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Nature Medicine, ISSN 1078-8956, 07/2004, Volume 10, Issue 7, pp. S2 - S9
The molecular bases underlying the pathogenesis of neurodegenerative diseases are gradually being disclosed. One problem that investigators face is... 
MEDICINE, RESEARCH & EXPERIMENTAL | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ONSET PARKINSONS-DISEASE | AXONAL-TRANSPORT | AMYLOID PRECURSOR PROTEIN | ALPHA-SYNUCLEIN | CELL BIOLOGY | A-BETA | MITOCHONDRIAL DYSFUNCTION | HUNTINGTONS-DISEASE | SUPEROXIDE-DISMUTASE | TRANSGENIC MICE | Protein Kinases - metabolism | Oncogene Proteins - genetics | Protein Kinases - genetics | Membrane Glycoproteins - metabolism | Humans | Huntington Disease - pathology | Membrane Glycoproteins - chemistry | Ubiquitin - metabolism | Nerve Degeneration - genetics | Protein Kinases - chemistry | Serum Amyloid A Protein - genetics | Serotonin Plasma Membrane Transport Proteins | Nerve Degeneration - metabolism | Alzheimer Disease - pathology | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Protein Denaturation | Carrier Proteins - chemistry | Parkinson Disease - metabolism | Parkinson Disease - pathology | Neurodegenerative Diseases - pathology | Serum Amyloid A Protein - metabolism | Oncogene Proteins - chemistry | Amyotrophic Lateral Sclerosis - genetics | Oncogene Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Parkinson Disease - genetics | Ubiquitin-Protein Ligases - chemistry | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Protein Folding | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Protein Deglycase DJ-1 | Amyotrophic Lateral Sclerosis - pathology | Animals | Carrier Proteins - metabolism | Serum Amyloid A Protein - chemistry | Membrane Transport Proteins | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Huntington Disease - genetics | Alzheimer Disease - genetics | Ubiquitin-Protein Ligases - genetics
Journal Article
Journal Article
Journal Article
Brain, ISSN 0006-8950, 2/2008, Volume 131, Issue 2, pp. 338 - 351
Mutations in OPA1, a dynamin-related GTPase involved in mitochondrial fusion, cristae organization and control of apoptosis, have been linked to non-syndromic... 
Chronic progressive external ophthalmoplegia | Dominant optic atrophy | Mitochondrial encephalomyopathy | Mitochondria | mtDNA multiple deletions | PROTEIN | mitochondria | NEUROSCIENCES | chronic progressive external ophthalmoplegia | R445H MUTATION | CLINICAL NEUROLOGY | mitochondrial encephalomyopathy | PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA | NEUROGASTROINTESTINAL ENCEPHALOMYOPATHY | HEARING-LOSS | GENE | DISEASE | dominant optic atrophy | DEAFNESS | FISSION | DELETIONS | Ophthalmoplegia, Chronic Progressive External - pathology | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Mutation, Missense | DNA Mutational Analysis - methods | Ophthalmoplegia, Chronic Progressive External - genetics | DNA, Mitochondrial - genetics | Base Sequence | Muscle, Skeletal - chemistry | Adult | Female | Optic Atrophy, Autosomal Dominant - pathology | Child | Muscle, Skeletal - ultrastructure | Models, Molecular | Fibroblasts - pathology | Mitochondrial Myopathies - pathology | Syndrome | Magnetic Resonance Imaging | Point Mutation | Mitochondrial Myopathies - genetics | GTP Phosphohydrolases - genetics | Pedigree | Optic Atrophy, Autosomal Dominant - genetics | Aged | GTP Phosphohydrolases | Neurons and Cognition | DNA, Mitochondrial | Life Sciences | DNA Mutational Analysis | Fibroblasts | Optic Atrophy, Autosomal Dominant | Mitochondrial Myopathies | Ophthalmoplegia, Chronic Progressive External | Muscle, Skeletal
Journal Article