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Journal of Biological Chemistry, ISSN 0021-9258, 10/2006, Volume 281, Issue 42, p. 31279
γ-Secretase is one of the critical enzymes required for the generation of amyloid-β peptides from the β-amyloid precursor protein. Because amyloid-β... 
Journal Article
Journal of lipid research, ISSN 0022-2275, 12/2004, Volume 45, Issue 12, p. 2368
Presenilin-1 (PS1) is an important determinant of the gamma-secretase activity necessary for the generation of beta-amyloid (Abeta), likely the central... 
Endopeptidases - metabolism | Cricetinae | Oleic Acid - metabolism | Presenilin-1 | Animals | Cricetulus | Aspartic Acid Endopeptidases | Alzheimer Disease - metabolism | Amyloid Precursor Protein Secretases | Membrane Proteins - metabolism | Cholesterol - metabolism | CHO Cells
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2006, Volume 281, Issue 42, pp. 31279 - 31289
gamma -Secretase is one of the critical enzymes required for the generation of amyloid- beta peptides from the beta -amyloid precursor protein. Because... 
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 04/2010, Volume 20, Issue 7, pp. 2279 - 2282
The development of a novel series of purines as g-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein.... 
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2004, Volume 90, Issue 6, pp. 1312 - 1320
γ‐Secretase performs the final processing step in the generation of amyloid‐β (Aβ) peptides, which are believed to be causative for Alzheimer's disease.... 
γ‐secretase | site‐directed mutagenesis | Alzheimer's disease | aspartyl protease | presenilin | Presenilin | Aspartyl protease | γ-secretase | Site-directed mutagenesis | site-directed mutagenesis | ENDOPROTEOLYSIS | COMPLEX | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | gamma-secretase | NICASTRIN | TRANSMEMBRANE ASPARTATES | STATE | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | BETA-APP | PEN-2 | PRESENILIN-1 | Peptide Fragments | Conserved Sequence - physiology | Embryo, Mammalian | Humans | Substrate Specificity | Kidney | Aspartic Acid - genetics | Culture Media, Conditioned - analysis | Endopeptidases - chemistry | Transfection | Mutagenesis, Site-Directed - physiology | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides | Amyloid beta-Protein Precursor - metabolism | Binding Sites - physiology | Aspartic Acid Endopeptidases - pharmacology | Cell Membrane - metabolism | Binding Sites - drug effects | Cell Membrane - drug effects | Tyrosine - chemistry | Protein Structure, Tertiary | Cell Line | Detergents - pharmacology | Endopeptidases - metabolism | Blotting, Western - methods | Chromosomal Proteins, Non-Histone - metabolism | Enzyme Inhibitors - pharmacology | Enzyme Activation - drug effects | Protein Folding | Cholic Acids - pharmacology | Tyrosine - metabolism | Endopeptidases - genetics | Cell-Free System | Aspartic Acid - metabolism | Aspartic Acid - chemistry | Enzyme Activation - physiology | Chromosomal Proteins, Non-Histone - chemistry | Protein Binding - physiology | Tyrosine - genetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2004, Volume 279, Issue 42, p. 43419
γ-Secretase is a multi-component enzyme complex that performs an intramembranous cleavage, releasing amyloid-β (Aβ) peptides from processing intermediates... 
Journal Article
Alzheimer's & Dementia, ISSN 1552-5260, 07/2006, Volume 2, Issue 3, pp. S26 - S27
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2004, Volume 25, Issue 9, pp. 1175 - 1185
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 04/2006, Volume 16, Issue 8, pp. 2219 - 2223
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 8, pp. 2219 - 2223
The subtle modification of a selection of Aβ inhibiting non-steroidal anti-inflammatory drugs (NSAIDs), through synthesis of the geminal dimethyl derivatives,... 
Cyclooxygenase | Alzheimer’s disease
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2001, Volume 98, Issue 16, p. 9312
  In neuronal cells, presenilin-dependent gamma-secretase activity cleaves amyloid precursor proteins to release Abeta peptides, and also catalyzes the release... 
Proteins | Enzymes | Peptides | Neurons | Alzheimers disease
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2005, Volume 280, Issue 13, pp. 12523 - 12535
Presenilins appear to form the active center of gamma -secretase but require the presence of the integral membrane proteins nicastrin, anterior pharynx... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2005, Volume 280, Issue 13, p. 12523
Presenilins appear to form the active center of γ-secretase but require the presence of the integral membrane proteins nicastrin, anterior pharynx defective... 
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2006, Volume 2, Issue 3, pp. S26 - S27
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2003, Volume 278, Issue 15, p. 13077
The final step in Aβ generation is the cleavage of the C-terminal 99 amino acid residues of the amyloid precursor protein by γ-secretase. γ-Secretase... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2004, Volume 279, Issue 42, pp. 43419 - 43426
gamma-Secretase is a multi-component enzyme complex that performs an intramembranous cleavage, releasing amyloid-beta (Abeta) peptides from processing... 
Journal Article
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