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1. Full Text The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities
by Miranda T. Schram and Simone J. S. Sep and Carla J. van der Kallen and Pieter C. Dagnelie and Annemarie Koster and Nicolaas Schaper and Ronald M. A. Henry and Coen D. A. Stehouwer
European Journal of Epidemiology, ISSN 0393-2990, 1/2014, Volume 29, Issue 6, pp. 439 - 451
The Maastricht Study is an extensive phenotyping study that focuses on the etiology of type 2 diabetes (T2DM), its classic complications, and its emerging... 
Musculoskeletal diseases | Diabetic neuropathies | Exercise | Vascular diseases | Diabetes complications | NEW STUDY | Comorbidity | Questionnaires | Type 2 diabetes mellitus | Diabetes | Cardiovascular diseases | Type 2 diabetes | Public Health | Pathophysiology | Chronic disease | Oncology | Cardiovascular disease | Epidemiology | Study design | Medicine & Public Health | Prospective cohort study | Infectious Diseases | Cardiology | METAANALYSIS | SEDENTARY TIME | EDUCATION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | PARTICIPANTS AGED 24-81 | LIFE-STYLE | DISEASE | PHYSICAL-ACTIVITY | QUESTIONNAIRE | NORMATIVE DATA | VALIDITY | Cardiovascular Diseases - etiology | Life Style | Prospective Studies | Humans | Middle Aged | Netherlands - epidemiology | Risk Factors | Social Support | Male | Socioeconomic Factors | Diabetes Mellitus, Type 2 - epidemiology | Cardiovascular Diseases - complications | Phenotype | Cardiovascular Diseases - epidemiology | Adult | Diabetes Mellitus, Type 2 - etiology | Female | Aged | Population Surveillance | Diabetes Mellitus, Type 2 - complications | Complications and side effects | Depression, Mental | Chronic diseases | Development and progression | Respiratory tract diseases | Genotype & phenotype | Index Medicus
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2. Full Text Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study
by van der Berg, J.D and Stehouwer, C.D and Bosma, H and van der Velde, J.H and Willems, P and Savelberg, Hans HCM and Schram, M.T and Sep, Simone and van der Kallen, C.J and Henry, R.M and Dagnelie, P.C and Schaper, N.C and Koster, A
Diabetologia, ISSN 0012-186X, 2016, Volume 59, Issue 4, pp. 709 - 718
The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic... 
Medicine & Public Health | Human Physiology | Metabolic Diseases | Sedentary lifestyle | Internal Medicine | Sedentary bouts | Sedentary time | Metabolic syndrome | Sedentary breaks | Accelerometry | Diabetes mellitus type 2 | ADULTS | MARKERS | RISK | TIME | BIOMARKERS | OBESITY | LIFE-STYLE | DISEASE | ENDOCRINOLOGY & METABOLISM | PHYSICAL-ACTIVITY | PEOPLE | Cross-Sectional Studies | Humans | Middle Aged | Risk Factors | Female | Male | Aged | Sedentary Lifestyle | Metabolic Syndrome - epidemiology | Diabetes Mellitus, Type 2 - epidemiology | Type 2 diabetes | Glucose metabolism | Medical research | Analysis | Resveratrol | Medicine, Experimental | Glucose | Glucose tolerance tests | Dextrose | Index Medicus
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3. Full Text Discriminatory ability of simple OGTT-based beta cell function indices for prediction of prediabetes and type 2 diabetes: the CODAM study
by den Biggelaar, Louise J. C. J and Sep, Simone J. S and Eussen, Simone J. P. M and Mari, Andrea and Ferrannini, Ele and van Greevenbroek, Marleen M. J and van der Kallen, Carla J. H and Schalkwijk, Casper G and Stehouwer, Coen D. A and Dagnelie, Pieter C
Diabetologia, ISSN 0012-186X, 3/2017, Volume 60, Issue 3, pp. 432 - 441
The hyperglycaemic clamp technique and the frequently sampled IVGTT are unsuitable techniques to assess beta cell function (BCF) in large cohorts. Therefore,... 
