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abstracts (11) 11
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humans (9) 9
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expression (5) 5
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medulloblastoma (4) 4
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atp binding cassette transporter, sub-family b - genetics (1) 1
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PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e108758
Aurora kinase inhibitors displayed activity in pre-clinical neuroblastoma models. Here, we studied the effects of the panaurora kinase inhibitor tozasertib... 
RADIATION RESPONSE | APOPTOSIS | INHIBITOR MLN8237 | RELAPSED NEUROBLASTOMA | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | MULTIDRUG-RESISTANCE | TUMOR-GROWTH | P53-DEFICIENT CANCER-CELLS | LINES | Proto-Oncogene Proteins c-mdm2 - genetics | Aurora Kinase B - metabolism | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Aurora Kinase A - antagonists & inhibitors | Aurora Kinase A - metabolism | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-mdm2 - metabolism | Aurora Kinase A - genetics | Aurora Kinase B - antagonists & inhibitors | Neuroblastoma - pathology | Aurora Kinase B - genetics | Signal Transduction | Neuroblastoma - genetics | Tumor Suppressor Protein p53 - metabolism | Brain Neoplasms - genetics | Imidazoles - pharmacology | Pyrimidines - pharmacology | Brain Neoplasms - drug therapy | Piperazines - pharmacology | Azepines - pharmacology | Drug Synergism | Histones - genetics | Cell Cycle Checkpoints - drug effects | Neuroblastoma - drug therapy | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Proliferation - drug effects | Neuroblastoma - metabolism | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Primary Cell Culture | ATP Binding Cassette Transporter, Sub-Family B - genetics | Neuroblastoma | Tumor proteins | Phosphotransferases | Apoptosis | Phosphorylation | MDM2 protein | p53 Protein | Leukemia | Substrate inhibition | Aurora kinase | Breast cancer | Drug resistance | Kinases | Neuroblastoma cells | Signaling | Inhibitors | Cell lines | Cell cycle | Binding sites | Histone H3
Journal Article
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Adriana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Hendrik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Rodriguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, Jürgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Andreas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and Driever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and Von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Gudrun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7697, pp. 469 - 474
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 03/2018, Volume 65, Issue 3, pp. e26893 - n/a
Infants with low‐grade glioma (LGG) and diencephalic syndrome have a poor outcome. The patient described here had a desmoplastic infantile astrocytoma... 
BRAF V600E inhibitor | vemurafenib | infant | desmoplastic infantile astrocytoma | low‐grade glioma | child | low-grade glioma | GLIOMA | TUMORS | INHIBITION | ONCOLOGY | PILOCYTIC ASTROCYTOMA | PEDIATRICS | STEM GANGLIOGLIOMA | HEMATOLOGY | EXPRESSION | Gene mutations | Gliomas | Chemotherapy | Inhibitors | Glioma | Addiction | Infants | Children | Astrocytoma
Journal Article
Neuro-Oncology, ISSN 1522-8517, 04/2019, Volume 21, Issue Supplement_2, pp. ii101 - ii101
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2016, Volume 22, Issue 16 Supplement, pp. A25 - A25
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i155 - i155
Abstract Identification of multiple distinct subtypes of pediatric brain tumors raises the need for more and better preclinical models reflecting these... 
Abstracts
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 12/2018
Pilocytic astrocytoma is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced... 
Journal Article
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2017, Volume 19, Issue suppl_4, pp. iv53 - iv53
Individualized treatment approaches require precise and robust diagnostics concerning diagnosis and detection of actionable alterations. The “pediatric... 
Abstracts
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 2019, Volume 25, Issue 6, pp. 1851 - 1866
Purpose: Pilocytic astrocytoma is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced... 
MAPK PATHWAY ACTIVATION | ONCOLOGY | PHOSPHORYLATION | GENES | RECEPTOR | GROWTH-FACTOR | NF-KAPPA-B | PRIMARY BRAIN | EXPRESSION | TUMORS | FAMILY
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i130 - i130
Abstract High-risk medulloblastoma (MB) is a deadly disease with poor overall survival. Survivors suffer from severe treatment-associated morbidity. Patients... 
Abstracts
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i182 - i182
Abstract Precise diagnosis and robust detection of actionable alterations is required for individualized treatments. The Pediatric Targeted Therapy (PTT) 2.0... 
Abstracts
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i106 - i106
Abstract The main challenge in the clinical management of pilocytic astrocytoma (PA) is its unpredictable growth behavior. PA cells are driven into... 
Abstracts
Journal Article
Klinische Pädiatrie, ISSN 0300-8630, 11/2018, Volume 230, Issue 6, pp. 305 - 313
AbstractCentral nervous system (CNS) tumors account for the highest mortality among pediatric malignancies. Accurate diagnosis is essential for optimal... 
Journal Article
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