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Chemistry - A European Journal, ISSN 0947-6539, 06/2012, Volume 18, Issue 23, pp. 7219 - 7223
Herein, we present two methods for an asymmetric transfer hydrogenation through the dynamic kinetic resolution of α-amido-β-ketoesters. These procedures yield... 
kinetic resolution | transfer hydrogenation | asymmetric synthesis | emulsions | amino acids | Emulsions | Chemistry Techniques, Analytical | Stereoisomerism | Amino Acids - chemistry | Esters | Molecular Structure | Kinetics | Hydrogenation | Sodium | Asymmetry | Dynamics | Formates | Substrates
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7664, pp. 453 - 457
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness(1-4). A... 
EPITHELIAL-MESENCHYMAL TRANSITION | METABOLISM | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | HUMAN-MELANOMA CELLS | SENSITIVITY | DEATH | INHIBITOR | EXPRESSION | SIGNATURE | REVEALS | Prostatic Neoplasms - metabolism | Cadherins - metabolism | Humans | Mesoderm - drug effects | Melanoma - enzymology | Male | Lipid Peroxides - metabolism | Zinc Finger E-box-Binding Homeobox 1 - genetics | Neoplasms - genetics | Mesoderm - enzymology | Cell Death | Epithelial-Mesenchymal Transition | Lipid Peroxidation - drug effects | Cell Transdifferentiation | Prostatic Neoplasms - drug therapy | Melanoma - metabolism | Glutathione Peroxidase - metabolism | Prostatic Neoplasms - pathology | Reproducibility of Results | Neoplasms - enzymology | Melanoma - pathology | Iron - metabolism | Neoplasms - drug therapy | Cell Lineage | Drug Resistance, Neoplasm - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Proteomics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mesoderm - metabolism | Neoplasms - pathology | Mesoderm - pathology | Peroxidase | Research | Chemical properties | Chemical synthesis | Analysis | Cancer cells | Therapy | Biotechnology | Carcinoma | Mesenchyme | Genes | Lipid peroxidation | Lipids | Iron | Genomes | Phospholipids | Kinases | Cancer therapies | Proteins | Organoids | Dissipation | Peroxides | Lipid metabolism | Glutathione | Transfer RNA | Peroxidation | Glutathione peroxidase | Enzymes | Mortality | Melanoma | Selenocysteine | Tumor cell lines | Metabolism | Substrates | Cell death | Lipoxygenase | Prostate cancer | Prostate | Tumors | Apoptosis | Cancer | Index Medicus
Journal Article
Journal Article
Organic Letters, ISSN 1523-7060, 08/2012, Volume 14, Issue 15, pp. 3858 - 3861
This study examines a domino carbopalladation-cross-coupling reaction for the formation of valuable oxindole scaffolds. Furthermore, the reaction sequence... 
ORGANIC-SYNTHESIS | CATALYSIS | BORONIC ACID | POTENT | CYCLIZATION-ANION CAPTURE | NATURAL-PRODUCTS | LEADS | CHEMISTRY, ORGANIC | AGENTS | INHIBITORS | STRUCTURE-BASED DESIGN | Potent | Structure-Based Design | Boronic Acid | Agents | Leads | Natural-Products | Chemical Sciences | Organic-Synthesis | Naturvetenskap | Inhibitors | Kemi | Natural Sciences | Organisk kemi | Catalysis | Cyclization-Anion Capture | Organic Chemistry
Journal Article
Journal Article
Journal of Biomolecular Screening, ISSN 1087-0571, 12/2016, Volume 21, Issue 10, pp. 1019 - 1033
The cellular thermal shift assay (CETSA) was introduced in 2013 as a means to assess drug binding in complex environments such as cell lysates, live cells, and... 
CETSA | chemical probe validation | protein unfolding | target engagement | structure-activity relationship | CELLS | STABILIZATION | STABILITY | DRUG DISCOVERY | BIOCHEMICAL RESEARCH METHODS | ISOTHERMAL DENATURATION | LIGANDS | CHEMICAL PROBES | INHIBITORS | PROTEINS
Journal Article
Chemistry, ISSN 0947-6539, 06/2012, Volume 18, Issue 23, p. 7219
  Herein, we present two methods for an asymmetric transfer hydrogenation through the dynamic kinetic resolution of [alpha]-amido-[beta]-ketoesters. These... 
Hydrogenation
Journal Article
Chemistry - A European Journal, ISSN 0947-6539, 06/2012, Volume 18, Issue 23, pp. 7219 - 7223
Journal Article
Chemistry - A European Journal, ISSN 0947-6539, 2012, Volume 18, Issue 23, p. 2719
Herein, we present two methods for an asymmetric transfer hydrogenation through the dynamic kinetic resolution of α-amido-β-ketoesters. These procedures yield... 
Naturvetenskap | asymmetric synthesis | Kemi | emulsions | amino acids | kinetic resolution | transfer hydrogenation | Natural Sciences | Organisk kemi | Chemical Sciences | Organic Chemistry
Journal Article
Organic Letters, ISSN 1523-7060, 09/2010, Volume 12, Issue 17, pp. 3732 - 3735
A domino carbopalladation-carbonylation sequence for substrates possessing beta-hydrogens is explored. This allows for the construction of complex... 
ASYMMETRIC-SYNTHESIS | CARBON | PEROPHORAMIDINE | ENANTIOSELECTIVE SYNTHESIS | COUPLING REACTIONS | ALPHA-ARYLATION | PALLADIUM-CATALYZED CYCLIZATION | CONSTRUCTION | OXINDOLES | CHEMISTRY, ORGANIC | INTRAMOLECULAR HECK REACTIONS | Chemistry | Naturvetenskap | Kemi | Natural Sciences | Organisk kemi | Chemical Sciences | Organic Chemistry
Journal Article
Journal Article
Journal of Visualized Experiments, ISSN 1940-087X, 11/2018, Volume 2018, Issue 141
Quantitating the interaction of small molecules with their intended protein target is critical for drug development, target validation and chemical probe... 
Cellular thermal shift assay (CETSA) | Single cell resolution | Imaging | High-throughput screening | Target engagement | P38α | Biochemistry | Issue 141 | DRUG | THERMAL SHIFT ASSAY | MULTIDISCIPLINARY SCIENCES | high-throughput screening | target engagement | imaging | p38 alpha | single cell resolution
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2017, Volume 13, Issue 10, pp. 1102 - 1108
Journal Article