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Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7711, pp. 523 - 525
MEDICAL RESEARCH Abnormal activity of the enzyme PI3K can drive cancer growth, and mutations in a PI3K subunit can sometimes lead to non-cancerous overgrowth.... 
Enzymes | Researchers | Cell division | Mutation | Metabolism | Insulin | Cancer therapies | Drug dosages | Cancer
Journal Article
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 2010, Volume 95, Issue 4, pp. 1544 - 1554
Journal Article
British Medical Bulletin, ISSN 0007-1420, 09/2011, Volume 99, Issue 1, pp. 53 - 71
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 04/2019, Volume 116, Issue 17, pp. 8380 - 8389
Journal Article
Diabetologia, ISSN 0012-186X, 7/2018, Volume 61, Issue 7, pp. 1662 - 1675
Bi-allelic loss-of-function mutations in the INSR gene (encoding the insulin receptor [INSR]) commonly cause extreme insulin resistance and early mortality.... 
Medicine & Public Health | Human Physiology | Metabolic Diseases | Monoclonal antibodies | Internal Medicine | Insulin resistance | Diabetes | Insulin signalling | Rabson–Mendenhall syndrome | Insulin receptor | Donohue syndrome | ACTIVATION | DOMAIN | PHOSPHORYLATION | TYROSINE KINASE | STIMULATE | ALLOSTERIC MONOCLONAL-ANTIBODY | SUFFICIENT | IMPROVES GLYCEMIC CONTROL | ENDOCRINOLOGY & METABOLISM | RESISTANCE | Rabson-Mendenhall syndrome | SUBSTRATE-1 IRS-1 | Antigens, CD - immunology | Insulin - pharmacology | Phosphorylation | Cricetulus | Humans | Adipocytes - drug effects | 3T3-L1 Cells | Antigens, CD - genetics | Antigens, CD - metabolism | Hypoglycemic Agents - pharmacology | Antibodies - pharmacology | Animals | Signal Transduction - drug effects | Receptor, Insulin - genetics | Adipocytes - metabolism | Insulin Resistance - genetics | Glucose - metabolism | Receptor, Insulin - metabolism | Mice | Mutation | Receptor, Insulin - agonists | Receptor, Insulin - immunology | Adipocytes - immunology | CHO Cells | Glucose metabolism | Analysis | Mortality | Insulin | Biopharmaceutics | Antigenic determinants | Diabetes therapy | Cell culture | Immunoglobulins | Animal models | Extracellular signal-regulated kinase | AKT protein | Adipocytes | Epitopes | Kinases | Antibody response | Insulin receptors | Transgenes
Journal Article
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7711, pp. 523 - 525
Abnormal activity of the enzyme PI3K can drive cancer growth, and mutations in a PI3K subunit can sometimes lead to non-cancerous overgrowth. A cancer drug... 
Medical research | Cancer | Antimitotic agents | Pharmaceutical research | Research | Antineoplastic agents
Journal Article
Diabetes care, ISSN 0149-5992, 11/2018, Volume 41, Issue 11, pp. 2353 - 2360
OBJECTIVEType B insulin resistance due to autoantibodies against the insulin receptor is characterized by diabetes refractory to massive doses of insulin,... 
AUTOANTIBODIES | ANTIBODIES | SYSTEMIC-LUPUS-ERYTHEMATOSUS | HODGKINS-DISEASE | CYCLOPHOSPHAMIDE | RITUXIMAB | ENDOCRINOLOGY & METABOLISM | CHRONIC LYMPHOCYTIC-LEUKEMIA | RECEPTOR | AUTOIMMUNE HYPOGLYCEMIA | CLINICAL-COURSE | Antigens, CD - immunology | Azathioprine - therapeutic use | Cyclophosphamide - administration & dosage | Follow-Up Studies | Autoantibodies - blood | Humans | Middle Aged | Diabetes Mellitus, Type 1 - metabolism | Dexamethasone - adverse effects | Male | Methylprednisolone - adverse effects | Cyclophosphamide - adverse effects | Hyperglycemia - drug therapy | Adult | Female | Remission Induction - methods | Maintenance Chemotherapy | Diabetes Mellitus, Type 1 - immunology | Drug Therapy, Combination | Receptor, Insulin - immunology | Immunosuppressive Agents - administration & dosage | Rituximab - adverse effects | Severity of Illness Index | Dexamethasone - administration & dosage | Hyperglycemia - immunology | Insulin - administration & dosage | Syndrome | Diabetes Mellitus, Type 1 - drug therapy | Rituximab - administration & dosage | Hyperglycemia - blood | Immunosuppressive Agents - adverse effects | Insulin Resistance - immunology | Insulin - adverse effects | Cohort Studies | Methylprednisolone - administration & dosage | Insulin resistance | Dosage and administration | Research | Diabetes | Drug therapy | Immunosuppressive agents
Journal Article
