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1. Full Text Case 12-2016
: An 8-Year-Old Boy with an Enlarging Mass in the Right Breast
by Misra, Madhusmita and Sagar, Pallavi and Friedmann, Alison M and Ryan, Daniel P and Sgroi, Dennis C
The New England Journal of Medicine, ISSN 0028-4793, 04/2016, Volume 374, Issue 16, pp. 1565 - 1574
An 8-year-old boy presented with a mass in the right breast that had been present for 18 months and had enlarged during the previous 6 months. On examination,... 
EXCESS | MEDICINE, GENERAL & INTERNAL | METASTASIS | FUSION | SECRETORY CARCINOMA | PREPUBERTAL GYNECOMASTIA | AROMATASE GENE | ADULTS | HYBRIDIZATION | CANCER | GAIN | Symptomatology | Care and treatment | Breast diseases | Analysis
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2. Full Text In vivo gene expression profile analysis of human breast cancer progression
by Sgroi, Dennis C and Teng, Sarena and Robinson, Greg and LeVangie, Rebbecca and Hudson Jr, James R and Elkahloun, Abdel G
Cancer Research, ISSN 0008-5472, 11/1999, Volume 59, Issue 22, pp. 5656 - 5661
The development and use of molecular-based therapy for breast cancer and other human malignancies will require a detailed molecular genetic analysis of patient... 
LASER CAPTURE MICRODISSECTION | CELLS | TISSUE-FACTOR | MICROARRAY | ONCOLOGY | CHEMOKINES | GENOME | ANNEXIN-I | Immunohistochemistry | Gene Expression | Dissection - methods | Humans | Disease Progression | Feasibility Studies | Polymerase Chain Reaction - methods | RNA, Neoplasm - analysis | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Lasers | Female | Neoplasm Proteins - analysis | Cytogenetic Analysis | Neoplasm Proteins - genetics | DNA, Complementary | Index Medicus
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3. Full Text Sequence analysis of mutations and translocations across breast cancer subtypes
by Banerji, Shantanu and Cibulskis, Kristian and Rangel-Escareno, Claudia and Brown, Kristin K and Carter, Scott L and Frederick, Abbie M and Lawrence, Michael S and Sivachenko, Andrey Y and Sougnez, Carrie and Zou, Lihua and Cortes, Maria L and Fernandez-Lopez, Juan C and Peng, Shouyong and Ardlie, Kristin G and Auclair, Daniel and Bautista-Piña, Veronica and Duke, Fujiko and Francis, Joshua and Jung, Joonil and Maffuz-Aziz, Antonio and Onofrio, Robert C and Parkin, Melissa and Pho, Nam H and Quintanar-Jurado, Valeria and Ramos, Alex H and Rebollar-Vega, Rosa and Rodriguez-Cuevas, Sergio and Romero-Cordoba, Sandra L and Schumacher, Steven E and Stransky, Nicolas and Thompson, Kristin M and Uribe-Figueroa, Laura and Baselga, Jose and Beroukhim, Rameen and Polyak, Kornelia and Sgroi, Dennis C and Richardson, Andrea L and Jimenez-Sanchez, Gerardo and Lander, Eric S and Gabriel, Stacey B and Garraway, Levi A and Golub, Todd R and Melendez-Zajgla, Jorge and Toker, Alex and Getz, Gad and Hidalgo-Miranda, Alfredo and Meyerson, Matthew
Nature, ISSN 0028-0836, 06/2012, Volume 486, Issue 7403, pp. 405 - 409
Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with an estimated 1.38 million new cases and 458,000 deaths in 2008... 
CELL LUNG-CANCER | FUSION | COLORECTAL CANCERS | PIK3CA GENE | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | KINASE | HIGH-FREQUENCY | PATTERNS | LANDSCAPES | GENOME | Breast Neoplasms - classification | Membrane Proteins - genetics | Humans | Core Binding Factor beta Subunit - genetics | Mutation - genetics | Proto-Oncogene Proteins c-akt - genetics | Gene Fusion - genetics | Exome - genetics | Vietnam | Algorithms | Breast Neoplasms - genetics | Breast Neoplasms - pathology | DNA Mutational Analysis | Female | Mexico | Proto-Oncogene Proteins c-akt - metabolism | Core Binding Factor Alpha 2 Subunit - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Translocation, Genetic - genetics | Translocation (Genetics) | Gene mutations | Exome sequencing | Breast cancer | Genetic aspects | Research | Cancer | Genetics | Mutation | Kinases | Genes | Index Medicus
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4. Full Text Gene expression profiling of the tumor microenvironment during breast cancer progression
by Ma, Xiao-Jun and Dahiya, Sonika and Richardson, Elizabeth and Erlander, Mark and Sgroi, Dennis C
Breast Cancer Research, ISSN 1465-5411, 02/2009, Volume 11, Issue 1, pp. R7 - R7
Introduction The importance of the tumor microenvironment in breast cancer has been increasingly recognized. Critical molecular changes in the tumor stroma... 
