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1. Full Text Comparing Human Genome Mapping Data
by Colin A. M. Semple and Kathryn L. Evans and Stewart W. Morris and David J. Porteous
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2001, Volume 293, Issue 5539, pp. 2394 - 2395
Letters | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Private Sector | Public Sector | Humans | Computational Biology | Contig Mapping | Chromosomes, Human, Pair 4 - genetics | Genome, Human | Human Genome Project | Sequence Analysis, DNA | Bipolar disorder | Genomes | Genetic aspects | Research | Human genetics | Colin Semple | Index Medicus
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2. Full Text Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline
by Kaiser, Vera B and Semple, Colin A
Genome Biology, ISSN 1474-7596, 07/2018, Volume 19, Issue 1, pp. 101 - 101
Recombination | Chromatin loops | Hi-C | DNA breakage | Cancer | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Human Umbilical Vein Endothelial Cells | Neoplasms - metabolism | Chromatin - metabolism | Genomic Instability | Epigenesis, Genetic | Humans | CCCTC-Binding Factor - genetics | CCCTC-Binding Factor - metabolism | Homologous Recombination | Neoplasms - genetics | Chromatin - chemistry | Lymphocytes - metabolism | Histone-Lysine N-Methyltransferase - genetics | Datasets as Topic | Meiosis | Germ Cells | Lymphocytes - pathology | Histones - genetics | Histone-Lysine N-Methyltransferase - metabolism | K562 Cells | Cell Line, Tumor | HeLa Cells | Histones - metabolism | Mutation | Genome, Human | Neoplasms - pathology | Clonal Evolution | Breakpoints | Chromatin | Leukemia | Genomes | Breast cancer | Regulatory sequences | Boundaries | Gene expression | DNA repair | Genomic instability | Fragile sites | Cell cycle | DNA methylation | Genetic recombination | Bioinformatics | Binding sites | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
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3. Full Text The genomic signature of trait-associated variants
by Kindt, Alida S.D and Navarro, Pau and Semple, Colin A.M and Haley, Chris S
BMC genomics, ISSN 1471-2164, 02/2013, Volume 14, Issue 1, pp. 108 - 108
Chromatin states | Genomic features | Permutations | GWAS | Trait-associated SNPs | Logistic regression, Prioritization | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Phenotype | Humans | Molecular Sequence Annotation | Conserved Sequence | Linkage Disequilibrium - genetics | Polymorphism, Single Nucleotide - genetics | Genomics - methods | Chromatin - genetics | Quantitative genetics | Chromatin | Genetic variation | Analysis | Genomics | Genomes | Single nucleotide polymorphisms | Studies | Confidence intervals | Variables | DNA methylation | Genetics | Logistics | Index Medicus | Quantitative trait loci | Molecular modelling | Evolutionary conservation | Linkage disequilibrium | Histones | genomics | Models | Single-nucleotide polymorphism | Regression analysis | Light effects
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4. Full Text Genome-wide analysis of mammalian promoter architecture and evolution
by Carninci, Piero and Sandelin, Albin and Lenhard, Boris and Katayama, Shintaro and Shimokawa, Kazuro and Ponjavic, Jasmina and Semple, Colin A M and Taylor, Martin S and Engström, Pär G and Frith, Martin C and Forrest, Alistair R R and Alkema, Wynand B and Tan, Sin Lam and Plessy, Charles and Kodzius, Rimantas and Ravasi, Timothy and Kasukawa, Takeya and Fukuda, Shiro and Kanamori-Katayama, Mutsumi and Kitazume, Yayoi and Kawaji, Hideya and Kai, Chikatoshi and Nakamura, Mari and Konno, Hideaki and Nakano, Kenji and Mottagui-Tabar, Salim and Arner, Peter and Chesi, Alessana and Gustincich, Stefano and Persichetti, Francesca and Suzuki, Harukazu and Grimmond, Sean M and Wells, Christine A and Orlando, Valerio and Wahlestedt, Claes and Liu, Edison T and Harbers, Matthias and Kawai, Jun and Bajic, Vladimir B and Hume, David A and Hayashizaki, Yoshihide
