Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 2030 - 2030
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 6617 - 6617
Journal Article
The Lancet Oncology, ISSN 1470-2045, 10/2017, Volume 18, Issue 10, pp. 1373 - 1385
Rindopepimut (also known as CDX-110), a vaccine targeting the deletion mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet...
GLIOMAS | ONCOLOGY | RECURSIVE PARTITIONING ANALYSIS | GROWTH-FACTOR | RADIOTHERAPY | CANCER | PEPTIDE | ADJUVANT TEMOZOLOMIDE | Dacarbazine - adverse effects | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Brain Neoplasms - pathology | ErbB Receptors - genetics | Gene Expression Regulation, Neoplastic | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Patient Selection | Dose-Response Relationship, Drug | Young Adult | Glioblastoma - genetics | Time Factors | Dacarbazine - analogs & derivatives | Adult | Female | Vaccines, Subunit - adverse effects | Brain Neoplasms - mortality | Dacarbazine - administration & dosage | Double-Blind Method | Drug Administration Schedule | Cancer Vaccines - administration & dosage | Kaplan-Meier Estimate | Proportional Hazards Models | Brain Neoplasms - genetics | Cancer Vaccines - adverse effects | Treatment Outcome | Brain Neoplasms - drug therapy | Disease-Free Survival | Internationality | Vaccines, Subunit - administration & dosage | Glioblastoma - pathology | Survival Analysis | Aged | Temozolomide | Glioblastoma - drug therapy | Glioblastoma - mortality | Antimitotic agents | Clinical trials | Care and treatment | Product development | Antineoplastic agents | Glioblastoma multiforme | Analysis
GLIOMAS | ONCOLOGY | RECURSIVE PARTITIONING ANALYSIS | GROWTH-FACTOR | RADIOTHERAPY | CANCER | PEPTIDE | ADJUVANT TEMOZOLOMIDE | Dacarbazine - adverse effects | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Brain Neoplasms - pathology | ErbB Receptors - genetics | Gene Expression Regulation, Neoplastic | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Patient Selection | Dose-Response Relationship, Drug | Young Adult | Glioblastoma - genetics | Time Factors | Dacarbazine - analogs & derivatives | Adult | Female | Vaccines, Subunit - adverse effects | Brain Neoplasms - mortality | Dacarbazine - administration & dosage | Double-Blind Method | Drug Administration Schedule | Cancer Vaccines - administration & dosage | Kaplan-Meier Estimate | Proportional Hazards Models | Brain Neoplasms - genetics | Cancer Vaccines - adverse effects | Treatment Outcome | Brain Neoplasms - drug therapy | Disease-Free Survival | Internationality | Vaccines, Subunit - administration & dosage | Glioblastoma - pathology | Survival Analysis | Aged | Temozolomide | Glioblastoma - drug therapy | Glioblastoma - mortality | Antimitotic agents | Clinical trials | Care and treatment | Product development | Antineoplastic agents | Glioblastoma multiforme | Analysis
Journal Article
2012, 1. ed., Tendencias, ISBN 6074339198, 341
Book
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 8 Supplement, pp. 3826 - 3826
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 2038 - 2038
Journal Article
Neuro-Oncology, ISSN 1522-8517, 08/2016, Volume 18, Issue 8, pp. 1146 - 1156
The combination of galunisertib, a transforming growth factor (TGF)-beta receptor (R)1 kinase inhibitor, and lomustine was found to have antitumor activity in...