TRANSITION | IMMUNE-SYSTEM | METASTASIS | SET ENRICHMENT ANALYSIS | ONCOLOGY | WNT PATHWAY | CARCINOMAS | PROLIFERATION | STROMAL CELLS | RECEPTORS | IN-SITU | Carcinoma, Ductal, Breast - genetics | Epithelial Cells - metabolism | Microdissection | Oligonucleotide Array Sequence Analysis | Stromal Cells - pathology | Humans | Middle Aged | Carcinoma, Intraductal, Noninfiltrating - metabolism | Extracellular Matrix - metabolism | Carcinoma, Intraductal, Noninfiltrating - genetics | Gene Expression Profiling | RNA, Messenger - metabolism | Immunoenzyme Techniques | Breast Neoplasms - metabolism | Lasers | Adult | Carcinoma, Ductal, Breast - pathology | Female | Carcinoma, Ductal, Breast - metabolism | Gene Expression Regulation, Neoplastic - physiology | Neoplasm Invasiveness | RNA, Messenger - genetics | Stromal Cells - metabolism | Epithelial Cells - pathology | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Breast Neoplasms - genetics | Carcinoma, Intraductal, Noninfiltrating - pathology | Breast Neoplasms - pathology | Extracellular Matrix - pathology | Genetic research | Development and progression | Breast cancer | Genetic aspects | Research | Gene expression | Risk factors | Methods | Index Medicus
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5. Full Text Abstract P4-11-19: Integration of breast cancer index (BCI) with clinicopathological factors for prediction of distant recurrence in ER+ breast cancer
by Sestak, Ivana and Zhang, Yi and Schroeder, Brock E and Goss, Paul E and Dowsett, Mitch and Sgroi, Dennis C and Schnabel, Catherine A and Cuzick, Jack
Cancer Research, ISSN 0008-5472, 05/2015, Volume 75, Issue 9 Supplement, pp. P4 - P4-11-19
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6. Full Text Gene expression profiles of beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes
by Marselli, Lorella and Thorne, Jeffrey and Dahiya, Sonika and Sgroi, Dennis C and Sharma, Arun and Bonner-Weir, Susan and Marchetti, Piero and Weir, Gordon C
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, pp. e11499 - e11499
Background: Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and... 
APOPTOSIS | PANCREATIC-ISLETS | PROTEIN | INSULIN-SECRETION | BIOLOGY | ENDOPLASMIC-RETICULUM | GROWTH-REGULATION | STRESS | TRANSCRIPTIONAL REGULATION | CHRONIC HYPERGLYCEMIA | GLUCOSE-TOLERANCE | Cell Cycle - genetics | Microdissection | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Apoptosis - genetics | Male | Gene Expression Profiling | Diabetes Mellitus, Type 2 - metabolism | Endoplasmic Reticulum - pathology | Insulin-Secreting Cells - metabolism | Matrix Metalloproteinase 7 - genetics | Lasers | Female | Aged | Diabetes Mellitus, Type 2 - pathology | In Vitro Techniques | Type 2 diabetes | Pancreatic beta cells | DNA microarrays | RNA | Analysis | Genes | Genetic aspects | Gene expression | Metallothionein | Diabetes therapy | Enrichment | Oxidative stress | Pathogenesis | Genomes | Biology | Glucose | Medical schools | Cell growth | Transgenic animals | Rodents | Cell cycle | Metalloproteinase | Pancreas | Deoxyribonucleic acid--DNA | Secretion | Diabetes mellitus | Metabolism | Ribonucleic acid--RNA | Insulin | Medicine | Studies | Beta cells | Pathology | Regeneration | Islets of Langerhans | Diabetes | Endoplasmic reticulum | Endocrinology | Apoptosis | Matrilysin | Index Medicus | Deoxyribonucleic acid | Ribonucleic acid | DNA
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7. Full Text Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: a prospective comparison of the breast-cancer index (BCI) assay, 21-gene recurrence score, and IHC4 in the TransATAC study population
by Sgroi, Dennis C, Prof and Sestak, Ivana, PhD and Cuzick, Jack, Prof and Zhang, Yi, PhD and Schnabel, Catherine A, PhD and Schroeder, Brock, PhD and Erlander, Mark G, PhD and Dunbier, Anita, PhD and Sidhu, Kally, BSc and Lopez-Knowles, Elena, PhD and Goss, Paul E, Prof and Dowsett, Mitch, Prof
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 11, pp. 1067 - 1076
Summary Background Biomarkers to improve the risk–benefit of extended adjuvant endocrine therapy for late recurrence in patients with... 