Nature genetics, ISSN 1061-4036, 04/2006, Volume 38, Issue 6, pp. 626 - 635
evolution, molecular | No Hanze research focus area applicable | Science | proteome | genome | 3' untranslated regions | Biochemistry, Genetics and Molecular Biology (miscellaneous) | biotechnologie | dna | promoter regions, genetic | animals | base sequence | 02g. No research line applicable | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Transcription. Transcription factor. Splicing. Rna processing | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Molecular genetics | Promoter Regions, Genetic | Animals | Base Sequence | DNA | TATA Box | Proteome | 3' Untranslated Regions | Genome | Evolution, Molecular | Physiological aspects | Molecular evolution | Genetic aspects | Promoters (Genetics) | Research | Genetic regulation | Proteins | Evolutionary biology | Mammals | Tissues | Genomics | Index Medicus | Medicin och hälsovetenskap
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5. Full Text Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes
by Yaghootkar, Hanieh and Lamina, Claudia and Scott, Robert and Dastani, Zari and Hivert, Marie-France and Warren, Liling and Stancáková, Alena and Buxbaum, Sarah and Lyytikäinen, Leo-Pekka and Henneman, Peter and Wu, Ying and Cheung, Chloe and Pankow, James and Jackson, Anne and Gustafsson, Stefan and Zhao, Jing Hua and Ballantyne, Christie and Xie, Weijia and Bergman, Richard and Boehnke, Michael and El Bouazzaoui, Fatiha and Collins, Francis and Dunn, Sana and Dupuis, Josée and Forouhi, Nita and Gillson, Christopher and Hattersley, Anew and Hong, Jaeyoung and Kähönen, Mika and Kuusisto, Johanna and Kedenko, Lyudmyla and Kronenberg, Florian and Doria, Anea and Assimes, Themistocles and Ferrannini, Ele and Hansen, Torben and Hao, Ke and Häring, Hans and Knowles, Joshua and Lindgren, Cecilia and Nolan, John and Paananen, Jussi and Pedersen, Oluf and Quertermous, Thomas and Smith, Ulf and Lehtimäki, Terho and Liu, Ching-Ti and Loos, Ruth and McCarthy, Mark and Morris, Anew and Vasan, Ramachanan Srini and Spector, Timothy and Teslovich, Tanya and Tuomilehto, Jaakko and Willems van Dijk, Ko and Viikari, Jorma and Zhu, Na and Langenberg, Claudia and Ingelsson, Erik and Semple, Robert and Sinaiko, Alan and Palmer, Colin and Walker, Mark and Lam, Karen and Paulweber, Bernhard and Mohlke, Karen and Duijn, Cornelia and Raitakari, Olli and Bidulescu, Aurelian and Wareham, Nick and Laakso, Markku and Waterworth, Dawn and Lawlor, Debbie and Meigs, James and Richards, Brent and Frayling, Timothy and RISC Consortium and GENESIS Consortium and the RISC Consortium and the GENESIS Consortium and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
Diabetes (New York, N.Y.), ISSN 0012-1797, 10/2013, Volume 62, Issue 10, pp. 3589 - 3598
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Genetic Predisposition to Disease | Diabetes Mellitus, Type 2 - genetics | Humans | Male | Adiponectin - blood | Genetic Variation | Regression Analysis | Diabetes Mellitus, Type 2 - blood | Adiponectin - genetics | Insulin Resistance - genetics | Mendelian Randomization Analysis | Female | Polymorphism, Single Nucleotide | Blood Glucose - metabolism | Odds Ratio | Type 2 diabetes | Insulin resistance | Health aspects | Risk factors | Diabetes therapy | Proteins | Sensitivity analysis | Genes | Diabetes | Causality | Experiments | Index Medicus | Abridged Index Medicus | Original Research | Insulin Resistance | Blood Glucose | Diabetes Mellitus | blood | Single Nucleotide | Adiponectin | genetics | Endokrinologi och diabetes | Type 2 | metabolism | Endocrinology and Diabetes | Polymorphism