Discrimination | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Indices | Beta cell function | Type 2 diabetes mellitus | Receiver operating characteristics | Prediabetes | OGTT | Insulin secretion | ORAL GLUCOSE-TOLERANCE | characteristics | HOMEOSTASIS MODEL ASSESSMENT | DISPOSITION INDEX | RELEASE | INSULIN SENSITIVITY | PLASMA | ENDOCRINOLOGY & METABOLISM | RESISTANCE | SECRETION | DYSFUNCTION | Receiver operating | Type 2 diabetesmellitus | ASSOCIATION | Body Mass Index | Insulin-Secreting Cells - physiology | Prediabetic State - blood | Humans | Middle Aged | Glucose Tolerance Test - methods | Male | Prediabetic State - diagnosis | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Female | ROC Curve | Aged | Blood Glucose - metabolism | Type 2 diabetes | Glucose metabolism | Pancreatic beta cells | Insulin resistance | Glucose | Glucose tolerance tests | Prediabetic state | Dextrose | Index Medicus
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4. Full Text Consumption of dairy foods in relation to impaired glucose metabolism and type 2 diabetes mellitus: the Maastricht Study
by Eussen, Simone J. P. M and van Dongen, Martinus and Wijckmans, Nicole and den Biggelaar, Louise and Elferink, Stefanie J. W. H. Oude and Singh-Povel, Cecile M and Schram, Miranda T and Sep, Simone J. S and van der Kallen, Carla J and Koster, Annemarie and Schaper, Nicolaas and Henry, Ronald M. A and Stehouwer, Coen D. A and Dagnelie, Pieter C
British Journal of Nutrition, ISSN 0007-1145, 04/2016, Volume 115, Issue 8, pp. 1453 - 1461
Observational studies suggest an inverse association between total dairy product intake and diabetes risk. However, there is a lack of information on the... 
FFQ | Dairy foods | Impaired glucose metabolism | Newly diagnosed type 2 diabetes mellitus | Observational studies | RISK-FACTORS | METAANALYSIS | FATTY-ACIDS | PREVALENCE | TRANS-PALMITOLEIC ACID | NUTRITION & DIETETICS | DIET | YOGURT CONSUMPTION | PRODUCTS | INSULIN-RESISTANCE | ASSOCIATION | Glucose Tolerance Test | Glucose Intolerance - epidemiology | Blood Glucose - analysis | Dairy Products - adverse effects | Diet - adverse effects | Humans | Middle Aged | Netherlands - epidemiology | Risk Factors | Glucose Metabolism Disorders - etiology | Male | Energy Intake | Diabetes Mellitus, Type 2 - epidemiology | Diabetes Mellitus, Type 2 - blood | Glucose Intolerance - etiology | Cultured Milk Products - adverse effects | Dietary Fats - administration & dosage | Adult | Diabetes Mellitus, Type 2 - etiology | Female | Surveys and Questionnaires | Aged | Glucose Metabolism Disorders - epidemiology | Odds Ratio | Index Medicus
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5. Full Text Which is more important for cardiometabolic health: sedentary time, higher intensity physical activity or cardiorespiratory fitness? The Maastricht Study
by van der Velde, Jeroen H. P. M and Schaper, Nicolaas C and Stehouwer, Coen D. A and van der Kallen, Carla J. H and Sep, Simone J. S and Schram, Miranda T and Henry, Ronald M. A and Dagnelie, Pieter C and Eussen, Simone J. P. M and van Dongen, Martien C. J. M and Savelberg, Hans H. C. M and Koster, Annemarie
Diabetologia, ISSN 0012-186X, 12/2018, Volume 61, Issue 12, pp. 2561 - 2569
Aims/hypothesesOur aim was to examine the independent and combined (cross-sectional) associations of sedentary time (ST), higher intensity physical activity... 
