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Nature Reviews Genetics, ISSN 1471-0056, 05/2015, Volume 16, Issue 5, pp. 299 - 311
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 186 - 191
Journal Article
Nature Cell Biology, ISSN 1465-7392, 11/2018, Volume 20, Issue 11, pp. 1235 - 1237
Functional genetic screening of mice and other mammals is exceedingly challenging. A CRISPR-based mutagenesis screen in mice has successfully revealed amino... 
STEM-CELLS | COMPLEX | GENERATION | GENOMIC DNA | BASE | CELL BIOLOGY | Medical colleges | Phenotype | Research | Analysis | Genetic screening | Cytology | Proteins | CRISPR | Screening | Missense mutation | Mutagenesis | Amino acids | Mice | Mutation | DND1 gene | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 09/2016, Volume 353, Issue 6307, pp. 1545 - 1549
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7669, pp. 537 - 542
Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based immunotherapies. Here we perturbed genes in human melanoma cells to mimic... 
CELL LUNG-CANCER | METASTATIC MELANOMA | DIFFERENTIAL GENE | CTLA-4 BLOCKADE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | RECEPTOR | T-CELLS | GENOME | LYMPHOCYTES | Neoplasms - metabolism | Humans | Genome - genetics | Adoptive Transfer | Janus Kinase 1 - metabolism | T-Lymphocytes, Cytotoxic - drug effects | Apelin - metabolism | Neoplasms - therapy | Apelin Receptors - genetics | Neoplasms - genetics | Melanoma - genetics | Immunotherapy | Female | Genes, Essential - genetics | Melanoma - metabolism | T-Lymphocytes, Cytotoxic - immunology | Knowledge Bases | Reproducibility of Results | Histocompatibility Antigens Class I - immunology | Antigen Presentation - genetics | CRISPR-Cas Systems - genetics | Apelin Receptors - metabolism | Animals | T-Lymphocytes, Cytotoxic - metabolism | Melanoma - immunology | Neoplasms - immunology | Interferon-gamma - immunology | Cell Line, Tumor | Mice | Mutation | Melanoma - therapy | Care and treatment | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Cancer | Cytolytic activity | Animal models | CD8 antigen | Genes | Genomics | Effector cells | Genomes | Lymphocytes T | Kinases | Cancer therapies | Lymphocytes | Janus kinase | Antigen presentation | Antigens | CRISPR | Melanoma | T cell receptors | Tumor cell lines | Signaling | Immune checkpoint | γ-Interferon | Interferon | Tumors
Journal Article