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6. Full Text High-throughput analysis of epistasis in genome-wide association studies with BiForce
by Gyenesei, Attila and Moody, Jonathan and Semple, Colin A. M and Haley, Chris S and Wei, Wen-Hua
Bioinformatics (Oxford, England), ISSN 1367-4803, 08/2012, Volume 28, Issue 15, pp. 1957 - 1964
Statistics & Probability | Biochemistry & Molecular Biology | Physical Sciences | Computer Science, Interdisciplinary Applications | Life Sciences & Biomedicine | Technology | Biochemical Research Methods | Computer Science | Mathematics | Biotechnology & Applied Microbiology | Science & Technology | Mathematical & Computational Biology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | General aspects | Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) | Computational Biology - methods | Genome-Wide Association Study | Algorithms | Epistasis, Genetic | Computer Simulation | Humans | Models, Genetic | Polymorphism, Single Nucleotide | Software | High-Throughput Nucleotide Sequencing - methods | Index Medicus | Original Papers
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7. Full Text Widespread signatures of recent selection linked to nucleosome positioning in the human lineage
by Prendergast, James G.D and Semple, Colin A.M
Genome research, ISSN 1088-9051, 11/2011, Volume 21, Issue 11, pp. 1777 - 1787
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Base Composition | Humans | Selection, Genetic | Chromatin Assembly and Disassembly | Nucleosomes - metabolism | Nucleosomes - genetics | Polymorphism, Single Nucleotide | Histones - metabolism | Evolution, Molecular | Nucleosomes | Genomic libraries | Research | Index Medicus
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8. Full Text Homologous recombination DNA repair pathway disruption and retinoblastoma protein loss are associated with exceptional survival in high-grade serous ovarian cancer
by Garsed, Dale W and Alsop, Kathryn and Fereday, Sian and Emmanuel, Catherine and Kennedy, Catherine J and Etemadmoghadam, Dariush and Gao, Bo and Gebski, Val and Gares, Valerie and Christie, Elizabeth L and Wouters, Maartje C.A and Milne, Katy and George, Joshy and Patch, Ann-Marie and Li, Jason and Arnau, Gisela Mir and Semple, Timothy and Gadipally, Sreeja R and Chiew, Yoke-Eng and Hendley, Joy and Mikeska, Thomas and Zapparoli, Giada V and Amarasinghe, Kaushalya and Grimmond, Sean M and Pearson, John V and Waddell, Nicola and Hung, Jillian and Stewart, Colin and Sharma, Raghwa and Allan, Prue E and Rambau, Peter F and Traficante, Nadia and McNally, Orla and Mileshkin, Linda and Hamilton, Anne and Ananda, Sumitra and Grossi, Marisa and Cohen, Paul A and Leung, Yee C and Rome, Robert M and Beale, Philip and Blomfield, Penny and Friedlander, Michael and Brand, Alison and Dobrovic, Alexander and Kobel, Martin and Harnett, Paul and Nelson, Brad H and Bowtell, David D. L and DeFazio, Anna and Australian Ovarian Canc Study Grp and Nadia Traficante, for the Australian Ovarian Cancer Study Group
Clinical cancer research, ISSN 1078-0432, 02/2018, Volume 24, Issue 3, pp. 569 - 580
Life Sciences & Biomedicine | Oncology | Science & Technology | Ovarian carcinoma | Tumor-infiltrating lymphocytes | CD8 antigen | Homologous recombination | Retinoblastoma protein | Homology | Genomes | Survival | Patients | DNA repair | Ovarian cancer | Gene sequencing | Chemotherapy | Experimental design | Lymphocytes | Medical prognosis | Determinants | Mutation | Repair | Retinoblastoma | Multiple objective | Deoxyribonucleic acid--DNA | Tumors | Cancer
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9. Full Text Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