Type 2 diabetes | Physical fitness | Physical activity | The metabolic syndrome | Sedentary behaviour | Accelerometry | MORTALITY | METABOLIC SYNDROME | METAANALYSIS | BEHAVIOR | DISEASE RISK-FACTORS | ADULTS | GENERAL-POPULATION | MEN | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | ASSOCIATION | Blood Glucose - analysis | Cross-Sectional Studies | Humans | Middle Aged | Logistic Models | Male | Metabolic Syndrome - metabolism | Diabetes Mellitus, Type 2 - metabolism | Cardiorespiratory Fitness - physiology | Diabetes Mellitus, Type 2 - physiopathology | Waist Circumference - physiology | Metabolic Syndrome - physiopathology | Adult | Female | Surveys and Questionnaires | Aged | Exercise - physiology | Sedentary Behavior | Glucose tolerance tests | Analysis | Prediabetic state | Glucose tolerance | Diabetes mellitus | Diabetes | Metabolic syndrome | Diabetes mellitus (non-insulin dependent) | Metabolic disorders | Fitness | Index Medicus
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6. Full Text Prediabetes and type 2 diabetes are associated with generalized microvascular dysfunction: the Maastricht Study
by Sorensen, BM and Houben, AJHM and Berendschot, TTJM Tos and Schouten, JSAG and Kroon, AA and Kallen, van der, CJH and Henry, RMA and Koster, Annemarie and Sep, SJs and Dagnelie, PC and Schaper, NC and Schram, MT and Stehouwer, CDA
Circulation, ISSN 0009-7322, 2016, Volume 134, Issue 18, pp. 1339 - 1352
BACKGROUND:Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular disease. This can be partly explained by large-artery dysfunction,... 
cardiovascular disease | epidemiology | microvascular dysfunction | diabetes mellitus type 2 | pathophysiology | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | DIAMETER RESPONSE | FLICKER LIGHT | IMPAIRED GLUCOSE-TOLERANCE | RISK | MELLITUS | BLOOD-FLOW | POTENTIAL MECHANISM | INSULIN-RESISTANCE | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | Blood Pressure | Microvessels - physiopathology | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Microvessels - pathology | Male | Retinal Vessels - pathology | Hyperemia - pathology | Exercise | Lipids - blood | Smoking - physiopathology | Hyperemia - blood | Adult | Female | Registries | Prediabetic State - pathology | Body Mass Index | Prediabetic State - blood | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - physiopathology | Prediabetic State - physiopathology | Hyperemia - physiopathology | Smoking - pathology | Retinal Vessels - physiopathology | Aged | Diabetes Mellitus, Type 2 - pathology | Blood Glucose - metabolism | Index Medicus | Abridged Index Medicus
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7. Full Text Amount and pattern of physical activity and sedentary behavior are associated with kidney function and kidney damage: The Maastricht Study
by Martens, Remy J.H and Van Der Berg, Julianne D and Stehouwer, Coen D.A and Henry, Ronald M.A and Bosma, Hans and Dagnelie, Pieter C and Van Dongen, Martien C.J.M and Eussen, Simone J.P.M and Schram, Miranda T and Sep, Simone J.S and Van Der Kallen, Carla J.H and Schaper, Nicolaas C and Savelberg, Hans H.C.M and Van Der Sande, Frank M and Kroon, Abraham A and Kooman, Jeroen P and Koster, Annemarie
PLoS ONE, ISSN 1932-6203, 04/2018, Volume 13, Issue 4, pp. e0195306 - e0195306
Background Chronic kidney disease, which is defined as having a reduced kidney function (estimated glomerular filtration rate (eGFR)) and/or signs of kidney... 
