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abstracts (11) 11
science & technology (10) 10
humans (9) 9
life sciences & biomedicine (8) 8
child (6) 6
oncology (6) 6
brain tumors (4) 4
clinical neurology (4) 4
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neurosciences & neurology (4) 4
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targeted therapy (3) 3
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analysis (2) 2
astrocytoma (2) 2
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brain neoplasms - diagnosis (2) 2
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brain tumor (2) 2
cell culture techniques (2) 2
cell line, tumor (2) 2
cell survival - drug effects (2) 2
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children (2) 2
comparative analysis (2) 2
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medicine (2) 2
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pathology, molecular - methods (2) 2
pediatric oncology (2) 2
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precision medicine - methods (2) 2
primary cell culture (2) 2
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pyrimidines - pharmacology (2) 2
retrospective studies (2) 2
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tumor proteins (2) 2
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atp binding cassette transporter, sub-family b - genetics (1) 1
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1. Full Text DNA methylation-based classification of central nervous system tumours
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Aiana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Henik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Roiguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, J. rgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Aneas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and ever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Guun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature (London), ISSN 0028-0836, 2018, Volume 555, Issue 7697, pp. 469 - 474
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Central Nervous System Neoplasms - classification | Reproducibility of Results | Central Nervous System Neoplasms - genetics | Humans | Middle Aged | Child, Preschool | Infant | Male | Unsupervised Machine Learning | Young Adult | Central Nervous System Neoplasms - pathology | DNA Methylation | Adolescent | Aged, 80 and over | Adult | Female | Aged | Central Nervous System Neoplasms - diagnosis | Child | Cohort Studies | Genetic aspects | Nucleotide sequencing | Diagnosis | Methylation | Observations | Methods | DNA sequencing | Tumors | Cancer | Analysis | DNA | Machine learning | Central nervous system | Classifiers | Brain cancer | Standardization | Clinical trials | Probability | Data processing | Nervous system | Genomes | Gene expression | Generalized linear models | Learning algorithms | Classification | Diagnostic software | DNA methylation | Diagnostic systems | Bioinformatics | Deoxyribonucleic acid--DNA | Index Medicus
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2. Full Text ABCG2 impairs the activity of the aurora kinase inhibitor tozasertib but not of alisertib
by Michaelis, Martin and Selt, Florian and Rothweiler, Florian and Wiese, Michael and Cinatl, Jindrich
BMC research notes, ISSN 1756-0500, 09/2015, Volume 8, Issue 1, pp. 484 - 484
Aurora kinase inhibitor | Alisertib | MLN8237 | VX680 | MK-0457 | Drug resistance | Tozasertib | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Cell Survival - drug effects | Aurora Kinases - metabolism | Humans | Aurora Kinases - antagonists & inhibitors | Treatment Outcome | Pyrimidines - pharmacology | Neoplasm Proteins - metabolism | Piperazines - pharmacology | Azepines - pharmacology | ATP-Binding Cassette Transporters - metabolism | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Cell Death - drug effects | Medical research | Care and treatment | RNA | Medicine, Experimental | Drug therapy | Comparative analysis | Cancer | Index Medicus
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3. Full Text Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets
by Sahm, Felix and Sahm, Felix and Schrimpf, Daniel and Schrimpf, Daniel and Jones, David T. W and Jones, David T. W and Meyer, Jochen and Meyer, Jochen and Kratz, Annekathrin and Kratz, Annekathrin and Reuss, David and Reuss, David and Capper, David and Capper, David and Koelsche, Christian and Koelsche, Christian and Korshunov, Andrey and Korshunov, Andrey and Wiestler, Benedikt and Wiestler, Benedikt and Buchhalter, Ivo and Buchhalter, Ivo and Milde, Till and Milde, Till and Selt, Florian and Selt, Florian and Sturm, Dominik and Sturm, Dominik and Kool, Marcel and Kool, Marcel and Hummel, Manuela and Hummel, Manuela and Bewerunge-Hudler, Melanie and Bewerunge-Hudler, Melanie and Mawrin, Christian and Mawrin, Christian and Schüller, Ulrich and Schüller, Ulrich and Jungk, Christine and Jungk, Christine and Wick, Antje and Wick, Antje and Witt, Olaf and Witt, Olaf and Platten, Michael and Platten, Michael and Herold-Mende, Christel and Herold-Mende, Christel and Unterberg, Andreas and Unterberg, Andreas and Pfister, Stefan M and Pfister, Stefan M and Wick, Wolfgang and Wick, Wolfgang and von Deimling, Andreas and von Deimling, Andreas
