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1. Full Text Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation
by Balestrieri, M L and Servillo, L and Esposito, A and D’Onofrio, N and Giovane, A and Casale, R and Barbieri, M and Paolisso, P and Rizzo, M R and Paolisso, G and Marfella, R
Diabetologia, ISSN 0012-186X, 1/2013, Volume 56, Issue 1, pp. 162 - 172
Downregulation of levels of endothelial progenitor cells (EPCs) during in-vitro short-term exposure to high glucose concentrations relates to reduced activity... 
Type 2 diabetes | Medicine & Public Health | Human Physiology | Platelet-activating factor | Metabolic Diseases | Endothelial progenitor cells | Internal Medicine | SIRT1 | OXIDATIVE STRESS | MACROPHAGES | BONE-MARROW | DOWN-REGULATION | MECHANISMS | ADHESION | VASCULAR COMPLICATIONS | TRANSACETYLASE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | END-PRODUCTS IMPAIR | Sirtuin 1 - metabolism | Receptors, G-Protein-Coupled - metabolism | Cell Count | Humans | Middle Aged | Endothelium, Vascular - drug effects | Male | Diabetes Mellitus, Type 2 - metabolism | Receptors, G-Protein-Coupled - agonists | RNA, Messenger - metabolism | Sirtuin 1 - genetics | Platelet Membrane Glycoproteins - antagonists & inhibitors | Diabetic Angiopathies - pathology | Platelet Membrane Glycoproteins - metabolism | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Membrane Glycoproteins - agonists | Adult Stem Cells - pathology | Diabetes Mellitus, Type 2 - complications | Adult Stem Cells - drug effects | Diabetic Angiopathies - metabolism | Cell Separation | Blood Buffy Coat - pathology | Cells, Cultured | Platelet Membrane Glycoproteins - genetics | Diabetic Angiopathies - drug therapy | Down-Regulation - drug effects | Phospholipid Ethers - pharmacology | Adult Stem Cells - metabolism | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | Endothelium, Vascular - pathology | Aged | Hyperglycemia - etiology | Receptors, G-Protein-Coupled - genetics | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Type 2 - drug therapy | Index Medicus
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2. Full Text Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - an observational study in 29 countries
by Kroell, Wolfgang and Metzler, Helfried and Struber, Gerd and Wegscheider, Thomas and Gombotz, Hans and Hiesmayr, Michael and Schmid, Werner and Urbanek, Bernhard and Leva, Brigitte and Damster, Sanine and Plichon, Benoit and Kahn, David and Momeni, Mona and Pospiech, Auey and Lois, Fernande and Forget, Patrice and Grosu, Irina and Poelaert, Jan and van Mossevelde, Veerle and van Malderen, Marie-Claire and Dylst, Dimitri and van Melkebeek, Jeroen and Beran, Maud and de Hert, Stefan and de Baerdemaeker, Luc and Heyse, Bjorn and van Limmen, Jurgen and Wyffels, Piet and Jacobs, Tom and Roels, Nathalie and de Bruyne, Ann and van de Velde, Stijn and Juros-Zovko, Marina and Djonoviċ-Omanoviċ, Dejana and Serpa Neto, Ary and Pernar, Selma and Zunic, Josip and Miskovic, Petar and Zilic, Antonio and Kvolik, Slavica and Ivic, Dubravka and Azenic-Venzera, Darija and Skiljic, Sonja and Vinkovic, Hrvoje and Oputric, Ivana and Juricic, Kazimir and Frkovic, Vean and Kopic, Jasminka and Mirkovic, Ivan and Karanovic, Nenad and Carev, Mladen and pulic, Natasa and Pavičić-Šarić, Jaanka and Erceg, Gorjana and Bogdanović Dvorščak, Matea and Mazul-Sunko, Branka and Pavicic, Anna Marija and Goranovic, Tanja and Maldini, Branka and Radocaj, Tomislav and Gavranovic, Zeljka and Mladic-Batinica, Inga and Sehovic, Mirna and Stourac, Petr and Harazim, Hana