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Human molecular genetics, ISSN 0964-6906, 06/2019
Proteus syndrome is a mosaic, progressive overgrowth disorder caused by a somatic activating variant c.49G>A p.(E17K) in AKT1. The presentation in affected... 
Journal Article
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2018, Volume 9, pp. 3079 - 3079
T follicular helper (Tfh) cells are a specialized population of CD4(+) T cells that provide help to B cells for the formation and maintenance germinal centers,... 
APDS | Tfr | autoimmunity | PI3K | Tfh cells | PASLI | ICOS | INTERLEUKIN-2 | PHOSPHATIDYLINOSITOL 3-KINASE | INDUCIBLE COSTIMULATOR | IMMUNOLOGY | CUTTING EDGE | EFFECTOR | RESPONSES | B-CELL | METABOLISM | TRANSCRIPTION FACTOR FOXO1 | Autoimmunity | Cellular signal transduction | Research | Cell differentiation | T cells
Journal Article
Current Protocols in Immunology, ISSN 1934-3671, 02/2019, Volume 124, Issue 1, pp. e62 - e62
The ability to alter gene expression directly in T lymphocytes has provided a powerful tool for understanding T cell biology, signaling, and function.... 
CRISPR | gene knockout | Cas9 | retroviral vector | murine T cells
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2011, Volume 365, Issue 7, pp. 611 - 619
Journal Article
European Journal of Immunology, ISSN 0014-2980, 12/2014, Volume 44, Issue 12, pp. 3522 - 3531
Journal Article
Immunity, ISSN 1074-7613, 2011, Volume 35, Issue 6, pp. 919 - 931
Journal Article
Immunity, ISSN 1074-7613, 06/2012, Volume 36, Issue 6, pp. 986 - 1002
Humans and mice deficient in the adaptor protein SAP ( ) have a major defect in humoral immunity, resulting from a lack of T cell help for B cells. The role of... 
SLAM FAMILY RECEPTORS | NATURAL-KILLER-CELLS | HUMORAL IMMUNITY | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | MOLECULE-ASSOCIATED PROTEIN | LINKED LYMPHOPROLIFERATIVE-DISEASE | PROTEIN-TYROSINE-PHOSPHATASE | GERMINAL-CENTER | GENE-PRODUCT | CUTTING EDGE | Phosphorylation | Germinal Center - immunology | Antigens, Ly - genetics | Inositol Polyphosphate 5-Phosphatases | CD4-Positive T-Lymphocytes - immunology | Intracellular Signaling Peptides and Proteins - deficiency | Lymphopoiesis - physiology | Phosphotyrosine - physiology | Antigens, Ly - physiology | Immunologic Deficiency Syndromes - immunology | Intracellular Signaling Peptides and Proteins - genetics | Mice, Inbred C57BL | Natural Killer T-Cells - cytology | Mice, Transgenic | Phosphoric Monoester Hydrolases - physiology | Amino Acid Motifs | Mice, Knockout | Animals | B-Lymphocytes - immunology | Signaling Lymphocytic Activation Molecule Associated Protein | Immunological Synapses - immunology | Immunologic Deficiency Syndromes - genetics | Mice | Protein Processing, Post-Translational | Intracellular Signaling Peptides and Proteins - physiology | Lymphocyte Cooperation - physiology | Computer software industry | T cells | Genetic disorders | Proteins | Confidence intervals | Biomedical research | Lymphocytes | Rodents | Viral infections | Immune system | Cell adhesion & migration | Index Medicus | Germinal centers | Lymphocytes B | SHP-1 protein | Cell adhesion | Immunity (humoral) | Immunological synapses | Lymphocytes T | Natural killer cells | Differentiation | adaptor proteins | SAP protein | CD4 antigen
Journal Article
Science, ISSN 0036-8075, 04/1999, Volume 284, Issue 5414, pp. 638 - 641
Journal Article
Cell, ISSN 0092-8674, 4/2014, Volume 157, Issue 2, pp. 499 - 513
A major goal of systems biology is the development of models that accurately predict responses to perturbation. Constructing such models requires collection of... 
Journal Article
Journal Article