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Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
by Chatrchyan, S and Khachatryan, V and Sirunyan, A.M and Tumasyan, A and Adam, N and Adam, W and Aguilo, E and Bergauer, T and Dragicevic, M and Erö, J and Fabjan, C and Friedl, M and Frühwirth, R and Ghete, V.M and Hammer, J and Hoch, M and Hörmann, N and Hrubec, J and Jeitler, M and Kiesenhofer, W and Knünz, V and Krammer, M and Krätschmer, I and Liko, D and Majerotto, W and Mikulec, I and Pernicka, M and Rahbaran, B and Rohringer, H and Rohringer, C and Schöfbeck, R and Strauss, J and Szoncsó, F and Taurok, A and Waltenberger, W and Walzel, G and Widl, E and Wulz, C.-E and Chekhovsky, V and Emeliantchik, I and Litomin, A and Makarenko, V and Mossolov, V and Shumeiko, N and Solin, A and Stefanovitch, R and Suarez Gonzalez, J and Fedorov, A and Korzhik, M and Missevitch, O and Zuyeuski, R and Bansal, M and Bansal, S and Beaumont, W and Cornelis, T and De Wolf, E.A and Druzhkin, D and Janssen, X and Luyckx, S and Mucibello, L and Ochesanu, S and Roland, B and Roland, C and Roland, G and Rougny, R and Selvaggi, G and Selvaggi, M and Staykova, Z and Van Haevermaet, H and Van Mechelen, P and Van Remortel, N and Van Spilbeeck, A and Blekman, F and Blyweert, S and DʼHondt, J and Devroede, O and Gonzalez Suarez, R and Goorens, R and Kalogeropoulos, A and Maes, M and Olbrechts, A and Tavernier, S and Van Doninck, W and Van Lancker, L and Van Mulders, P and Van Onsem, G.P and Villella, I and Clerbaux, B and De Lentdecker, G and Dero, V and Dewulf, J.P and Gay, A.P.R and Hreus, T and Léonard, A and Marage, P.E and Mohammadi, A and Reis, T and Rugovac, S and Thomas, S and Thomas, M and ... and CMS Collaboration and Los Alamos National Lab. (LANL), Los Alamos, NM (United States) and Argonne National Lab. (ANL), Argonne, IL (United States) and Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States) and Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Physics Letters B, ISSN 0370-2693, 09/2012, Volume 716, Issue 1, pp. 30 - 61
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 17, pp. 6844 - 6863
Journal Article