Journal of Experimental Medicine, ISSN 0022-1007, 05/2009, Volume 206, Issue 5, pp. 974 - 975
Virologist and published author Shane Crotty sees immune memory as the key to making a better vaccine.
HELP | MEDICINE, RESEARCH & EXPERIMENTAL | HUMORAL IMMUNITY | SAP | IMMUNOLOGY | ANTIBODY-RESPONSES | People & Ideas
HELP | MEDICINE, RESEARCH & EXPERIMENTAL | HUMORAL IMMUNITY | SAP | IMMUNOLOGY | ANTIBODY-RESPONSES | People & Ideas
Journal Article
Immunity, ISSN 1074-7613, 10/2014, Volume 41, Issue 4, pp. 529 - 542
Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and...
GERMINAL CENTER FORMATION | B-CELLS | MESSENGER-RNAS | TFH CELLS | CENTER LIGHT | CD4(+) | BCL6 EXPRESSION | IMMUNOLOGY | TRANSCRIPTION FACTOR | C-MAF | NEGATIVE REGULATOR | DNA-Binding Proteins - immunology | Germinal Center - immunology | Humans | Hematopoiesis - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | Interleukin-12 Subunit p35 - immunology | T-Lymphocytes, Helper-Inducer - immunology | Antibodies - immunology | Immunologic Memory | Mice | Proto-Oncogene Proteins c-bcl-6 | Cell differentiation | B cells | Lymphocyte receptors | Disease | Lymphocytes | Cell division | T cell receptors | Biology | Autoimmune diseases | Chemokines | Cancer
GERMINAL CENTER FORMATION | B-CELLS | MESSENGER-RNAS | TFH CELLS | CENTER LIGHT | CD4(+) | BCL6 EXPRESSION | IMMUNOLOGY | TRANSCRIPTION FACTOR | C-MAF | NEGATIVE REGULATOR | DNA-Binding Proteins - immunology | Germinal Center - immunology | Humans | Hematopoiesis - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | Interleukin-12 Subunit p35 - immunology | T-Lymphocytes, Helper-Inducer - immunology | Antibodies - immunology | Immunologic Memory | Mice | Proto-Oncogene Proteins c-bcl-6 | Cell differentiation | B cells | Lymphocyte receptors | Disease | Lymphocytes | Cell division | T cell receptors | Biology | Autoimmune diseases | Chemokines | Cancer
Journal Article
Annual Review of Immunology, ISSN 0732-0582, 04/2011, Volume 29, Issue 1, pp. 621 - 663
T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of immunological memory. Follicular helper CD4 T (T-FH) cells are the...
cytokines | human diseases | transcription factors | CD4 T cell differentiation | DENDRITIC CELLS | ACTIVATION MOLECULE | IMMUNOLOGY | CUTTING EDGE | CXC CHEMOKINE RECEPTOR-5 | MEMORY B-CELLS | HUMORAL IMMUNITY | FACTOR C-MAF | ANTIBODY-SECRETING CELLS | GERMINAL CENTER DEVELOPMENT | TRANSCRIPTION FACTOR | Lymphoid Tissue - cytology | Animals | B-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - immunology | Humans | T-Lymphocytes, Helper-Inducer - cytology | Germinal Center - cytology | Lymphoid Tissue - immunology | Physiological aspects | Genetic aspects | Genetic transcription | T cells | Cell differentiation | Growth
cytokines | human diseases | transcription factors | CD4 T cell differentiation | DENDRITIC CELLS | ACTIVATION MOLECULE | IMMUNOLOGY | CUTTING EDGE | CXC CHEMOKINE RECEPTOR-5 | MEMORY B-CELLS | HUMORAL IMMUNITY | FACTOR C-MAF | ANTIBODY-SECRETING CELLS | GERMINAL CENTER DEVELOPMENT | TRANSCRIPTION FACTOR | Lymphoid Tissue - cytology | Animals | B-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - immunology | Humans | T-Lymphocytes, Helper-Inducer - cytology | Germinal Center - cytology | Lymphoid Tissue - immunology | Physiological aspects | Genetic aspects | Genetic transcription | T cells | Cell differentiation | Growth
Journal Article
The Journal of experimental medicine, 05/2009, Volume 206, Issue 5, p. 974
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 03/2015, Volume 15, Issue 3, pp. 185 - 189
In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years...
