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1. Full Text Comment
by Shedden, Kerby
Journal of the American Statistical Association, ISSN 0162-1459, 12/2013, Volume 108, Issue 504, pp. 1162 - 1163
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2. Full Text Comment
by Shedden, Kerby
Journal of the American Statistical Association, ISSN 0162-1459, 12/2013, Volume 108, Issue 504, pp. 1162 - 1163
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3. Full Text Comment
by Shedden, Kerby
Journal of the American Statistical Association, ISSN 0162-1459, 2013, Volume 108, Issue 504, pp. 1162 - 1163
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4. Full Text Comment
by Shedden, Kerby
Journal of the American Statistical Association, ISSN 0162-1459, 09/2011, Volume 106, Issue 495, pp. 796 - 797
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5. Full Text Comment
by Shedden, Kerby
Journal of the American Statistical Association, ISSN 0162-1459, 2011, Volume 106, Issue 495, pp. 796 - 797
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6. Full Text GAGE: Generally applicable gene set enrichment for pathway analysis
by Luo, Weijun and Friedman, Michael S and Shedden, Kerby and Hankenson, Kurt D and Woolf, Peter J
BMC Bioinformatics, ISSN 1471-2105, 05/2009, Volume 10, Issue 1, pp. 161 - 161
Background: Gene set analysis (GSA) is a widely used strategy for gene expression data analysis based on pathway knowledge. GSA focuses on sets of related... 
SURVIVAL | SIGNAL | STEM-CELLS | OSTEOBLAST DIFFERENTIATION | ADENOCARCINOMA | BIOCHEMICAL RESEARCH METHODS | PROTEIN-COUPLED RECEPTORS | LEVEL | EXPRESSION DATA | FALSE DISCOVERY RATE | LUNG-CANCER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | Lung Neoplasms - genetics | Reproducibility of Results | Oligonucleotide Array Sequence Analysis | Signal Transduction | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling - methods | Models, Statistical | Gene Regulatory Networks | Algorithms | Bone Morphogenetic Protein 6 - metabolism | Bone Morphogenetic Protein 6 - genetics | Computer Simulation | Sensitivity and Specificity | Software | Usage | DNA microarrays | Cellular signal transduction | Genetic aspects | Research | Gene expression | Applications software
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7. Full Text The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells
by Liu, Rui and Wang, Xinhao and Chen, Grace Y and Dalerba, Piero and Gurney, Austin and Hoey, Timothy and Sherlock, Gavin and Lewicki, John and Shedden, Kerby and Clarke, Michael F
The New England Journal of Medicine, ISSN 0028-4793, 01/2007, Volume 356, Issue 3, pp. 217 - 226
A small population of distinctive breast-cancer cells can recapitulate an entire breast cancer when injected into immunodeficient mice. These cells express a... 
SURVIVAL | MEDICINE, GENERAL & INTERNAL | METASTASIS | THERAPY | PATTERNS | IDENTIFICATION | EXPRESSION SIGNATURE | Lung Neoplasms - genetics | Prognosis | Oligonucleotide Array Sequence Analysis | Lung Neoplasms - mortality | Neoplasm Invasiveness | Humans | Hyaluronan Receptors | Male | Gene Expression Profiling | Medulloblastoma - mortality | Epithelium | Prostatic Neoplasms - mortality | CD24 Antigen | Neoplasm Metastasis | Breast Neoplasms - genetics | Prostatic Neoplasms - genetics | Breast Neoplasms - pathology | Breast Neoplasms - mortality | Female | Medulloblastoma - genetics | Breast - pathology | Breast cancer | Research | Cancer cells | Statistical analysis | Patients | Genes | Data bases
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8. Full Text Joint Mean and Covariance Estimation with Unreplicated Matrix-Variate Data
by Hornstein, Michael and Fan, Roger and Shedden, Kerby and Zhou, Shuheng
Journal of the American Statistical Association, ISSN 0162-1459, 04/2019, Volume 114, Issue 526, pp. 682 - 696
It has been proposed that complex populations, such as those that arise in genomics studies, may exhibit dependencies among observations as well as among... 
Graphical modeling | Generalized least squares | Sparsity | Two-group comparison | Genomics | FALSE DISCOVERY RATE | SET | GENE-EXPRESSION | SPARSE | STATISTICS & PROBABILITY | MODEL | SELECTION | Data analysis | Parameter estimation | Covariance | Dimensional analysis | Dependence | Gene expression | Statistical tests | Convergence
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9. Full Text Ontology-Based Combinatorial Comparative Analysis of Adverse Events Associated with Killed and Live Influenza Vaccines
by Sarntivijai, Sirarat and Xiang, Zuoshuang and Shedden, Kerby A and Markel, Howard and Omenn, Gilbert S and Athey, Brian D and He, Yongqun
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e49941
Vaccine adverse events (VAEs) are adverse bodily changes occurring after vaccination. Understanding the adverse event (AE) profiles is a crucial step to... 