UNITED-STATES | GLOMERULAR-FILTRATION-RATE | ESTIMATED GFR | METAANALYSIS | ALBUMINURIA | MICROALBUMINURIA | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | ADULTS | RISK | SITTING TIME | Sedentary behavior | Kidney diseases | Health aspects | Risk factors | Glomerular filtration rate | Physical activity | Bias | Clinical trials | Cardiovascular disease | Systematic review | Epidemiology | Exercise | Public health | Accelerometers | Hypertension | Medical research | Excretion | Kidneys | Nutrition | Internal medicine | Epidermal growth factor receptors | Health risks | Risk taking | Regression analysis | Metabolism | Risk analysis | Aerobics | Damage patterns | Meta-analysis | Medicine | Physical fitness | Diabetes | Cardiovascular diseases | Index Medicus
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8. Full Text Sedentary Behavior, Physical Activity, and Fitness-The Maastricht Study
by Velde, J.H. van der and Koster, A and Berg, J.D. van der and Sep, S.J and Kallen, C.J. van der and Dagnelie, P.C and Schram, M.T and Henry, R.M and Eussen, S.J and Dongen, M.C. van and Stehouwer, C.D and Schaper, N.C and Savelberg, H.H
Medicine and Science in Sports and Exercise, ISSN 0195-9131, 2017, Volume 49, Issue 8, pp. 1583 - 1591
PURPOSE: This cross-sectional study examined the mutual independent associations of sedentary behavior, lower intensity physical activity (LPA) and higher... 
Sedentary lifestyle | Physical fitness | High-intensity physical activity | Sedentary patterns | Accelerometry | POPULATION | SPORT SCIENCES | SEDENTARY LIFE-STYLE | DETERMINANTS | TIME | OXYGEN-UPTAKE | ALL-CAUSE MORTALITY | CARDIORESPIRATORY FITNESS | SEDENTARY PATTERNS | HIGH-INTENSITY PHYSICAL ACTIVITY | PHYSICAL FITNESS | MEN | CARDIOVASCULAR-DISEASE | HEALTH | ASSOCIATION | ACCELEROMETRY | Prospective Studies | Cross-Sectional Studies | Humans | Middle Aged | Male | Sedentary Lifestyle | Cardiorespiratory Fitness - physiology | Posture | Adult | Female | Accelerometry - methods | Aged | Exercise - physiology | Index Medicus
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9. Full Text Prospective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study
by den Biggelaar, Louise J. C. J and Eussen, Simone J. P. M and Sep, Simone J. S and Mari, Andrea and Ferrannini, Ele and van Greevenbroek, Marleen M and van der Kallen, Carla J and Schalkwijk, Casper G and Arts, Ilja C. W and Stehouwer, Coen D. A and Dagnelie, Pieter C
European Journal of Nutrition, ISSN 1436-6207, 3/2019, Volume 58, Issue 2, pp. 597 - 608
Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF... 
Chemistry | Nutrition | Fat | Carbohydrate | β-Cell function | Type 2 diabetes mellitus | Protein | Potentiation | Secretion | Diabetes mellitus | Population studies | Dietary intake | Glucose | Insulin | Cholesterol | Trans fats | Glucose tolerance | Etiology | Insulin resistance | Pancreas | Dietary fiber | Diabetes mellitus (non-insulin dependent) | Index Medicus | Original Contribution
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10. Full Text Replacement Effects of Sedentary Time on Metabolic Outcomes: The Maastricht Study
by Berg, J.D. van der and Velde, J. van der and Bosma, H and Savelberg, H and Schaper, N.C and Bergh, J.P.W. van den and Geusens, P and Schram, M.T and Sep, S.J and Kallen, C.J. van der and Henry, R.M and Dagnelie, P.C and Eussen, S and Dongen, M.C.J.M. van and Kohler, S and Kroon, A.A and Stehouwer, C.D and Koster, A
Medicine and Science in Sports and Exercise, ISSN 0195-9131, 2017, Volume 49, Issue 7, pp. 1351 - 1358
INTRODUCTION: Sedentary time has been associated with detrimental health effects, so in some countries, guidelines to reduce sedentary time have been... 
