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Antiviral Research, ISSN 0166-3542, 02/2019, Volume 162, pp. 5 - 21
This is the second of two invited articles reviewing the development of nucleoside analogue antiviral drugs, written for a target audience of virologists and... 
Antiviral | Prodrugs | Anti-cancer | Nucleoside analogues | Structural modifications | C VIRUS-REPLICATION | NUCLEOTIDE POLYMERASE INHIBITOR | PHASE-II | ACUTE MYELOID-LEUKEMIA | REVERSE-TRANSCRIPTASE INHIBITOR | HIGHLY POTENT INHIBITORS | VIROLOGY | ANTI-HIV ACTIVITY | SOFOSBUVIR PLUS RIBAVIRIN | PHARMACOLOGY & PHARMACY | DENGUE VIRUS | INTRACELLULAR METABOLISM
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2016, Volume 24, Issue 11, pp. 2476 - 2485
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 10/2011, Volume 19, Issue 19, pp. 5794 - 5802
Non-nucleoside reverse transcriptase inhibitors (NNRTI) are key components in highly active antiretroviral therapy for treating HIV-1. Herein we present the... 
HIV-1 | Non-nucleoside reverse transcriptase inhibitors | Reverse transcriptase | Uracil | Benzophenone
Journal Article
Antiviral research, 12/2018, Volume 162, p. 5
This is the second of two invited articles reviewing the development of nucleoside analogue antiviral drugs, written for a target audience of virologists and... 
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 02/2013, Volume 54, Issue 6, pp. 576 - 578
A series of heterocyclic compounds were designed as potential nonnucleoside HIV reverse transcriptase inhibitors. Although the compounds ultimately proved... 
Synthesis (chemistry) | Inhibitors | HIV | Heterocyclic compounds | Tetrahedrons | Byproducts | Adaptation
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 07/2013, Volume 21, Issue 14, pp. 4151 - 4157
HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In... 
Antiviral activity
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2008, Volume 130, Issue 10, pp. 3231 - 3232
Journal Article
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 2018, Volume 14, Issue 1, pp. 772 - 785
Journal Article
Nucleosides, Nucleotides and Nucleic Acids, ISSN 1525-7770, 01/2013, Volume 32, Issue 3, pp. 137 - 154
Journal Article
MedChemComm, ISSN 2040-2503, 07/2011, Volume 2, Issue 7, pp. 650 - 654
A series of 5'-nor carbocyclic "reverse" flexible nucleosides or "fleximers" have been designed wherein the nucleobase scaffold resembles a "split" purine as... 
CHEMISTRY, MEDICINAL | INHIBITION | REPLICATION | 3-BETA-D-RIBOFURANOSYLADENINE | NUCLEOSIDES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GTP FUCOSE PYROPHOSPHORYLASE | FLEXIBILITY | COMPLEXES | TRANSCRIPTASE | VIRUS TYPE-1 | HYDROLASE
Journal Article
MOLECULES, ISSN 1420-3049, 09/2019, Volume 24, Issue 17, p. 3184
Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of... 
fleximers | DESIGN | SERIES | NUCLEOSIDE ANALOGS | SAR | BIOCHEMISTRY & MOLECULAR BIOLOGY | nucleoside | filovirus | CHEMISTRY, MULTIDISCIPLINARY | flavivirus
Journal Article
Nucleosides, nucleotides & nucleic acids, 2013, Volume 32, Issue 3, p. 137
A series of flexible carbocyclic pyrimidine nucleosides has been designed and synthesized. In contrast to previously reported "fleximers" from our laboratory,... 
Binding Sites - genetics | Pyrimidine Nucleosides - chemistry | Adenosine Deaminase - metabolism | Pyrimidine Nucleosides - chemical synthesis | Adenosine - analogs & derivatives | Adenosine Deaminase Inhibitors - chemical synthesis
Journal Article
ISSN 2040-2503, 10/2013, Volume 4, Issue 11, pp. 1443 - 1451
A new series of potential nonnucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) based on the carbocyclic 5′-nor-uracil scaffold were designed and... 
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 07/2013, Volume 78, Issue 14, pp. 7305 - 7311
During the synthesis of a series of 2′-deoxy-9-deaza nucleosides using Heck methodology, the necessity for a pyrrole protecting group was discovered. The...