and Smekalova, Olga and Kosinova, Martina and Kolacek, Tomas and Hudacek, Kamil and b, Michal and Brujevic, Jan and Vitkova, Katerina and Jirmanova, Katerina and Volfova, Ivana and Dzurnakova, Paula and Liskova, Katarina and Dudas, Radovan and Filipsky, Radek and El Kafrawy, Samir and Hosny Abdelwahab, Hisham and Metwally, Tarek and Abdel-Razek, Ahmed and El-Shaarawy, Ahmed Mostafa and Fathy Hasan, Wael and Gouda Ahmed, Ahmed and Yassin, Hany and Magdy, Mohamed and Abdelhady, Mahdy and Mahran, Mohamed and Herodes, Eiko and Kivik, Peeter and Oganjan, Juri and Aun, Annika and Sormus, Alar and Sarapuu, Kaili and Mall, Merilin and Karjagin, Juri and Futier, Emmanuel and Petit, Antoine and Gerard, Adeline and ... and LAS VEGAS Investigators and LAS VEGAS investigators and The LAS VEGAS investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper and Klinisk fysiologi
European journal of anaesthesiology, ISSN 0265-0215, 2017, Volume 34, Issue 8, pp. 492 - 507
BACKGROUNDLimited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs),... 
NONCARDIOTHORACIC SURGERY | BERLIN DEFINITION | ACUTE LUNG INJURY | ANESTHESIOLOGY | PROTECTIVE MECHANICAL VENTILATION | END-EXPIRATORY-PRESSURE | GENERAL-ANESTHESIA | PRACTICE PATTERNS | MAJOR NONCARDIAC SURGERY | ABDOMINAL-SURGERY | RESPIRATORY-DISTRESS-SYNDROME | Index Medicus | Ventilation | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Anestesi och intensivvård | Anesthesiology and Intensive Care
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3. Full Text Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications
by Cortegiani, A and Gregoretti, C and Neto, A.S and Hemmes, S.N.T and Hemmes, S and Ball, L and Canet, J and Hiesmayr, M and Hollmann, M and Hollmann, M.W and Mills, G.H and Mills, G and Melo, M.F.V and Melo, M.V and Putensen, C and Schmid, W and Severgnini, P and Wrigge, H and Gama de Abreu, M and Schultz, M and Schultz, M.J and Pelosi, P and Kroell, W and Metzler, H and Struber, G and Wegscheider, T and Gombotz, H and Urbanek, B and Kahn, D and Momeni, M and Pospiech, A and Lois, F and Forget, P and Grosu, I and Poelaert, J and Mossevelde, V and van Malderen, M.C and Dylst, D and Melkebeek, J.V and Beran, M and Hert, S.D and Baerdemaeker, L.D and Heyse, B and Limmen, J.V and Wyffels, P and Jacobs, T and Roels, N and Bruyne, A.D and Velde, S.V.D and Marina, J.Z and Dejana, D.O and Pernar, S and Zunic, J and Miskovic, P and Zilic, A and Kvolik, S and Ivic, D and Darija, A.V and Skiljic, S and Vinkovic, H and Oputric, I and Juricic, K and Frkovic, V and Kopic, J and Mirkovic, I and Saric, J.P and Erceg, G and Dvorscak, M.B and Branka, M.S and Pavicic, A.M and Goranovic, T and Maldini, B and Radocaj, T and Gavranovic, Z and Inga, M.B and Sehovic, M and Stourac, P and Harazim, H and Smekalova, O and Kosinova, M and Kolacek, T and Hudacek, K and Drab, M and Brujevic, J and Vitkova, K and Jirmanova, K and Volfova, I and Dzurnakova, P and Liskova, K and Dudas, R and Filipsky, R and Kafrawy, S.E and Abdelwahab, H.H and Metwally, T and Ahmed, A.G and Ahmed, A.R and Ahmed Mostafa, E.S and Hasan, W.F and Yassin, H and Magdy, M and ... and PROVE Network and European Soc Anaesthesiology and LAS VEGAS Investigators and LAS VEGAS Investigators, the PROVE Network, and the Clinical Trial Network of the European Society of Anaesthesiology
British Journal of Anaesthesia, ISSN 0007-0912, 03/2019, Volume 122, Issue 3, pp. 361 - 369
The aim of this analysis of a large cohort study was to evaluate the association between night-time surgery and the occurrence of intraoperative adverse events... 
