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1. Full Text Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors
by Alam, Mahbub and Beevers, Rebekah E and Ceska, Tom and Davenport, Richard J and Dickson, Karen M and Fortunato, Mara and Gowers, Lewis and Haughan, Alan F and James, Lynwen A and Jones, Mark W and Kinsella, Natasha and Lowe, Christopher and Meissner, Johannes W.G and Nicolas, Anne-Lise and Perry, Benjamin G and Phillips, David J and Pitt, William R and Platt, Adam and Ratcliffe, Andrew J and Sharpe, Andrew and Tait, Laura J
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2007, Volume 17, Issue 12, pp. 3463 - 3467
JNK1 | JNK2 | Aminopyrimidines | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Models, Chemical | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Index Medicus
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2. Full Text Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma
by Braun, David A and Hou, Yue and Bakouny, Ziad and Ficial, Miriam and Sant' Angelo, Miriam and Forman, Juliet and Ross-Macdonald, Petra and Berger, Ashton C and Jegede, Opeyemi A and Elagina, Liudmilla and Steinharter, John and Sun, Maxine and Wind-Rotolo, Megan and Pignon, Jean-Christophe and Cherniack, Andrew D and Lichtenstein, Lee and Neuberg, Donna and Catalano, Paul and Freeman, Gordon J and Sharpe, Arlene H and McDermott, David F and Van Allen, Eliezer M and Signoretti, Sabina and Wu, Catherine J and Shukla, Sachet A and Choueiri, Toni K
Nature medicine, ISSN 1078-8956, 06/2020, Volume 26, Issue 6, pp. 909 - 918
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Kidney Neoplasms - genetics | CD8-Positive T-Lymphocytes - pathology | Class I Phosphatidylinositol 3-Kinases - genetics | Prognosis | Genomics | Humans | Middle Aged | Kidney Neoplasms - immunology | Carcinoma, Renal Cell - genetics | Male | Tuberous Sclerosis Complex 1 Protein - genetics | Histone Demethylases - genetics | Carcinoma, Renal Cell - immunology | Chromosomes, Human, Pair 9 - genetics | TOR Serine-Threonine Kinases - genetics | Gene Deletion | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Adult | Female | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Carcinoma, Renal Cell - drug therapy | Chromosome Deletion | PTEN Phosphohydrolase - genetics | Histone-Lysine N-Methyltransferase - genetics | Carcinoma, Renal Cell - pathology | Antigen Presentation - genetics | Nivolumab - therapeutic use | Transcription Factors - genetics | Chromosomes, Human, Pair 6 | DNA-Binding Proteins - genetics | Ubiquitin Thiolesterase - genetics | Whole Exome Sequencing | Proteasome Endopeptidase Complex - genetics | Sequence Analysis, RNA | Lymphocytes, Tumor-Infiltrating - pathology | Antineoplastic Agents, Immunological - therapeutic use | Fluorescent Antibody Technique | Kidney Neoplasms - pathology | Aged | Histocompatibility Antigens Class II - genetics | Mutation | CD8-Positive T-Lymphocytes - immunology | Kidney Neoplasms - drug therapy | Lymphocytes, Tumor-Infiltrating - immunology | Resistors | Phenotypes | PD-1 protein | CD8 antigen | Clinical trials | Lymphocytes T | Ribonucleic acid--RNA | Patients | Metastases | Gene sequencing | Alterations | Lymphocytes | Genetic analysis | Kidney cancer | Infiltration | Immunofluorescence | Clear cell-type renal cell carcinoma | Tumors | Immune system | Cancer | Index Medicus
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3. Full Text Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea
by Parkin, Isobel A.P and Koh, Chushin and Tang, Haibao and Robinson, Stephen J and Kagale, Sateesh and Clarke, Wayne E and Town, Chris D and Nixon, John and Krishnakumar, Vivek and Bidwell, Shelby L and Denoeud, France and Belcram, Harry and Links, Matthew G and Just, Jérémy and Clarke, Carling and Bender, Tricia and Huebert, Terry and Mason, Annaliese S and Chris Pires, J and Barker, Guy and Moore, Jonathan and Walley, Peter G and Manoli, Sahana and Batley, Jacqueline and Edwards, David and Nelson, Matthew N and Wang, Xiyin and Paterson, Andrew H and King, Graham and Bancroft, Ian and Chalhoub, Boulos and Sharpe, Andrew G
