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by Vergote, Ignace and Scambia, Giovanni and O'Malley, David M and Van Calster, Ben and Park, Sang-Yoon and del Campo, Josep M and Meier, Werner and Bamias, Aristotelis and Colombo, Nicoletta and Wenham, Robert M and Covens, Al and Marth, Christian and Raza Mirza, Mansoor and Kroep, Judith R and Ma, Haijun and Pickett, Cheryl A and Monk, Bradley J and Vergote, Ignace and Scambia, Giovanni and Park, Sang Yoon and Song, Yong Sang and Makarova, Yulia and Trinidad, Joshua and Ngan, Hextan Yuen Sheung and Bamias, Aristotelis and Aravantinos, Gerasimos and Nam, Joo-Hyun and Gorbunova, Vera and Krikunova, Ludmila and Bae, Duk-Soo and Arija, Jose Angel Arranz and Mirza, Mansoor Raza and Zamagni, Claudio and Papandreou, Christos and Raspagliesi, Francesco and Lisyanskaya, Alla and Benzaquen, Ana Oaknin and Tognon, Germana and Ortega, Eugenia and Herraez, Antonio Casado and Buscema, Joseph and Green, Andrew and Burger, Robert and Sakaeva, Dina and Sanchez, Andres Redondo and Ghamande, Sharad and King, Laurel and Petru, Edgar and Peen, Ulla and Takeuchi, Satoshi and Ushijima, Kimio and Martin, Antonio Gonzalez and Kamelle, Scott and Carney, Michael and Marth, Christian and Forget, Frédéric and Bentley, James and Sehouli, Jalid and Colombo, Nicoletta and Zola, Paolo and Kato, Hidenori and Fadeeva, Natalya and Gotovkin, Evgeny and Vladimirov, Vladimir and Marin, Margarita Romeo and Alia, Eva Guerra and Shahin, Mark and Bhoola, Snehalkumar and Tewari, Krishnansu and Anderson, Daniel and Honhon, Brigitte and Pelgrims, Joseph (Gino) and Oza, Amit and Jimenez, Jesus Garcia-Donas and Hansen, Vincent and O'Malley, David and Benjamin, Ivor and Renard, Vincent and Van den Bulck, Heidi and Meier, Werner and Haenle, Claudia and Koumakis, Georgios and Yokota, Harushige and Popov, Vadim and Bradley, William and Wenham, Robert and Reid, Robert and McNamara, Donna and Friedman, Richard and Barlin, Joyce and Spirtos, Nicola and Chapman, Julia and Sevelda, Paul and Huizing, Manon and Lamot, Caroline and Goffin, Frédéric and Hondt, Lionel D and Covens, Allan and Spadafora, Silvana and Rautenberg, Beate and ... and TRINOVA-3/ENGOT-ov2/GOG-3001 investigators and TRINOVA-3 ENGOT-ov2 GOG-3001 Inves
The Lancet Oncology, ISSN 1470-2045, 06/2019, Volume 20, Issue 6, pp. 862 - 876
Angiopoietin 1 and 2 regulate angiogenesis and vascular remodelling by interacting with the tyrosine kinase receptor Tie2, and inhibition of angiogenesis has... 
WOMEN | THERAPY | INHIBITION | ANGIOGENESIS | ONCOLOGY | FUNCTIONAL ASSESSMENT | BEVACIZUMAB | SUPPRESSION | TUMOR-GROWTH | AMG 386 | CHEMOTHERAPY | Care and treatment | Analysis | Carboplatin | Clinical trials | Product development | Ovarian cancer | Cancer
Journal Article
by Thorsson, Vésteinn and Gibbs, David L and Brown, Scott D and Wolf, Denise and Bortone, Dante S and Ou Yang, Tai-Hsien and Porta-Pardo, Eduard and Gao, Galen F and Plaisier, Christopher L and Eddy, James A and Ziv, Elad and Culhane, Aedin C and Paull, Evan O and Sivakumar, I.K. Ashok and Gentles, Andrew J and Malhotra, Raunaq and Farshidfar, Farshad and Colaprico, Antonio and Parker, Joel S and Mose, Lisle E and Vo, Nam Sy and Liu, Jianfang and Liu, Yuexin and Rader, Janet and Dhankani, Varsha and Reynolds, Sheila M and Bowlby, Reanne and Califano, Andrea and Cherniack, Andrew D and Anastassiou, Dimitris and Bedognetti, Davide and Mokrab, Younes and Newman, Aaron M and Rao, Arvind and Chen, Ken and Krasnitz, Alexander and Hu, Hai and Malta, Tathiane M and Noushmehr, Houtan and Pedamallu, Chandra Sekhar and Bullman, Susan and Ojesina, Akinyemi I and Lamb, Andrew and Zhou, Wanding and Shen, Hui and Choueiri, Toni K and Weinstein, John N and Guinney, Justin and Saltz, Joel and Holt, Robert A and Rabkin, Charles S and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Chudamani, Sudha and Liu, Jia and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Kim, Jaegil and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Liu, Yuexin and Miller, Michael and Reynolds, Sheila and Shmulevich, Ilya and Thorsson, Vesteinn and Zhang, Wei and Akbani, Rehan and Broom, Bradley M and Hegde, Apurva M and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 812 - 830.e14
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across... 