intraoperative complications | postoperative complications | pulmonary | patient safety | general anaesthesia | MORTALITY | PERFORMANCE | SLEEP-DEPRIVATION | MECHANICAL VENTILATION | TIME | STRATEGIES | ANESTHESIA | INCREASED RISK | ANESTHESIOLOGY | OUTCOMES | Intraoperative Complications - epidemiology | Prospective Studies | Surgical Procedures, Operative | Humans | Middle Aged | Risk Factors | Male | Postoperative Complications - epidemiology | After-Hours Care - statistics & numerical data | Incidence | Internationality | Adult | Female | Aged | Lung Diseases - epidemiology | Cohort Studies | Index Medicus
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4. Full Text Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone
by Martinelli, V and Cocco, E and Capra, R and Salemi, G and Gallo, P and Capobianco, M and Pesci, I and Ghezzi, A and Pozzilli, C and Lugaresi, A and Bellantonio, P and Amato, M.P and Grimaldi, L.M and Trojano, M and Mancardi, G.L and Bergamaschi, R and Gasperini, C and Rodegher, M and Straffi, L and Ponzio, M and Comi, G and Radaelli, M and Esposito, F and Moiola, L and Colombo, B and Rossi, P and Marrosu, M.G and Frau, J and Lorefice, L and Coghe, G and Savettieri, G and Ragonese, P and Cusimano, V and Perini, P and Rinaldi, F and Vidali, A and Bertolotto, A and Malucchi, S and Di Sapio, A and Montanari, E and Guareschi, A and Rizzo, A and Zaffaroni, M and Baldini, S and De Rossi, N and Cordioli, C and Rasia, S and Salvetti, M and Buttinelli, C and Ausili Cefaro, L and De Luca, Giovanna and Tommaso, D and Farina, D and Fantozzi, R and Ruggieri, S and Hakiki, B and Zipoli, V and Portaccio, E and Bartolozzi, M.L and Scandellari, C and Stecchi, S and Marchello, L.P and Palmeri, B and Vitello, G and Iaffaldano, P and Lucchese, G and Dattola, V and Buccafusca, M and Sola, P and Simone, A.M and Barreca, F and Patti, F and Laisa, P and Cavalla, P and Masera, S and Tavazzi, E and Galgani, S and Tedeschi, G and Sacco, R and Provinciali, L and Maura, D and Lus, G and Alfieri, G and Ticca, A and Piras, M.L and Maimone, D and Bianca, M and Iudice, A and Giro, M.E and Galeotti, M and Florio, C and Spitalieri, P and La Mantia, L and Motti, L and Rottoli, M.R and Granella, F and Solaro, C and Scarpini, E and Servillo, G and Cavaletti, G and Italian Mitoxantrone Grp and Italian Mitoxantrone Group and For The Italian Mitoxantrone Group
Neurology, ISSN 0028-3878, 11/2011, Volume 77, Issue 21, pp. 1887 - 1895
Objectives: To evaluate the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML) in the network of Italian multiple... 
MULTICENTER | THERAPY | PROFILE | EFFICACY | SAFETY | CANCER-RISK | CLINICAL NEUROLOGY | ACUTE PROMYELOCYTIC LEUKEMIA | NOVANTRONE | Follow-Up Studies | Humans | Statistics, Nonparametric | Female | Italy - epidemiology | Male | Aged | Retrospective Studies | Leukemia, Myeloid, Acute - chemically induced | Mitoxantrone - adverse effects | Analgesics - adverse effects | Multiple Sclerosis - drug therapy | Index Medicus | Abridged Index Medicus
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5. Full Text Early neutropenia with thrombocytopenia following alemtuzumab treatment for multiple sclerosis: case report and review of literature
by Maniscalco, G.T and Cerillo, I and Servillo, G and Napolitano, M and Guarcello, G and Abate, V and Improta, G and Florio, C
Clinical Neurology and Neurosurgery, ISSN 0303-8467, 12/2018, Volume 175, pp. 134 - 136
Alemtuzumab is a monoclonal antibody targeting the CD52 antigen used in the treatment of relapsing-remitting multiple sclerosis (RRMS). CD52 is expressed by... 