Antitumor activity | Galunisertib monohydrate (LY2157299) | Bayesian design | Safety | Pharmacokinetics | Phase II randomized study | SURVIVAL | CELLS | DIAGNOSIS | TGF-BETA | KINASE INHIBITOR | CLINICAL NEUROLOGY | INHIBITOR LY2157299 MONOHYDRATE | ONCOLOGY | antitumor activity | safety | GROWTH | pharmacokinetics | galunisertib monohydrate (LY2157299) | ASSOCIATION | Pyrazoles - therapeutic use | Humans | Lomustine - adverse effects | Middle Aged | Kaplan-Meier Estimate | Male | Treatment Outcome | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Quinolines - pharmacokinetics | Disease-Free Survival | Drug Therapy, Combination - adverse effects | Drug Therapy, Combination - methods | Lomustine - pharmacokinetics | Female | Lomustine - therapeutic use | Quinolines - therapeutic use | Antineoplastic Agents, Alkylating - adverse effects | Glioblastoma - drug therapy | Pyrazoles - pharmacokinetics | Quinolines - adverse effects | Pyrazoles - adverse effects | Clinical Investigations
Antitumor activity | Galunisertib monohydrate (LY2157299) | Bayesian design | Safety | Pharmacokinetics | Phase II randomized study | SURVIVAL | CELLS | DIAGNOSIS | TGF-BETA | KINASE INHIBITOR | CLINICAL NEUROLOGY | INHIBITOR LY2157299 MONOHYDRATE | ONCOLOGY | antitumor activity | safety | GROWTH | pharmacokinetics | galunisertib monohydrate (LY2157299) | ASSOCIATION | Pyrazoles - therapeutic use | Humans | Lomustine - adverse effects | Middle Aged | Kaplan-Meier Estimate | Male | Treatment Outcome | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Quinolines - pharmacokinetics | Disease-Free Survival | Drug Therapy, Combination - adverse effects | Drug Therapy, Combination - methods | Lomustine - pharmacokinetics | Female | Lomustine - therapeutic use | Quinolines - therapeutic use | Antineoplastic Agents, Alkylating - adverse effects | Glioblastoma - drug therapy | Pyrazoles - pharmacokinetics | Quinolines - adverse effects | Pyrazoles - adverse effects | Clinical Investigations
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. e13517 - e13517
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 3015 - 3015
Journal Article
Current diabetes reviews, ISSN 1573-3998, 2010, Volume 6, Issue 5, pp. 313 - 322
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Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 2001 - 2001
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2017, Volume 18, Issue 5, p. 995
Galunisertib, a Transforming growth factor-beta RI (TGF-beta RI) kinase inhibitor, blocks TGF-beta-mediated tumor growth in glioblastoma. In a three-arm study...
Biomarkers | pSMAD2 | TGF-β | Galunisertib monohydrate (LY2157299) | CDK4/CDK6 | SURVIVAL | IMMUNE CELLS | biomarkers | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-II | CANCER | CHEMISTRY, MULTIDISCIPLINARY | TUMOR-INFILTRATING LYMPHOCYTES | TGF-beta | galunisertib monohydrate (LY2157299) | RADIOTHERAPY | Pyrazoles - therapeutic use | Humans | Lomustine - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Quinolines - administration & dosage | Neoplasm Recurrence, Local - pathology | CD4-CD8 Ratio | Forkhead Transcription Factors - metabolism | Biomarkers, Tumor - metabolism | Adult | Female | Lomustine - therapeutic use | Neoplasm Recurrence, Local - blood | Cytokines - blood | Pyrazoles - adverse effects | Glioblastoma - blood | Smad2 Protein - metabolism | Antineoplastic Combined Chemotherapy Protocols | Biomarkers, Tumor - blood | Pyrazoles - administration & dosage | Forkhead Transcription Factors - blood | Glioblastoma - pathology | Survival Analysis | Isocitrate Dehydrogenase - metabolism | Quinolines - therapeutic use | Glioblastoma - drug therapy | Lomustine - administration & dosage | Quinolines - adverse effects | Therapy | CD8 antigen | Glioblastoma | Transforming growth factor-a | Lymphocytes T | Dehydrogenase | Kinases | Macrophages | CCL22 protein | Alterations | Macrophage-derived chemokine | Histopathology | Lymphocytes | Foxp3 protein | Isocitrate dehydrogenase | Dosing | Leukocytes (eosinophilic) | Glial fibrillary acidic protein | Markers | Pharmacology | CD3 antigen | Assessments | Patients | Survival | CD4 antigen | Pathology | Inhibitors | Chemokines | Cytoplasm | Plasmas (physics) | Eosinophils | Tumors
