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Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2016, Volume 374, Issue 4, pp. 311 - 322
An oral inhibitor of BCL2 produces substantial responses in the majority of patients with refractory chronic lymphocytic leukemia. The agent is so effective... 
DOSE-ESCALATION | APOPTOSIS | MEDICINE, GENERAL & INTERNAL | CLL | INTERNATIONAL WORKSHOP | CYCLOPHOSPHAMIDE | RITUXIMAB | IBRUTINIB | INHIBITOR | PHASE-I | FLUDARABINE | Recurrence | Humans | Middle Aged | Male | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Antineoplastic Agents - administration & dosage | Remission Induction | Sulfonamides - pharmacokinetics | Dose-Response Relationship, Drug | Disease-Free Survival | Bridged Bicyclo Compounds, Heterocyclic - adverse effects | Tumor Lysis Syndrome - etiology | Antineoplastic Agents - adverse effects | Aged, 80 and over | Sulfonamides - adverse effects | Adult | Female | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aged | Antineoplastic Agents - pharmacokinetics | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Sulfonamides - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics | Antimitotic agents | Treatment outcome | Care and treatment | Usage | Safety and security measures | Lymphocytic leukemia | Analysis | Clinical trials | Dosage and administration | Antineoplastic agents | Pharmacokinetics | Risk factors | Flow cytometry | Chronic lymphatic leukemia | Cell survival | Leukemia | Minimal residual disease | Diarrhea | Chromosome deletion | Nausea | Lymphatic leukemia | Lymphoma | Patients | Proteins | Chemotherapy | Fludarabine | Clonal deletion | Lysis | Respiratory tract diseases | Lymphomas | Chromosome 17 | Neutropenia | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 11/2016, Volume 56, Issue 11, pp. 1335 - 1343
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 10/2016, Volume 78, Issue 4, pp. 847 - 853
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 04/2017, Volume 83, Issue 4, pp. 846 - 854
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 2008, Volume 47, Issue 11, pp. 753 - 764
Background: Recombinant methionyl human leptin (r-metHuLeptin) has demonstrated efficacy in improving hormonal and metabolic parameters in leptin-deficient... 
Adipokines, pharmacokinetics | Gender differences | Fasting | Metreleptin, pharmacokinetics | Research and development | Weight loss | WOMEN | THERAPY | METABOLISM | KINETICS | IN-VIVO | NEUROENDOCRINE | WEIGHT-LOSS | PHARMACOLOGY & PHARMACY | STARVATION | OBESE | KIDNEY
Journal Article
Journal Article