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Immunity, ISSN 1074-7613, 2005, Volume 22, Issue 5, pp. 633 - 642
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2004, Volume 114, Issue 2, pp. 280 - 290
One mechanism contributing to immunologic unresponsiveness toward tumors may be presentation of tumor antigens by tolerogenic host APCs. We show that mouse... 
MEDICINE, RESEARCH & EXPERIMENTAL | COLONY-STIMULATING FACTOR | HUMAN-FIBROBLASTS | INTERFERON-GAMMA | REGULATORY T-CELLS | ANTIGEN-PRESENTING CELLS | CLONAL ANERGY | ANTITUMOR IMMUNITY | SELF-ANTIGENS | TRYPTOPHAN CATABOLISM | CROSS-PRESENTATION
Journal Article
Cancer Research, ISSN 0008-5472, 09/2018, Volume 78, Issue 18, pp. 5191 - 5199
Regulatory T cells (Tregs) are an important contributor to the immunosuppressive tumor microenvironment. To date, however, they have been difficult to target... 
ACTIVATION | DENDRITIC CELLS | ONCOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | REG CELLS | APOPTOTIC CELLS | KINASE | REGULATORY T-CELLS | DIFFERENTIATION | SUPPRESSION | FOXP3 | PTEN | Indoleamine 2,3-dioxygenase | Chemotherapy | Regulatory T cells | Treg plasticity | IDO
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 04/2004, Volume 172, Issue 7, pp. 4100 - 4110
Human monocyte-derived dendritic cells (DCs) are capable of expressing the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO), which allows them to... 
RESPONSES | SERUM-FREE CONDITIONS | INHIBITION | KILLER-CELL | MECHANISM | SUBSETS | ANTIGEN-PRESENTING CELLS | PROLIFERATION | IMMUNOLOGY | INDUCE TOLERANCE | TRYPTOPHAN CATABOLISM | Antigens, CD - immunology | Tryptophan Oxygenase - antagonists & inhibitors | Membrane Glycoproteins - metabolism | T-Lymphocyte Subsets - cytology | Antigens, CD - biosynthesis | Dendritic Cells - immunology | Humans | Membrane Glycoproteins - biosynthesis | Antibodies, Blocking - pharmacology | CD4-Positive T-Lymphocytes - enzymology | Enzyme Induction - immunology | Tryptophan - metabolism | Enzyme Activation - immunology | Tryptophan Oxygenase - physiology | Antigens, CD - metabolism | Lymphocyte Culture Test, Mixed | CD4-Positive T-Lymphocytes - immunology | Immunoconjugates - immunology | B7-2 Antigen | Membrane Glycoproteins - physiology | Tryptophan Oxygenase - biosynthesis | Flow Cytometry | Abatacept | Immunosuppressive Agents - metabolism | B7-1 Antigen - biosynthesis | Membrane Glycoproteins - immunology | B7-1 Antigen - immunology | CD4-Positive T-Lymphocytes - cytology | Cells, Cultured | B7-1 Antigen - physiology | Interferon-gamma - physiology | B7-1 Antigen - metabolism | CD28 Antigens - immunology | Growth Inhibitors - metabolism | Tryptophan Oxygenase - metabolism | Up-Regulation - immunology | Dendritic Cells - enzymology | Down-Regulation - immunology | T-Lymphocyte Subsets - enzymology | Growth Inhibitors - physiology | Antigens, CD - physiology | Ligands | Indoleamine-Pyrrole 2,3,-Dioxygenase
Journal Article
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 33, Issue 6, pp. 942 - 954
Foxp3 regulatory T (Treg) cells can undergo reprogramming into a phenotype expressing proinflammatory cytokines. However, the biologic significance of this... 
PLASMACYTOID DENDRITIC CELLS | IMMUNITY | TREGS | TRANSCRIPTION FACTOR FOXP3 | INDOLEAMINE 2,3-DIOXYGENASE | INDUCTION | IMMUNOLOGY | SUPPRESSION | BLOCKADE | DRAINING LYMPH-NODES | ANTIGEN | T-Lymphocytes, Regulatory - metabolism | Oligodeoxyribonucleotides - administration & dosage | CD8-Positive T-Lymphocytes - pathology | Melanoma, Experimental - drug therapy | Adoptive Transfer | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Helper-Inducer - drug effects | Toll-Like Receptor 9 - immunology | Cross-Priming - drug effects | Melanoma, Experimental - immunology | T-Lymphocytes, Helper-Inducer - immunology | Tryptophan - analogs & derivatives | Cell Transdifferentiation - drug effects | CD8-Positive T-Lymphocytes - metabolism | T-Lymphocytes, Helper-Inducer - pathology | Forkhead Transcription Factors - biosynthesis | T-Lymphocytes, Helper-Inducer - metabolism | Cells, Cultured | Mice, Inbred Strains | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocyte Activation - drug effects | Antigens - immunology | Mice | Tryptophan - pharmacology | CD8-Positive T-Lymphocytes - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Proteins | Studies | Design | Genotype & phenotype | Rodents | Ligands | T cell receptors | Experiments | Immune system | Tumors
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 01/2018, Volume 48, Issue 1, pp. 91 - 106.e6
Journal Article