Thrombocytopenia | CD52 | Multiple sclerosis | Alemtuzumab | Neutropenia | SURGERY | CLINICAL NEUROLOGY | Complications and side effects | Antigens | Drug therapy | Hyperthermia | Fever | Nuclear magnetic resonance--NMR | Hematology | Cytokines | Neutrophils | Leukocytes (neutrophilic) | Patients | Blood | Literature reviews | Infusion | Monocytes | Blood platelets | Purpura | Lymphocytes | CD52 antigen | Monoclonal antibodies | Bone marrow | Platelets
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6. Full Text The World Health Organisation surgical safety checklist does not reduce mortality in general surgery
by Vargas, M and Servillo, G
British Journal of Anaesthesia, ISSN 0007-0912, 05/2018, Volume 120, Issue 5, pp. 1135 - 1137
mortality | postoperative complications | WHO surgical safety checklist | International Surgical Outcome Study | HOSPITAL MORTALITY | ANESTHESIOLOGY | COHORT | OUTCOMES | Index Medicus
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7. Full Text Tracheostomy procedures in the intensive care unit: An international survey
by Vargas, Maria and Sutherasan, Yuda and Antonelli, Massimo and Brunetti, Iole and Corcione, Antonio and Laffey, John G and Putensen, Christian and Servillo, Giuseppe and Pelosi, Paolo
Critical Care, ISSN 1364-8535, 08/2015, Volume 19, Issue 1, pp. 291 - 291
Introduction: Percutaneous dilatational tracheostomy (PDT) is one of the most frequent procedures performed in the intensive care unit (ICU). PDT may add... 
ICU PATIENTS | SURGICAL TRACHEOTOMY | PERCUTANEOUS DILATATIONAL TRACHEOSTOMY | TIME | VENTILATED PATIENTS | BRONCHOSCOPY | CRITICAL CARE MEDICINE | Tracheostomy - methods | Tracheostomy - statistics & numerical data | Practice Patterns, Physicians' - statistics & numerical data | Intensive Care Units - statistics & numerical data | Surveys and Questionnaires | Humans | Neuromuscular blocking agents | Surveys | Practice guidelines (Medicine) | Tracheostomy | Public opinion | Medicine | Ventilators | Ostomy | Airway management | Intensive care | Statistical analysis | Critical care | Manuscripts | Index Medicus | Research
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8. Full Text Sensing of mammalian IL-17A regulates fungal adaptation and virulence
by Zelante, Teresa and Iannitti, Rossana G and De Luca, Antonella and Arroyo, Javier and Blanco, Noelia and Servillo, Giuseppe and Sanglard, Dominique and Reichard, Utz and Palmer, Glen E and Latgè, Jean-Paul and Puccetti, Paolo and Romani, Luigina
Nature Communications, ISSN 2041-1723, 2012, Volume 3, Issue 1, pp. 683 - 683
Infections by opportunistic fungi have traditionally been viewed as the gross result of a pathogenic automatism, which makes a weakened host more vulnerable to... 
