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abstracts (11) 11
index medicus (10) 10
humans (9) 9
child (5) 5
expression (5) 5
cancer (4) 4
child, preschool (4) 4
medulloblastoma (4) 4
oncology (4) 4
pediatrics (4) 4
brain neoplasms - genetics (3) 3
brain tumors (3) 3
children (3) 3
classification (3) 3
clinical neurology (3) 3
female (3) 3
infant (3) 3
male (3) 3
neurosciences (3) 3
pilocytic astrocytoma (3) 3
subgroups (3) 3
tumors (3) 3
adolescent (2) 2
analysis (2) 2
apoptosis - drug effects (2) 2
astrocytoma (2) 2
azepines - pharmacology (2) 2
brain neoplasms - diagnosis (2) 2
brain neoplasms - drug therapy (2) 2
brain neoplasms - pathology (2) 2
brain tumor (2) 2
cell culture techniques (2) 2
cell line, tumor (2) 2
cell proliferation - drug effects (2) 2
cell survival - drug effects (2) 2
comparative analysis (2) 2
dna (2) 2
dna methylation (2) 2
drug resistance (2) 2
embryonic structures (2) 2
entity (2) 2
ependymoma (2) 2
glioma (2) 2
gliomas (2) 2
in-vivo (2) 2
inhibitors (2) 2
mapk pathway activation (2) 2
medicine (2) 2
multidisciplinary sciences (2) 2
neuroblastoma (2) 2
pathology (2) 2
pathology, molecular - methods (2) 2
pediatric oncology (2) 2
phosphorylation (2) 2
piperazines - pharmacology (2) 2
precision medicine - methods (2) 2
protein kinase inhibitors - pharmacology (2) 2
pyrimidines - pharmacology (2) 2
retrospective studies (2) 2
rna (2) 2
targeted therapy (2) 2
tumor proteins (2) 2
young adult (2) 2
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abcg2 (1) 1
acquired-resistance (1) 1
actinomycin d (1) 1
acute myelogenous leukemia (1) 1
addiction (1) 1
adult (1) 1
aged (1) 1
aged, 80 and over (1) 1
alisertib (1) 1
animal structures (1) 1
animals (1) 1
annotation (1) 1
antibiotics, antineoplastic - pharmacology (1) 1
antigens, polyomavirus transforming - genetics (1) 1
antineoplastic agents - pharmacology (1) 1
apoptosis (1) 1
article (1) 1
astrocytomas (1) 1
atp binding cassette transporter, sub-family b - genetics (1) 1
atp binding cassette transporter, sub-family b - metabolism (1) 1
atp binding cassette transporter, sub-family g, member 2 (1) 1
atp-binding cassette transporters - metabolism (1) 1
aurora kinase (1) 1
aurora kinase a - antagonists & inhibitors (1) 1
aurora kinase a - genetics (1) 1
aurora kinase a - metabolism (1) 1
aurora kinase b - antagonists & inhibitors (1) 1
aurora kinase b - genetics (1) 1
aurora kinase b - metabolism (1) 1
aurora kinase inhibitor (1) 1
aurora kinases - antagonists & inhibitors (1) 1
aurora kinases - metabolism (1) 1
basic and translational investigations (1) 1
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1. Full Text Aurora kinases as targets in drug-resistant neuroblastoma cells
by Michaelis, Martin and Selt, Florian and Rothweiler, Florian and Löschmann, Nadine and Nüsse, Benedikt and Dirks, Wilhelm G and Zehner, Richard and Cinatl, Jindrich
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e108758
Aurora kinase inhibitors displayed activity in pre-clinical neuroblastoma models. Here, we studied the effects of the panaurora kinase inhibitor tozasertib... 
