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Journal of Molecular Biology, ISSN 0022-2836, 05/2019, Volume 431, Issue 12, pp. 2223 - 2247
Antigenic mimicry is a fundamental tenet of structure-based vaccinology. Vaccine strategies for the human immunodeficiency virus type 1 (HIV-1) focus on the... 
human immunodeficiency virus | glycosylation | antibodies | structure | vaccinology | B-CELL RECEPTORS | ENVELOPE GLYCOPROTEIN TRIMERS | SITE-SPECIFIC ANALYSIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | DEPENDENT EPITOPE | BROADLY NEUTRALIZING ANTIBODY | N-LINKED GLYCOSYLATION | ENV TRIMERS | MONOCLONAL-ANTIBODIES | AIDS vaccines | HIV (Viruses) | Health aspects | Antigenic determinants | Env, envelope spike | CHO, Chinese hamster ovary | UFO, uncleaved prefusion-optimized | BCR, B cell receptor | EM, electron microscopy | MPER, membrane proximal external region | HIV-1, human immunodeficiency virus type 1 | 2, heptad repeat 1 or 2 | Glc, glucose | bnAb(s), broadly neutralizing antibody(ies) | HCDR3, third heavy-chain complementarity-determining regions | NFL, native flexibly linked | GlcNAc, N-acetylglucosamine | CT, cytoplasmic tail | PNGS, potential N-glycosylation sites | Neu5Ac, N-acetylneuraminic acid (sialic acid) | nAb(s), neutralizing antibody(ies) | CDR, complementarity-determining regions | α-man I and II, α-mannosidase I and II | gl-bnAb(s), germline-bnAb(s) | TAMP, trimer-associated mannose patch | HEK, human embryonic kidney | LOS, lipooligosaccharides | GnT I, N-acetylglucosaminyltransferase I | AIDS, acquired immune deficiency syndrome | CD4bs, CD4 binding site | Gal, galactose | PBMC, peripheral blood mononuclear cell | CCR5, C-C chemokine receptor type 5 | TM, transmembrane region | SP, signal peptide | Man, mannose | founder | HR1 | KDO, 2-keto-3-deoxy-D-manno-octulosonic acid | SC, single-chain | Fuc, fucose | PNS, peripheral nervous system | CXCR4, C-X-C chemokine receptor type 4 | TF, transmitted | GlcN, glucosamine | cGMP, current good manufacturing practices | ER, endoplasmic reticulum | IMP, intrinsic mannose patch
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2018, Volume 115, Issue 28, p. 7320
Lassa virus is an Old World arenavirus endemic to West Africa that causes severe hemorrhagic fever. Vaccine development has focused on the envelope... 
Carbohydrates | Hemorrhagic fever | Immune response | Glycoprotein | Viruses | Amino acids | Glycosylation | Vaccines | Hemorrhage | Fever | Immune response (humoral) | Glycan | Disease resistance | Polysaccharides | Immunology | Clusters | Immune system
Journal Article
Analytical Chemistry, ISSN 0003-2700, 06/2018, Volume 90, Issue 12, p. 7325
The development of domain-exchanged antibodies offers a route to high-affinity targeting to clustered multivalent epitopes, such as those associated with viral... 
Spectroscopy | Immunoglobulins | Human immunodeficiency virus--HIV | Ionic mobility | Antibodies | Viruses | Sensors | Mutation | Mass spectrometry
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2018, Volume 115, Issue 28, pp. 7320 - 7325
Journal Article
Journal Article
Analytical Chemistry, ISSN 0003-2700, 06/2018, Volume 90, Issue 12, pp. 7325 - 7331
The development of domain-exchanged antibodies offers a route to high-affinity targeting to clustered multivalent epitopes, such as those associated with viral... 
