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Cell, ISSN 0092-8674, 01/2019, Volume 176, Issue 1-2, pp. 73 - 84.e15
Local translation meets protein turnover and plasticity demands at synapses, however, the location of its energy supply is unknown. We found that local... 
cytoskeleton | mitochondria | protein synthesis | synaptic plasticity | compartments | local translation | ATP | nascent protein | energy | AXONS | LOCALIZATION | MAINTENANCE | RECRUITMENT | HOMEOSTASIS | MICROTUBULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DYNAMICS | LONG-TERM POTENTIATION | DENDRITIC PROTEIN-SYNTHESIS | CELL BIOLOGY | Proteins | Physiological aspects
Journal Article
Nature, ISSN 0028-0836, 10/2004, Volume 431, Issue 7009, pp. 699 - 703
Journal Article
NATURE METHODS, ISSN 1548-7091, 08/2019, Volume 16, Issue 8, pp. 699 - 699
Chemical inhibitors have revealed requirements for protein synthesis that drive cellular plasticity. We developed a genetically encodable protein synthesis... 
RIBOSOME-INACTIVATING PROTEIN | VISUALIZATION | BIOCHEMICAL RESEARCH METHODS | Protein biosynthesis | Chemical inhibitors | Genetic aspects | Proteins | Organic chemistry | Inhibitors | Protein synthesis | Plasticity | Plastic properties | Chemical synthesis | Neuronal-glial interactions | Plastic foam
Journal Article
NATURE STRUCTURAL & MOLECULAR BIOLOGY, ISSN 1545-9993, 07/2019, Volume 26, Issue 7, pp. 557 - 566
Journal Article
Neuron, ISSN 0896-6273, 09/2019, Volume 103, Issue 6, pp. 1109 - 1122.e7
Proteins drive the function of neuronal synapses. The synapses are distributed throughout the dendritic arbor, often hundreds of micrometers away from the... 
protein dynamics | dendritic dynamics | computational model | dendrites | neuron | synaptic plasticity | local translation | Proteins | Active transport | Plasticity (synaptic) | Transcription | Computational neuroscience | Computer applications | Protein biosynthesis | mRNA | Localization | Plasticity (dendritic)
Journal Article
Current Opinion in Neurobiology, ISSN 0959-4388, 08/2019, Volume 57, pp. 141 - 148
Neurons exhibit a unique degree of spatial compartmentalization and are able to maintain and remodel their proteomes independently from the cell body. While... 
DENDRITES | LOCALIZATION | IN-VITRO | MESSENGER-RNA | TRANSCRIPTOME | TERM PLASTICITY | AXON | POLYRIBOSOMES | PROTEIN-SYNTHESIS | NEUROSCIENCES | REVEALS | Protein biosynthesis | RNA | Neurons | Genetic translation
Journal Article
Science, ISSN 0036-8075, 2014, Volume 343, Issue 6169, pp. 375 - 376
  The localization of messenger RNA (mRNA) within a cell provides the opportunity for proteins to be expressed in specific subcellular compartments. This... 
DENDRITES | NEURONS | TRANSCRIPTS | PARTICLES | MULTIDISCIPLINARY SCIENCES | Protein expression | Ribonucleic acid--RNA | Protein synthesis | Binding sites
Journal Article
Nature Reviews Neuroscience, ISSN 1471-003X, 09/2013, Volume 14, Issue 9, pp. 638 - 648
Like all cells, neurons are made of proteins that have characteristic synthesis and degradation profiles. Unlike other cells, however, neurons have a unique... 
Cell Compartmentation - physiology | Nerve Tissue Proteins - metabolism | Dendrites - metabolism | Prions - metabolism | Animals | Neurons - ultrastructure | Synapses - metabolism | Humans | Nerve Tissue Proteins - biosynthesis | Neurons - metabolism | Physiological aspects | Protein biosynthesis | Neural transmission | Genetic aspects | Research
Journal Article
PROTEOMICS, ISSN 1615-9853, 07/2019, Volume 19, Issue 14, pp. e1900028 - n/a
Adaptation to the environment during development influences the life‐long survival of an animal. While brain‐wide proteomic changes are expected to underlie... 
adaptation | environmental challenge | zebrafish | proteomics | brain | EMBRYO PROTEOME | ANNOTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | BIOCHEMICAL RESEARCH METHODS | Proteins | Physiological aspects | Environmental law
Journal Article
ChemBioChem, ISSN 1439-4227, 12/2018, Volume 19, Issue 23, pp. 2423 - 2423
The cover feature picture shows a novel photocaged antibiotic puromycin for the spatiotemporal control and monitoring of nascent polypeptide chain translation.... 
puromycin | analytical chemistry | neuronal control | coumarin | light control
Journal Article