Hematology, Oncology and Palliative Medicine | ATAC TRIAL | STOCKHOLM TRIAL | PROGNOSTIC-FACTORS | CLINICAL-TRIAL | ONCOLOGY | TAMOXIFEN | ADJUVANT TREATMENT | FOLLOW-UP | MOLECULAR GRADE INDEX | HORMONAL-THERAPY | POSTMENOPAUSAL PATIENTS | Receptors, Estrogen - metabolism | Prognosis | Prospective Studies | Follow-Up Studies | Neoplasm Recurrence, Local - metabolism | Humans | Middle Aged | Gene Expression Profiling | Neoplasm Recurrence, Local - diagnosis | Breast Neoplasms - drug therapy | Neoplasm Recurrence, Local - etiology | Immunoenzyme Techniques | Breast Neoplasms - metabolism | Breast Neoplasms - genetics | Antineoplastic Agents, Hormonal - therapeutic use | Tamoxifen - therapeutic use | Aged, 80 and over | Female | Aged | Neoplasm Staging | Nitriles - therapeutic use | Triazoles - therapeutic use | Cancer patients | Oncology, Experimental | Adjuvant treatment | Breast cancer | Research | Comparative analysis | Tamoxifen | Cancer | Index Medicus
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8. Full Text Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
by Le Gallo, Matthieu and O'Hara, Andrea J and Rudd, Meghan L and Urick, Mary Ellen and Hansen, Nancy F and O'Neil, Nigel J and Price, Jessica C and Zhang, Suiyuan and England, Bryant M and Godwin, Andrew K and Sgroi, Dennis C and Hieter, Philip and Mullikin, James C and Merino, Maria J and Bell, Daphne W and NIH Intramural Sequencing Ctr NISC and NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program
Nature Genetics, ISSN 1061-4036, 12/2012, Volume 44, Issue 12, pp. 1310 - 1315
Endometrial cancer is the sixth most commonly diagnosed cancer in women worldwide, causing similar to 74,000 deaths annually(1). Serous endometrial cancers are... 
FACTOR CHD4 | SUPPRESSOR | FREQUENT MUTATIONS | DNA-DAMAGE | PROSTATE-CANCER | GENETICS & HEREDITY | ARID1A | NURD | HISTONE DEACETYLASE | RENAL-CARCINOMA | CELL CARCINOMA | F-Box-WD Repeat-Containing Protein 7 | Receptors, Drug - genetics | Humans | E1A-Associated p300 Protein - genetics | Molecular Sequence Data | Chromatin Assembly and Disassembly - genetics | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Ubiquitin-Protein Ligase Complexes - genetics | Sulfonylurea Receptors | Autoantigens - genetics | ATP-Binding Cassette Transporters - genetics | Endometrial Neoplasms - genetics | Base Sequence | Cell Cycle Proteins - genetics | Adult | Female | Nuclear Proteins - genetics | Carcinoma, Endometrioid - genetics | Gene Frequency | Repressor Proteins - genetics | Potassium Channels, Inwardly Rectifying - genetics | Transcription Factors - genetics | Sequence Analysis, DNA | MAP Kinase Kinase Kinase 4 - genetics | Exome - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | Adenocarcinoma, Clear Cell - genetics | F-Box Proteins - genetics | Usage | Endometrial cancer | Gene mutations | Exome sequencing | Genetic aspects | Diagnosis | Research | Health aspects | Proteins | Medical research | Genetics | Cancer | Tumors | Index Medicus
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9. Full Text Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer
by Daniel P. Silver and Andrea L. Richardson and Aron C. Eklund and Zhigang C. Wang and Zoltan Szallasi and Qiyuan Li and Nicolai Juul and Chee-Onn Leong and Diana Calogrias and Ayodele Buraimoh and Aquila Fatima and Rebecca S. Gelman and Paula D. Ryan and Nadine M. Tung and Arcangela De Nicolo and Shridar Ganesan and Alexander Miron and Christian Colin and Dennis C. Sgroi and Leif W. Ellisen and Eric P. Winer and Judy E. Garber
Journal of Clinical Oncology, ISSN 0732-183X, 03/2010, Volume 28, Issue 7, pp. 1145 - 1153
Purpose Cisplatin is a chemotherapeutic agent not used routinely for breast cancer treatment. As a DNA cross-linking agent, cisplatin may be effective... 