RADIATION RESPONSE | APOPTOSIS | INHIBITOR MLN8237 | RELAPSED NEUROBLASTOMA | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | MULTIDRUG-RESISTANCE | TUMOR-GROWTH | P53-DEFICIENT CANCER-CELLS | LINES | Proto-Oncogene Proteins c-mdm2 - genetics | Aurora Kinase B - metabolism | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Aurora Kinase A - antagonists & inhibitors | Aurora Kinase A - metabolism | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-mdm2 - metabolism | Aurora Kinase A - genetics | Aurora Kinase B - antagonists & inhibitors | Neuroblastoma - pathology | Aurora Kinase B - genetics | Signal Transduction | Neuroblastoma - genetics | Tumor Suppressor Protein p53 - metabolism | Brain Neoplasms - genetics | Imidazoles - pharmacology | Pyrimidines - pharmacology | Brain Neoplasms - drug therapy | Piperazines - pharmacology | Azepines - pharmacology | Drug Synergism | Histones - genetics | Cell Cycle Checkpoints - drug effects | Neuroblastoma - drug therapy | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Proliferation - drug effects | Neuroblastoma - metabolism | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Primary Cell Culture | ATP Binding Cassette Transporter, Sub-Family B - genetics | Neuroblastoma | Tumor proteins | Phosphotransferases | Apoptosis | Phosphorylation | MDM2 protein | p53 Protein | Leukemia | Substrate inhibition | Aurora kinase | Breast cancer | Drug resistance | Kinases | Neuroblastoma cells | Signaling | Inhibitors | Cell lines | Cell cycle | Binding sites | Histone H3
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2. Full Text ABCG2 impairs the activity of the aurora kinase inhibitor tozasertib but not of alisertib
by Michaelis, Martin and Selt, Florian and Rothweiler, Florian and Wiese, Michael and Cinatl, Jindrich
BMC Research Notes, ISSN 1756-0500, 09/2015, Volume 8, Issue 1, p. 484
Recently, we have shown that the ATP-binding cassette (ABC) transporter ABCB1 interferes with the anti-cancer activity of the pan-aurora kinase inhibitor... 
Aurora kinase inhibitor | Alisertib | MLN8237 | VX680 | MK-0457 | Drug resistance | Tozasertib | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Cell Survival - drug effects | Aurora Kinases - metabolism | Humans | Aurora Kinases - antagonists & inhibitors | Treatment Outcome | Pyrimidines - pharmacology | Neoplasm Proteins - metabolism | Piperazines - pharmacology | Azepines - pharmacology | ATP-Binding Cassette Transporters - metabolism | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Cell Death - drug effects | Medical research | Care and treatment | RNA | Medicine, Experimental | Drug therapy | Comparative analysis | Cancer
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3. Full Text DNA methylation-based classification of central nervous system tumours
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Adriana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Hendrik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Rodriguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, Jürgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Andreas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and Driever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and Von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Gudrun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7697, pp. 469 - 474
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous... 
MOLECULAR CLASSIFICATION | MULTICENTER | ENTITY | GLIOMA | MULTIDISCIPLINARY SCIENCES | PILOCYTIC ASTROCYTOMA | CLASS PROBABILITY ESTIMATION | SUBGROUPS | MEDULLOBLASTOMA | EXPRESSION | BIOCONDUCTOR | Central Nervous System Neoplasms - classification | Reproducibility of Results | Central Nervous System Neoplasms - genetics | Humans | Middle Aged | Child, Preschool | Infant | Male | Unsupervised Machine Learning | Young Adult | Central Nervous System Neoplasms - pathology | DNA Methylation | Adolescent | Aged, 80 and over | Adult | Female | Aged | Central Nervous System Neoplasms - diagnosis | Child | Cohort Studies | Genetic aspects | Nucleotide sequencing | Diagnosis | Methylation | Observations | Methods | DNA sequencing | Tumors | Cancer | Analysis | DNA | Machine learning | Central nervous system | Classifiers | Brain cancer | Standardization | Clinical trials | Probability | Data processing | Nervous system | Genomes | Gene expression | Generalized linear models | Learning algorithms | Classification | Diagnostic software | DNA methylation | Diagnostic systems | Bioinformatics | Deoxyribonucleic acid--DNA
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4. Full Text Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets
by Sahm, Felix and Schrimpf, Daniel and Jones, David T. W and Meyer, Jochen and Kratz, Annekathrin and Reuss, David and Capper, David and Koelsche, Christian and Korshunov, Andrey and Wiestler, Benedikt and Buchhalter, Ivo and Milde, Till and Selt, Florian and Sturm, Dominik and Kool, Marcel and Hummel, Manuela and Bewerunge-Hudler, Melanie and Mawrin, Christian and Schüller, Ulrich and Jungk, Christine and Wick, Antje and Witt, Olaf and Platten, Michael and Herold-Mende, Christel and Unterberg, Andreas and Pfister, Stefan M and Wick, Wolfgang and von Deimling, Andreas
Acta Neuropathologica, ISSN 0001-6322, 6/2016, Volume 131, Issue 6, pp. 903 - 910
With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of... 