DIABETES MELLITUS TYPE 2 | ISOTEMPORAL SUBSTITUTION MODELING | METABOLIC SYNDROME | SEDENTARY LIFESTYLE | ACCELEROMETRY | SPORT SCIENCES | ASSOCIATIONS | METAANALYSIS | ADULTS | RISK | SITTING TIME | BIOMARKERS | ISOTEMPORAL SUBSTITUTION | CARDIOVASCULAR-DISEASE | PHYSICAL-ACTIVITY | Body Mass Index | Prospective Studies | Cross-Sectional Studies | Cholesterol - blood | Humans | Middle Aged | Diabetes Mellitus, Type 2 - prevention & control | Male | Sedentary Lifestyle | Insulin - blood | Waist Circumference | Posture - physiology | Triglycerides - blood | Adult | Female | Metabolic Syndrome - prevention & control | Aged | Blood Glucose - metabolism | Accelerometry | Stair Climbing - physiology | Type 2 diabetes | Sedentary behavior | Research | Metabolism | Health aspects | Index Medicus
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11. Full Text Consumption of dairy products in relation to the presence of clinical knee osteoarthritis: The Maastricht Study
by Denissen, Karlijn F. M and Boonen, Annelies and Nielen, Johannes T. H and Feitsma, Anouk L and van den Heuvel, Ellen G. H. M and Emans, Pieter J and Stehouwer, Coen D. A and Sep, Simone J. S and van Dongen, Martien C. J. M and Dagnelie, Pieter C and Eussen, Simone J. P. M
European Journal of Nutrition, ISSN 1436-6207, 2018, pp. 1 - 12
Observational studies showed inverse associations between milk consumption and knee osteoarthritis (knee OA). There is lack of information on the role of... 
FFQ | Dairy products | Knee osteoarthritis | Observational studies | Osteoarthritis | Milk | Knee | Vitamin D | Nutrition | Cheese | Arthritis | Fermentation
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12. Full Text Direct comparison of clinical decision limits for cardiac troponin T and I
by Kimenai, Dorien M and Henry, Ronald MA and van der Kallen, Carla JH and Dagnelie, Pieter C and Schram, Miranda T and Stehouwer, Coen DA and van Suijlen, Jeroen DE and Niens, Marijke and Bekers, Otto and Sep, Simone JS and Schaper, Nicolaas C and van Dieijen-Visser, Marja P and Meex, Steven JR
Heart, ISSN 1355-6037, 04/2016, Volume 102, Issue 8, pp. 610 - 616
ObjectiveThe 99th percentile upper reference limit of high-sensitivity cardiac troponin (hs-cTn) from a healthy reference population is used for diagnosing... 
CARDIAC & CARDIOVASCULAR SYSTEMS | POPULATION SELECTION | HEALTHY POPULATION | MYOCARDIAL-INFARCTION | NORMALITY | 99TH PERCENTILE VALUES | ASSAYS | COHORT | AGE | Myocardial Infarction - diagnosis | Age Distribution | Prospective Studies | Humans | Middle Aged | Male | Reference Values | Biomarkers - blood | Clinical Decision-Making - methods | Troponin I - blood | Troponin T - blood | Sensitivity and Specificity | Sex Distribution | Adult | Female | Aged | Decision-making | Care and treatment | Analysis | Heart attack | Glomerular filtration rate | Index Medicus | Abridged Index Medicus
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13. Full Text Associations of low grade inflammation and endothelial dysfunction with depression – The Maastricht Study
by van Dooren, Fleur E.P and Schram, Miranda T and Schalkwijk, Casper G and Stehouwer, Coen D.A and Henry, Ronald M.A and Dagnelie, Pieter C and Schaper, Nicolaas C and van der Kallen, Carla J.H and Koster, Annemarie and Sep, Simone J.S and Denollet, Johan and Verhey, Frans R.J and Pouwer, Frans
Brain Behavi