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Toxicon, ISSN 0041-0101, 03/2019, Volume 159, pp. S31 - S31
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2013, Volume 45, Issue 10, pp. 1261 - 1261
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2013, Volume 45, Issue 10, p. 1261
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Nature Genetics, ISSN 1061-4036, 02/2013, Volume 45, Issue 2, pp. 121 - 122
Our understanding of inherited risk factors for colorectal cancer (CRC) is incomplete. A new study reports the identification of germline CRC risk variants... 
MUTATOR | PHENOTYPES | DELTA | GENETICS & HEREDITY | Poly-ADP-Ribose Binding Proteins | DNA Polymerase III - genetics | Models, Biological | Colorectal Neoplasms - genetics | Humans | DNA Replication - genetics | DNA Mismatch Repair - genetics | Germ-Line Mutation - genetics | DNA Polymerase II - genetics | Mutation | Colon | Colorectal cancer | Tumors
Journal Article
NATURE GENETICS, ISSN 1061-4036, 10/2013, Volume 45, Issue 10, pp. 1261 - 1261
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2016, Volume 48, Issue 4, pp. 407 - 416
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Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 660 - 664
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Nature Biotechnology, ISSN 1087-0156, 01/2015, Volume 33, Issue 3, pp. 306 - 312
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2012, Volume 44, Issue 10, pp. 1111 - 1116
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have... 
SELECTIVE INHIBITOR | POTENT | EFFICACY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-RAF | HETERODIMERIZATION | B-RAF | PROTEIN-KINASE KINASE | CANCER | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Index Medicus | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
Journal Article
Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7308, pp. 869 - 873
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 110 - 114
Journal Article