Medicine & Public Health | Pathology | Neurosciences | GLIOBLASTOMA | DNA | ANNOTATION | ASTROCYTOMAS | R PACKAGE | COPY NUMBER ANALYSIS | GENETIC-VARIANTS | MUTATIONS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | Molecular Probe Techniques | Brain Neoplasms - diagnosis | Humans | Brain Neoplasms - genetics | Pathology, Molecular - methods | High-Throughput Nucleotide Sequencing - methods | Mutation - genetics | Genetic markers | Gliomas | Analysis | Brain tumors | Formaldehyde
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5. Full Text Response in a child with a BRAF V600E mutated desmoplastic infantile astrocytoma upon retreatment with vemurafenib
by Tilburg, Cornelis M and Selt, Florian and Sahm, Felix and Bächli, Heidi and Pfister, Stefan M and Witt, Olaf and Milde, Till
Pediatric Blood & Cancer, ISSN 1545-5009, 03/2018, Volume 65, Issue 3, pp. e26893 - n/a
Infants with low‐grade glioma (LGG) and diencephalic syndrome have a poor outcome. The patient described here had a desmoplastic infantile astrocytoma... 
BRAF V600E inhibitor | vemurafenib | infant | desmoplastic infantile astrocytoma | low‐grade glioma | child | low-grade glioma | GLIOMA | TUMORS | INHIBITION | ONCOLOGY | PILOCYTIC ASTROCYTOMA | PEDIATRICS | STEM GANGLIOGLIOMA | HEMATOLOGY | EXPRESSION | Gene mutations | Gliomas | Chemotherapy | Inhibitors | Glioma | Addiction | Infants | Children | Astrocytoma
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6. Full Text LGG-11. ESTABLISHMENT OF A HUMAN 3-DIMENSIONAL LOW-GRADE GLIOMA TUMOR MODEL IN INDUCED PLURIPOTENT STEM CELL DERIVED BRAIN ORGANOIDS
by Bahr, Annabelle and Capper, David and Witt, Olaf and Milde, Till and Selt, Florian and Buhl, Juliane and Stachelscheid, Harald and Driever, Pablo Hernáiz
Neuro-Oncology, ISSN 1522-8517, 04/2019, Volume 21, Issue Supplement_2, pp. ii101 - ii101
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7. Full Text Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors
by Selt, Florian and Deiß, Alica and Korshunov, Andrey and Capper, David and Witt, Hendrik and van Tilburg, Cornelis M and Jones, David T. W and Witt, Ruth and Sahm, Felix and Reuss, David and Kölsche, Christian and Ecker, Jonas and Oehme, Ina and Hielscher, Thomas and von Deimling, Andreas and Kulozik, Andreas E and Pfister, Stefan M and Witt, Olaf and Milde, Till
Brain Pathology, ISSN 1015-6305, 07/2016, Volume 26, Issue 4, pp. 506 - 516
The “pediatric targeted therapy” (PTT) program aims to identify the presence and activity of druggable targets and evaluate the clinical benefit of a... 
targeted therapy | brain tumors | pediatric oncology | relapsed childhood tumors | predictive markers | personalized medicine | Pediatric oncology | Predictive markers | Personalized medicine | Targeted therapy | Brain tumors | Relapsed childhood tumors | SURVIVAL | EPENDYMOMA | SUBGROUPS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | BIOMARKERS | CELL LYMPHOMA | CRIZOTINIB | REVEALS | Biomarkers, Tumor - analysis | Humans | Child, Preschool | Neoplasm Recurrence, Local - drug therapy | Infant | Male | Feasibility Studies | Neoplasms - drug therapy | Young Adult | Adolescent | Female | Retrospective Studies | Child | Infant, Newborn | Molecular Targeted Therapy - methods | Precision Medicine - methods | Immunohistochemistry | Pediatrics | Relapse | Pharmacogenetics | Children | Tumor proteins | Health aspects | Diseases | Cancer
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8. Full Text Abstract A25: Establishment of orthotopic patient-derived xenograft models of pediatric brain tumors – the Heidelberg experience
by Mack, Norman L and Brabetz, Sebastian and Selt, Florian and Christina, Xanthopolous and Sumerauer, David and Bächli, Heidi and Pekrun, Arnulf and Schuhmann, Martin U and Pfister, Stefan M and Witt, Olaf and Milde, Till and Kool, Marcel
Clinical Cancer Research, ISSN 1078-0432, 08/2016, Volume 22, Issue 16 Supplement, pp. A25 - A25
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9. Full Text PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH
by Brabetz, Sebastian and Groebner, Susanne N and Jaeger, Natalie and Milde, Till and Ecker, Jonas and Selt, Florian and Witt, Olaf and Rusert, Jessica M and Koster, Jan and Leary, Sarah E and Li, Xiao-Nan and Wechsler-Reya, Robert J and Olson, James M and Pfister, Stefan M and Kool, Marcel
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i155 - i155
Abstract Identification of multiple distinct subtypes of pediatric brain tumors raises the need for more and better preclinical models reflecting these... 
