X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (54) 54
humans (51) 51
cancer (36) 36
cell line, tumor (26) 26
oncology (26) 26
animals (23) 23
cell biology (22) 22
mutation (21) 21
antineoplastic agents - pharmacology (20) 20
mice (19) 19
article (15) 15
neoplasms - drug therapy (14) 14
tumors (14) 14
antineoplastic agents - therapeutic use (13) 13
female (13) 13
neoplasms - genetics (13) 13
protein kinase inhibitors - pharmacology (13) 13
genetic aspects (12) 12
lung-cancer (12) 12
receptor, epidermal growth factor - genetics (12) 12
research (12) 12
biochemistry & molecular biology (11) 11
breast-cancer (11) 11
drug resistance (11) 11
xenograft model antitumor assays (11) 11
care and treatment (9) 9
cell lung-cancer (9) 9
drug resistance, neoplasm - genetics (9) 9
growth (9) 9
health aspects (9) 9
kinases (9) 9
lung neoplasms - genetics (9) 9
acquired-resistance (8) 8
drug therapy (8) 8
gene expression regulation, neoplastic (8) 8
human necessities (8) 8
hygiene (8) 8
lung neoplasms - drug therapy (8) 8
medical or veterinary science (8) 8
multidisciplinary sciences (8) 8
physiological aspects (8) 8
preparations for medical, dental, or toilet purposes (8) 8
quinazolines - pharmacology (8) 8
signal transduction - drug effects (8) 8
specific therapeutic activity of chemical compounds ormedicinal preparations (8) 8
antimitotic agents (7) 7
antineoplastic agents (7) 7
apoptosis (7) 7
cell survival - drug effects (7) 7
drug resistance, neoplasm (7) 7
drug resistance, neoplasm - drug effects (7) 7
erlotinib hydrochloride (7) 7
lung cancer (7) 7
lung neoplasms - metabolism (7) 7
melanoma (7) 7
mice, nude (7) 7
neoplasms - pathology (7) 7
protein kinase inhibitors - therapeutic use (7) 7
resistance (7) 7
sensitivity (7) 7
carcinoma, non-small-cell lung - genetics (6) 6
egfr (6) 6
gene (6) 6
gene expression (6) 6
genomics (6) 6
metastasis (6) 6
phosphotransferases (6) 6
proteins (6) 6
rna interference (6) 6
biochemistry, genetics and molecular biology (5) 5
biomarkers (5) 5
carcinoma, non-small-cell lung - metabolism (5) 5
cells (5) 5
gastrointestinal stromal tumors (5) 5
gefitinib (5) 5
genetics & heredity (5) 5
genotype (5) 5
genotype-correlated sensitivity (5) 5
male (5) 5
mutations (5) 5
oncogene addiction (5) 5
ras (5) 5
signal transduction (5) 5
signal transduction - physiology (5) 5
stem-cells (5) 5
therapy (5) 5
tyrosine kinase (5) 5
activation (4) 4
cancer cells (4) 4
cancer research (4) 4
carcinoma, non-small-cell lung - drug therapy (4) 4
cell survival (4) 4
chronic myeloid-leukemia (4) 4
drug synergism (4) 4
drug-sensitivity (4) 4
growth-factor-receptor (4) 4
inhibition (4) 4
kinase inhibitors (4) 4
ligands (4) 4
lung neoplasms - pathology (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 505 - 509
Mutationally activated kinases define a clinically validated class of targets for cancer drug therapy(1). However, the efficacy of kinase inhibitors in... 
CELL LUNG-CANCER | SURVIVAL | HETEROGENEITY | ACTIVATION | RECEPTOR TYROSINE KINASES | THERAPY | MET AMPLIFICATION | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | SENSITIVITY | TUMOR-CELLS | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Melanoma - enzymology | Phosphatidylinositol 3-Kinases - metabolism | Hepatocyte Growth Factor - pharmacology | Breast Neoplasms - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Ligands | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Antimitotic agents | Physiological aspects | Antineoplastic agents | Growth factors | Health aspects | Phosphotransferases | Substance abuse treatment | Epidermal growth factor | Rodents | Biomarkers | Breast cancer | Insulin-like growth factors | Kinases | Drug resistance | Tumors | Index Medicus
Journal Article
NATURE, ISSN 0028-0836, 01/2016, Volume 529, Issue 7586, pp. 289 - 290
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 2, pp. 588 - 589
Comment on: Takagi S, Banno H, Hayashi A, Tamura T, Ishikawa T, Ohta Y. HER2 and HER3 cooperatively regulate cancer cell growth and determine sensitivity to... 
Journal Article
Cell Cycle, ISSN 1538-4101, 09/2016, Volume 15, Issue 18, pp. 2387 - 2388
Journal Article
Nature, ISSN 0028-0836, 03/2007, Volume 446, Issue 7132, pp. 145 - 146
Cancer results from an accumulation of mutations and other heritable changes in susceptible cells. Studies that have provided the first unbiased, large-scale... 
LUNG-CANCER | GEFITINIB | HUMAN BREAST | MUTATIONS | GENE | MULTIDISCIPLINARY SCIENCES | Protein Kinases - genetics | Neoplasms - genetics | Genomics | Humans | DNA Mutational Analysis - trends | Mutation - genetics | Genes, Neoplasm - genetics | Genome, Human - genetics | Mutation | Cellular biology | Deoxyribonucleic acid | DNA | Cancer
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2017, Volume 23, Issue 8, pp. 913 - 914
Journal Article
Cell, ISSN 0092-8674, 03/2016, Volume 164, Issue 6, pp. 1101 - 1104
The discovery and development of new medicines that promote human health and potentially extend natural life remains a remarkably challenging endeavor. In this... 
United States | Humans | Drug Therapy | Drug Approval | Drug Discovery | United States Food and Drug Administration | Communication | Precision Medicine | Drug approval | Drugs | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7565, pp. 361 - 365
Journal Article
Cell, ISSN 0092-8674, 03/2016, Volume 164, Issue 6, pp. 1101 - 1104
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2007, Volume 104, Issue 50, pp. 19936 - 19941
Journal Article
Genome Medicine, ISSN 1756-994X, 04/2014, Volume 6, Issue 4, pp. 30 - 30
Selective inhibitors of the kinases BRAF and MEK for the treatment of patients with otherwise refractory BRAF mutant melanoma have demonstrated impressive... 
IMPROVED SURVIVAL | MUTATIONS | MEK INHIBITION | CANCER | GENETICS & HEREDITY | Care and treatment | Gene mutations | Analysis | Melanoma | Genetic aspects | Drug resistance | Drug therapy | Cancer
Journal Article
Cell, ISSN 0092-8674, 06/2014, Volume 157, Issue 7, pp. 1509 - 1514
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2014, Volume 26, Issue 2, pp. 207 - 221
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2004, Volume 350, Issue 21, pp. 2129 - 2139
Journal Article