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Molecular Cell, ISSN 1097-2765, 11/2014, Volume 56, Issue 4, pp. 481 - 495
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e42386
Understanding the mechanisms by which pathogens induce vascular inflammation and dysfunction may reveal novel therapeutic targets in sepsis and related... 
NUCLEOTIDE OLIGOMERIZATION DOMAIN | KAPPA-B ACTIVATION | SMOOTH-MUSCLE | NITRIC-OXIDE SYNTHASE | TOLL-LIKE RECEPTOR | BIOLOGY | SEPTIC SHOCK | ORGAN-CULTURE | INDUCTION | PATTERN-RECOGNITION RECEPTORS | SEVERE SEPSIS | Peptidoglycan - metabolism | Vasculitis - metabolism | Humans | Nod1 Signaling Adaptor Protein - agonists | Vasculitis - pathology | NF-kappa B - immunology | Muscle, Smooth, Vascular - immunology | Male | NF-kappa B - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - immunology | Gram-Negative Bacteria - metabolism | Peptidoglycan - immunology | Gram-Negative Bacteria - immunology | MAP Kinase Signaling System - immunology | Nod1 Signaling Adaptor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Vasculitis - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Endothelium, Vascular - immunology | Vasculitis - therapy | Endothelial Cells - metabolism | Cells, Cultured | Rats | MAP Kinase Kinase Kinases - metabolism | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Nod1 Signaling Adaptor Protein - immunology | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | MAP Kinase Kinase Kinases - immunology | Endothelial Cells - immunology | Muscle, Smooth, Vascular - pathology | Animals | Endothelium, Vascular - pathology | Endothelial Cells - pathology | Infection | Septic shock | Inflammation | Health aspects | Endothelium | Heart | Cell culture | Gram-positive bacteria | Smooth muscle | Inflammatory response | Stimulation | Activation | Blood | Signal transduction | Pathways | Rodents | Toll-like receptors | Nod1 protein | TAK1 protein | Pulmonary arteries | Therapeutic applications | Cell walls | Feature recognition | Peptidoglycans | Muscles | Blood vessels | MAP kinase | Pharmacology | Pattern recognition | TLR4 protein | Endothelial cells | Signaling | Organ culture | Sepsis | Ligands | In vivo methods and tests | Adapter proteins
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 43, pp. 31268 - 31279
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e69619
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e96737
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2017, Volume 60, Issue 4, pp. 1247 - 1261
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 09/1995, Volume 60, Issue 18, pp. 5966 - 5968
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/1999, Volume 121, Issue 1, pp. 54 - 62
Concise, efficient total syntheses of ningalin A (1), lamellarin O (2), lukianol A (3), and permethyl storniamide A (5) are detailed on the basis of a common... 
DIDEMNUM-SP | ACID | DIMETHYL "1,2,4,5-TETRAZINE-3,6-DICARBOXYLATE | SCOPE | A-D | TUNICATE | MULTIDRUG-RESISTANCE | CHEMISTRY, MULTIDISCIPLINARY | ALKALOIDS | Marine resources | Research | Diels-Alder reaction | Antineoplastic agents | Drug resistance
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2007, Volume 50, Issue 1, pp. 6 - 9
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2010, Volume 30, Issue 2, pp. 253 - 259
PURPOSE—This study assessed the pharmacological effect of a novel selective C-C chemokine receptor (CCR) 2 antagonist (GSK1344386B) on monocyte/macrophage... 
ApoE/CCR2 | Magnetic Resonance Imaging | Inflammation | USPIO | Atherosclerosis | HYPERLIPIDEMIC RABBITS | ATHEROSCLEROTIC PLAQUES | ApoE(-/-) CCR2 | LESION FORMATION | CCR2 ANTAGONIST | ANGIOTENSIN-II | ULTRASMALL SUPERPARAMAGNETIC PARTICLES | REDUCES ATHEROSCLEROSIS | IRON-OXIDE PARTICLES | IN-VIVO | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | E-DEFICIENT MICE | Immunohistochemistry | Receptors, CCR2 - genetics | Angiotensin II - administration & dosage | Apolipoproteins E - deficiency | Humans | Receptors, CCR2 - antagonists & inhibitors | Ferrosoferric Oxide | Dextrans | Time Factors | Peritonitis - prevention & control | Dietary Fats - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Macrophages - immunology | Magnetite Nanoparticles | Aortic Diseases - pathology | Disease Models, Animal | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Atherosclerosis - immunology | Infusion Pumps, Implantable | Macrophages - pathology | Anti-Inflammatory Agents - pharmacology | Aortic Diseases - immunology | Mice, Transgenic | Peritonitis - immunology | Mice, Knockout | Receptors, CCR2 - metabolism | Animals | Contrast Media | Naphthyridines - pharmacokinetics | Aortic Diseases - diet therapy | Apolipoproteins E - genetics | Macrophages - drug effects | Mice | Naphthyridines - pharmacology
Journal Article
Molecular cell, ISSN 1097-2765, 11/2014, Volume 56, Issue 4, pp. 481 - 495
Receptor interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease.... 
Ripoptosome | programmed necrosis | cytomegalovirus | TNF | herpesvirus
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 11/2010, Volume 75, Issue 22, pp. 7950 - 7953
Journal Article
Journal Article