by Folegatti, Pedro M and Ewer, Katie J and Aley, Parvinder K and Angus, Brian and Becker, Stephan and Belij-Rammerstorfer, Sandra and Bellamy, Duncan and Bibi, Sagida and Bittaye, Mustapha and Clutterbuck, Elizabeth A and Dold, Christina and Faust, Saul N and Finn, Adam and Flaxman, Amy L and Hallis, Bassam and Heath, Paul and Jenkin, Daniel and Lazarus, Rajeka and Makinson, Rebecca and Minassian, Angela M and Pollock, Katrina M and Ramasamy, Maheshi and Robinson, Hannah and Snape, Matthew and Tarrant, Richard and Voysey, Merryn and Green, Catherine and Douglas, Alexander D and Hill, Adrian V S and Lambe, Teresa and Gilbert, Sarah C and Pollard, Andrew J and Aboagye, Jeremy and Adams, Kelly and Ali, Aabidah and Allen, Elizabeth and Allison, Jennifer L and Anslow, Rachel and Arbe-Barnes, Edward H and Babbage, Gavin and Baillie, Kenneth and Baker, Megan and Baker, Natalie and Baker, Philip and Baleanu, Ioana and Ballaminut, Juliana and Barnes, Eleanor and Barrett, Jordan and Bates, Louise and Batten, Alexander and Beadon, Kirsten and Beckley, Rebecca and Berrie, Eleanor and Berry, Lisa and Beveridge, Amy and Bewley, Kevin R and Bijker, Else Margreet and Bingham, Tracey and Blackwell, Luke and Blundell, Caitlin L and Bolam, Emma and Boland, Elena and Borthwick, Nicola and Bower, Thomas and Boyd, Amy and Brenner, Tanja and Bright, Philip D and Brown-O'Sullivan, Charlie and Brunt, Emily and Burbage, Jamie and Burge, Sharon and Buttigieg, Karen R and Byard, Nicholas and Cabera Puig, Ingrid and Calvert, Anna and Camara, Susana and Cao, Michelangelo and Cappuccini, Federica and Carr, Melanie and Carroll, Miles W and Carter, Victoria and Cathie, Katrina and Challis, Ruth J and Charlton, Sue and Chelysheva, Irina and Cho, Jee-Sun and Cicconi, Paola and Cifuentes, Liliana and Clark, Helen and Clark, Elizabeth and Cole, Tom and Colin-Jones, Rachel and Conlon, Christopher P and Cook, Aislinn and Coombes, Naomi S and Cooper, Rachel and Cosgrove, Catherine A and Coy, Karen and Crocker, Wendy E.M and Cunningham, Christina J and ... and Oxford COVID Vaccine Trial Group and Oxford COVID Vaccine Trial Grp
The Lancet (British edition), ISSN 0140-6736, 08/2020, Volume 396, Issue 10249, pp. 467 - 478
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Coronavirus Infections - prevention & control | Single-Blind Method | Genetic Vectors - administration & dosage | Immunoglobulin G - blood | Coronavirus Infections - drug therapy | Humans | Pandemics - prevention & control | Pneumonia, Viral - drug therapy | Male | Viral Vaccines - adverse effects | Antibodies, Viral - blood | Adenoviruses, Simian - genetics | Betacoronavirus - immunology | COVID-19 | SARS-CoV-2 | Immunization, Secondary | Adult | Female | Spike Glycoprotein, Coronavirus - immunology | Acetaminophen - therapeutic use | United Kingdom | Analgesics, Non-Narcotic - therapeutic use | Coronavirus Infections - immunology | Viral Vaccines - administration & dosage | Pneumonia, Viral - prevention & control | COVID-19 Vaccines | T-Lymphocytes - immunology | Viral Vaccines - immunology | Antibodies, Neutralizing - blood | Health aspects | Analysis | Vaccines | Epidemics | Headache | Immunoassay | Schedules | Pandemics | Laboratories | Immunoglobulin G | Vaccination | Viral diseases | Innovations | Antibodies | Research facilities | Clinical trials | Homology | Viruses | Leukocytes (mononuclear) | Lymphocytes T | Infections | Serology | Middle East respiratory syndrome | Chills | Proteins | Prevention | Paracetamol | Randomization | Pain | Older people | Peripheral blood mononuclear cells | Safety | Enzyme-linked immunosorbent assay | Spike protein | Severe acute respiratory syndrome | Muscles | Glycoproteins | Coronaviruses | Immune response (humoral) | Severe acute respiratory syndrome coronavirus 2 | Hospitals | Disease transmission | Immunogenicity | Correlation analysis | Respiratory diseases | γ-Interferon | Adenoviruses | Interferon | Index Medicus | Abridged Index Medicus
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