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Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1410 - 1416
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice.... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-PICTURE | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | AUTOIMMUNITY | REGULATORY T-CELLS | GERMLINE MUTATIONS | MICE | BLOCKADE | IMMUNODEFICIENCY | ABATACEPT | Recurrence | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Purpura, Thrombocytopenic, Idiopathic - genetics | Exons | Immune System Diseases - genetics | Humans | Middle Aged | Male | Anemia, Hemolytic, Autoimmune - genetics | Mutation, Missense | Respiratory Tract Infections - genetics | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Young Adult | Purpura, Thrombocytopenic, Idiopathic - immunology | Adult | Female | Endocytosis - genetics | Polyendocrinopathies, Autoimmune - genetics | Child | Endocytosis - immunology | Granuloma - genetics | Autoimmune Diseases - immunology | CTLA-4 Antigen - genetics | B7-1 Antigen - metabolism | Codon, Nonsense | CTLA-4 Antigen - immunology | Syndrome | Polyendocrinopathies, Autoimmune - immunology | Lung Diseases, Interstitial - immunology | Animals | B-Lymphocytes - immunology | Lung Diseases, Interstitial - genetics | Pedigree | Anemia, Hemolytic, Autoimmune - immunology | Adolescent | Respiratory Tract Infections - immunology | Granuloma - immunology | Heterozygote | Mice | Antigens | Gene mutations | Physiological aspects | Genetic aspects | Immunologic diseases | Research | Risk factors | Proteins | Homeostasis | Cytotoxicity | Ligands | T cell receptors | Mutation | Immune system
Journal Article
Immunotherapy, 08/2019, Volume 11, Issue 12, p. 1015
This prospective study compares nonmodified and modified house dust mite extracts for allergen immunotherapy (AIT) in pediatric patients with allergic asthma.... 
Journal Article
by Schwab, Charlotte and Gabrysch, Annemarie and Olbrich, Peter and Patiño, Virginia and Warnatz, Klaus and Wolff, Daniel and Hoshino, Akihiro and Kobayashi, Masao and Imai, Kohsuke and Takagi, Masatoshi and Dybedal, Ingunn and Haddock, Jamanda A and Sansom, David M and Lucena, Jose M and Seidl, Maximilian and Schmitt-Graeff, Annette and Reiser, Veronika and Emmerich, Florian and Frede, Natalie and Bulashevska, Alla and Salzer, Ulrich and Schubert, Desirée and Hayakawa, Seiichi and Okada, Satoshi and Kanariou, Maria and Kucuk, Zeynep Yesim and Chapdelaine, Hugo and Petruzelkova, Lenka and Sumnik, Zdenek and Sediva, Anna and Slatter, Mary and Arkwright, Peter D and Cant, Andrew and Lorenz, Hanns-Martin and Giese, Thomas and Lougaris, Vassilios and Plebani, Alessandro and Price, Christina and Sullivan, Kathleen E and Moutschen, Michel and Litzman, Jiri and Freiberger, Tomas and van de Veerdonk, Frank L and Recher, Mike and Albert, Michael H and Hauck, Fabian and Seneviratne, Suranjith and Pachlopnik Schmid, Jana and Kolios, Antonios and Unglik, Gary and Klemann, Christian and Speckmann, Carsten and Ehl, Stephan and Leichtner, Alan and Blumberg, Richard and Franke, Andre and Snapper, Scott and Zeissig, Sebastian and Cunningham-Rundles, Charlotte and Giulino-Roth, Lisa and Elemento, Olivier and Dückers, Gregor and Niehues, Tim and Fronkova, Eva and Kanderová, Veronika and Platt, Craig D and Chou, Janet and Chatila, Talal A and Geha, Raif and McDermott, Elizabeth and Bunn, Su and Kurzai, Monika and Schulz, Ansgar and Alsina, Laia and Casals, Ferran and Deyà-Martinez, Angela and Hambleton, Sophie and Kanegane, Hirokazu and Taskén, Kjetil and Neth, Olaf and Grimbacher, Bodo
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 12/2018, Volume 142, Issue 6, pp. 1932 - 1946
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 04/2018, Volume 141, Issue 4, pp. 1427 - 1438
Primary antibody deficiencies (PADs) are the most frequent primary immunodeficiencies in human subjects. The genetic causes of PADs are largely unknown. Sec61... 
SEC61A1 | multiple myeloma | translocon | antibody deficiency | calcium homeostasis | plasma cell | endoplasmic reticulum stress | protein translocation | DIAGNOSIS | PROTEIN | RENIN | ER STRESS | IMMUNOLOGY | HYPERURICEMIA | ALLERGY | GENES | ENDOPLASMIC-RETICULUM | DIFFERENTIATION | ANEMIA | TRANSCRIPTION FACTOR | Agammaglobulinemia - genetics | Calcium - metabolism | Humans | Respiratory Tract Infections - genetics | Agammaglobulinemia - metabolism | Plasma Cells - pathology | Cell Differentiation - genetics | Agammaglobulinemia - pathology | T-Lymphocytes - metabolism | HEK293 Cells | Plasma Cells - metabolism | B-Lymphocytes - pathology | T-Lymphocytes - pathology | B-Lymphocytes - metabolism | Respiratory Tract Infections - pathology | Cell Line | Respiratory Tract Infections - metabolism | Unfolded Protein Response - genetics | Mutation - genetics | Protein Transport - genetics | Exome - genetics | SEC Translocation Channels - genetics | Cell Line, Tumor | Immunologic Deficiency Syndromes - genetics | Immunologic Deficiency Syndromes - metabolism | Heterozygote | HeLa Cells | Biotechnology | Disease | Calcium | Laboratories | Identification methods | Pathogenesis | Genes | Multiple myeloma | Differentiation (biology) | Homeostasis | Lymphocytes T | Hypogammaglobulinemia | Kinases | Gene sequencing | Proteins | Respiratory tract | Ethics | Genotype & phenotype | Protein folding | Genetic analysis | Activating transcription factor 1 | Respiratory tract diseases | Protein transport | Calcium homeostasis | Translocation | Subpopulations | Phenotypes | Immunoglobulins | Cell survival | Polypeptides | Tumor cell lines | Cell differentiation | Patients | Human subjects | Lymphocytes B | Plasmids | Protein synthesis | Cell lines | Diabetes | Mutation | Endoplasmic reticulum
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 04/2019, Volume 10, p. 568
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are prone to recurrent bacterial... 