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | Immunology | Infectious Diseases | Immunology and Allergy | GENOMIC ANALYSES | INFORMATION | T-CELL-RECEPTOR | REGULATORY NETWORK | CLASSIFICATION | IMMUNOLOGY | SEQUENCING DATA | SOMATIC MUTATIONS | COMPREHENSIVE ANALYSIS | PREDICTION | REVEALS | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | miRNA | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
Journal Article
by Ricketts, Christopher J and De Cubas, Aguirre A and Fan, Huihui and Smith, Christof C and Lang, Martin and Reznik, Ed and Bowlby, Reanne and Gibb, Ewan A and Akbani, Rehan and Beroukhim, Rameen and Bottaro, Donald P and Choueiri, Toni K and Gibbs, Richard A and Godwin, Andrew K and Haake, Scott and Hakimi, A. Ari and Henske, Elizabeth P and Hsieh, James J and Ho, Thai H and Kanchi, Rupa S and Krishnan, Bhavani and Kwiatkowski, David J and Lui, Wembin and Merino, Maria J and Mills, Gordon B and Myers, Jerome and Nickerson, Michael L and Reuter, Victor E and Schmidt, Laura S and Shelley, C. Simon and Shen, Hui and Shuch, Brian and Signoretti, Sabina and Srinivasan, Ramaprasad and Tamboli, Pheroze and Thomas, George and Vincent, Benjamin G and Vocke, Cathy D and Wheeler, David A and Yang, Lixing and Kim, William Y and Robertson, A. Gordon and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Chudamani, Sudha and Liu, Jia and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Kim, Jaegil and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Liu, Yuexin and Miller, Michael and Reynolds, Sheila and Shmulevich, Ilya and Thorsson, Vesteinn and Zhang, Wei and Akbani, Rehan and Broom, Bradley M and Hegde, Apurva M and Ju, Zhenlin and Kanchi, Rupa S and Korkut, Anil and Li, Jun and Liang, Han and Ling, Shiyun and Liu, Wenbin and Lu, Yiling and Mills, Gordon B and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 313 - 326.e5
Journal Article
by Seiler, Michael and Peng, Shouyong and Agrawal, Anant A and Palacino, James and Teng, Teng and Zhu, Ping and Smith, Peter G and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Chudamani, Sudha and Liu, Jia and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Kim, Jaegil and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Liu, Yuexin and Miller, Michael and Reynolds, Sheila and Shmulevich, Ilya and Thorsson, Vesteinn and Zhang, Wei and Akbani, Rehan and Broom, Bradley M and Hegde, Apurva M and Ju, Zhenlin and Kanchi, Rupa S and Korkut, Anil and Li, Jun and Liang, Han and Ling, Shiyun and Liu, Wenbin and Lu, Yiling and Mills, Gordon B and Ng, Kwok-Shing and Rao, Arvind and Ryan, Michael and Wang, Jing and Weinstein, John N and Zhang, Jiexin and Abeshouse, Adam and Armenia, Joshua and Chakravarty, Debyani and Chatila, Walid K and de Bruijn, Ino and Gao, Jianjiong and Gross, Benjamin E and Heins, Zachary J and Kundra, Ritika and La, Konnor and Ladanyi, Marc and Luna, Augustin and Nissan, Moriah G and Ochoa, Angelica and Phillips, Sarah M and Reznik, Ed and Sanchez-Vega, Francisco and Sander, Chris and Schultz, Nikolaus and Sheridan, Robert and Sumer, S. Onur and Sun, Yichao and Taylor, Barry S and Wang, Jioajiao and Zhang, Hongxin and Anur, Pavana and Peto, Myron and Spellman, Paul and Benz, Christopher and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 282 - 296.e4
Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA... 
mutation | FUBP1 | SRSF2 | U2AF1 | cancer | splicing | SF3B1 | RBM10 | Biochemistry, Genetics and Molecular Biology(all) | U2AF1 MUTATIONS | BREAST-CANCER | RNA-BINDING | SPLICEOSOME | C-MYC | FAR UPSTREAM ELEMENT | EXPRESSION PROFILES | MYELODYSPLASTIC SYNDROMES | GENOME | CELL BIOLOGY
Journal Article