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2011, Methods in molecular biology, ISBN 1617792039, Volume 768., xi, 367
Book
1991, ISBN 9783805556989, Volume 45, no. 5/6., [237]-324, [i]-iv.
Book
Journal of Molecular Biology, ISSN 0022-2836, 03/2019, Volume 431, Issue 5, pp. 904 - 907
Journal Article
Hepatology, ISSN 0270-9139, 11/2013, Volume 58, Issue 5, pp. 1861 - 1862
Journal Article
Hepatology, ISSN 0270-9139, 11/2013, Volume 58, Issue 5, p. 1861
Journal Article
Hepatology, ISSN 0270-9139, 11/2013, Volume 58, Issue 5, pp. 1861 - 1862
Journal Article
Hepatology, ISSN 0270-9139, 11/2013, Volume 58, Issue 5, pp. 1861 - 1862
Journal Article
Circulation Research, ISSN 0009-7330, 03/2014, Volume 114, Issue 6, pp. 1022 - 1036
Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has attracted a lot of attention from the scientific community and... 
hyperlipoproteinemia type II | clinical trials | LDL cholesterol | phase III as topic | PLASMA PCSK9 | PROPROTEIN CONVERTASE PCSK9 | CARDIAC & CARDIOVASCULAR SYSTEMS | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | SUBTILISIN/KEXIN TYPE 9 | PCSK9-MEDIATED DEGRADATION | MONOCLONAL-ANTIBODY | OF-FUNCTION MUTATIONS | MESSENGER-RNA | PERIPHERAL VASCULAR DISEASE | CHOLESTEROL HOMEOSTASIS | LIPOPROTEIN-RECEPTOR LDLR | HEMATOLOGY | Proprotein Convertases - antagonists & inhibitors | Hepatitis C - metabolism | Vertebrates - genetics | Humans | Serine Endopeptidases - physiology | Male | Risk | Hepatocytes - metabolism | Molecular Targeted Therapy | Cardiovascular Diseases - genetics | Proprotein Convertases - genetics | Endosomes - metabolism | Clinical Trials, Phase III as Topic | Lysosomes - metabolism | Insulin Resistance - physiology | Serine Endopeptidases - genetics | Cardiovascular Diseases - blood | Adult | Cholesterol, LDL - blood | Female | Lipoproteins, LDL - metabolism | Hyperlipoproteinemia Type II - drug therapy | Chromosomes, Human, Pair 1 - genetics | Child | Disease Models, Animal | Genetic Predisposition to Disease | Serine Endopeptidases - deficiency | Cardiovascular Diseases - metabolism | Rodentia | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Organ Specificity | Proprotein Convertases - deficiency | Gene Expression Regulation, Enzymologic | Hyperlipoproteinemia Type II - metabolism | Pregnancy | Proprotein Convertases - physiology | Animals | Diet | Protein Processing, Post-Translational | Mutation | Aging - metabolism | Hyperlipoproteinemia Type II - genetics | Proprotein Convertase 9
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 10/2017, Volume 24, Issue 10, pp. 785 - 786
PCSK9 enhances LDL cholesterol (LDL-c) levels by escorting the liver LDL receptor (LDLR) to endosomes and lysosomes for degradation. PCSK9 monoclonal... 
BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | PROPROTEIN | MUTATIONS | BINDING | PEPTIDE | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Cholesterol, LDL - antagonists & inhibitors | Anticholesteremic Agents - chemistry | Hepatocytes - metabolism | Hypercholesterolemia - drug therapy | Endosomes - metabolism | Proteolysis - drug effects | Hepatocytes - cytology | Lysosomes - metabolism | Hypercholesterolemia - pathology | Liver - drug effects | Endosomes - drug effects | Biological Transport - drug effects | Antibodies, Monoclonal - chemistry | Hepatocytes - drug effects | Lysosomes - drug effects | Receptors, LDL - genetics | Antibodies, Monoclonal - pharmacology | Liver - metabolism | Receptors, LDL - metabolism | Proprotein Convertase 9 - genetics | Proprotein Convertase 9 - metabolism | Animals | Proprotein Convertase 9 - antagonists & inhibitors | Cholesterol, LDL - metabolism | Mice | Hypercholesterolemia - genetics | Proprotein Convertase 9 - chemistry | Hypercholesterolemia - metabolism | Anticholesteremic Agents - pharmacology | RNA, Small Interfering - metabolism | Low density lipoproteins | Atherosclerosis | Development and progression | Cholesterol, LDL | Dosage and administration | Research | Health aspects | Risk factors | Statins | Drugs | Lipoproteins (low density) | Immunoglobulins | Drug therapy | Cardiovascular diseases | Cholesterol
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 05/2013, Volume 19, Issue 17, pp. 3161 - 3172
The discovery of PCSK9 in 2003 and its identification as the third protagonist responsible for ADH opened many new avenues of research in the cardiovascular... 
Journal Article
Atherosclerosis (Supplements) (Component), ISSN 1567-5688, 06/2018, Volume 32, pp. 61 - 61
Journal Article
Journal of Clinical Lipidology, ISSN 1933-2874, 2017, Volume 11, Issue 3, pp. 600 - 601
Highlights • LDLs provide cholesterol to peripheral cells, including cancer cells • Cancer cells have higher cholesterol requirements to sustain tumor growth •... 
Cardiovascular | TRIAL | PHARMACOLOGY & PHARMACY | THERAPY | CHOLESTEROL | Neoplasms - metabolism | Proprotein Convertase 9 - antagonists & inhibitors | Humans | Cell Proliferation - drug effects | Cholesterol - metabolism | Neoplasms - pathology | Serine Proteinase Inhibitors - pharmacology | Care and treatment | Research | Hypocholesteremia | Cancer
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 03/2011, Volume 1220, Issue 1, pp. 149 - 161
Journal Article
Journal Article