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1. Full Text Glucose metabolism and cancer
by Shaw, Reuben J
Current Opinion in Cell Biology, ISSN 0955-0674, 2006, Volume 18, Issue 6, pp. 598 - 608
The first identified biochemical hallmark of tumor cells was a shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis. We now know... 
LIFE-SPAN | ENERGY STRESS | ACTIVATED PROTEIN-KINASE | INDUCIBLE FACTOR 1-ALPHA | PEUTZ-JEGHERS-SYNDROME | GROWTH | GLYCOLYTIC-ENZYMES | FACTOR-I | CELL-CYCLE PROGRESSION | HYPOXIA | CELL BIOLOGY | Neoplasms - metabolism | Humans | Oxidative Phosphorylation | Multienzyme Complexes - metabolism | Electron Transport Chain Complex Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Hypoxia-Inducible Factor 1 - metabolism | AMP-Activated Protein Kinases | Glycolysis - physiology | Animals | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Glucose - metabolism | Energy Metabolism - physiology | Protein-Serine-Threonine Kinases - metabolism | Physiological aspects | Glycolysis | Glucose | Dextrose | Cancer
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2. Full Text AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
by Garcia, Daniel and Shaw, Reuben J
Molecular Cell, ISSN 1097-2765, 06/2017, Volume 66, Issue 6, pp. 789 - 800
AMPK is a highly conserved master regulator of metabolism, which restores energy balance during metabolic stress both at the cellular and physiological levels.... 
AMPK | trimeric complex | therapeutic activation | energy restoration | metabolic adaptation | SKELETAL-MUSCLE | GLUCOSE-HOMEOSTASIS | ACTIVATED PROTEIN-KINASE | STRUCTURAL BASIS | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | UPSTREAM KINASE | TRANSCRIPTION FACTOR | DIRECT PHOSPHORYLATION | MEDIATED REGULATION | ADIPOSE-TISSUE | CELL BIOLOGY | Mitochondria - enzymology | AMP-Activated Protein Kinases - metabolism | Metabolic Diseases - pathology | Phosphorylation | Metabolic Diseases - enzymology | TOR Serine-Threonine Kinases - metabolism | Enzyme Activators - therapeutic use | Humans | Models, Molecular | Metabolic Diseases - drug therapy | Structure-Activity Relationship | Mitochondria - pathology | Autophagy | AMP-Activated Protein Kinases - chemistry | Mitochondrial Degradation | Animals | Signal Transduction - drug effects | Proteolysis | Protein Conformation | Enzyme Activation | Energy Metabolism - drug effects | Physiological aspects | Stress (Physiology)
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3. Full Text Abstract IA13: The LKB1-AMPK pathway reprograms cancer cell metabolism
by Shaw, Reuben J
Molecular Cancer Research, ISSN 1541-7786, 01/2016, Volume 14, Issue 1 Supplement, pp. IA13 - IA13
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4. Full Text AMPK: Guardian of metabolism and mitochondrial homeostasis
by Herzig, Sébastien and Shaw, Reuben J
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 01/2018, Volume 19, Issue 2, pp. 121 - 135
Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient availability. Eukaryotes have evolved a very sophisticated system to... 
GAMMA-SUBUNIT ISOFORMS | ENERGY STRESS | GLUCOSE-HOMEOSTASIS | ACTIVATED PROTEIN-KINASE | FATTY-ACID OXIDATION | TUMOR-CELL-SURVIVAL | ACETYL-COA CARBOXYLASE | STARVATION-INDUCED AUTOPHAGY | MAMMALIAN-CELLS | HUMAN SKELETAL-MUSCLE | CELL BIOLOGY | Type 2 diabetes | Glucose metabolism | Enzymes | Physiological aspects | Homeostasis | Glucose | Protein kinases | Dextrose | Energy metabolism | AMP | Threonine | AMP-activated protein kinase | Metabolism | Kinases | Autophagy | Substrates | Eukaryotes | Mitochondria | Nutrient availability | Catabolism | Protein-serine/threonine kinase | Lipid metabolism | ATP | Phagocytosis
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5. Full Text The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
by Mihaylova, Maria M and Shaw, Reuben J
Nature Cell Biology, ISSN 1465-7392, 09/2011, Volume 13, Issue 9, pp. 1016 - 1023
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular... 