Abstracts
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10. Full Text The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma
by Buhl, Juliane L and Selt, Florian and Hielscher, Thomas and Guiho, Romain and Ecker, Jonas and Sahm, Felix and Ridinger, Johannes and Riehl, Dennis and Usta, Diren and Ismer, Britta and Sommerkamp, Alexander C and Martinez-Barbera, J P and Wefers, Annika K and Remke, Marc and Picard, Daniel and Pusch, Stefan and Gronych, Jan and Oehme, Ina and van Tilburg, Cornelis M and Kool, Marcel and Kuhn, Daniela and Capper, David and von Deimling, Andreas and Schuhmann, Martin U and Herold-Mende, Christel and Korshunov, Andrey and Brummer, Tilman and Pfister, Stefan M and Jones, David T W and Witt, Olaf and Milde, Till
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 12/2018
Pilocytic astrocytoma is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced... 
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11. Full Text Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients
by Schmidt, Christin and Schubert, Nil A and Brabetz, Sebastian and Mack, Norman and Schwalm, Benjamin and Chan, Jennifer A and Selt, Florian and Herold-Mende, Christel and Witt, Olaf and Milde, Till and Pfister, Stefan M and Korshunov, Andrey and Kool, Marcel
Neuro-Oncology, ISSN 1522-8517, 12/2017, Volume 19, Issue 12, pp. 1607 - 1617
Background. Embryonal tumor with multilayered rosettes (ETMR) is a rare and aggressive embryonal brain tumor that solely occurs in infants and young children... 
volasertib | actinomycin D | brain tumor | ETMR | topotecan | MULTILAYERED ROSETTES | CLASSIFICATION | EMBRYONAL TUMOR | CLINICAL NEUROLOGY | CHILDREN | ENTITY | ONCOLOGY | COMPRISE | MEDULLOBLASTOMA | EXPRESSION | CNS-PNETS | Pteridines - pharmacology | Topotecan - pharmacology | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Neuroectodermal Tumors, Primitive - drug therapy | Humans | Brain Neoplasms - pathology | Child, Preschool | Brain Neoplasms - drug therapy | Mice, SCID | Xenograft Model Antitumor Assays | Topoisomerase I Inhibitors - pharmacology | Animals | Female | Mice, Inbred NOD | Neoplasms, Germ Cell and Embryonal - drug therapy | Cell Proliferation - drug effects | Mice | Tumor Cells, Cultured | Cell Cycle - drug effects | Dactinomycin - pharmacology | Neoplasms, Germ Cell and Embryonal - pathology | Neuroectodermal Tumors, Primitive - pathology | Basic and Translational Investigations
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12. Full Text Establishment of a 3-dimensional Low-grade Glioma Model in Induced Pluripotent Stem-cell-derived Brain Organoids
by Bahr, Annabelle and Michèle, Simon and Capper, David and Witt, Olaf and Milde, Till and Selt, Florian and Buhl, Juliane and Stachelscheid, Harald and Driever, Pablo Hernáiz
Neuropediatrics, ISSN 0174-304X, 09/2019, Volume 50, Issue S 02
Poster Presentations
Conference Proceeding
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13. Full Text Abstract 1935: Molecular characterization of orthotopic patient-derived xenograft models of pediatric brain tumors
by Brabetz, Sebastian and Gröbner, Susanne N and Seker-Cin, Huriye and Selt, Florian and Milde, Till and Jones, David T and Wise, Madison T and Rusert, Jessica M and Pedro, Kyle and Strand, Andy and Witt, Olaf and Leary, Sarah E and Li, Xiao-Nan and Wechsler-Reya, Robert J and Olson, James M and Pfister, Stefan M and Kool, Marcel
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 1935 - 1935
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14. Full Text TRTH-09. PTT2.0: DEVELOPING PERSONALIZED PEDIATRIC ONCOLOGY
by Milde, Till and Ecker, Jonas and Selt, Florian and Capper, David and Sahm, Felix and Korshunov, Andrey and van Tilburg, Cornelis M and Witt, Hendrik and von Deimling, Andreas and Jones, David and Pfister, Stefan and Witt, Olaf
Neuro-Oncology, ISSN 1522-8517, 06/2017, Volume 19, Issue suppl_4, pp. iv53 - iv53
Individualized treatment approaches require precise and robust diagnostics concerning diagnosis and detection of actionable alterations. The “pediatric... 