Genome Biology, ISSN 1474-7596, 06/2014, Volume 15, Issue 6, pp. R77 - R77
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Brassica - metabolism | Epigenesis, Genetic | Molecular Sequence Annotation | Transcriptome | Molecular Sequence Data | Aneuploidy | Chromosome Mapping | Genome, Plant | Sequence Analysis, DNA | DNA Methylation | Brassica - genetics | Gene Expression Regulation, Plant | Evolution, Molecular | Index Medicus | Life Sciences | Vegetal Biology | Research
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4. Full Text The UK INFINITY Study - Early Experience and Complications of a Multicenter series of 504 Total Ankle Arthroplasties
by Townshend, David N and Kakwani, Rajesh and Aradhyula, Murty N and Mckinley, John C and Shalaby, Hisham and Smith, Robert and Davenport, James H and Karski, Michael and Clough, Timothy and Blundell, Chris and Davies, Howard and Raglan, Martin and Dhar, Sunil and Hepple, Steve and Taylor, Heath and Davis, James and Sharpe, Ian T and Bing, Andrew J and Goldberg, Andrew J
Foot & ankle orthopaedics, ISSN 2473-0114, 10/2020, Volume 5, Issue 4
Ankle | Prostheses | Arthritis | Patients
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5. Full Text Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis
by Twigg, Stephen R.F and Vorgia, Elena and Mcgowan, Simon J and Peraki, Ioanna and Fenwick, Aimée L and Sharma, Vikram P and Allegra, Maryline and Zaragkoulias, Andreas and Akha, Elham Sadighi and Knight, Samantha J.L and Lord, Helen and Lester, Tracy and Izatt, Louise and Lampe, Anne K and Mohammed, Shehla N and Stewart, Fiona J and Verloes, Alain and Wilson, Louise C and Healy, Chris and Sharpe, Paul T and Hammond, Peter and Hughes, Jim and Taylor, Stephen and Johnson, David and Wall, Steven A and Mavrothalassitis, George and Wilkie, Andrew O.M
Nature genetics, ISSN 1061-4036, 03/2013, Volume 45, Issue 3, pp. 308 - 313
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Signal Transduction | Craniosynostoses - genetics | Humans | Cranial Sutures - metabolism | Embryonic Development - genetics | Molecular Sequence Data | Repressor Proteins - genetics | Craniosynostoses - physiopathology | Transcription Factor AP-1 - metabolism | Cranial Sutures - pathology | MAP Kinase Signaling System | Animals | Cranial Sutures - growth & development | Core Binding Factor alpha Subunits - metabolism | Fibroblasts - cytology | Mice | Mutation | Osteogenesis - genetics | Fibroblasts - metabolism | Craniosynostoses | Transcription factors | Growth | Physiological aspects | Bones | Genetic aspects | Research | Nucleotide sequencing | Health aspects | Phosphotransferases | DNA sequencing | Pediatrics | Signal transduction | Genotype & phenotype | Biomedical research | Colleges & universities | Genetics | Genomes | Experiments | Bioinformatics | Index Medicus
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6. Full Text Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
by Wang, Hansen and Muiznieks, Lisa D and Ghosh, Punam and Williams, Declan and Solarski, Michael and Fang, Andrew and Ruiz-Riquelme, Alejandro and Pomès, Régis and Watts, Joel C and Chakrabartty, Avi and Wille, Holger and Sharpe, Simon and Schmitt-Ulms, Gerold
eLife, ISSN 2050-084X, 06/2017, Volume 6
Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Molecular Weight | Hormones - metabolism | Humans | Mass Spectrometry | Protein Multimerization | Amyloid beta-Peptides - metabolism | Brain - pathology | Protein Binding | Amyloid beta-Peptides - chemistry | Somatostatin - metabolism | Dehydrogenases | Disease | Peptides | Neurodegenerative diseases | Gel electrophoresis | Neurons | Tryptophan | Mass spectroscopy | Biochemistry | Electron microscopy | Apolipoproteins | Nanoparticles | Studies | Proteins | Brain research | Etiology | N-Terminus | β-Amyloid | Scientific imaging | Somatostatin | Mass spectrometry | Alzheimer's disease | Index Medicus