by Kilpeläinen, Tuomas and Zillikens, Carola and Stancáková, Alena and Finucane, Francis and Ried, Janina and Langenberg, Claudia and Zhang, Weihua and Beckmann, Jacques and Luan, J and Vandenput, Liesbeth and Styrkarsdottir, Unnur and Zhou, Yanhua and Smith, Albert Vernon and Zhao, Jing Hua and Amin, Najaf and Vedantam, Sailaja and Shin, S.-Y and Haritunians, Talin and Fu, Mao and Feitosa, Mary Furlan and Kumari, Meena and Halldorsson, Bjarni and Tikkanen, Emmi and Mangino, Massimo and Hayward, Caroline and Song, Ci and Arnold, Alice and Oostra, Ben and Campbell, Harry and Cupples, Aienne and Davis, Kathryn and Döring, Angela and Eiriksdottir, Gudny and Estrada Gil, Karol and Fernández-Real, J.M and Garcia, Melissa and Gieger, Christian and Glazer, Nicole and Guiducci, Candace and Hofman, Albert and Humphries, Steve and Isomaa, Bo and Jacobs, Leonie and Jula, Antti and Karasik, David and Karlsson, Magnus and Khaw, Kay-Tee and Kim, Lauren and Kivimaki, Mika and Klopp, Norman and Kuhnel, Brigitte and Kuusisto, Johanna and Liu, Yongmei and Ljunggren, Ö and Lorentzon, Mattias and Luben, Robert and McKnight, Barbara and Mellström, Dan and Mitchell, Braxton and Mooser, Vincent and Moreno, J.M and Männistö, Satu and O'Connell, Jeffery and Pascoe, Laura and Peltonen, Leena Johanna and Peral, Belén and Perola, Markus and Psaty, Bruce and Salomaa, Veikko and Savage, David and Semple, Robert and Skaric-Juric, Tatjana and Sigurdsson, Gunnar and Spector, Timothy and Syvänen, A.-C and Talmud, Philippa and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Uitterlinden, Ané and Tikka-Kleemola, Päivi and Vidal-Puig, Antonio and Wild, Sarah and Wright, Alan and Clegg, Deborah and Schadt, Eric and Wilson, James and Rudan, Igor and Ripatti, Samuli and Borecki, Ingrid and Shuldiner, Alan and Ingelsson, Erik and Jansson, J.O and Kaplan, Robert and Gudnason, Vilmundur and Harris, Tamara and Groop, Leif and Kiel, Douglas and Rivadeneira Ramirez, Fernando and Walker, Mark and Barroso, Inês and ... and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Geriatrik and Uppsala universitet and Institutionen för medicinska vetenskaper and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 08/2011, Volume 43, Issue 8, pp. 753 - 760
Journal Article
Diabetes Care, ISSN 0149-5992, 05/2008, Volume 31, Issue 5, pp. 977 - 979
Plasma Adiponectin as a Marker of Insulin Receptor Dysfunction Clinical utility in severe insulin resistance Robert K. Semple , MB, PHD 1 , Elaine K. Cochran ,... 
Journal Article
by Walter, Klaudia and Min, Josine L and Huang, Jie and Crooks, Lucy and Memari, Yasin and McCarthy, Shane and Perry, John and Xu, Changjiang and Futema, Marta and Lawson, Daniel and Iotchkova, Valentina and Schiffels, Stephan and Henicks, Auey E and Danecek, Petr and Li, Rui and Floyd, James and Wain, Louise and Barroso, Inês and Humphries, Steve and Hurles, Matthew and Zeggini, Eleftheria and Barrett, Jeffrey C and Plagnol, Vincent and Richards, Brent and Greenwood, Celia and Timpson, Nicholas and Durbin, Richard and Bala, Senduran and Clapham, Peter and Coates, Guy and Cox, Tony and Daly, Allan and Du, Yuanping and Edkins, Ted and Ellis, Peter and Flicek, Paul and Guo, Xiaosen and Guo, Xueqin and Huang, Liren and Jackson, David K and Joyce, Chris and Keane, Thomas and Kolb-Kokocinski, Anja and Langford, Cordelia and Li, Yingrui and Liang, Jieqin and Lin, Hong and Liu, Ryan and Maslen, John and Muddyman, Dawn and Quail, Michael A and Stalker, Jim and Sun, Jianping and Tian, Jing and Wang, Guangbiao and Wang, Jun and Wang, Yu and Wong, Kim and Zhang, Pingbo and Birney, Ewan and Boustred, Chris and Chen, Lu and Clement, Gail and Cocca, Massimiliano and Smith, G.D and Day, Ian N.M and Day-Williams, Aaron and Down, Thomas and Dunham, David and Evans, David M and Gaunt, Tom and Geihs, Matthias and Hart, Deborah and Howie, Bryan and Hubbard, Tim and Hysi, Pirro and Jamshidi, Yalda and Karczewski, Konrad and Kemp, John and Lachance, Genevieve and Lek, Monkol and Lopes, Margarida and MacArthur, Daniel G and Marchini, Jonathan and Mangino, Massimo and Mathieson, Iain and Metrustry, Sarah and Moayyeri, Alireza and Northstone, Kate and Panoutsopoulou, Kalliope and Paternoster, Lavinia and Quaye, Lydia and Ring, Susan and Ritchie, Graham R.S and Shihab, Hashem A and Shin, So-Youn and Small, Kerrin and Artigas, M.S and Soranzo, Nicole and Southam, Lorraine and ... and UCLEB Consortium and UK10K Consortium and The UK10K Consortium
Nature: international weekly journal of science, ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 82 - 89
Journal Article
2018, ISBN 2889454258
Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity... 
type 2 diabetes mellitus | Obesity | disease | non-alcoholic fatty liver disease | rodent models
eBook
Journal of Clinical Investigation, ISSN 0021-9738, 03/2006, Volume 116, Issue 3, pp. 581 - 589