Abstracts
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15. Full Text The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma
by Buhl, Juliane L and Selt, Florian and Hielscher, Thomas and Guiho, Romain and Ecker, Jonas and Sahm, Felix and Ridinger, Johannes and Riehl, Dennis and Usta, Diren and Ismer, Britta and Sommerkamp, Alexander C and Martinez-Barbera, J.P and Wefers, Annika K and Remke, Marc and Picard, Daniel and Pusch, Stefan and Gronych, Jan and Oehme, Ina and van Tilburg, Cornelis M and Kool, Marcel and Kuhn, Daniela and Capper, David and von Deimling, Andreas and Schuhmann, Martin U and Herold-Mende, Christel and Korshunov, Andrey and Brummer, Tilman and Pfister, Stefan M and Jones, David T.W and Witt, Olaf and Milde, Till
Clinical Cancer Research, ISSN 1078-0432, 2019, Volume 25, Issue 6, pp. 1851 - 1866
Purpose: Pilocytic astrocytoma is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced... 
MAPK PATHWAY ACTIVATION | ONCOLOGY | PHOSPHORYLATION | GENES | RECEPTOR | GROWTH-FACTOR | NF-KAPPA-B | PRIMARY BRAIN | EXPRESSION | TUMORS | FAMILY
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16. Full Text MBRS-12. INTERFERENCE WITH THE FUNCTION OF MYC IN GROUP 3 MEDULLOBLASTOMA
by Ecker, Jonas and Thatikonda, Venu and Oehme, Ina and Valinciute, Gintvile and Selt, Florian and Buhl, Juliane L and Usta, Diren and Tilburg, Cornelis M van and Herold-Mende, Christel and Schnölzer, Martina and Warnken, Uwe and Kool, Marcel and Jäger, Natalie and Pfister, Stefan M and Witt, Olaf and Milde, Till
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i130 - i130
Abstract High-risk medulloblastoma (MB) is a deadly disease with poor overall survival. Survivors suffer from severe treatment-associated morbidity. Patients... 
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17. Full Text TBIO-10. PEDIATRIC TARGETED THERAPY 2.0: DEVELOPMENT OF PERSONALIZED PEDIATRIC ONCOLOGY
by Ecker, Jonas and Selt, Florian and Sahm, Felix and Capper, David and Korshunov, Andrey and Grund, Kerstin and Dikow, Nicola and Sutter, Christian and van Tilburg, Cornelis and Witt, Hendrik and von Deimling, Andreas and Jones, David T W and Pfister, Stefan M and Witt, Olaf and Milde, Till
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i182 - i182
Abstract Precise diagnosis and robust detection of actionable alterations is required for individualized treatments. The Pediatric Targeted Therapy (PTT) 2.0... 
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18. Full Text LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA
by Buhl, Juliane L and Selt, Florian and Hielscher, Thomas and Sahm, Felix and Capper, David and Schramm, Kathrin and Ridinger, Johannes and Usta, Diren and Ecker, Jonas and Oehme, Ina and Tilburg, Cornelis M van and Kool, Marcel and von Deimling, Andreas and Schuhmann, Martin U and Korshunov, Andrey and Pfister, Stefan M and Brummer, Tilman and Jones, David T W and Witt, Olaf and Milde, Till
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i106 - i106
Abstract The main challenge in the clinical management of pilocytic astrocytoma (PA) is its unpredictable growth behavior. PA cells are driven into... 
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19. Full Text Molecular Diagnostics in Pediatric Brain Tumors: Impact on Diagnosis and Clinical Decision-Making — A Selected Case Series
by Bächli, Heidi and Ecker, Jonas and van Tilburg, Cornelis and Sturm, Dominik and Selt, Florian and Sahm, Felix and Koelsche, Christian and Grund, Kerstin and Sutter, Christian and Pietsch, Torsten and Witt, Hendrik and Herold-Mende, Christel and von Deimling, Andreas and Jones, David and Pfister, Stefan and Witt, Olaf and Milde, Till
Klinische Pädiatrie, ISSN 0300-8630, 11/2018, Volume 230, Issue 6, pp. 305 - 313
AbstractCentral nervous system (CNS) tumors account for the highest mortality among pediatric malignancies. Accurate diagnosis is essential for optimal... 
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20.