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1. Full Text Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial
by Bots, Michiel L, Dr and Visseren, Frank L, MD and Evans, Gregory W, MA and Riley, Ward A, Prof and Revkin, James H, MD and Tegeler, Charles H, Prof and Shear, Charles L, DrPH and Duggan, William T, PhD and Vicari, Ralph M, MD and Grobbee, Diederick E, Prof and Kastelein, John J, Prof and RADIANCE 2 Investigators
Lancet, The, ISSN 0140-6736, 2007, Volume 370, Issue 9582, pp. 153 - 160
Summary Background Patients with mixed dyslipidaemia have raised triglycerides, low high-density lipoprotein (HDL) cholesterol, and high low-density... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | METABOLIC SYNDROME | COMBINED HYPERLIPIDEMIA | ESTER TRANSFER PROTEIN | CHOLESTEROL LEVELS | CARDIOVASCULAR-DISEASE | ATHEROSCLEROSIS | HDL CHOLESTEROL | CORONARY-HEART-DISEASE | SECONDARY PREVENTION | HIGH-DENSITY-LIPOPROTEIN | Carotid Arteries - drug effects | Dyslipidemias - drug therapy | Double-Blind Method | Cholesterol - blood | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Male | Heptanoic Acids - adverse effects | Anticholesteremic Agents - adverse effects | Tunica Intima - drug effects | Atorvastatin Calcium | Dyslipidemias - blood | Anticholesteremic Agents - therapeutic use | Tunica Intima - pathology | Pyrroles - adverse effects | Female | Blood Pressure - drug effects | Quinolines - therapeutic use | Pyrroles - therapeutic use | Quinolines - adverse effects | Studies | Medical research | Digital imaging | Diet | Mortality | Cardiovascular disease | Metabolic syndrome | Protocol | Low density lipoprotein | Patients | Cholesterol | Veins & arteries | Lipoproteins (low density) | Laboratories | Clinical trials | Segments | Density | Carotid arteries | Blood | Proteins | Randomization | Ultrasonic imaging | Radiance | Atherosclerosis | Blood pressure | Lipoproteins (high density) | Ultrasound | Media | Triglycerides | Cholesteryl ester transfer protein | Arteriosclerosis | Atorvastatin | Titration | Diabetes | Health risk assessment | Mercury | Index Medicus | Abridged Index Medicus
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2. Full Text Efficacy and Safety of Torcetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor, in Individuals With Below-Average High-Density Lipoprotein Cholesterol Levels on a Background of Atorvastatin
by McKenney, James M and Davidson, Michael H and Shear, Charles L and Revkin, James H
Journal of the American College of Cardiology, ISSN 0735-1097, 11/2006, Volume 48, Issue 9, pp. 1782 - 1790
Objectives: This study sought to evaluate the efficacy and safety of torcetrapib in patients with low high-density lipoprotein cholesterol (HDL-C) levels... 
CARDIAC & CARDIOVASCULAR SYSTEMS | PLASMA | DISEASE | ATHEROSCLEROSIS | PREVENTION | STATINS | PROGRESSION | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Double-Blind Method | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Male | Heptanoic Acids - adverse effects | Quinolines - pharmacology | Atorvastatin Calcium | Cholesterol Ester Transfer Proteins - blood | Pyrroles - pharmacology | Cholesterol, HDL - blood | Pyrroles - adverse effects | Adult | Female | Quinolines - therapeutic use | Pyrroles - therapeutic use | Heptanoic Acids - pharmacology | Quinolines - adverse effects | Index Medicus | Abridged Index Medicus
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3. Full Text Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
by Ridker, Paul M and Revkin, James and Amarenco, Pierre and Brunell, Robert and Curto, Madelyn and Civeira, Fernando and Flather, Marcus and Glynn, Robert J and Gregoire, Jean and Jukema, J. Wouter and Karpov, Yuri and Kastelein, John J.P and Koenig, Wolfgang and Lorenzatti, Alberto and Manga, Pravin and Masiukiewicz, Urszula and Miller, Michael and Mosterd, Arend and Murin, Jan and Nicolau, Jose C and Nissen, Steven and Ponikowski, Piotr and Santos, Raul D and Schwartz, Pamela F and Soran, Handrean and White, Harvey and Wright, R. Scott and Vrablik, Michal and Yunis, Carla and Shear, Charles L and Tardif, Jean-Claude and SPIRE Cardiovascular Outcome Inve and SPIRE Cardiovascular Outcome Investigators
The New England Journal of Medicine, ISSN 0028-4793, 04/2017, Volume 376, Issue 16, pp. 1527 - 1539
In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events... 