Acta neuropathologica, ISSN 0001-6322, 6/2016, Volume 131, Issue 6, pp. 903 - 910
Medicine & Public Health | Pathology | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Molecular Probe Techniques | Brain Neoplasms - diagnosis | Humans | Brain Neoplasms - genetics | Pathology, Molecular - methods | High-Throughput Nucleotide Sequencing - methods | Mutation - genetics | Genetic markers | Gliomas | Analysis | Brain tumors | Formaldehyde | Index Medicus
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4. Full Text Response in a child with a BRAF V600E mutated desmoplastic infantile astrocytoma upon retreatment with vemurafenib
by Tilburg, Cornelis M and Selt, Florian and Sahm, Felix and Bächli, Heidi and Pfister, Stefan M and Witt, Olaf and Milde, Till
Pediatric blood & cancer, ISSN 1545-5009, 03/2018, Volume 65, Issue 3, pp. e26893 - n/a
BRAF V600E inhibitor | vemurafenib | infant | desmoplastic infantile astrocytoma | low‐grade glioma | child | low-grade glioma | Pediatrics | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Gene mutations | Gliomas | Chemotherapy | Inhibitors | Glioma | Addiction | Infants | Children | Astrocytoma | Index Medicus
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5. Full Text Response to trametinib treatment in progressive pediatric low-grade glioma patients
by Selt, Florian and van Tilburg, Cornelis M and Bison, Brigitte and Sievers, Philipp and Harting, Inga and Ecker, Jonas and Pajtler, Kristian W and Sahm, Felix and Bahr, Annabelle and Simon, Michele and Jones, David T. W and Well, Lennart and Mautner, Victor-Felix and Capper, David and Hernaiz Driever, Pablo and Gnekow, Astrid and Pfister, Stefan M and Witt, Olaf and Milde, Till
Journal of neuro-oncology, ISSN 0167-594X, 09/2020, Volume 149, Issue 3, pp. 499 - 510
Oncology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Pediatrics | Toxicity | Brain tumors | MEK inhibitors | MAP kinase | Kinases | Disease control | Recklinghausen's disease | Patients | Chemotherapy | Glioma | Protein kinase | Neurofibromatosis | Index Medicus | MAPK pathway | Pediatric low-grade glioma | Targeted therapy | NF1 | BRAF | MEK inhibitor | Clinical Study | Trametinib
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6. Full Text LGG-11. ESTABLISHMENT OF A HUMAN 3-DIMENSIONAL LOW-GRADE GLIOMA TUMOR MODEL IN INDUCED PLURIPOTENT STEM CELL DERIVED BRAIN ORGANOIDS
by Bahr, Annabelle and Capper, David and Witt, Olaf and Milde, Till and Selt, Florian and Buhl, Juliane and Stachelscheid, Harald and Driever, Pablo Hernáiz
Neuro-oncology (Charlottesville, Va.), ISSN 1522-8517, 04/2019, Volume 21, Issue Supplement_2, pp. ii101 - ii101
Low Grade Glioma
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7. Full Text Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients
by Schmidt, Christin and Schubert, Nil A and Brabetz, Sebastian and Mack, Norman and Schwalm, Benjamin and Chan, Jennifer A and Selt, Florian and Herold-Mende, Christel and Witt, Olaf and Milde, Till and Pfister, Stefan M and Korshunov, Andrey and Kool, Marcel
Neuro-oncology (Charlottesville, Va.), ISSN 1522-8517, 12/2017, Volume 19, Issue 12, pp. 1607 - 1617
volasertib | actinomycin D | brain tumor | ETMR | topotecan | Oncology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Index Medicus | Basic and Translational Investigations
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8. Full Text Aurora kinases as targets in drug-resistant neuroblastoma cells
by Michaelis, Martin and Selt, Florian and Rothweiler, Florian and Löschmann, Nadine and Nüsse, Benedikt and Dirks, Wilhelm G and Zehner, Richard and Cinatl, Jindrich
PloS one, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e108758 - e108758
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Proto-Oncogene Proteins c-mdm2 - genetics | Aurora Kinase B - metabolism | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Aurora Kinase A - antagonists & inhibitors | Aurora Kinase A - metabolism | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-mdm2 - metabolism | Aurora Kinase A - genetics | Aurora Kinase B - antagonists & inhibitors | Neuroblastoma - pathology | Aurora Kinase B - genetics | Signal Transduction | Neuroblastoma - genetics | Tumor Suppressor Protein p53 - metabolism | Brain Neoplasms - genetics | Imidazoles - pharmacology | Pyrimidines - pharmacology | Brain Neoplasms - drug therapy | Piperazines - pharmacology | Azepines - pharmacology | Drug Synergism | Histones - genetics | Cell Cycle Checkpoints - drug effects | Neuroblastoma - drug therapy | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Proliferation - drug effects | Neuroblastoma - metabolism | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Primary Cell Culture | ATP Binding Cassette Transporter, Sub-Family B - genetics | Neuroblastoma | Tumor proteins | Phosphotransferases | Apoptosis | Phosphorylation | MDM2 protein | p53 Protein | Leukemia | Substrate inhibition | Aurora kinase | Breast cancer | Drug resistance | Kinases | Neuroblastoma cells | Signaling | Inhibitors | Cell lines | Cell cycle | Binding sites | Histone H3 | Index Medicus