Biomarkers | pSMAD2 | TGF-β | Galunisertib monohydrate (LY2157299) | CDK4/CDK6 | SURVIVAL | IMMUNE CELLS | biomarkers | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-II | CANCER | CHEMISTRY, MULTIDISCIPLINARY | TUMOR-INFILTRATING LYMPHOCYTES | TGF-beta | galunisertib monohydrate (LY2157299) | RADIOTHERAPY | Pyrazoles - therapeutic use | Humans | Lomustine - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Quinolines - administration & dosage | Neoplasm Recurrence, Local - pathology | CD4-CD8 Ratio | Forkhead Transcription Factors - metabolism | Biomarkers, Tumor - metabolism | Adult | Female | Lomustine - therapeutic use | Neoplasm Recurrence, Local - blood | Cytokines - blood | Pyrazoles - adverse effects | Glioblastoma - blood | Smad2 Protein - metabolism | Antineoplastic Combined Chemotherapy Protocols | Biomarkers, Tumor - blood | Pyrazoles - administration & dosage | Forkhead Transcription Factors - blood | Glioblastoma - pathology | Survival Analysis | Isocitrate Dehydrogenase - metabolism | Quinolines - therapeutic use | Glioblastoma - drug therapy | Lomustine - administration & dosage | Quinolines - adverse effects | Therapy | CD8 antigen | Glioblastoma | Transforming growth factor-a | Lymphocytes T | Dehydrogenase | Kinases | Macrophages | CCL22 protein | Alterations | Macrophage-derived chemokine | Histopathology | Lymphocytes | Foxp3 protein | Isocitrate dehydrogenase | Dosing | Leukocytes (eosinophilic) | Glial fibrillary acidic protein | Markers | Pharmacology | CD3 antigen | Assessments | Patients | Survival | CD4 antigen | Pathology | Inhibitors | Chemokines | Cytoplasm | Plasmas (physics) | Eosinophils | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 06/2016, Volume 113, Issue 23, p. E3231
Large-conductance [Ca.sup.2+]- and voltage-activated [K.sup.+] (BK) channels are involved in a large variety of physiological processes. Regulatory...
Electrophysiology | Calcium channels | Potassium channels | Observations | Health aspects
Electrophysiology | Calcium channels | Potassium channels | Observations | Health aspects
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 06/2016, Volume 113, Issue 23, pp. E3231 - E3231
Large-conductance Ca super( 2+)- and voltage-activated K super( +) (BK) channels are involved in a large variety of physiological processes. Regulatory beta...
Journal Article
Oncology Letters, ISSN 1792-1074, 2015, Volume 9, Issue 6, pp. 2442 - 2448
Transforming growth factor-beta (TGF-beta) signaling is associated with tumor progression and vascularization in malignant glioma. In the present study,...
Lomustine | Transforming growth factor‑β inhibitor LY2157299 | Magnetic resonance imaging | Combination therapy | Glioblastoma | magnetic resonance imaging | CEREBRAL BLOOD-VOLUME | RESPONSE CRITERIA | ANGIOGENESIS | BEVACIZUMAB | PHASE-II | INDUCTION | lomustine | MALIGNANT GLIOMA | glioblastoma | ONCOLOGY | transforming growth factor-beta inhibitor LY2157299 | combination therapy | GRADE | IRINOTECAN | TUMOR-GROWTH
Lomustine | Transforming growth factor‑β inhibitor LY2157299 | Magnetic resonance imaging | Combination therapy | Glioblastoma | magnetic resonance imaging | CEREBRAL BLOOD-VOLUME | RESPONSE CRITERIA | ANGIOGENESIS | BEVACIZUMAB | PHASE-II | INDUCTION | lomustine | MALIGNANT GLIOMA | glioblastoma | ONCOLOGY | transforming growth factor-beta inhibitor LY2157299 | combination therapy | GRADE | IRINOTECAN | TUMOR-GROWTH
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2015, Volume 21, Issue 3, pp. 553 - 560
Purpose: TGF beta signaling plays a key role in tumor progression, including malignant glioma. Small-molecule inhibitors such as LY2157299 monohydrate...