TRIALS | MEDICINE, GENERAL & INTERNAL | EVENTS | METAANALYSIS | REDUCTION | STATIN THERAPY | REDUCING LIPIDS | PCSK9 | GENETIC-VARIANTS | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Risk Factors | Male | Injections, Subcutaneous - adverse effects | Proprotein Convertase 9 - immunology | Hypercholesterolemia - drug therapy | Anticholesteremic Agents - adverse effects | Anticholesteremic Agents - immunology | Anticholesteremic Agents - therapeutic use | Proprotein Convertase 9 - antagonists & inhibitors | Lipids - blood | Treatment Failure | Antibodies - blood | Cholesterol, LDL - blood | Female | Antibodies, Monoclonal, Humanized - immunology | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Immunoglobulins | Stroke | Risk groups | Clinical trials | Cardiovascular disease | Lipids | Subtilisin | Angina | Low density lipoprotein | Manuscripts | Cholesterol | Disease prevention | Kexin | Monoclonal antibodies | Cardiovascular diseases | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology
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4. Full Text Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab
by Ridker, Paul M and Tardif, Jean-Claude and Amarenco, Pierre and Duggan, William and Glynn, Robert J and Jukema, J. Wouter and Kastelein, John J.P and Kim, Albert M and Koenig, Wolfgang and Nissen, Steven and Revkin, James and Rose, Lynda M and Santos, Raul D and Schwartz, Pamela F and Shear, Charles L and Yunis, Carla and SPIRE Investigators
The New England Journal of Medicine, ISSN 0028-4793, 04/2017, Volume 376, Issue 16, pp. 1517 - 1526
In six trials comparing the anti–PCSK9 antibody bococizumab with placebo, the reduction in LDL cholesterol at 12 weeks was 55.2 percentage points lower with... 
TRIALS | MEDICINE, GENERAL & INTERNAL | EFFICACY | CARDIOVASCULAR EVENTS | STATIN THERAPY | SAFETY | REDUCING LIPIDS | VASCULAR EVENTS | RISK | MONOCLONAL-ANTIBODY | Hypercholesterolemia - immunology | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Follow-Up Studies | Humans | Middle Aged | Male | Treatment Outcome | Injections, Subcutaneous - adverse effects | Proprotein Convertase 9 - immunology | Hypercholesterolemia - drug therapy | Anticholesteremic Agents - adverse effects | Anticholesteremic Agents - immunology | Anticholesteremic Agents - therapeutic use | Proprotein Convertase 9 - antagonists & inhibitors | Lipids - blood | Proprotein Convertase 9 - blood | Antibodies - blood | Cholesterol, LDL - blood | Female | Antibodies, Monoclonal, Humanized - immunology | Complications and side effects | Treatment outcome | Immune response | Patient outcomes | Analysis | Dosage and administration | Antilipemic agents | Lipoproteins (low density) | Hyperlipidemia | Clinical trials | Lipids | Subtilisin | Apolipoproteins | Patients | Low density lipoprotein | Cholesterol | Studies | Apolipoprotein B | Kexin | Monoclonal antibodies | Statins | Index Medicus | Abridged Index Medicus
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5. Full Text Effects of Torcetrapib in Patients at High Risk for Coronary Events
by Barter, Philip J and Caulfield, Mark and Eriksson, Mats and Grundy, Scott M and Kastelein, John J.P and Komajda, Michel and Lopez-Sendon, Jose and Mosca, Lori and Tardif, Jean-Claude and Waters, David D and Shear, Charles L and Revkin, James H and Buhr, Kevin A and Fisher, Marian R and Tall, Alan R and Brewer, Bryan and ILLUMINATE Investigators
The New England Journal of Medicine, ISSN 0028-4793, 11/2007, Volume 357, Issue 21, pp. 2109 - 2122
Torcetrapib, a cholesteryl ester transfer protein inhibitor, markedly raises levels of high-density lipoprotein cholesterol. Unexpectedly, in the ILLUMINATE... 