UNITED-STATES | MORTALITY | SIGNAL GENERATION | SAFETY | MULTIDISCIPLINARY SCIENCES | GUILLAIN-BARRE-SYNDROME | REPORTING-SYSTEM VAERS | VACCINATION | CASE-SERIES | H1N1 | CHILDHOOD | Vaccines, Inactivated - adverse effects | Vaccines, Attenuated - adverse effects | Influenza, Human - prevention & control | Humans | Influenza Vaccines - adverse effects | Influenza vaccines | Medicine, Experimental | Medical research | Influenza | Vaccination | Enrichment | Immunization | Ontology | Guillain-Barre syndrome | Disorders | Data processing | Inflammatory response | Inflammation | Vaccines | Statistical tests | Patients | Respiratory system | Swine flu | Classification | Paralysis | Comparative analysis | Bioinformatics | Combinatorial analysis | Movement disorders
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10. Full Text Finite Mixture Modeling with Mixture Outcomes Using the EM Algorithm
by Muthen B and Shedden K
Biometrics, ISSN 0006-341X, 06/1999, Volume 55, Issue 2, pp. 463 - 469
This paper discusses the analysis of an extended finite mixture model where the latent classes corresponding to the mixture components for one set of observed... 
Latent variables | Growth modeling | Maximum likelihood | Latent class analysis | Trajectory classes | Logistic regression | Analytical estimating | Alcohol drinking | Trajectories | Standard error | Parametric models | Modeling | Covariance matrices | Alcohols | Normativity | MATHEMATICS, APPLIED | latent variables | maximum likelihood | STATISTICS & PROBABILITY | latent class analysis | trajectory classes | growth modeling | BIOLOGY, MISCELLANEOUS | Likelihood Functions | Algorithms | Alcoholism - etiology | Humans | Adolescent | Adult | Female | Male | Models, Statistical | Alcohol Drinking - adverse effects | Biometry
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11. Full Text The high burden of alcoholic cirrhosis in privately insured persons in the United States
by Mellinger, Jessica L and Shedden, Kerby and Winder, Gerald Scott and Tapper, Elliot and Adams, Megan and Fontana, Robert J and Volk, Michael L and Blow, Frederic C and Lok, Anna S.F
Hepatology, ISSN 0270-9139, 09/2018, Volume 68, Issue 3, pp. 872 - 882
Alcoholic cirrhosis (AC) is a major cause of liver‐related morbidity and mortality in the United States. Rising rates of alcohol use disorders in the United... 
GLOBAL BURDEN | HEPATOCELLULAR-CARCINOMA | VIRUS-INFECTION | NATIONAL EPIDEMIOLOGIC SURVEY | USE DISORDER | HEALTH-CARE | PREVALENCE | LIVER-DISEASE | CLINICAL-COURSE | GASTROENTEROLOGY & HEPATOLOGY | VIRAL-HEPATITIS | Hypertension | Cirrhosis | Liver diseases | Diagnosis | Morbidity | Alcohol use
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12. Full Text Cost considerations for efficient group testing studies
by Huang, Shih-Hao and Huang, Mong-Na Lo and Shedden, Kerby
Statistica Sinica, ISSN 1017-0405, 2020
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13. Full Text Cell-intrinsic determinants of ibrutinib-induced apoptosis in chronic lymphocytic leukemia
by Amin, Nisar A and Balasubramanian, Sriram and Saiya-Cork, Kamlai and Shedden, Kerby and Hu, Nan and Malek, Sami N
Clinical Cancer Research, ISSN 1078-0432, 02/2017, Volume 23, Issue 4, pp. 1049 - 1059
Purpose: Ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, is approved for the treatment of relapsed chronic lymphocytic leukemia (CLL) and CLL with del17p.... 
