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Pathogens and Disease, ISSN 2049-632X, 2017, Volume 75, Issue 2
Neisseria meningitidis is one of the most common aetiological agents of bacterial meningitis, affecting predominantly children and young adults. The... 
Ceramide | Neisseria meningitidis | Blood-cerebrospinal fluid barrier | Signal-transduction mechanisms | Surface adhesins and invasins | INFECTIOUS DISEASES | TYROSINE-KINASE | MEMBRANE-PROTEIN | RECEPTOR | MICROBIOLOGY | IMMUNOLOGY | HUMAN ENDOTHELIAL-CELLS | ceramide | blood-cerebrospinal fluid barrier | ADHESION MOLECULE | EPITHELIAL-CELLS | surface adhesins and invasins | signal-transduction mechanisms | GENE-EXPRESSION | IV PILI | OPA PROTEINS | CARCINOEMBRYONIC ANTIGENS CD66 | Neisseria meningitidis - pathogenicity | Blood-Brain Barrier - cytology | Signal Transduction | Endothelial Cells - metabolism | Humans | Meningitis, Meningococcal - metabolism | Meningitis, Meningococcal - genetics | Transcriptome | Receptors, Cell Surface - metabolism | Sphingolipids - metabolism | Blood-Brain Barrier - microbiology | Meningitis, Meningococcal - immunology | Blood-Brain Barrier - metabolism | Bacterial Adhesion | Endothelial Cells - microbiology | Host-Pathogen Interactions | Animals | Meningitis, Meningococcal - microbiology | Protein Binding | Bacterial Proteins - metabolism | Virulence Factors - metabolism | Bacterial Proteins - immunology | Neisseria meningitidis - physiology | Brain | Epidemics | Young adults | Bacterial infections | Blood vessels | Cerebrospinal fluid | Blood | Endothelial cells | Signal transduction | Signaling | Molecular modelling | Pathways | Meningitis | Bacteria | Adults | Children | Gram-negative bacteria | Health risk assessment
Journal Article
Biological Chemistry, ISSN 1431-6730, 09/2018, Volume 399, Issue 10, pp. 1135 - 1146
Acid sphingomyelinase (ASM) is a key enzyme in sphingolipid metabolism that converts sphingomyelin to ceramide, thereby modulating membrane structures and... 
bacterial infection | sphingolipids | acid sphingomyelinase | MYCOBACTERIUM-TUBERCULOSIS | LISTERIA-MONOCYTOGENES | DELTA-MEDIATED PHOSPHORYLATION | RICH MEMBRANE RAFTS | INDUCED APOPTOSIS | CHLAMYDIA-TRACHOMATIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEISSERIA-MENINGITIDIS | NIEMANN-PICK-DISEASE | STAPHYLOCOCCUS-AUREUS | CYSTIC-FIBROSIS
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 6, p. e1004160
The interaction with brain endothelial cells is central to the pathogenicity of Neisseria meningitidis infections. Here, we show that N. meningitidis causes... 
MOLECULAR MECHANISMS | TYROSINE-KINASE | RICH MEMBRANE RAFTS | INDUCED APOPTOSIS | PHOSPHOLIPASE-C | MICROBIOLOGY | PATHOGENIC NEISSERIAE | MENINGOCOCCAL-DISEASE | VIROLOGY | EPITHELIAL-CELLS | OPA PROTEINS | IV PILI | PARASITOLOGY | Brain - microbiology | Membrane Microdomains - metabolism | Humans | Microvessels - metabolism | Microvessels - microbiology | Type C Phospholipases - metabolism | Endothelium, Vascular - drug effects | Host-Pathogen Interactions - drug effects | Brain - metabolism | Brain - blood supply | Transendothelial and Transepithelial Migration - drug effects | Meningitis, Meningococcal - microbiology | Sphingomyelin Phosphodiesterase - metabolism | Surface Properties - drug effects | Cell Membrane - metabolism | Bacterial Adhesion - drug effects | Meningitis, Meningococcal - enzymology | Neisseria meningitidis - physiology | Bacterial Outer Membrane Proteins - genetics | Cell Membrane - drug effects | Neisseria meningitidis - pathogenicity | Ceramides - metabolism | Membrane Microdomains - enzymology | Meningitis, Meningococcal - metabolism | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Microvessels - drug effects | Enzyme Activation - drug effects | Endothelium, Vascular - microbiology | Brain - drug effects | Up-Regulation - drug effects | Cell Membrane - enzymology | Sphingomyelin Phosphodiesterase - antagonists & inhibitors | Bacterial Outer Membrane Proteins - metabolism | Endothelium, Vascular - metabolism | Membrane Microdomains - drug effects | Type C Phospholipases - genetics | Bacterial Proteins - metabolism | Mutation | Cell Line, Transformed | Care and treatment | Neisseria meningitidis | Phospholipases | Health aspects | Distribution | Endothelium | Proteins | Heparan sulfate | Enzymes | Flow cytometry | Acids | Meningitis | Bacteria | Infections | Experiments | Bacteriology
Journal Article
Journal Article
Infection and Immunity, ISSN 0019-9567, 06/2019, Volume 87, Issue 8
ABSTRACT Acid sphingomyelinase (ASM) is a lipid hydrolase that converts sphingomyelin to ceramide and that can be activated by various cellular stress... 
Journal Article
Angewandte Chemie, ISSN 0044-8249, 05/2017, Volume 129, Issue 22, pp. 6227 - 6231
The sphingolipid ceramide regulates cellular processes such as differentiation, proliferation, growth arrest, and apoptosis. Ceramide‐rich membrane areas... 
Ceramid-reiche Plattformen | Ceramide | dSTORM | Sphingolipide | Superauflösungsmikroskopie | Cell Membrane - metabolism | Ceramides - metabolism | Biological Transport | Stochastic Processes | Humans | Ceramides | Cell membranes | Plant lipids | Cell differentiation | Microscope and microscopy
Journal Article
BioDrugs, ISSN 1173-8804, 10/2013, Volume 27, Issue 5, pp. 419 - 419
Genome-based reverse vaccinology (RV) is a multi-step experimental strategy which starts from in silico analysis of whole genome sequences, from which vaccine... 
Journal Article