CXC CHEMOKINE RECEPTOR-5 | DEFECTIVE EXPRESSION | IMMUNE-RESPONSE | BCL6 | HUMORAL IMMUNITY | X-LINKED IMMUNODEFICIENCY | CD40 LIGAND | IMMUNOLOGY | HEMOLYSIN-FORMING CELLS | MEMORY B | CUTTING EDGE | B-Lymphocytes - immunology | History, 21st Century | Allergy and Immunology - history | T-Lymphocytes, Helper-Inducer - immunology | History, 20th Century | Humans | Medical research | Immune response | Medicine, Experimental | B cells | Research | T cells | Properties
CXC CHEMOKINE RECEPTOR-5 | DEFECTIVE EXPRESSION | IMMUNE-RESPONSE | BCL6 | HUMORAL IMMUNITY | X-LINKED IMMUNODEFICIENCY | CD40 LIGAND | IMMUNOLOGY | HEMOLYSIN-FORMING CELLS | MEMORY B | CUTTING EDGE | B-Lymphocytes - immunology | History, 21st Century | Allergy and Immunology - history | T-Lymphocytes, Helper-Inducer - immunology | History, 20th Century | Humans | Medical research | Immune response | Medicine, Experimental | B cells | Research | T cells | Properties
Journal Article
2018, Cold Spring Harbor perspectives in biology, ISBN 1621821544, ix, 418 pages
Book
Immunity, ISSN 1074-7613, 05/2019, Volume 50, Issue 5, pp. 1132 - 1148
Helping B cells and antibody responses is a major function of CD4 T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining...
GERMINAL CENTER RESPONSES | NONHUMAN-PRIMATES | CENTER B-CELLS | TFH CELLS | REGULATORY CELLS | IMMUNOLOGY | NEUTRALIZING ANTIBODY-RESPONSES | TRANSCRIPTION FACTOR | FH CELLS | DYNAMIC REGULATION | HUMORAL RESPONSES | Viral antibodies | Antigens | Communicable diseases | Atherosclerosis | Transplantation of organs, tissues, etc | Antibodies | B cells | T cells | Cell differentiation | Differentiation (biology) | Cytotoxicity | Lymphocytes T | Biology | Vaccines | Germinal centers | Lymphocytes | Immunotherapy | Immune system | Cytokines | Transplants | T cell receptors | Gene expression | Allergies | CD4 antigen | Infectious diseases | Lymphocytes B | Arteriosclerosis | Mutation | Autoimmune diseases | Cancer | Bcl-6 protein
GERMINAL CENTER RESPONSES | NONHUMAN-PRIMATES | CENTER B-CELLS | TFH CELLS | REGULATORY CELLS | IMMUNOLOGY | NEUTRALIZING ANTIBODY-RESPONSES | TRANSCRIPTION FACTOR | FH CELLS | DYNAMIC REGULATION | HUMORAL RESPONSES | Viral antibodies | Antigens | Communicable diseases | Atherosclerosis | Transplantation of organs, tissues, etc | Antibodies | B cells | T cells | Cell differentiation | Differentiation (biology) | Cytotoxicity | Lymphocytes T | Biology | Vaccines | Germinal centers | Lymphocytes | Immunotherapy | Immune system | Cytokines | Transplants | T cell receptors | Gene expression | Allergies | CD4 antigen | Infectious diseases | Lymphocytes B | Arteriosclerosis | Mutation | Autoimmune diseases | Cancer | Bcl-6 protein
Journal Article
Current Opinion in Immunology, ISSN 0952-7915, 08/2019, Volume 59, pp. iii - v
Journal Article
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 03/2018, Volume 10, Issue 3
Plasticity is the ability of a cell type to convert to another cell type. There are multiple effector CD4 T-cell subtypes, including T(H)1, T(H)2, T(H)17,...
RESPONSES | CXCR5(+) | IMMUNITY | TFH CELLS | DISTINCT | BCL6 EXPRESSION | DIFFERENTIATION | CYTOMETRY | TH17 CELLS | LONG | CELL BIOLOGY | T-Lymphocytes, Helper-Inducer - physiology | Animals | Humans | Cell Plasticity | Immunologic Memory | Cell Differentiation | CD4-Positive T-Lymphocytes - physiology | Cellular Reprogramming
RESPONSES | CXCR5(+) | IMMUNITY | TFH CELLS | DISTINCT | BCL6 EXPRESSION | DIFFERENTIATION | CYTOMETRY | TH17 CELLS | LONG | CELL BIOLOGY | T-Lymphocytes, Helper-Inducer - physiology | Animals | Humans | Cell Plasticity | Immunologic Memory | Cell Differentiation | CD4-Positive T-Lymphocytes - physiology | Cellular Reprogramming
Journal Article
Library Journal, ISSN 0363-0277, 03/2016, Volume 141, Issue 5, p. 84
Journal Article
Nature reviews. Immunology, ISSN 1474-1733, 02/2018, Volume 18, Issue 2, pp. 79 - 79
Journal Article
Immunological Reviews, ISSN 0105-2896, 05/2012, Volume 247, Issue 1, pp. 133 - 142
T‐cell help to B cells is a fundamental aspect of adaptive immunity and the generation of B‐cell memory (memory B cells and plasma cells). Follicular helper...