BTK INHIBITOR IBRUTINIB | ONCOLOGY | PHASE 1B/2 | THERAPEUTIC TARGET | IN-VIVO | PCI-32765 | FOLLOW-UP | RECEPTOR | CLONAL EVOLUTION | MUTATIONS | SINGLE-ARM | Apoptosis - drug effects | Pyrimidines - administration & dosage | Humans | Biomarkers, Pharmacological | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Tumor Suppressor Protein p53 - genetics | Whole Exome Sequencing | Drug Resistance, Neoplasm - genetics | Pyrazoles - administration & dosage | Pyrimidines - adverse effects | Female | Polymorphism, Single Nucleotide | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Pyrazoles - adverse effects | Tyrosine | Trisomy | Chronic lymphatic leukemia | Leukemia | p53 Protein | Immunoblotting | ZAP-70 protein | Lymphatic leukemia | B-cell receptor | Resistance factors | Bruton's tyrosine kinase | Signaling | Sensitivity | Chemotherapy | Lymphocytes B | Experimental design | Cell lines | Mutation | Protein-tyrosine kinase | Cancer | Apoptosis | apoptosis | CLL | TP53 mutations | del17p | Ibrutinib
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14. Full Text Analysis of cell-cyle gene expression in Saccharomyces cerevisiae using microarrays and multiple synchronization methods
by Shedden, Kerby and Cooper, Stephen
Nucleic Acids Research, ISSN 0305-1048, 07/2002, Volume 30, Issue 13, pp. 2920 - 2929
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15. Full Text Comparison of the Effectiveness of Radiofrequency Ablation With Stereotactic Body Radiation Therapy in Inoperable Stage I Non-Small Cell Lung Cancer: A Systemic Review and Pooled Analysis
by Bi, Nan, MD, PhD and Shedden, Kerby, PhD and Zheng, Xiangpeng, MD and Kong, Feng-Ming (Spring), MD, PhD, FACR
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2016, Volume 95, Issue 5, pp. 1378 - 1390
Purpose To performed a systematic review and pooled analysis to compare clinical outcomes of stereotactic body radiation therapy (SBRT) and radiofrequency... 
Radiology | Hematology, Oncology and Palliative Medicine | 4 FRACTIONS | TRIAL | HIGH-RISK PATIENTS | ONCOLOGY | INTENTION-TO-TREAT | PROSPECTIVE PHASE-II | DOSE IRRADIATION | EXPERIENCE | HYPOFRACTIONATED RADIOTHERAPY | TUMORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CLINICAL-OUTCOMES | Catheter Ablation - mortality | Catheter Ablation - statistics & numerical data | Prevalence | Lung Neoplasms - mortality | Humans | Middle Aged | Postoperative Complications - prevention & control | Male | Carcinoma, Non-Small-Cell Lung - diagnosis | Radiosurgery - statistics & numerical data | Postoperative Complications - mortality | Radiation Pneumonitis - prevention & control | Radiation Pneumonitis - mortality | Radiation Injuries | Aged, 80 and over | Female | Risk Factors | Survival Rate | Treatment Outcome | Lung Neoplasms - therapy | Carcinoma, Non-Small-Cell Lung - mortality | Carcinoma, Non-Small-Cell Lung - therapy | Aged | Radiosurgery - mortality | Lung Neoplasms - diagnosis | Longitudinal Studies | Medical colleges | Ablation (Surgery) | Radiation | Lung cancer, Small cell | Comparative analysis | Radiotherapy | Lung cancer, Non-small cell | Medical research | Analysis | Medicine, Experimental | REVIEWS | PATIENTS | NEOPLASMS | LUNGS | RADIOLOGY AND NUCLEAR MEDICINE | ABLATION | REGRESSION ANALYSIS | RADIOTHERAPY | LOAD COLLECTOR RATIO | RADIOWAVE RADIATION | Radiofrequency ablation | Stage I | Stereotactic body radiation therapy | Non-small cell lung cancer | Medically inoperable
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16. Full Text The respiratory microbiome and susceptibility to influenza virus infection
by Lee, Kyu Han and Gordon, Aubree and Shedden, Kerby and Kuan, Guillermina and Ng, Sophia and Balmaseda, Angel and Foxman, Betsy
PLoS ONE, ISSN 1932-6203, 01/2019, Volume 14, Issue 1, p. e0207898
Influenza is a major cause of morbidity and mortality worldwide. However, vaccine effectiveness has been low to moderate in recent years and vaccine coverage... 
