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Nature Medicine, ISSN 1078-8956, 06/2015, Volume 21, Issue 6, pp. 591 - 600
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47648
The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We... 
TIM-3 EXPRESSION | IMMUNITY | GALECTIN-9 | BINDING | MULTIDISCIPLINARY SCIENCES | Liver - virology | Up-Regulation | Hepatitis B, Chronic - immunology | Humans | Middle Aged | Male | Kupffer Cells - virology | T-Lymphocytes - virology | CD4-Positive T-Lymphocytes - immunology | Young Adult | Liver - immunology | Hepatitis B, Chronic - genetics | T-Lymphocytes - metabolism | Galectins - immunology | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | Kupffer Cells - metabolism | CD4-Positive T-Lymphocytes - virology | Signal Transduction | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Membrane Proteins - immunology | Hepatitis A Virus Cellular Receptor 2 | Hepatitis B virus - physiology | Host-Pathogen Interactions | CD8-Positive T-Lymphocytes - virology | T-Lymphocytes - immunology | Aged | CD8-Positive T-Lymphocytes - immunology | Galectins - genetics | Kupffer Cells - immunology | Infection | Antiviral agents | Peptides | Liver | Hepatitis B virus | T cells | Health aspects | Apoptosis | Hepatitis B | Flow cytometry | Disease | PD-1 protein | Toxicity | CD8 antigen | Viremia | Kupffer cells | Chronic infection | Cytotoxicity | Viruses | Lymphocytes T | Infections | Inactivation | Hepatitis | Galectin-9 | Clonal deletion | Lymphocytes | Hepatology | Deletion | Deactivation | Cytokines | Dentistry | Tumor necrosis factor-α | Patients | CD4 antigen | Hepatocytes | Cell death | Exhaustion | γ-Interferon | Interferon | Histocompatibility antigen HLA | Viral infections
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 06/2017, Volume 214, Issue 6, pp. 1567 - 1580
The liver provides a tolerogenic immune niche exploited by several highly prevalent pathogens as well as by primary and metastatic tumors. We have sampled... 
PD-1 protein | CD8 antigen | Liver | Viruses | Infections | Lymphocytes T | Immunity | Metastases | Homing | Proteins | Hepatitis | CD69 antigen | CD103 antigen | Interleukin 2 | Lymphocytes | Immunotherapy | Hepatitis B virus | Immunological memory | Memory cells | Cytokines | Markers | Immunosurveillance | CXCR3 protein | Epitopes | Interleukin 15 | Hepatocytes | Exhaustion | γ-Interferon | Cell migration | Hepatitis B | Tumors | 312 | 317 | 321
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2013, Volume 9, Issue 3, p. e1003208
Optimal immune activation of naive CD8 T cells requires signal 1 mediated by the T cell receptor, signal 2 mediated by co-stimulation and signal 3 provided by... 
CLEARANCE | ACTIVATION | VIRUS-INFECTION | CHRONIC HEPATITIS-B | INTERLEUKIN-12 | MICROBIOLOGY | CHRONIC VIRAL-INFECTION | PERSISTENCE IN-VIVO | EFFECTOR | RESPONSES | VIROLOGY | DYSFUNCTION | PARASITOLOGY | Hepatitis B, Chronic - immunology | Species Specificity | Antiviral Agents - immunology | Humans | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - metabolism | Antiviral Agents - metabolism | Signal Transduction - immunology | Bcl-2-Like Protein 11 | CD8-Positive T-Lymphocytes - metabolism | Cytomegalovirus Infections - virology | Membrane Proteins - metabolism | Hepatitis B virus - immunology | Cytokines - immunology | Hepatitis B, Chronic - metabolism | Proto-Oncogene Proteins - metabolism | Interferon-alpha - metabolism | Cytokines - metabolism | Lymphocyte Activation | Down-Regulation | Programmed Cell Death 1 Receptor - metabolism | Interleukin-12 - metabolism | Apoptosis Regulatory Proteins - metabolism | Interferon-alpha - immunology | Hepatitis B, Chronic - virology | Cytomegalovirus - immunology | Gene Expression Regulation, Viral | Interleukin-12 - immunology | CD8-Positive T-Lymphocytes - immunology | Interleukin-12 | Physiological aspects | Host-parasite relationships | Hepatitis B virus | Research | T cells | Health aspects | Hepatitis | Cytomegalovirus | Peptides | Cytokines | Lymphocytes | Mortality | T cell receptors | Patients | Viral infections | Evacuations & rescues
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 10/2019, Volume 10
Upon activation naive T cells undergo metabolic changes to support the differentiation into subsets of effector or regulatory cells, and enable subsequent... 
LACTIC-ACID | hypoxia | GLUTAMINE | T cell | ACID-METABOLISM | RECEPTOR | IMMUNOLOGY | virus | CANCER | MESSENGER-RNA | TCA CYCLE | tumor | LACTATE | EXOSOMES | metabolism | Immune response | Research | T cells | Cancer cells
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2014, Volume 5, p. 468
The immune system cannot be continuously reactivated throughout the lifetime of an organism; there is a finite point at which repeated antigenic challenge... 
Senescence | Bioenergetics | Metabolism | Chronic viral infection | Exhaustion | senescence | exhaustion
Journal Article
Cell Reports, ISSN 2211-1247, 08/2016, Volume 16, Issue 5, pp. 1243 - 1252
T cells undergo profound metabolic changes to meet the increased energy demands of maintaining an antiviral response. We postulated that differences in... 
GLYCOLYSIS | SURVIVAL | OXYGEN | ACTIVATION | MEMORY | CHRONIC VIRAL-INFECTION | HEPATITIS-B | PD-1 | HBV | CELL BIOLOGY
Journal Article