SKELETAL-MUSCLE | ACTIVATED PROTEIN-KINASE | HISTONE DEACETYLASES | FATTY-ACID | GENE-EXPRESSION | ELEMENT-BINDING PROTEIN | UPSTREAM KINASE | TRANSCRIPTION FACTOR | HEPATIC STEATOSIS | DIRECT PHOSPHORYLATION | CELL BIOLOGY | Eukaryota - cytology | AMP-Activated Protein Kinases - metabolism | Animals | Cell Proliferation | Models, Biological | Humans | Cell Polarity - physiology | Signal Transduction - physiology | Autophagy - physiology | Eukaryota - metabolism | Protein Subunits - metabolism | Physiological aspects | Cellular signal transduction | Research | Metabolism | Protein kinases
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6. Full Text The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
by Shackelford, David B and Shaw, Reuben J
Nature Reviews Cancer, ISSN 1474-175X, 08/2009, Volume 9, Issue 8, pp. 563 - 575
In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel signalling pathway that links cell metabolism to growth control and cell... 
CANCER-CELLS | SIGNAL-TRANSDUCTION PATHWAYS | MESSENGER-RNA TRANSLATION | ACTIVATED PROTEIN-KINASE | TUBEROUS SCLEROSIS COMPLEX | PEUTZ-JEGHERS POLYPOSIS | COA-CARBOXYLASE-ALPHA | ONCOLOGY | EPITHELIAL-CELL POLARITY | CREB COACTIVATOR TORC2 | FATTY-ACID SYNTHASE | Neoplasms - metabolism | Protein-Serine-Threonine Kinases - physiology | Humans | AMP-Activated Protein Kinases - drug effects | Hypoglycemic Agents - pharmacology | Neoplasms - drug therapy | AMP-Activated Protein Kinases - physiology | Animals | Protein Kinase Inhibitors - therapeutic use | Protein Kinases - physiology | Protein-Serine-Threonine Kinases - drug effects | Signal Transduction - physiology | Mice | TOR Serine-Threonine Kinases | Blood Glucose - metabolism | Neoplasms - pathology | Disease Models, Animal | Physiological aspects | Research | Metabolism | Growth | Protein kinases | Tumors | Adipose tissue | Diabetes mellitus | Liver | Muscles | Drug development | Cholesterol | Glucose metabolism | LKB1 protein | Signal transduction | Reviews | Polarity | Protein-serine/threonine kinase | Lipid metabolism | Cancer
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7. Full Text Ras, PI(3)K and mTOR signalling controls tumour cell growth
by Shaw, Reuben J and Cantley, Lewis C
Nature, ISSN 0028-0836, 05/2006, Volume 441, Issue 7092, pp. 424 - 430
All eukaryotic cells coordinate cell growth with the availability of nutrients in their environment. The mTOR protein kinase has emerged as a critical... 
MAMMALIAN TARGET | SUPPRESSOR | ENERGY STRESS | TUBEROUS SCLEROSIS COMPLEX | PATHWAY | PHOSPHORYLATION | AKT/PROTEIN-KINASE-B | MULTIDISCIPLINARY SCIENCES | RIBOSOMAL S6 KINASE | AKT | HUMAN CANCER-CELLS | Neoplasms - metabolism | Protein Kinases - metabolism | Animals | Signal Transduction | Humans | ras Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | TOR Serine-Threonine Kinases | Neoplasms - pathology | Cell Growth Processes | Proteins | Oncology | Eukaryotes | Cell growth | Research
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