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Molecular Cancer Research, ISSN 1541-7786, 04/2017, Volume 15, Issue 4 Supplement, pp. IA08 - IA08
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 3019 - 3019
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 08/2019, Volume 25, Issue 20, pp. 6206 - 6216
Irinotecan and topotecan are used to treat a variety of different cancers. However, they have limitations including chemical instability and severe side... 
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 2390 - 2390
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 3952 - 3952
Journal Article
Oncotarget, ISSN 1949-2553, 2012, Volume 3, Issue 1, pp. 5 - 6
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7612, pp. 382 - 387
Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are... 
BREAST-CANCER | RECOMBINATION | LYSINE-4 METHYLTRANSFERASE COMPLEX | MUTANT-CELLS | 53BP1 | MULTIDISCIPLINARY SCIENCES | RESISTANCE | HOMOLOGY-DIRECTED REPAIR | CONDITIONAL MOUSE MODEL | END RESECTION | DNA-REPAIR | Embryonic Stem Cells - metabolism | DNA Replication - drug effects | Homologous Recombination | DNA Repair - genetics | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Neoplasms - genetics | Gene Deletion | Nuclear Proteins - deficiency | DNA Repair Enzymes - metabolism | DNA Damage - genetics | Genes, BRCA2 | DNA - biosynthesis | Female | DNA Repair Enzymes - antagonists & inhibitors | Genes, BRCA1 | Nuclear Proteins - genetics | DNA Helicases - genetics | DNA Damage - drug effects | DNA Repair - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Cisplatin - pharmacology | DNA - metabolism | Carrier Proteins - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Poly(ADP-ribose) Polymerases - genetics | DNA Replication - physiology | Embryonic Stem Cells - drug effects | Cell Line, Tumor | Mice | Poly (ADP-Ribose) Polymerase-1 | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Physiological aspects | Chemotherapy | Replication fork | B cells | DNA damage | Cancer | Proteins | Lymphocytes | Stem cells | Breast cancer | Drug resistance | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 537 - 15
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2011, Volume 17, Issue 10, pp. 1275 - 1282
Journal Article
Transcription, ISSN 2154-1264, 01/2013, Volume 4, Issue 1, p. 1
Mutation in BRCA1 accounts for half of all familial breast cancer cases. Recent studies have shown its role in the epigenetic regulation of an oncogenic... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis
Journal Article
Nature Communications, ISSN 2041-1723, 08/2016, Volume 7, Issue 1, pp. 12425 - 12425
Poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib has been approved for treatment of advanced ovarian cancer associated with BRCA1 and BRCA2... 
POLY(ADP-RIBOSE) POLYMERASE | REPAIR | REPLICATION FORKS | LETHALITY | MUTANT-CELLS | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | PARP | HOMOLOGOUS RECOMBINATION | OVARIAN-CANCER | OLAPARIB MAINTENANCE THERAPY | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 08/2016, Volume 12, Issue 8, p. e1006236
Journal Article