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7. Transgender jurisprudence
: dysphoric bodies of law
by Sharpe, Andrew N
2002, ISBN 9781859416662, xxiii, 229
Transsexuals | Sociological jurisprudence | Legal status, laws, etc
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8. Full Text Upper-limb muscle responses to epidural, subdural and intraspinal stimulation of the cervical spinal cord
by Sharpe, Abigail N and Jackson, Andrew
Journal of neural engineering, ISSN 1741-2560, 1/2014, Volume 11, Issue 1, pp. 016005 - 16
Neurostimulation | upper-limb | spinal cord | motor control | Engineering | Neurosciences | Life Sciences & Biomedicine | Technology | Engineering, Biomedical | Neurosciences & Neurology | Science & Technology | Epidural Space - physiology | Cervical Vertebrae | Electric Stimulation | Subdural Space - physiology | Neural Prostheses | Electrodes, Implanted | Macaca mulatta | Prosthesis Design | Recruitment, Neurophysiological - physiology | Upper Extremity - physiology | Algorithms | Animals | Analysis of Variance | Spinal Cord - physiology | Female | Electromyography | Index Medicus | Electrodes | Spinal cord | Effectiveness | Neuroprostheses | Muscles | Stimulation | Motors | Stimuli
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9. Full Text Ultra-high bandwidth quantum secured data transmission
by Dynes, James F and Tam, Winci W-S and Plews, Alan and Fröhlich, Bernd and Sharpe, Andrew W and Lucamarini, Marco and Yuan, Zhiliang and Radig, Christian and Straw, Andrew and Edwards, Tim and Shields, Andrew J
Scientific reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, pp. 35149 - 35149
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Disease transmission | Bandwidths | Coexistence | Physics - Quantum Physics
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10. Full Text Draft genome sequence of chickpea (Cicer arietinum) provides a resource for trait improvement
by Varshney, Rajeev K and Song, Chi and Saxena, Rachit K and Azam, Sarwar and Yu, Sheng and Sharpe, Andrew G and Cannon, Steven and Baek, Jongmin and Rosen, Benjamin D and Tar'an, Bunyamin and Millan, Teresa and Zhang, Xudong and Ramsay, Larissa D and Iwata, Aiko and Wang, Ying and Nelson, William and Farmer, Andrew D and Gaur, Pooran M and Soderlund, Carol and Penmetsa, R Varma and Xu, Chunyan and Bharti, Arvind K and He, Weiming and Winter, Peter and Zhao, Shancen and Hane, James K and Carrasquilla-Garcia, Noelia and Condie, Janet A and Padhyaya, Hari D and Luo, Ming-Cheng and Thudi, Mahendar and Gowda C.L.L, C.L.L and Singh, Narendra P and Lichtenzveig, Judith and Gali, Krishna K and Rubio, Josefa and Nadarajan, N and Dolezel, Jaroslav and Bansal, Kailash C and Xu, Xun and Edwards, David and Zhang, Gengyun and Kahl, Guenter and Gil, Juan and Singh, Karam B and Datta, Swapan K and Jackson, Scott A and Wang, Jun and Cook, Douglas R
Nature biotechnology, ISSN 1087-0156, 03/2013, Volume 31, Issue 3, pp. 240 - 246
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | DNA - genetics | Genetic Variation | DNA - chemistry | Disease Resistance | Cicer - genetics | Cicer - physiology | Repetitive Sequences, Nucleic Acid | Genotype | Agriculture | Genome, Plant - physiology | Phylogeny | Sequence Analysis, DNA | Plant breeding | Nucleotide sequence | Plant immunology | Chickpea | Genetic aspects | Research | Natural history | Legumes | Agricultural biotechnology | Food supply | Transgenic plants | Genomics | Index Medicus
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