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Chemical Communications: Chem Comm, ISSN 1359-7345, 12/2014, Volume 51, Issue 2, pp. 302 - 305
A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely... 
Binding | Enzymes | Inhibitors | Carbonic anhydrase | Pocket | Carboxylates | Adducts
Journal Article
Phytotherapy Research, ISSN 0951-418X, 06/2017, Volume 31, Issue 6, pp. 937 - 944
Harpagophytum procumbens has a long story of use for the treatment of inflammatory diseases. Considering both the antiinflammatory effects of H. procumbens in... 
PGE2 | serotonin | TNFα | microwave‐assisted extraction | 8‐iso‐PGF2α | ROS | Harpagophytum procumbens | viability | microwave-assisted extraction | 8-iso-PGF | PGE | OXIDATIVE STRESS | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | TRADITIONAL MEDICINE | TNF | BOWEL-DISEASE | INTESTINAL INFLAMMATION | IN-VITRO | EXPERIMENTAL COLITIS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TNF-ALPHA | MULTICOMPONENT PATTERN | Inflammatory Bowel Diseases - drug therapy | Tumor Necrosis Factor-alpha - metabolism | Harpagophytum - chemistry | Plant Extracts - pharmacology | Humans | Colon - drug effects | Rats | Male | Dinoprost - metabolism | Glycosides - pharmacology | Rats, Sprague-Dawley | Lipopolysaccharides | Dinoprostone - metabolism | Animals | Plant Roots - chemistry | Cell Line, Tumor | Dinoprost - analogs & derivatives | Mice | Oxidative Stress - drug effects | Pyrans - pharmacology | Mitogens | Colon cancer | Ulcerative colitis | Adenocarcinoma | Biotechnology | Oxidative stress | Inflammatory bowel diseases | Hydrogen peroxide | Medical services | Prostaglandin E2 | Tissues | Inflammatory diseases | Optimization | Prevention | Intestine | Rodents | Tumor necrosis factor-TNF | Extraction | Colon | Inhibition | Immune system | Oxygen | Immune response | Effectiveness | Stability | Serotonin | Management | Tumor cell lines | Biological activity | Diseases | Inflammatory bowel disease | Tumor necrosis factor | Viability | Cancer
Journal Article
Journal Article
Journal of Chromatography A, ISSN 0021-9673, 05/2017, Volume 1499, p. 140
* This paper describes the HPLC behavior of a set of chiral pyrazolines on the IA-3 CSP. * Retention curves were obtained by plotting retention vs alcohol... 
Enantiomers
Journal Article
Journal of Chromatography A, ISSN 0021-9673, 01/2018, Volume 1531, pp. 151 - 156
In previous studies, Okamoto et al. described the results of the exceptionally large chiral recognition of 2-(benzylsulfinyl)benzamide onto a coated-type... 
2-(Benzylsulfinyl)benzamide | High enantioselectivity | Enantiomers | Chiralpak IC-3 | Absolute configuration | H-bonding | CHEMISTRY, ANALYTICAL | ENANTIOSELECTIVITY | AMYLOSE | RESOLUTION | BIOCHEMICAL RESEARCH METHODS | PERFORMANCE LIQUID-CHROMATOGRAPHY | ENANTIOSEPARATION | SULFOXIDES | SEPARATION | SILICA | DERIVATIVES
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2016, Volume 107, pp. 82 - 96
Journal Article
ChemMedChem, ISSN 1860-7179, 05/2013, Volume 8, Issue 5, pp. 800 - 811
Herein we report novel pyrrole‐ and benzene‐based hydroxamates (8, 10) and 2′‐aminoanilides (9, 11) bearing the tert‐butylcarbamate group at the CAP moiety as... 
apoptosis | hydroxamates | pyrroles | anilides | tert‐butylcarbamates | Anilides | tert-butylcarbamates | Pyrroles | Apoptosis | Hydroxamates | HDAC INHIBITORS | BINDING MODE | DESIGN | CHEMISTRY, MEDICINAL | THERAPY | LEUKEMIA-CELLS | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | HYDROXYAMIDES | DIFFERENTIATION | EXPRESSION | CLASS-II | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Carbamates - chemistry | Repressor Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Histone Deacetylase Inhibitors - chemical synthesis | MCF-7 Cells | U937 Cells | Histone Deacetylase 1 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Repressor Proteins - metabolism | Carbamates - pharmacology | Recombinant Proteins - metabolism | Histone Deacetylase 6 | HCT116 Cells | Models, Molecular | Histone Deacetylases - metabolism | Antineoplastic Agents - chemistry | Histone Deacetylase Inhibitors - chemistry | Neoplasms - drug therapy | HT29 Cells | Carbamates - chemical synthesis | Cell Differentiation - drug effects | K562 Cells | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Cell Proliferation - drug effects | Neoplasms - pathology | Drug Screening Assays, Antitumor | Histone Deacetylase 1 - metabolism | Heterocyclic compounds | Benzene | Leukemia | Cancer cells | Thiophene | Tubulins | Telomerase | Medical research | Cells | Cancer
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 1543 - 1552
Journal Article