germinal centers | IL‐21 | Maf | plasma cells | vaccines | CD4 + T‐cell differentiation | CD4 | Germinal centers | Plasma cells | T-cell differentiation | Vaccines | IL-21 | FOLLICULAR HELPER-CELL | CD4(+) T-CELLS | FACTOR BATF CONTROLS | IMMUNOLOGY | GERMINAL-CENTER | INFECTIOUS-DISEASES | IN-VIVO | FACTOR C-MAF | MYELOID-LEUKEMIA | CD4+T-cell differentiation | TRANSCRIPTION FACTOR | CENTER B-CELL | Germinal Center - physiology | Transcription Factors - metabolism | T-Lymphocytes, Helper-Inducer - physiology | Animals | B-Lymphocytes - immunology | Signal Transduction | Models, Biological | T-Lymphocytes, Helper-Inducer - immunology | Humans | T-Lymphocytes, Helper-Inducer - cytology | T-Lymphocytes - immunology | Cell Differentiation | Cells | Immunological memory | Memory cells | Transcription factors | Lymphocytes B | Lymphocytes T | Differentiation | Bcl-6 protein | CD4 antigen
germinal centers | IL‐21 | Maf | plasma cells | vaccines | CD4 + T‐cell differentiation | CD4 | Germinal centers | Plasma cells | T-cell differentiation | Vaccines | IL-21 | FOLLICULAR HELPER-CELL | CD4(+) T-CELLS | FACTOR BATF CONTROLS | IMMUNOLOGY | GERMINAL-CENTER | INFECTIOUS-DISEASES | IN-VIVO | FACTOR C-MAF | MYELOID-LEUKEMIA | CD4+T-cell differentiation | TRANSCRIPTION FACTOR | CENTER B-CELL | Germinal Center - physiology | Transcription Factors - metabolism | T-Lymphocytes, Helper-Inducer - physiology | Animals | B-Lymphocytes - immunology | Signal Transduction | Models, Biological | T-Lymphocytes, Helper-Inducer - immunology | Humans | T-Lymphocytes, Helper-Inducer - cytology | T-Lymphocytes - immunology | Cell Differentiation | Cells | Immunological memory | Memory cells | Transcription factors | Lymphocytes B | Lymphocytes T | Differentiation | Bcl-6 protein | CD4 antigen
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2010, Volume 11, Issue 2, pp. 114 - 120
Bcl-6 and Blimp-1 have recently been identified as key transcriptional regulators of effector and memory differentiation in CD4(+) T cells and CD8(+) T cells....
FOLLICULAR-HELPER-CELLS | SOMATIC HYPERMUTATION | SECRETING PLASMA-CELLS | IMMUNE-RESPONSES | IN-VIVO | FINGER ENCODING GENE | TRANSCRIPTIONAL REPRESSOR BLIMP-1 | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | II TRANSACTIVATOR EXPRESSION | GERMINAL CENTER DEVELOPMENT | B-Lymphocytes - cytology | DNA-Binding Proteins - immunology | Humans | Repressor Proteins - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Cell Differentiation - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | T-Lymphocytes - cytology | T-Lymphocytes - metabolism | Repressor Proteins - immunology | T-Lymphocytes - immunology | B-Lymphocytes - metabolism | Immunologic Memory - genetics | Immunologic Memory - immunology | Repressor Proteins - metabolism | Positive Regulatory Domain I-Binding Factor 1 | Proto-Oncogene Proteins c-bcl-6 | Physiological aspects | Genetic aspects | B cells | Research | Cell differentiation | Gene expression | T cells
FOLLICULAR-HELPER-CELLS | SOMATIC HYPERMUTATION | SECRETING PLASMA-CELLS | IMMUNE-RESPONSES | IN-VIVO | FINGER ENCODING GENE | TRANSCRIPTIONAL REPRESSOR BLIMP-1 | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | II TRANSACTIVATOR EXPRESSION | GERMINAL CENTER DEVELOPMENT | B-Lymphocytes - cytology | DNA-Binding Proteins - immunology | Humans | Repressor Proteins - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Cell Differentiation - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | T-Lymphocytes - cytology | T-Lymphocytes - metabolism | Repressor Proteins - immunology | T-Lymphocytes - immunology | B-Lymphocytes - metabolism | Immunologic Memory - genetics | Immunologic Memory - immunology | Repressor Proteins - metabolism | Positive Regulatory Domain I-Binding Factor 1 | Proto-Oncogene Proteins c-bcl-6 | Physiological aspects | Genetic aspects | B cells | Research | Cell differentiation | Gene expression | T cells
Journal Article