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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2019, Volume 63, Issue 12
ABSTRACT The U.S. Centers for Disease Control and Prevention (CDC) lists Neisseria gonorrhoeae as one of the most urgent antibiotic-resistant threats in the... 
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, p. e0199710
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2019, Volume 62, Issue 17, pp. 7998 - 8010
The narrow antibacterial spectrum of phenylthiazole antibiotics was expanded by replacing central thiazole with a pyrazole ring while maintaining its other... 
PHYSICOCHEMICAL PROPERTIES | IN-VITRO | ANTIBIOTICS | INFECTIONS | CHEMISTRY, MEDICINAL | VANCOMYCIN | STAPHYLOCOCCUS-AUREUS | EPIDERMIDIS | EPIDEMIOLOGY | OXADIAZOLE LINKER | ENTEROBACTERIACEAE
Journal Article
International Journal of Antimicrobial Agents, ISSN 0924-8579, 10/2019
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111593
A novel series of phenylthiazoles bearing cyclic amines at the phenyl-4 position was prepared with the objective of decreasing lipophilicity and improving the... 
Journal Article
Scientific Reports, ISSN 2045-2322, 07/2016, Volume 6, Issue 1, p. 29707
Methicillin-resistant Staphylococcus aureus (MRSA) infections present a serious challenge because of the emergence of resistance to numerous conventional... 
SOFT-TISSUE INFECTIONS | PERSISTER CELLS | ANTIBIOTICS | VANCOMYCIN | MULTIDISCIPLINARY SCIENCES | DISEASE | PENETRATION | MECHANISMS | EPIDERMIDIS | PEXIGANAN | SKIN
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2018, Volume 140, Issue 40, pp. 13125 - 13126
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 2018, Volume 140, Issue 40, p. 13125
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2018, Volume 155, pp. 797 - 805
Journal Article
PLOS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, pp. e0164227 - e0164227
Bacterial infections present a serious challenge to healthcare practitioners due to the emergence of resistance to numerous conventional antibacterial drugs.... 
(Z)-5-ARYLMETHYLIDENE RHODANINES | GRAM-NEGATIVE BACTERIA | MULTIDISCIPLINARY SCIENCES | STAPHYLOCOCCAL INFECTIONS | DRUGS | DAPTOMYCIN | Cell Line | Rhodanine - chemistry | Humans | Bacteria - drug effects | Anti-Bacterial Agents - metabolism | Rhodanine - metabolism | Microbial Sensitivity Tests | Animals | Rhodanine - pharmacology | Rhodanine - toxicity | Anti-Bacterial Agents - chemistry | Bacteria - cytology | Hydrophobic and Hydrophilic Interactions | Anti-Bacterial Agents - pharmacology | Cell Membrane - metabolism | Mice | Anti-Bacterial Agents - toxicity | Drug Resistance, Bacterial - drug effects | Cell Membrane - drug effects | Serum Albumin - metabolism | Albumin | Drug resistance in microorganisms | Bacterial infections | Antibacterial agents | Health aspects | Escherichia coli | Klebsiella | Health care | Drugs | Health sciences | Salmonella | Veterinary colleges | Antimicrobial activity | Laboratories | Clinical isolates | Infections | Vancomycin | Drug resistance | Veterinary medicine | Macrophages | Methicillin | E coli | Antibiotic resistance | Pseudomonas aeruginosa | Carboxyl group | Bacteria | Antibacterial activity | Gram-negative bacteria | Strains (organisms) | Pharmaceutical sciences | Pathogens | Human serum albumin | Keratinocytes | Staphylococcus infections | Antimicrobial agents | Serum albumin | Derivatives | Bactericidal activity | Biofilms | Antibiotics | Pharmacy | Minimum inhibitory concentration | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2020, Volume 185, p. 111830
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2018, Volume 13, Issue 3, pp. e0193217 - e0193217
Antibiotic resistance of bacteria common to the ocular surface is an evolving problem. Thus, novel treatment options with new modes of action are required. We... 
