rate-limiting enzyme of... 
OXIDATION | DISTRIBUTIONS | GLYCOLYSIS | REDUCTIVE GLUTAMINE-METABOLISM | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | TUMOR | PROLIFERATION | GROWTH-FACTOR | CANCER | CULTURE | Carnitine O-Palmitoyltransferase - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Neovascularization, Pathologic - pathology | Nucleotides - chemistry | Carnitine O-Palmitoyltransferase - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Carnitine O-Palmitoyltransferase - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Nucleotides - biosynthesis | Nucleotides - pharmacology | Oxidation-Reduction - drug effects | DNA - biosynthesis | Carnitine O-Palmitoyltransferase - deficiency | Fatty Acids - metabolism | Disease Models, Animal | Carbon - metabolism | Fatty Acids - chemistry | Human Umbilical Vein Endothelial Cells - drug effects | Endothelial Cells - metabolism | Gene Silencing | Acetic Acid - pharmacology | Blood Vessels - cytology | Citric Acid Cycle | Animals | Retinopathy of Prematurity - drug therapy | Endothelial Cells - cytology | Neovascularization, Pathologic - drug therapy | Blood Vessels - drug effects | Cell Line, Tumor | Glucose - metabolism | Human Umbilical Vein Endothelial Cells - pathology | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Retinopathy of Prematurity - metabolism | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Retinopathy of Prematurity - pathology | Physiological aspects | Deoxyribonucleotides | Fatty acids | Carbon | Endothelium | Proteins | Angiogenesis | Protein synthesis | Glucose | Kinases | Deoxyribonucleic acid--DNA | Cells
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7618, pp. 63 - 68
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2017, Volume 36, Issue 16, pp. 2334 - 2352
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2004, Volume 101, Issue 5, pp. 1327 - 1332
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2007, Volume 9, Issue 6, pp. 666 - 674
Journal Article
Cell, ISSN 0092-8674, 08/2013, Volume 154, Issue 3, pp. 651 - 663
Journal Article
Nature, ISSN 0028-0836, 09/2018, Volume 561, Issue 7721, pp. 63 - 69
Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but... 
GLYCOLYSIS | MIGRATION | RHO GTPASE | PATHWAY | VASCULATURE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | JUNCTIONS | PROTEIN PALMITOYLATION | MODEL | DEFICIENCY | Palmitic Acid - metabolism | Glutamine - biosynthesis | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Actins - metabolism | Neovascularization, Pathologic | Glutamate-Ammonia Ligase - physiology | rho-Associated Kinases - metabolism | Human Umbilical Vein Endothelial Cells - cytology | HEK293 Cells | rho GTP-Binding Proteins - chemistry | Female | Glutamate-Ammonia Ligase - metabolism | Lipoylation | Endothelial Cells - metabolism | Glutamate-Ammonia Ligase - deficiency | Stress Fibers - metabolism | Animals | Human Umbilical Vein Endothelial Cells - enzymology | Glutamate-Ammonia Ligase - genetics | rho GTP-Binding Proteins - metabolism | Mice | Protein Processing, Post-Translational | Endothelial Cells - pathology | Endothelial Cells - enzymology | Cell Movement | Glutamine synthetase | Biosynthesis | Research | Neovascularization | Glutamine | Cell proliferation | Palmitoylation | Activation | Kinases | Cell adhesion & migration | Fibers | Proteins | Angiogenesis | Clonal deletion | Actin | Deletion | Skin diseases | Physiology | Inhibition | Localization | Glutamate-ammonia ligase | Enzymes | Pharmacology | Endothelial cells | Rho-associated kinase | Ammonia | Position (location) | Umbilical vein | Cell migration | Guanosinetriphosphatase
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1488 - 15
Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune... 
LIVER RECEPTOR HOMOLOG-1 | RISK-FACTORS | DENDRITIC CELLS | ALPHA-CELLS | MACROPHAGES | REGENERATION | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | REGULATORY T-CELLS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | MICE | Islets of Langerhans - drug effects | Apoptosis - drug effects | Streptozocin | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Experimental - genetics | Male | Transplantation, Heterologous | Diabetes Mellitus, Experimental - therapy | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Receptors, Cytoplasmic and Nuclear - immunology | Diabetes Mellitus, Type 2 - immunology | Islets of Langerhans Transplantation | Female | Diabetes Mellitus, Experimental - chemically induced | Macrophages - immunology | Cell Survival - drug effects | Islets of Langerhans - pathology | Macrophages - pathology | Mice, Inbred C57BL | Gene Expression Regulation | Islets of Langerhans - immunology | Phenalenes - pharmacology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Immunity, Innate | Insulin-Secreting Cells - immunology | Hypoglycemic Agents - pharmacology | Diabetes Mellitus, Experimental - immunology | Insulin - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Insulin-Secreting Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Mice | Diabetes Mellitus, Type 2 - pathology | Insulin-Secreting Cells - pathology | Repressing | Animal models | Cell survival | Target recognition | Secretion | Liver | Diabetes mellitus | Organs | Homology | Diabetes mellitus (insulin dependent) | Glucose | Insulin | Beta cells | Regeneration | Hyperglycemia | Hepatocytes | Islet cells | Diabetes | Islets of Langerhans | Pancreas | Apoptosis | Immune system
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2016, Volume 30, Issue 6, pp. 968 - 985
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7639, pp. 49 - 54
Journal Article