MULTIDISCIPLINARY SCIENCES | RHINOVIRUS | INFANTS | NASOPHARYNGEAL PNEUMOCOCCAL DENSITY | SYNCYTIAL VIRUS | SEVERITY | CHILDREN | Prevention | Influenza vaccines | Usage | Microbiota (Symbiotic organisms) | Influenza | Physiological aspects | Development and progression | Research | Risk factors | Microbial activity | Pneumonia | Communities | Taxonomy | Microbiomes | Ear diseases | Viruses | Systematic review | Infections | Vaccines | Epidemiology | Immunity | Streptococcus infections | Respiratory tract | Microbiota | Microorganisms | Throats | Nose | Children | Public health | Community structure | Young adults | Households | Epithelium | Pharynx | Morbidity | Studies | Antibiotics | Relative abundance | Adults
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17. Full Text Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease
by Fukuda, Akihiro and Wickman, Larysa T and Venkatareddy, Madhusudan P and Sato, Yuji and Chowdhury, Mahboob A and Wang, Su Q and Shedden, Kerby A and Dysko, Robert C and Wiggins, Jocelyn E and Wiggins, Roger C
Kidney International, ISSN 0085-2538, 01/2012, Volume 81, Issue 1, pp. 40 - 55
Podocyte depletion is a major mechanism driving glomerulosclerosis. Progression is the process by which progressive glomerulosclerosis leads to end stage... 
glomerulosclerosis | proteinuria | renin–angiotensin system | podocyte | renin-angiotensin system | MESSENGER-RNA EXPRESSION | VIABLE PODOCYTES | URINARY-EXCRETION | HUMAN DIABETIC-NEPHROPATHY | RENAL-DISEASE | RECEPTOR BLOCKER | ACQUIRED PROTEINURIC DISEASES | HIV-ASSOCIATED NEPHROPATHY | UROLOGY & NEPHROLOGY | NEPHRIN EXPRESSION | FOCAL SEGMENTAL GLOMERULOSCLEROSIS | Antihypertensive Agents - pharmacology | Podocytes - metabolism | Angiotensin II - metabolism | Rats, Transgenic | Membrane Proteins - genetics | Humans | Kidney Failure, Chronic - drug therapy | RNA, Messenger - genetics | Rats, Inbred F344 | Angiotensin II - antagonists & inhibitors | Rats | Male | Kidney Glomerulus - pathology | Podocytes - pathology | RNA, Messenger - metabolism | Rats, Sprague-Dawley | Kidney Failure, Chronic - metabolism | Kidney Failure, Chronic - genetics | Animals | Podocytes - drug effects | Kidney Failure, Chronic - pathology | Kidney Glomerulus - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Disease Models, Animal
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18. Full Text Distribution and outcomes of infection of Mycobacterium avium complex species in cystic fibrosis
by Azar, Michelle and Zimbric, Madsen and Shedden, Kerby and Caverly, Lindsay J
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, ISSN 1569-1993, 08/2019
The majority of nontuberculous mycobacterial (NTM) pulmonary infections in people with cystic fibrosis (CF) are caused by Mycobacterium avium complex (MAC)... 
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19. Full Text An Expandable Mechanopharmaceutical Device (3): a Versatile Raman Spectral Cytometry Approach to Study the Drug Cargo Capacity of Individual Macrophages
by LaLone, Vernon and LaLone, Vernon and Mourão, Márcio A and Mourão, Márcio A and Standiford, Theodore J and Standiford, Theodore J and Raghavendran, Krishnan and Raghavendran, Krishnan and Shedden, Kerby and Shedden, Kerby and Stringer, Kathleen A and Stringer, Kathleen A and Rosania, Gus R and Rosania, Gus R
Pharmaceutical Research, ISSN 0724-8741, 1/2019, Volume 36, Issue 1, pp. 1 - 11
To improve cytometric phenotyping abilities and better understand cell populations with high interindividual variability, a novel Raman-based microanalysis was... 
Biochemistry, general | Biomedicine | lipid-laden foamy macrophages | Pharmacy | intracellular drug bioaccumulation | Medical Law | confocal Raman microscopy | pulmonary alveolar macrophages | Pharmacology/Toxicology | Biomedical Engineering and Bioengineering | single-cell chemical imaging | CELLS | PULMONARY TOXICITY | COMPONENT ANALYSIS | MICROSPECTROSCOPY | CHEMISTRY, MULTIDISCIPLINARY | AMINE-CONTAINING DRUGS | INDUCED PHOSPHOLIPIDOSIS | SPECTROSCOPY | SCATTERING MICROSCOPY | IN-VIVO | ALVEOLAR MACROPHAGES | PHARMACOLOGY & PHARMACY | Macrophages | Algorithms | Drug discovery | Populations | Chloroquine | Feasibility studies | Data processing | Lipids | Organic chemistry | Cytometry | Toxicology | Cargo capacity | Phase separation | Phenotyping | Signal processing | Biomolecules | Chemical composition | Intracellular | Alveoli | Content analysis
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