INFECTIONS | EFFICACY | ACID AQUEOUS-SOLUTION | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | CERAGENINS | ANTIMICROBIAL PEPTIDES | PREVALENCE | METHICILLIN-RESISTANT STAPHYLOCOCCUS | POLYMYXIN-B | Pharmacology, Experimental | Antibiotics | Ophthalmic drugs | Testing | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2019, Volume 175, pp. 49 - 62
Antibiotic resistance remains a pressing medical challenge for which novel antibacterial agents are urgently needed. The phenylthiazole scaffold represents a... 
METHICILLIN-RESISTANT | ANTIBIOTICS | CHEMISTRY, MEDICINAL | VANCOMYCIN | SERIES | MRSA | RIFAMPIN | ANTIBACTERIAL EVALUATION | RESISTANT STAPHYLOCOCCUS-AUREUS | PROTEINS | DISCOVERY | Drug resistance | Antibacterial agents | Staphylococcus aureus infections
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2019, Volume 27, Issue 9, pp. 1845 - 1854
Antibiotic resistance remains a major global public health threat that requires sustained discovery of novel antibacterial agents with unexploited scaffolds.... 
SOFT-TISSUE INFECTIONS | DRUG | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CHEMISTRY, ORGANIC | VANCOMYCIN RESISTANCE | MECHANISMS | EMERGENCE | MEDICINAL CHEMISTRY | THERAPY | SKIN | PERMEABILITY BARRIER | Methicillin | Drug resistance in microorganisms | Analysis | Skin | Drug discovery | Research institutes | Staphylococcus aureus
Journal Article
International Journal of Antimicrobial Agents, ISSN 0924-8579, 01/2019, Volume 53, Issue 1, pp. 54 - 62
is a deadly, opportunistic bacterial pathogen. In the last two decades, infections (CDIs) have become a national concern because of the emergence of... 
Spores formation | Anti-toxin | Antibacterial | Repurposing | C. difficile infection | Auranofin | VITRO | INFECTIOUS DISEASES | MICROBIOLOGY | VANCOMYCIN-RESISTANT ENTEROCOCCI | SPORULATION | INDUCTION | FIDAXOMICIN | IN-VIVO | PHARMACOLOGY & PHARMACY | INFECTION | RECURRENCE | METRONIDAZOLE | TOXIN PRODUCTION
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2019, Volume 62, Issue 5, pp. 2564 - 2581
We report that alkyl-substituted bisphosphonates have activity against Bacillus anthracis Sterne (0.40 mu g/mL), Mycobacterium smegmatis (1.4 mu g/mL),... 
FARNESYL DIPHOSPHATE SYNTHASE | CHEMISTRY, MEDICINAL | OCTAPRENYL PYROPHOSPHATE SYNTHASE | TRYPANOSOMA-BRUCEI | ISOPRENOID BIOSYNTHESIS | STRUCTURAL BASIS | ANALOGS | NITROGEN-CONTAINING BISPHOSPHONATES | GROWTH | CRYSTAL-STRUCTURES | INHIBITORS
Journal Article
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 53, pp. 7238 - 7241
A novel and efficient palladium-catalyzed aminocarbonylative lactonization of amino propargylic alcohols has been developed to provide rapid access to various... 
OXIDATIVE CARBONYLATION | ALCOHOLS | CYCLOCARBONYLATION | CARBON-MONOXIDE | O-ALKYNYLPHENOLS | COMPLEXES | EFFICIENT SYNTHESIS | CARBONYLATIVE ANNULATION | TERMINAL ALKYNES | CASCADE | CHEMISTRY, MULTIDISCIPLINARY | Clostridium | Fungi | Pathogens | Synthesis | Palladium | Alcohols | Lactones
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2017, Volume 62, Issue 3
ABSTRACTInvasive candidiasis presents an emerging global public health challenge due to the emergence of resistance to the frontline treatment options, such as... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2018, Volume 152, pp. 318 - 328
With the continued rise of antibiotic resistance and reduced susceptibility to almost all front-line antibiotics, multidrug-resistant Gram-positive bacterial... 
Methicillin-resistant Staphylococcus aureus (MRSA) | Vancomycin-resistant Enterococci (VRE) | Pharmacokinetics | Antibiotic resistance | Methicillin | Drug resistance in microorganisms | Pneumonia | Pyrimidines | Pathogenic microorganisms | Bacterial pneumonia | Staphylococcal infections | Health care industry | Bacteria | Antibacterial agents
Journal Article