CANDIDA-ALBICANS | GENE | RECOGNITION | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | HOST-DEFENSE | RECEPTOR | AUTOPHAGY | PROTEINS | EXPRESSION | Adaptation, Physiological | Candida albicans - pathogenicity | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | Mice, Inbred C57BL | Gene Expression Profiling | Candida albicans - immunology | Aspergillus fumigatus - pathogenicity | Autophagy | Host-Pathogen Interactions | Interleukin-17 - metabolism | Animals | Cyclic AMP - biosynthesis | Aspergillus fumigatus - immunology | Aspergillus fumigatus - physiology | Candida albicans - physiology | Female | Mice | Index Medicus
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9. Full Text Retinal vascular density in multiple sclerosis: a 1‐year follow‐up
by Lanzillo, R and Cennamo, G and Moccia, M and Criscuolo, C and Carotenuto, A and Frattaruolo, N and Sparnelli, F and Melenzane, A and Lamberti, A and Servillo, G and Tranfa, F and De Crecchio, G and Brescia Morra, V
European Journal of Neurology, ISSN 1351-5101, 01/2019, Volume 26, Issue 1, pp. 198 - 201
Background and purpose Vascular pathology is increasingly acknowledged as a risk factor for multiple sclerosis (MS). Vascular density (VD) is reduced in the... 
parafovea | vascular density | optical coherence tomography | retina | multiple sclerosis | COHERENCE TOMOGRAPHY ANGIOGRAPHY | NEUROSCIENCES | CLINICAL NEUROLOGY | Disability Evaluation | Prospective Studies | Angiography | Follow-Up Studies | Tomography, Optical Coherence | Humans | Middle Aged | Male | Multiple Sclerosis - diagnostic imaging | Fovea Centralis - diagnostic imaging | Disease Progression | Retinal Vessels - diagnostic imaging | Adult | Female | Fovea Centralis - blood supply | Multiple sclerosis | Analysis | Brain | Medical imaging | Statistical analysis | Retina | Regression analysis | Risk analysis | Patients | Density | Risk factors | Confidence intervals | Atrophy | Thermal expansion | Regression models | Optical Coherence Tomography | Biomarkers | Eye (anatomy) | Bioindicators | Sexually-transmitted diseases | Index Medicus
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10. Full Text Aryl hydrocarbon receptor control of a disease tolerance defence pathway
by Bessede, Alban and Gargaro, Marco and Pallotta, Maria T and Matino, Davide and Servillo, Giuseppe and Brunacci, Cinzia and Bicciato, Silvio and Mazza, Emilia M. C and Macchiarulo, Antonio and Vacca, Carmine and Iannitti, Rossana and Tissi, Luciana and Volpi, Claudia and Belladonna, Maria L and Orabona, Ciriana and Bianchi, Roberta and Lanz, Tobias V and Platten, Michael and Della Fazia, Maria A and Piobbico, Danilo and Zelante, Teresa and Funakoshi, Hiroshi and Nakamura, Toshikazu and Gilot, David and Denison, Michael S and Guillemin, Gilles J and Duhadaway, James B and Prendergast, George C and Metz, Richard and Geffard, Michel and Boon, Louis and Pirro, Matteo and Iorio, Alfonso and Veyret, Bernard and Romani, Luigina and Grohmann, Ursula and Fallarino, Francesca and Puccetti, Paolo
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7508, pp. 184 - 190
Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new... 
KYNURENINE | LIGAND-BINDING | DENDRITIC CELLS | IDO | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | ENDOTOXIN TOLERANCE | REGULATORY T-CELLS | AH RECEPTOR | INFECTION | TRYPTOPHAN CATABOLISM | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Phosphorylation | Signal Transduction | Endotoxemia - genetics | Receptors, Aryl Hydrocarbon - genetics | Disease Resistance - drug effects | Disease Resistance - immunology | Enzyme Activation - drug effects | Gene Expression Regulation - drug effects | Tryptophan Oxygenase - metabolism | Inflammation - metabolism | Animals | Bacterial Infections - immunology | Endotoxemia - immunology | Lipopolysaccharides - pharmacology | src-Family Kinases - metabolism | Inflammation - genetics | Receptors, Aryl Hydrocarbon - metabolism | Mice | Kynurenine - metabolism | Endotoxemia - metabolism | Disease Resistance - genetics | Inflammation - enzymology | Bacterial Infections - metabolism | Medicine, Experimental | Medical research | Sepsis | Research | Endotoxins | Studies | Immunology | Cytokines | Rodents | Ligands | Infections | Gram-negative bacteria | Kinases | Gene expression | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | Adaptive immunology
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