CELLS | INDUCTION | ONCOLOGY | INTEGRATED GENOMIC ANALYSIS | Pyrazoles - therapeutic use | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Quinolines - pharmacology | Young Adult | Neoplasm Grading | Glioma - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adult | Female | Antineoplastic Agents - pharmacology | Pyrazoles - pharmacology | Treatment Outcome | Neoplasms - drug therapy | Magnetic Resonance Imaging | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Aged | Protein Kinase Inhibitors - pharmacology | Quinolines - therapeutic use | Neoplasm Staging | Neoplasms - pathology | Glioma - drug therapy
CELLS | INDUCTION | ONCOLOGY | INTEGRATED GENOMIC ANALYSIS | Pyrazoles - therapeutic use | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Quinolines - pharmacology | Young Adult | Neoplasm Grading | Glioma - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adult | Female | Antineoplastic Agents - pharmacology | Pyrazoles - pharmacology | Treatment Outcome | Neoplasms - drug therapy | Magnetic Resonance Imaging | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Aged | Protein Kinase Inhibitors - pharmacology | Quinolines - therapeutic use | Neoplasm Staging | Neoplasms - pathology | Glioma - drug therapy
Journal Article
Revista de Neurologia, ISSN 0210-0010, 07/2015, Volume 61, Issue 2, pp. 85 - 93
Journal Article
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, ISSN 1942-0900, 08/2019, Volume 2019, pp. 9719730 - 12
Glioblastoma (GBM) is the most common and devastating primary brain tumor. The presence of cancer stem cells (CSCs) has been linked to their therapy...
OXIDATIVE STRESS | ACTIVATION | INHIBITION | COLORECTAL-CANCER | PHENOTYPE | DIFFERENTIATION | ORAL SOLUTION | TUMORS | PROGRESSION | EGFR | CELL BIOLOGY | Antioxidants | Ethylenediaminetetraacetic acid | Medical equipment and supplies industry | Medical test kit industry | Brain tumors | Stem cells | Dietary supplements | Transplantation | Macrophages | Glioblastoma multiforme | Cancer | Oxidative stress | Medical research | Medical prognosis | Brain cancer | Penicillin | Cancer therapies
OXIDATIVE STRESS | ACTIVATION | INHIBITION | COLORECTAL-CANCER | PHENOTYPE | DIFFERENTIATION | ORAL SOLUTION | TUMORS | PROGRESSION | EGFR | CELL BIOLOGY | Antioxidants | Ethylenediaminetetraacetic acid | Medical equipment and supplies industry | Medical test kit industry | Brain tumors | Stem cells | Dietary supplements | Transplantation | Macrophages | Glioblastoma multiforme | Cancer | Oxidative stress | Medical research | Medical prognosis | Brain cancer | Penicillin | Cancer therapies
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2017, Volume 19, Issue 11, pp. 1522 - 1531
Background. We conducted a multicenter, 2-stage, open-label, phase II trial to assess the efficacy and safety of dacomitinib in adult patients with recurrent...
Dacomitinib | High-grade glioma | EGFR | Glioblastoma | GEFITINIB | dacomitinib | OPEN-LABEL | CLINICAL NEUROLOGY | TEMOZOLOMIDE | CELL LUNG-CANCER | HETEROGENEITY | GROWTH-FACTOR RECEPTOR | ERBB INHIBITOR | glioblastoma | ONCOLOGY | PATHWAY | high-grade glioma | HIGH-GRADE GLIOMAS | ERLOTINIB | Clinical Investigations
Dacomitinib | High-grade glioma | EGFR | Glioblastoma | GEFITINIB | dacomitinib | OPEN-LABEL | CLINICAL NEUROLOGY | TEMOZOLOMIDE | CELL LUNG-CANCER | HETEROGENEITY | GROWTH-FACTOR RECEPTOR | ERBB INHIBITOR | glioblastoma | ONCOLOGY | PATHWAY | high-grade glioma | HIGH-GRADE GLIOMAS | ERLOTINIB | Clinical Investigations
Journal Article
Journal of Urology, The, ISSN 0022-5347, 2013, Volume 189, Issue 4, pp. e192 - e193
Journal Article
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