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by Kool, Marcel and Jones, David T.W and Jäger, Natalie and Northcott, Paul A and Pugh, Trevor J and Hovestadt, Volker and Piro, Rosario M and Esparza, L. Adriana and Markant, Shirley L and Remke, Marc and Milde, Till and Bourdeaut, Franck and Ryzhova, Marina and Sturm, Dominik and Pfaff, Elke and Stark, Sebastian and Hutter, Sonja and Şeker-Cin, Huriye and Johann, Pascal and Bender, Sebastian and Schmidt, Christin and Schmidt, Sabine and Rausch, Tobias and Shih, David and Reimand, Jüri and Sieber, Laura and Wittmann, Andrea and Linke, Linda and Witt, Olaf and Witt, Hendrik and Weber, Ursula D and Zapatka, Marc and König, Rainer and Beroukhim, Rameen and Bergthold, Guillaume and van Sluis, Peter and Volckmann, Richard and Koster, Jan and Versteeg, Rogier and Wolf, Stephan and Lawerenz, Chris and Bartholomae, Cynthia C and von Kalle, Christof and Unterberg, Andreas and Herold-Mende, Christel and Hofer, Silvia and Kulozik, Andreas E and von Deimling, Andreas and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Hasselblatt, Martin and Crawford, John R and Grant, Gerald A and Jabado, Nada and Perry, Arie and Cowdrey, Cynthia and Croul, Sydney and Zadeh, Gelareh and Korbel, Jan O and Doz, Francois and Delattre, Olivier and Bader, Gary D and McCabe, Martin G and Collins, V. Peter and Kieran, Mark W and Cho, Yoon-Jae and Pomeroy, Scott L and Brors, Benedikt and Taylor, Michael D and Schüller, Ulrich and Korshunov, Andrey and Eils, Roland and Wechsler-Reya, Robert J and Lichter, Peter and Pfister, Stefan M and ICGC PedBrain Tumor Project
Cancer Cell, ISSN 1535-6108, 03/2014, Volume 25, Issue 3, pp. 393 - 405
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To... 
NERVOUS-SYSTEM | TERT PROMOTER MUTATIONS | ONCOLOGY | GROWTH | HEDGEHOG PATHWAY INHIBITOR | ITRACONAZOLE | PEDIATRIC MEDULLOBLASTOMA | CANCER | TUMORS | MOUSE MODELS | ADULT | CELL BIOLOGY | Neoplasm Transplantation | Oncogene Proteins - genetics | Humans | Zinc Finger Protein Gli2 | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Biphenyl Compounds - therapeutic use | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Young Adult | Telomerase - genetics | Hedgehog Proteins - genetics | Base Sequence | Smoothened Receptor | Adult | Female | N-Myc Proto-Oncogene Protein | Patched Receptors | Medulloblastoma - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Child | Pyridines - therapeutic use | Cerebellar Neoplasms - drug therapy | Repressor Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Mice, SCID | Phosphatidylinositol 3-Kinases - genetics | DEAD-box RNA Helicases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Adolescent | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Genetic aspects | Nucleotide sequencing | Analysis | Medulloblastoma | Genomics | DNA sequencing | Index Medicus
Journal Article
by Jones, David T. W and Hutter, Barbara and Jäger, Natalie and Korshunov, Aney and Kool, Marcel and Warnatz, Hans-Jörg and Zichner, Thomas and Lambert, Sally R and Ryzhova, Marina and Quang, Dong Anh Khuong and Fontebasso, Adam M and Stütz, Aian M and Hutter, Sonja and Zuckermann, Marc and Sturm, Dominik and Gronych, Jan and Lasitschka, Bärbel and Schmidt, Sabine and Seker-Cin, Huriye and Witt, Henik and Sultan, Marc and Ralser, Meryem and Northcott, Paul A and Hovestadt, Volker and Bender, Sebastian and Pfaff, Elke and Stark, Sebastian and Faury, Damien and Schwartzentruber, Jeremy and Majewski, Jacek and Weber, Ursula D and Zapatka, Marc and Raeder, Benjamin and