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9. Full Text A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells
by Usta, Diren and Sigaud, Romain and Buhl, Juliane L and Selt, Florian and Marquardt, Viktoria and Pauck, David and Jansen, Jennifer and Pusch, Stefan and Ecker, Jonas and Hielscher, Thomas and Vollmer, Johanna and Sommerkamp, Alexander C and Rubner, Tobias and Hargrave, Darren and van Tilburg, Cornelis M and Pfister, Stefan M and Jones, David T W and Remke, Marc and Brummer, Tilman and Witt, Olaf and Milde, Till
Molecular cancer therapeutics, ISSN 1535-7163, 05/2020, Volume 19, Issue 8, pp. 1736 - 1750
Index Medicus
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10. Full Text Abstract A25: Establishment of orthotopic patient-derived xenograft models of pediatric brain tumors – the Heidelberg experience
by Mack, Norman L and Brabetz, Sebastian and Selt, Florian and Christina, Xanthopolous and Sumerauer, David and Bächli, Heidi and Pekrun, Arnulf and Schuhmann, Martin U and Pfister, Stefan M and Witt, Olaf and Milde, Till and Kool, Marcel
Clinical cancer research, ISSN 1078-0432, 08/2016, Volume 22, Issue 16 Supplement, pp. A25 - A25
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11. Full Text Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma
by Ecker, Jonas and Thatikonda, Venu and Sigismondo, Gianluca and Selt, Florian and Valinciute, Gintvile and Oehme, Ina and Müller, Carina and Buhl, Juliane L and Ridinger, Johannes and Usta, Diren and Qin, Nan and van Tilburg, Cornelis M and Herold-Mende, Christel and Remke, Marc and Sahm, Felix and Westermann, Frank and Kool, Marcel and Wechsler-Reya, Robert J and Chavez, Lukas and Krijgsveld, Jeroen and Jäger, Natalie and Pfister, Stefan M and Witt, Olaf and Milde, Till
Neuro-oncology (Charlottesville, Va.), ISSN 1522-8517, 08/2020
Index Medicus
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12. Full Text The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma
by Buhl, Juliane L and Selt, Florian and Hielscher, Thomas and Guiho, Romain and Ecker, Jonas and Sahm, Felix and Ridinger, Johannes and Riehl, Dennis and Usta, Diren and Ismer, Britta and Sommerkamp, Alexander C and Martinez-Barbera, J.P and Wefers, Annika K and Remke, Marc and Picard, Daniel and Pusch, Stefan and Gronych, Jan and Oehme, Ina and van Tilburg, Cornelis M and Kool, Marcel and Kuhn, Daniela and Capper, David and von Deimling, Andreas and Schuhmann, Martin U and Herold-Mende, Christel and Korshunov, Andrey and Brummer, Tilman and Pfister, Stefan M and Jones, David T.W and Witt, Olaf and Milde, Till
Clinical cancer research, ISSN 1078-0432, 2019, Volume 25, Issue 6, pp. 1851 - 1866
Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Proliferation | Datasets as Topic | Prognosis | Humans | Brain Neoplasms - pathology | Male | Gene Expression Profiling | Brain Neoplasms - surgery | Astrocytoma - pathology | Animals | Cellular Senescence | Interleukin-1beta - metabolism | Progression-Free Survival | Female | Mice | Brain Neoplasms - mortality | Primary Cell Culture | Tumor Cells, Cultured | Child | Astrocytoma - mortality | Astrocytoma - surgery | Culture Media, Conditioned - metabolism | Disease Models, Animal | Index Medicus
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13. Full Text Establishment and application of a novel patient-derived KIAA1549: BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing
by Selt, Florian and Hohloch, Juliane and Hielscher, Thomas and Sahm, Felix and Capper, David and Korshunov, Andrey and Usta, Diren and Brabetz, Sebastian and Ridinger, Johannes and Ecker, Jonas and Oehme, Ina and Gronych, Jan and Marquardt, Viktoria and Pauck, David and Bächli, Heidi and Stiles, Charles D and von Deimling, Andreas and Remke, Marc and Schuhmann, Martin U and Pfister, Stefan M and Brummer, Tilman and Jones, David T.W and Witt, Olaf and Milde, Till
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 7, pp. 11460 - 11479
KIAA1549:BRAF-fusion | Oncogene-induced senescence (OIS) | Pediatric low grade glioma | Pilocytic astrocytoma | MAPK-inhibitors | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Transduction, Genetic | Antigens, Polyomavirus Transforming - genetics | Humans | Cell Proliferation - physiology | Transcriptome | Cellular Senescence - physiology | Child, Preschool | Male | Gene Expression Profiling | Blotting, Western | Brain Neoplasms | Oncogene Proteins, Fusion - genetics | Proto-Oncogene Proteins B-raf - genetics | Polymerase Chain Reaction | Cell Line, Tumor | Cell Culture Techniques | Astrocytoma | Drug Screening Assays, Antitumor | Index Medicus
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