monogenic defects | IKAROS | COMMON VARIABLE IMMUNODEFICIENCY | TRAIL RECEPTORS | IMMUNOLOGY | PERICENTROMERIC HETEROCHROMATIN | INBORN-ERRORS | FAMILY | B-CELLS | CVID | GENE | TRAIL DNA binding | nuclear localization | DIFFERENTIATION | TRANSCRIPTION FACTOR | T-CELLS | Gastrointestinal diseases | Bacterial infections | DNA binding proteins | TRAIL | DNA binding
Journal Article
by Schwab, Charlotte and Gabrysch, Annemarie and Olbrich, Peter and Patiño, Virginia and Warnatz, Klaus and Wolff, Daniel and Hoshino, Akihiro and Kobayashi, Masao and Imai, Kohsuke and Takagi, Masatoshi and Dybedal, Ingunn and Haddock, Jamanda A and Sansom, David M and Lucena, Jose M and Seidl, Maximilian and Schmitt-Graeff, Annette and Reiser, Veronika and Emmerich, Florian and Frede, Natalie and Bulashevska, Alla and Salzer, Ulrich and Schubert, Desirée and Hayakawa, Seiichi and Okada, Satoshi and Kanariou, Maria and Kucuk, Zeynep Yesim and Chapdelaine, Hugo and Petruzelkova, Lenka and Sumnik, Zdenek and Sediva, Anna and Slatter, Mary and Arkwright, Peter D and Cant, Andrew and Lorenz, Hanns-Martin and Giese, Thomas and Lougaris, Vassilios and Plebani, Alessandro and Price, Christina and Sullivan, Kathleen E and Moutschen, Michel and Litzman, Jiří and Freiberger, Tomas and van de Veerdonk, Frank L and Recher, Mike and Albert, Michael H and Hauck, Fabian and Seneviratne, Suranjith and Pachlopnik Schmid, Jana and Kolios, Antonios and Unglik, Gary and Klemann, Christian and Speckmann, Carsten and Ehl, Stephan and Leichtner, Alan and Blumberg, Richard and Franke, Andre and Snapper, Scott and Zeissig, Sebastian and Cunningham-Rundles, Charlotte and Giulino-Roth, Lisa and Elemento, Olivier and Dückers, Gregor and Niehues, Tim and Fronkova, Eva and Kanderová, Veronika and Platt, Craig D and Chou, Janet and Chatila, Talal A and Geha, Raif and McDermott, Elizabeth and Bunn, Su and Kurzai, Monika and Schulz, Ansgar and Alsina, Laia and Casals, Ferran and Deyà-Martinez, Angela and Hambleton, Sophie and Kanegane, Hirokazu and Tasken, Kjetil and Neth, Olaf and Grimbacher, Bodo
ISSN 0091-6749, 2018
Objective: We sought to characterize the penetrance, clinical features, and best treatment options in 133 CTLA4 mutation carriers. Methods: Genetics, clinical... 
Journal Article
Proceedings of SPIE - The International Society for Optical Engineering, ISSN 0277-786X, 7/2018, Volume 10699, pp. 106993K - 106993K-11
We present the expected coating performance based on design and simulations, tested coating performance evaluated by means of X-ray reflectometry and short and... 
multilayer | effective area | SPO | X-ray mirrors | X-ray optics | Ir/SiC | XRR | coating design | Ir/B | ATHENA
Conference Proceeding
Journal of the Science of Food and Agriculture, ISSN 0022-5142, 06/2018, Volume 98, Issue 8, pp. 3161 - 3168
Journal Article
Journal of the science of food and agriculture, 12/2017
Chloride sensitivity of the potato (Solanum tuberosum L.) cultivars Marabel and Désirée was investigated in two pot experiments (soil/sand mixture and... 
Journal Article
McClatchy - Tribune Business News, 01/2008
The scoring has come primarily from senior point guard Desiree Pina (19.3 ppg) and sophomore Alyssa Martino (11.3). Six-foot-1 forward Lindsay Horbatuck is... 
College basketball | Athletes
Newspaper Article
Hartford Courant, ISSN 1047-4153, 01/2008
The scoring has come primarily from senior point guard Desiree Pina (19.3 ppg) and sophomore Alyssa Martino (11.3). Six-foot-1 forward Lindsay Horbatuck is... 
College basketball | Athletes
Newspaper Article
McClatchy - Tribune Business News, 02/2007, p. 1
I think our kids truly buy the team concept," Plainville coach Lisa Mandeville said. "Obviously when you look at Plainville, you have to start with Amanda... 
Newspaper Article
Hartford Courant, ISSN 1047-4153, 12/2006
* Cierra Baker, 5-9, Sr., G and Jhenel Franklin, 5-11, Sr., G, Windsor: Potential to be state's most dynamic backcourt. Franklin can break down defenders and... 
Newspaper Article
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