BISPECIFIC ANTIBODIES | HIV-1 | CHEMISTRY, ANALYTICAL | ION-MOBILITY | VARIANTS | STABILITY | HUMAN-IGG | GLYCOSYLATION | 2G12 RECOGNIZES | CLUSTER | INSIGHTS
Journal Article
Journal of virology, ISSN 0022-538X, 2019, Volume 93, Issue 4
In HIV-1 vaccine research, native-like, soluble envelope glycoprotein SOSIP trimers are widely used for immunizing animals. The epitopes of autologous... 
HIV-1 | glycan hole | immunization | neutralization | SOSIP | antibodies | epitope | Env trimer | STRAINS | COEVOLUTION | PANEL | MECHANISM | RECOGNITION | GLYCOSYLATION | ENV | IDENTIFICATION | IMMUNOGENICITY | VIROLOGY | CRYO-EM STRUCTURE
Journal Article
Cell Reports, ISSN 2211-1247, 08/2018, Volume 24, Issue 8, pp. 1958 - 1966.e5
Many broadly neutralizing antibodies (bnAbs) against HIV-1 recognize and/or penetrate the glycan shield on native, virion-associated envelope glycoprotein... 
glycosylation | mass spectrometry | HIV | envelope glycoprotein | POTENT | EPITOPE | STRUCTURAL BASIS | BROADLY NEUTRALIZING ANTIBODIES | PURIFICATION | IMMUNODEFICIENCY-VIRUS TYPE-1 | ENVELOPE GLYCOPROTEIN | GP120 | CELL | N-GLYCAN RECOGNITION | CELL BIOLOGY
Journal Article
Molecular Immunology, ISSN 0161-5890, 12/2015, Volume 68, Issue 2, pp. 234 - 243
Effective use of adenovirus-5 (Ad5) in cancer therapy is heavily dependent on the degree to which the virus’s natural tropism can be subverted to one that... 
Fc Receptor | Glycosylation | Adenovirus | Antibody | Endoglycosidase S | Cancer | DOMAIN | PROTEIN | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IGG | RECEPTOR | MONOCLONAL-ANTIBODY | IMMUNOLOGY | SELECTIVE GENE-THERAPY | DELIVERY | BREAST-CANCER CELLS | VECTORS | Recombinant Fusion Proteins - immunology | Immunotherapy - methods | Receptor, ErbB-2 - genetics | Breast Neoplasms - immunology | Humans | Bacterial Proteins - chemistry | Receptors, IgG - chemistry | Molecular Sequence Data | Antigens, Viral - genetics | Coxsackie and Adenovirus Receptor-Like Membrane Protein - immunology | Antibodies, Bispecific - genetics | Antigens, Neoplasm - chemistry | Breast Neoplasms - therapy | Receptors, IgG - genetics | HEK293 Cells | Protein Engineering | Adenoviridae - genetics | Glycoside Hydrolases - chemistry | Female | Receptor, ErbB-2 - immunology | Adenoviridae - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Trastuzumab - chemistry | Amino Acid Sequence | Antigens, Neoplasm - genetics | Antigens, Neoplasm - immunology | Antineoplastic Agents - immunology | Antigens, Viral - chemistry | Receptors, IgG - immunology | Recombinant Fusion Proteins - chemistry | Antineoplastic Agents - chemistry | Antibodies, Bispecific - immunology | Immunoconjugates - chemistry | Antigens, Viral - immunology | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Immunoconjugates - genetics | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Antibodies, Bispecific - chemistry | Bacterial Proteins - metabolism | Glycoside Hydrolases - metabolism | Genetic Vectors | Coxsackie and Adenovirus Receptor-Like Membrane Protein - genetics | Trastuzumab - immunology | Viral antibodies | Viral proteins | Adenoviruses | Antibodies | Health aspects | Biopharmaceutics | Tumors | Glutathione transferase | Immunoglobulin G | Immunotherapy | Monoclonal antibodies | Coxsackievirus infections | Immunity | High performance liquid chromatography
Journal Article