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British Journal of Cancer, ISSN 0007-0920, 12/2018, Volume 119, Issue 12, pp. 1471 - 1476
BACKGROUND: This phase Ib study evaluated the safety, maximum-tolerated dose (MTD), pharmacokinetics, pharmacodynamics, and preliminary efficacy of pimasertib... 
XL765 | ONCOLOGY | COMBINATION | PATHWAY | SAR245409 | TRAMETINIB | TOR protein | Pharmacodynamics | MEK inhibitors | Diarrhea | Fatigue | MAP kinase | Nausea | Pharmacology | Patients | Anticancer properties | 1-Phosphatidylinositol 3-kinase | Inhibitors | Safety engineering | Safety | Solid tumors | Pharmacokinetics | Expansion | Tumors
Journal Article
Annual Review of Medicine, ISSN 0066-4219, 01/2018, Volume 69, p. 319
Understanding a tumor's detailed molecular profile has become increasingly necessary to deliver the standard of care for patients with advanced cancer.... 
Medical research | Genomics | Innovations | Clinical trials | Oncology | Genomes | Knowledge base | Histology | Drug development | Patients | Model matching | Cancer | Tumors
Journal Article
Blood, ISSN 0006-4971, 05/2015, Volume 125, Issue 19, pp. 2908 - 2914
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 4104 - 4104
Abstract Introduction Hemophagocytic Lymphohistiocytosis (HLH) is a rare disorder of uncontrolled immune activation characterized by clinical and laboratory... 
Journal Article
by Zehir, Ahmet and Benayed, Ryma and Shah, Ronak H and Syed, Aijazuddin and Middha, Sumit and Kim, Hyunjae R and Srinivasan, Preethi and Gao, Jianjiong and Chakravarty, Debyani and Devlin, Sean M and Hellmann, Matthew D and Barron, David A and Schram, Alison M and Hameed, Meera and Dogan, Snjezana and Ross, Dara S and Hechtman, Jaclyn F and DeLair, Deborah F and Yao, JinJuan and Mandelker, Diana L and Cheng, Donavan T and Chandramohan, Raghu and Mohanty, Abhinita S and Ptashkin, Ryan N and Jayakumaran, Gowtham and Prasad, Meera and Syed, Mustafa H and Rema, Anoop Balakrishnan and Liu, Zhen Y and Nafa, Khedoudja and Borsu, Laetitia and Sadowska, Justyna and Casanova, Jacklyn and Bacares, Ruben and Kiecka, Iwona J and Razumova, Anna and Son, Julie B and Stewart, Lisa and Baldi, Tessara and Mullaney, Kerry A and Al-Ahmadie, Hikmat and Vakiani, Efsevia and Abeshouse, Adam A and Penson, Alexander V and Jonsson, Philip and Camacho, Niedzica and Chang, Matthew T and Won, Helen H and Gross, Benjamin E and Kundra, Ritika and Heins, Zachary J and Chen, Hsiao-Wei and Phillips, Sarah and Zhang, Hongxin and Wang, Jiaojiao and Ochoa, Angelica and Wills, Jonathan and Eubank, Michael and Thomas, Stacy B and Gardos, Stuart M and Reales, Dalicia N and Galle, Jesse and Durany, Robert and Cambria, Roy and Abida, Wassim and Cercek, Andrea and Feldman, Darren R and Gounder, Mrinal M and Hakimi, A. Ari and Harding, James J and Iyer, Gopa and Janjigian, Yelena Y and Jordan, Emmet J and Kelly, Ciara M and Lowery, Maeve A and Morris, Luc G. T and Omuro, Antonio M and Raj, Nitya and Razavi, Pedram and Shoushtari, Alexander N and Shukla, Neerav and Soumerai, Tara E and Varghese, Anna M and Yaeger, Rona and Coleman, Jonathan and Bochner, Bernard and Riely, Gregory J and Saltz, Leonard B and Scher, Howard I and Sabbatini, Paul J and Robson, Mark E and Klimstra, David S and Taylor, Barry S and Baselga, Jose and Schultz, Nikolaus and Hyman, David M and Arcila, Maria E and Solit, David B and Ladanyi, Marc and Berger, Michael F
Nature Medicine, ISSN 1078-8956, 06/2017, Volume 23, Issue 6, pp. 703 - 713
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7691, pp. 189 - 194
Journal Article
The New England journal of medicine, 02/2017, Volume 376, Issue 8, p. 801
Journal Article
Annual Review of Medicine, ISSN 0066-4219, 1/2018, Volume 69, Issue 1, pp. 319 - 331
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 3129 - 3129
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2017, Volume 376, Issue 8, pp. 801 - 802
To the Editor: Mirza and colleagues (Dec. 1 issue) 1 report encouraging results regarding niraparib maintenance therapy in patients with platinum-sensitive,... 
MEDICINE, GENERAL & INTERNAL | Female | Neoplasms, Glandular and Epithelial | Ovarian Neoplasms | Humans | Neoplasm Recurrence, Local | Chemotherapy | Platinum | Cross-resistance | Survival | Patients | Cancer therapies | Ovarian cancer | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 2017, Volume 7, Issue 6, pp. 552 - 554
The excitement surrounding genomically selected cancer therapy has led many to question whether this treatment paradigm is living up to its initial promise.... 
ONCOLOGY | MATCHED CLINICAL-TRIALS | MEDICINE | Medical Oncology | Neoplasms - therapy | Neoplasms - genetics | Humans | Treatment Outcome | Genome, Human | Molecular Targeted Therapy
Journal Article