TARGET | MEDICINE, GENERAL & INTERNAL | ESTER TRANSFER PROTEIN | CARDIOVASCULAR-DISEASE | ATHEROSCLEROSIS | HDL-CHOLESTEROL | INHIBITOR | HIGH-DENSITY-LIPOPROTEIN | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Cardiovascular Diseases - drug therapy | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Male | Heptanoic Acids - adverse effects | Coronary Disease - mortality | Cardiovascular Diseases - mortality | Pyrroles - adverse effects | Cholesterol, LDL - blood | Female | Drug Therapy, Combination | Pyrroles - therapeutic use | Double-Blind Method | Mortality | Anticholesteremic Agents - adverse effects | Atorvastatin Calcium | Coronary Disease - prevention & control | Anticholesteremic Agents - therapeutic use | Cholesterol, HDL - blood | Aged | Cardiovascular Diseases - chemically induced | Quinolines - therapeutic use | Quinolines - adverse effects | Clinical trials | Cardiovascular disease | Side effects | Pharmacology | Inhibitor drugs | Cholesterol | Index Medicus | Abridged Index Medicus
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6. Full Text Effect of Torcetrapib on the Progression of Coronary Atherosclerosis
by Nissen, Steven E and Tardif, Jean-Claude and Nicholls, Stephen J and Revkin, James H and Shear, Charles L and Duggan, William T and Ruzyllo, Witold and Bachinsky, William B and Lasala, Gabriel P and Tuzcu, E. Murat and ILLUSTRATE Investigators
The New England Journal of Medicine, ISSN 0028-4793, 03/2007, Volume 356, Issue 13, pp. 1304 - 1316
In this 24-month clinical trial, torcetrapib, a cholesteryl ester transfer protein inhibitor, failed to cause regression of coronary atherosclerosis, as seen... 
MEDICINE, GENERAL & INTERNAL | ESTER TRANSFER PROTEIN | STATIN THERAPY | CHOLESTEROL LEVELS | CARDIOVASCULAR-DISEASE | INTRAVASCULAR ULTRASOUND | HDL CHOLESTEROL | GENE MUTATION | RANDOMIZED CONTROLLED-TRIAL | BLOOD-PRESSURE | HIGH-DENSITY-LIPOPROTEIN | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Prospective Studies | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Ultrasonography, Interventional | Male | Cholesterol Ester Transfer Proteins - adverse effects | Coronary Artery Disease - pathology | Adult | Cholesterol, LDL - blood | Female | Blood Pressure - drug effects | Drug Therapy, Combination | Pyrroles - therapeutic use | Double-Blind Method | Cholesterol, HDL - metabolism | Coronary Artery Disease - drug therapy | Anticholesteremic Agents - adverse effects | Disease Progression | Atorvastatin Calcium | Coronary Artery Disease - diagnostic imaging | Anticholesteremic Agents - therapeutic use | Cholesterol, HDL - blood | Aged | Cardiovascular Diseases - chemically induced | Quinolines - therapeutic use | Quinolines - adverse effects | Prevention | Causes of | Risk factors | Atherosclerosis | Lipoproteins | Ultrasonic imaging | Medical imaging | Clinical trials | Cardiovascular disease | Blood pressure | Cholesterol | Index Medicus | Abridged Index Medicus
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7. Full Text CSL112 Enhances Biomarkers of Reverse Cholesterol Transport After Single and Multiple Infusions in Healthy Subjects
by Gille, Andreas and Easton, Rachael and D’Andrea, Denise and Wright, Samuel D and Shear, Charles L
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2014, Volume 34, Issue 9, pp. 2106 - 2114
OBJECTIVE—The ability of apolipoprotein A-I (apoA-I) to transport cholesterol from atherosclerotic plaque is thought to underlie its inverse correlation with... 
reverse cholesterol transport | acute coronary syndrome | CSL112 | HUMAN ATHEROSCLEROTIC PLAQUE | ACUTE CORONARY SYNDROMES | APOA-I | MECHANISMS | RANDOMIZED CONTROLLED-TRIAL | FORMULATION | EFFLUX | THERAPY | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | CLINICAL-OUTCOMES | Cholesterol Esters - metabolism | Lipoproteins, HDL - administration & dosage | Lipoproteins, HDL - pharmacokinetics | Cholesterol - blood | Humans | Male | ATP Binding Cassette Transporter 1 - blood | Apolipoprotein A-I - metabolism | Lipoproteins, HDL - pharmacology | Dose-Response Relationship, Drug | Young Adult | Biological Transport | Biomarkers | Cholesterol, HDL - blood | Adult | Female | Infusions, Intravenous | Phosphatidylcholine-Sterol O-Acyltransferase - metabolism | Index Medicus
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