P53 MUTATIONS | SURVIVAL | BASAL-LIKE | CHEMOSENSITIVITY | PREOPERATIVE CHEMOTHERAPY | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | BRCA1 MUTATIONS | ESTROGEN-RECEPTOR STATUS | EXPRESSION PROFILES | TUMORS | Nuclear Proteins - analysis | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | DNA-Binding Proteins - analysis | Antineoplastic Agents - therapeutic use | Receptors, Estrogen - analysis | Receptors, Progesterone - analysis | Breast Neoplasms - chemistry | DNA Methylation | Genes, p53 | Adult | Female | Neoadjuvant Therapy | Genes, BRCA1 | Promoter Regions, Genetic | Breast Neoplasms - drug therapy | Tumor Protein p73 | Breast Neoplasms - genetics | Cisplatin - therapeutic use | Cisplatin - adverse effects | Aged | Mutation | Receptor, ErbB-2 - analysis | Tumor Suppressor Proteins - analysis | Index Medicus | To4 | Original Reports | To14 | To13 | Bc5 | Bc8
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10. Full Text Relapse-free survival of statistically standardized continuous RT-PCR estrogen receptor , and human epidermal growth factor receptor 2 : NCIC CTG MA.14
by Chapman, Judith-Anne W and Sgroi, Dennis C and Goss, Paul E and Zarella, Elizabeth and Binns, Shemeica and Zhang, Yi and Schnabel, Catherine A and Erlander, Mark G and Pritchard, Kathleen I and Han, Lei and Badovinac-Crnjevic, Tanja and Shepherd, Lois E and Pollak, Michael N
Breast Cancer Research and Treatment, ISSN 0167-6806, 05/2016, Volume 157, Issue 1, p. 101
Public relations | Epidermal growth factor | Analysis | Patient outcomes | Estrogen | Quality control | Phenols | Postmenopausal women | Rankings | Progesterone | Tamoxifen
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11. Full Text Abstract P3-06-06: Prediction of benefit from endocrine therapy in ER+ early stage breast cancer: Correlative studies of the breast cancer index HoxB13/IL17BR (H/I) ratio, ER, PR, and HER2 expression in the randomized Stockholm trial
by Zhang, Yi and Schroeder, Brock E and Jerevall Jannok, Piiha-Lotta and Fornander, Tommy and Stal, Olle and Schnabel, Catherine A and Sgroi, Dennis C
Cancer Research, ISSN 0008-5472, 05/2015, Volume 75, Issue 9 Supplement, pp. P3 - P3-06-06
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12. Full Text Amplification of MET May Identify a Subset of Cancers with Extreme Sensitivity to the Selective Tyrosine Kinase Inhibitor PHA-665752
by Gromoslaw A. Smolen and Raffaella Sordella and Beth Muir and Gayatry Mohapatra and Anne Barmettler and Heidi Archibald and Woo J. Kim and Ross A. Okimoto and Daphne W. Bell and Dennis C. Sgroi and James G. Christensen and Jeffrey Settleman and Daniel A. Haber
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2006, Volume 103, Issue 7, pp. 2316 - 2321
The success of molecular targeted therapy in cancer may depend on the selection of appropriate tumor types whose survival depends on the drug target, so-called... 