Schlesner, Matthias and Worth, Catherine L and Bartholomae, Cynthia C and von Kalle, Christof and Imbusch, Charles D and Radomski, Sylwester and Lawerenz, Chris and van Sluis, Peter and Koster, Jan and Volckmann, Richard and Versteeg, Rogier and Lehrach, Hans and Monoranu, Camelia and Winkler, Beate and Unterberg, Aneas and Herold-Mende, Christel and Milde, Till and Kulozik, Aneas E and Ebinger, Martin and Schuhmann, Martin U and Cho, Yoon-Jae and Pomeroy, Scott L and von Deimling, Aneas and Witt, Olaf and Taylor, Michael D and Wolf, Stephan and Karajannis, Matthias A and Eberhart, Charles G and Scheurlen, Wolfram and Hasselblatt, Martin and Ligon, Keith L and Kieran, Mark W and Korbel, Jan O and Yaspo, Marie-Laure and Brors, Benedikt and Felsberg, Jörg and Reifenberger, Guido and Collins, V. Peter and Jabado, Nada and Eils, Roland and Lichter, Peter and Pfister, Stefan M and Int Canc Genome Consortium and International Cancer Genome Consortium PedBrain Tumor Project and the International Cancer Genome Consortium PedBrain Tumor Project
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 8, pp. 927 - 932
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2013, Volume 24, Issue 5, pp. 660 - 672
Journal Article
by Northcott, Paul A and Lee, Catherine and Zichner, Thomas and Stütz, Aian M and Erkek, Serap and Kawauchi, Daisuke and Shih, David J. H and Hovestadt, Volker and Zapatka, Marc and Sturm, Dominik and Jones, David T. W and Kool, Marcel and Remke, Marc and Cavalli, Florence M. G and Zuyderduyn, Scott and Bader, Gary D and VandenBerg, Scott and Esparza, Lourdes Aiana and Ryzhova, Marina and Wang, Wei and Wittmann, Anea and Stark, Sebastian and Sieber, Laura and Seker-Cin, Huriye and Linke, Linda and Kratochwil, Fabian and Jäger, Natalie and Buchhalter, Ivo and Imbusch, Charles D and Zipprich, Gideon and Raeder, Benjamin and Schmidt, Sabine and Diessl, Nicolle and Wolf, Stephan and Wiemann, Stefan and Brors, Benedikt and Lawerenz, Chris and Eils, Jürgen and Warnatz, Hans-Jörg and Risch, Thomas and Yaspo, Marie-Laure and Weber, Ursula D and Bartholomae, Cynthia C and von Kalle, Christof and Turányi, Eszter and Hauser, Peter and Sanden, Emma and Darabi, Anna and Siesjö, Peter and Sterba, Jaroslav and Zitterbart, Karel and Sumerauer, David and van Sluis, Peter and Versteeg, Rogier and Volckmann, Richard and Koster, Jan and Schuhmann, Martin U and Ebinger, Martin and Grimes, H. Leighton and Robinson, Giles W and Gajjar, Amar and Mynarek, Martin and von Hoff, Katja and Rutkowski, Stefan and Pietsch, Torsten and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Kulozik, Aneas E and von Deimling, Aneas and Witt, Olaf and Eils, Roland and Gilbertson, Richard J and Korshunov, Aney and Taylor, Michael D and Lichter, Peter and Korbel, Jan O and Wechsler-Reya, Robert J and Pfister, Stefan M and Neurosurgery and Neurokirurgi and Lund University and BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation and Lunds universitet
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7510, pp. 428 - 434
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 31, pp. 31844 - 31856
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2018, Volume 24, Issue 11, pp. 1752 - 1761
Journal Article
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2017, Volume 19, Issue suppl_4, pp. iv49 - iv49
Genomic studies have shown that multiple molecular subtypes of pediatric brain tumors exist that are biologically and clinically highly distinct. These... 
Abstracts
Journal Article
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