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Journal Article
Cold Spring Harbor Perspectives in Medicine, ISSN 2157-1422, 05/2016, Volume 6, Issue 5, p. a026070
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 2013, Volume 4, p. 19
DNA damage contributes to cancer development and aging. Congenital syndromes that affect DNA repair processes are characterized by cancer susceptibility,... 
Genetic | Transcription | DNA repair | DNA damage | Progeria | Cancer | Transcription, Genetic | DNA Damage | DNA Repair
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 3, pp. 201 - 207
Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that... 
LIFE-SPAN | OXIDATIVE STRESS | TELOMERE DYSFUNCTION | MICE LEADS | DNA-DAMAGE | GROWTH | SELF-RENEWAL | ATM | SENESCENCE | CANCER | CELL BIOLOGY | Adult Stem Cells - physiology | Animals | Cellular Senescence | DNA Repair | Humans | Cells, Cultured | Aneuploidy | DNA Damage | Genome, Human | Neoplasms - pathology | Cell research | DNA damage | Stem cells | Physiological aspects | Aging | Genetic aspects | Research | Cells
Journal Article
Molecular Cancer, ISSN 1476-4598, 11/2012, Volume 11, Issue 1, pp. 85 - 85
Background: Due to the frequent dysregulation of the PI3K/AKT/mTOR signaling pathway, mTOR represents a suitable therapeutic target in hepatocellular carcinoma... 
Hepatocellular carcinoma | MK-2206 | AKT | AKT isoform kinase assay | Proliferation | RAD001 | MAMMALIAN TARGET | RAPAMYCIN | ACTIVATION | ADVANCED SOLID TUMORS | KINASE B-GAMMA | EVEROLIMUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BREAST-CANCER | ONCOLOGY | TERMINAL HYDROPHOBIC DOMAIN | PHASE-I | HUMAN CANCER | TOR Serine-Threonine Kinases - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Liver Neoplasms - chemistry | Proto-Oncogene Proteins c-akt - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Drug Delivery Systems | Gene Knockdown Techniques | TOR Serine-Threonine Kinases - antagonists & inhibitors | Carcinoma, Hepatocellular - drug therapy | TOR Serine-Threonine Kinases - genetics | Isoenzymes - metabolism | Female | Carcinoma, Hepatocellular - chemistry | Liver Neoplasms - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Everolimus | Sirolimus - analogs & derivatives | Isoenzymes - genetics | Liver Neoplasms - drug therapy | Carcinoma, Hepatocellular - enzymology | Mice, SCID | Sirolimus - pharmacology | Hep G2 Cells | Drug Synergism | Phosphatidylinositol 3-Kinases - genetics | Sirolimus - administration & dosage | Feedback, Physiological | Animals | Signal Transduction - drug effects | Heterocyclic Compounds, 3-Ring - administration & dosage | Liver Neoplasms - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Isoenzymes - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Carcinoma, Hepatocellular - metabolism | Enzymes | Angiogenesis inhibitors | Hepatoma | Health aspects | Analysis | Liver
Journal Article
Trends in Genetics, ISSN 0168-9525, 2013, Volume 30, Issue 3, pp. 95 - 102
Journal Article
Journal Article
F1000Research, ISSN 2046-1402, 2019, Volume 8, p. 1403
The field of aging research has progressed significantly over the past decades. Exogenously and endogenously inflicted molecular damage ranging from genotoxic... 
Senescence | Wound healing | Congenital diseases | Mortality | DNA damage | Genotoxicity | Homeostasis | Cell division | Genomes | Longevity | Metabolism | DNA repair | Autophagy | Proteins | Cell cycle | Aging | Age | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article