Tumor cell line | Receptors | Hepatocytes | Non small cell lung carcinoma | Cell lines | Antibodies | Small interfering RNA | Viability | Cancer | Tumors | Gene amplification | Molecular marker | Targeted therapy | Oncogene addiction | targeted therapy | GEFITINIB | HUMAN-BREAST-CANCER | MULTIDISCIPLINARY SCIENCES | IN-SITU HYBRIDIZATION | COMBINATION | CELL LUNG-CANCER | TRIAL | oncogene addiction | molecular marker | C-MET | LINE | MUTATIONS | COMPARATIVE GENOMIC HYBRIDIZATION | gene amplification | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Genetic Testing | Humans | Proto-Oncogene Proteins c-met | Proto-Oncogene Proteins - genetics | Sulfones - pharmacology | Receptors, Growth Factor - genetics | Drug Resistance, Neoplasm - genetics | Gene Amplification | Cell Line, Tumor | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Biomarkers, Tumor - genetics | Apoptosis | Cell Movement | Protein-Tyrosine Kinases - antagonists & inhibitors | Oncogenes | Research | Drug therapy | Chromosomes | Cells | Index Medicus | Biological Sciences
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13. Full Text Transforming Properties of YAP, a Candidate Oncogene on the Chromosome 11q22 Amplicon
by Michael Overholtzer and Jianmin Zhang and Gromoslaw A. Smolen and Beth Muir and Wenmei Li and Dennis C. Sgroi and Chu-Xia Deng and Joan S. Brugge and Daniel A. Haber
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2006, Volume 103, Issue 33, pp. 12405 - 12410
In a screen for gene copy-number changes in mouse mammary tumors, we identified a tumor with a small 350-kb amplicon from a region that is syntenic to a much... 
Cell growth | 3T3 cells | Epithelial cells | Drosophila | Genes | Cell lines | Oncogenes | Apoptosis | Tumors | Cancer | Breast | Transformation | Yorkie | Mammary | YES-ASSOCIATED PROTEIN | PROLIFERATION ARREST | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTIONAL COACTIVATOR | transformation | BREAST-CANCER | mammary | SQUAMOUS-CELL CARCINOMA | AMINO-ACID CHANGE | TUMOR-SUPPRESSOR | COMPARATIVE GENOMIC HYBRIDIZATION | breast | MAMMARY EPITHELIAL-CELLS | PROMOTES APOPTOSIS | Neoplasms - metabolism | Cell Proliferation | Epithelial Cells - metabolism | Humans | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Neoplasms - genetics | Cell Shape | Trans-Activators - genetics | Epithelial Cells - cytology | Nuclear Proteins - genetics | Mammary Glands, Human - cytology | Nuclear Proteins - metabolism | Phosphoproteins - genetics | Animals | Cell Transformation, Neoplastic | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Signal Transduction - physiology | Trans-Activators - metabolism | Chromosomes, Human, Pair 11 | Mice | Apoptosis - physiology | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Mammary glands | Genetic aspects | Research | Hippopotamus | Insects | Rodents | Gene loci | Chromosomes | Cells | Index Medicus | Biological Sciences
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14. Full Text A unique spectrum of somatic PIK3CA (p110α) mutations within primary endometrial carcinomas
by Rudd, Meghan L and Price, Jessica C and Fogoros, Sarah and Godwin, Andrew K and Sgroi, Dennis C and Merino, Maria J and Bell, Daphne W
Clinical Cancer Research, ISSN 1078-0432, 03/2011, Volume 17, Issue 6, pp. 1331 - 1340
Purpose: The goal of this study was to comprehensively define the incidence of mutations in all exons of PIK3CA in both endometrioid endometrial cancer (EEC)... 
GENE-MUTATIONS | DOMAIN | CARCINOGENESIS | ONCOLOGY | PATHWAY | POOR-PROGNOSIS | PHOSPHATASE | HIGH-FREQUENCY | PTEN | TUMOR-SUPPRESSOR | HUMAN CANCER | PTEN Phosphohydrolase - genetics | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins p21(ras) | Exons | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Endometrial Neoplasms - genetics | DNA Mutational Analysis | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Carcinoma - genetics | Female | Mutation | Proto-Oncogene Proteins c-akt - metabolism | Index Medicus | mutation | cancer | Endometrial | PIK3CA | spectrum
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